Abstract：
:Recent progress in molecular biology has markedly expanded our knowledge of the molecular mechanism behind the proliferation and differentiation processes of Schwann cells, the myelin-forming cells in peripheral nervous systems. Intracellular signaling molecules participate in integrating various stimuli from cytokines and other humoral factors and control the transcriptional activities of the genes that regulate mitosis or differentiation. This article provides an overview of the roles played by the intracellular pathways regulating Schwann cell functions. In Schwann cell proliferation, cyclic adenosine monophosphate signals and mitogen-activated protein kinase pathways play pivotal roles and may also interact with each other. Regarding differentiation, myelin formation is regulated by various cytokines and extracellular matrix molecules. Specifically, platelet-derived growth factor, neuregulin, and insulin-like growth factor-I all are classified as ligands for receptor-type tyrosine kinase and activate common intracellular signaling cascades, mitogen-activated protein kinase pathways, and phosphatidylinositol-3-kinase pathways. The balance of activities between these two pathways appears crucial in regulating Schwann cell differentiation, in which phosphatidylinositol-3-kinase pathways promote myelin formation. Analysis of these signaling molecules in Schwann cells will enable us not only to understand their physiological development but also to innovate new approaches to treat disorders related to myelination.
journal_name
Mol Neurobioljournal_title
Molecular neurobiologyauthors
Ogata T,Yamamoto S,Nakamura K,Tanaka Sdoi
10.1385/mn:33:1:051subject
Has Abstractpub_date
2006-02-01 00:00:00pages
51-62issue
1eissn
0893-7648issn
1559-1182pii
MN:33:1:051journal_volume
33pub_type
杂志文章,评审abstract：:Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) and the BK channel are enriched at the presynaptic nerve terminal, where CaMKII associates with synaptic vesicles whereas the BK channel colocalizes with voltage-sensitive Ca(2+) channels in the plasma membrane. Mounting evidence suggests that these two proteins p...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s12035-008-8039-7
更新日期：2008-10-01 00:00:00
abstract：:Hippocampus-dependent memories, such as social recognition (SRM), are modulated by neurogenesis. However, the precise role of newborn neurons in social memory processing is still unknown. We showed previously that 1 week of enriched environment (EE) is sufficient to increase neurogenesis in the hippocampus (HIP) and t...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-016-9922-2
更新日期：2017-07-01 00:00:00
abstract：:Amyloid-β oligomers (AβOs) toxicity causes mitochondrial dysfunction, leading to synaptic failure in Alzheimer's disease (AD). Considering presynaptic high energy demand and tight Ca2+ regulation, impairment of mitochondrial function can lead to deteriorated neural activity and cell death. In this study, an AD mouse m...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-020-02064-4
更新日期：2020-11-01 00:00:00
abstract：:Astroglial scaring and limited neurogenesis are two problematic issues in recovery of spinal cord injury (SCI). In the meantime, it seems that mechanical manipulations of scaffold to inhibit astroglial scarring and improve neurogenesis is worthy of value. In the present investigation, the effect of nanofiber (gel) con...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-016-9836-z
更新日期：2017-05-01 00:00:00
abstract：:The limited capacity for the central nervous system (CNS) to repair itself was first described over 100 years ago by Spanish neuroscientist Ramon Y. Cajal. However, the exact mechanisms underlying this failure in neuronal regeneration remain unclear and, as such, no effective therapeutics yet exist. Numerous studies h...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s12035-017-0433-6
更新日期：2018-03-01 00:00:00
abstract：:Angelman syndrome (AS) is a neurodevelopmental disorder largely caused by the loss of function of maternally inherited UBE3A. UBE3A-maternal deficient mice (AS mice) exhibit many typical features of AS including cognitive and motor deficits but the underlying mechanism of these behavioral abnormalities is poorly under...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-016-0080-3
更新日期：2017-09-01 00:00:00
abstract：:Fatty acid-binding proteins (FABPs) bind and internalize long-chain fatty acids, controlling lipid dynamics. Recent studies have proposed the involvement of FABPs, particularly FABP7, in lipid droplet (LD) formation in glioma, but the physiological significance of LDs is poorly understood. In this study, we sought to ...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-019-1489-2
更新日期：2019-08-01 00:00:00
abstract：:The administration of the anorexigenic drug d,l-fenfluramine (Ponderax) to laboratory animals results in a dose-dependent reduction in presynaptically located serotonergic reuptake transporter protein. This long-term effect may represent an altered mechanism of synthesis of the transporter (downregulation). Alternativ...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/BF02740693
更新日期：1995-08-01 00:00:00
abstract：:Rotenone, a pesticide, causes neurotoxicity via the mitochondrial complex-I inhibition. The present study was conducted to evaluate the role of endoplasmic reticulum (ER) stress in rotenone-induced neuronal death. Cell viability, cytotoxicity, reactive oxygen species (ROS) generation, nitrite level, mitochondrial memb...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-014-9001-5
更新日期：2016-01-01 00:00:00
abstract：:The endocannabinoid system (ECS) actively participates in several physiological processes within the central nervous system. Among such, its involvement in the downregulation of the N-methyl-D-aspartate receptor (NMDAr) through a modulatory input at the cannabinoid receptors (CBr) has been established. After its produ...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-018-1129-2
更新日期：2019-02-01 00:00:00
abstract：:The complement component (3b/4b) receptor 1 gene (CR1) is considered as one of the most important genetic susceptibility loci in Alzheimer's disease (AD). However, to date, few studies were performed to discover the possible effect of CR1 genetic variants on AD pathology in the brain. Here, we evaluated the potential ...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-015-9638-8
更新日期：2017-01-01 00:00:00
abstract：:α-Synuclein (α-syn) has been recognized to induce neuroinflammation and to disturb nerve repair process in Parkinson's disease. However, the potential mechanisms underlying α-syn-induced impairment of adult neurogenesis remain unclear. In the present study, A53T mutant α--synuclein transgenic (A53Ttg/tg) mice, caspase...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-015-9620-5
更新日期：2016-12-01 00:00:00
abstract：:YKL-40 is the most highly expressed gene in glioblastoma compared with normal brain tissues. Previous studies assessing the association between YKL-40 and survival in glioblastoma patients reported varying magnitude of estimates. The objective of this meta-analysis was to determine the prognostic value of YKL-40 in gl...
journal_title：Molecular neurobiology
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s12035-016-9878-2
更新日期：2017-07-01 00:00:00
abstract：:The NMDA receptor, which is heavily involved in several human brain diseases, is a heteromeric ligand-gated ion channel that interacts with multiple intracellular proteins through the C-termini of different subunits. GluN2A and GluN2B are the two primary types of GluN2 subunits in the forebrain. During the development...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s12035-016-9715-7
更新日期：2017-03-01 00:00:00
abstract：:Major advances in the identification of genes expressed in malformation-associated epileptic disorders have been made. Some of these changes reflect the complex gene interactions necessary for proper neurodevelopment, whereas others suggest specific synaptic aberrations that could result in a hyperexcitable, and ultim...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1385/MN:26:1:109
更新日期：2002-08-01 00:00:00
abstract：:Epidemiological, population-based case-control, and experimental studies at the molecular, cellular, and organism levels revealed that exposure to various environmental agents, including a number of structurally different agrochemicals, may contribute to the pathogenesis of Parkinson's disease (PD) and several other n...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s12035-012-8333-2
更新日期：2013-04-01 00:00:00
abstract：:The signaling cascades triggered by neurotrophins such as BDNF and by several neurotransmitters and hormones lead to the rapid induction of gene transcription by increasing the intracellular concentration of cAMP and Ca2+. This review examines the mechanisms by which these second messengers control transcriptional ini...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1385/MN:30:1:091
更新日期：2004-08-01 00:00:00
abstract：:Early life stress is considered a risk factor for the development of long-term psychiatric disorders. Maternal deprivation (MD) is a useful paradigm to understand the neurobiological underpinnings of early stress-induced changes in neurodevelopment trajectory. The goal of the present study was to examine the effects o...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-020-02164-1
更新日期：2020-10-15 00:00:00
abstract：:Alzheimer's disease (AD) is an age-related neurodegenerative disorder characterized by intelligence decline, behavioral disorders and cognitive disability. The purpose of this study was to investigate gene expression in AD, based on published microarray data on Tg2576 mice. Hierarchical Cluster Analysis and Gene Ontol...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-012-8384-4
更新日期：2013-06-01 00:00:00
abstract：:Neuroblastoma (NB) is an extracranial solid cancer and the most common cancer in infancy. Despite the standard treatment for NB is based on the combination of chemotherapeutic drugs such as doxorubicin, vincristine, cyclophosphamide, and cisplatin, chemoresistance occurs over the time. The aim of the present research ...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-017-0575-6
更新日期：2018-04-01 00:00:00
abstract：:Thyroid hormone plays an important role in central nervous system (CNS) development, including the myelination of variable axonal calibers. It is well-established that thyroid hormone is required for the terminal differentiation of oligodendrocyte precursor cells (OPCs) into myelinating oligodendrocytes by inducing ra...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s12035-016-0013-1
更新日期：2016-11-01 00:00:00
abstract：:Clinical studies demonstrated a positive correlation between hypertension and cognitive decline. Beneficial effects of angiotensin II receptor blockers on cognitive functions have also been reported earlier; however, its role in chronic neuroinflammation-induced memory impairment in the hypertensive state is not well ...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-017-0450-5
更新日期：2018-02-01 00:00:00
abstract：:Although neurons in the adult mammalian CNS are inherently incapable of regeneration after injury, we previously showed that exogenous delivery of pigment epithelium-derived factor (PEDF), a 50-kDa neurotrophic factor (NTF), promoted adult retinal ganglion cell neuroprotection and axon regeneration. Here, we show that...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-019-1614-2
更新日期：2019-11-01 00:00:00
abstract：:A large body of evidences indicates that axonal transport (AT) defects play an important role in the pathogenesis of Alzheimer' disease (AD). AT, a critical cellular process for the maintenance and function of a neuron, requires components of the cytoskeletons as "tracks", motor proteins and ATP as "driving force", ad...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s12035-014-8810-x
更新日期：2015-01-01 00:00:00
abstract：:B-50 (GAP-43) is an axonal, plasma membrane-associated protein involved in growth cone morphology and function. We have conducted immunocytochemical, electron microscopic, and time-lapse experiments to visualize morphological consequences of local accumulations of B-50 at the plasma membrane of B-50-transfected PC-B2 ...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/BF02741362
更新日期：1999-08-01 00:00:00
abstract：:Physiological mechanisms of neuronal information processing have been shaped during evolution by a continual interplay between organisms and their sensory surroundings. Thus, when asking for the functional significance of such mechanisms, the natural conditions under which they operate must be considered. This has bee...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1385/MN:27:1:13
更新日期：2003-02-01 00:00:00
abstract：:Mutations in TAR DNA-binding protein 43 (TDP-43) are associated with familial forms of amyotrophic lateral sclerosis (ALS), while wild-type TDP-43 is a pathological hallmark of patients with sporadic ALS and frontotemporal lobar degeneration (FTLD). Various in vitro and in vivo studies have also demonstrated toxicity ...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-013-8427-5
更新日期：2013-08-01 00:00:00
abstract：:Stromal cell-derived factor-1 alpha (SDF-1a) or CXCL12 is an important cytokine with multiple functions in the brain during development and in adulthood. The inflammatory response initiated by spinal cord injury (SCI) involves the processing of interleukin-1beta (IL-1ß) and IL-18 mediated by caspase-1 which is under t...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-015-9203-5
更新日期：2016-07-01 00:00:00
abstract：:Five-prime repressor element under dual repression binding protein-1 (Freud-1)/CC2D1A is genetically linked to intellectual disability and implicated in neuronal development. Freud-1 represses the serotonin-1A (5-HT1A) receptor gene HTR1A by histone deacetylase (HDAC)-dependent or HDAC-independent mechanisms in 5-HT1A...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-016-0306-4
更新日期：2017-12-01 00:00:00
abstract：:Parkinson's disease and dementia with Lewy bodies are major challenges in research and clinical medicine world-wide and contribute to the most common neurodegenerative disorders. Previously, specific mitochondrial polymorphisms have been found to enhance clearance of amyloid-β from the brain of APP-transgenic mice lea...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-015-9399-4
更新日期：2016-09-01 00:00:00
