Abstract:
:Evidence indicates that neural stem cells (NSCs) can ameliorate cerebral ischemia in animal models. In this study, we investigated the mechanism underlying one of the neuroprotective effects of NSCs: tunneling nanotube (TNT) formation. We addressed whether the control of cell-to-cell communication processes between NSCs and brain microvascular endothelial cells (BMECs) and, particularly, the control of TNT formation could influence the rescue function of stem cells. In an attempt to mimic the cellular microenvironment in vitro, a co-culture system consisting of terminally differentiated BMECs from mice in a distressed state and NSCs was constructed. Additionally, engraftment experiments with infarcted mouse brains revealed that control of TNT formation influenced the effects of stem cell transplantation in vivo. In conclusion, our findings provide the first evidence that TNTs exist between NSCs and BMECs and that regulation of TNT formation alters cell function.
journal_name
Mol Neurobioljournal_title
Molecular neurobiologyauthors
Wang X,Yu X,Xie C,Tan Z,Tian Q,Zhu D,Liu M,Guan Ydoi
10.1007/s12035-015-9225-zsubject
Has Abstractpub_date
2016-05-01 00:00:00pages
2480-8issue
4eissn
0893-7648issn
1559-1182pii
10.1007/s12035-015-9225-zjournal_volume
53pub_type
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