The Pharmacological Inhibition of Fatty Acid Amide Hydrolase Prevents Excitotoxic Damage in the Rat Striatum: Possible Involvement of CB1 Receptors Regulation.

abstract：:Specific variations in the amino acid sequence of prion protein (PrP) are key determinants of susceptibility to prion diseases. We previously showed that an amino acid substitution specific to canids confers resistance to prion diseases when expressed in mice and demonstrated its dominant-negative protective effect ag...

journal_title：Molecular neurobiology

authors： Otero A,Hedman C,Fernández-Borges N,Eraña H,Marín B,Monzón M,Sánchez-Martín MA,Nonno R,Badiola JJ,Bolea R,Castilla J

更新日期：2019-09-01 00:00:00

abstract：:Cerebellar degeneration is a devastating manifestation of cerebellar-type multiple-system atrophy (MSA), a rapidly progressive neurodegenerative disease, and the exact pathogenesis is unknown. Here, we examined the expression of micro-RNAs (miRNAs), which are short noncoding RNAs, in the cerebellum of MSA and the key ...

journal_title：Molecular neurobiology

authors： Lee ST,Chu K,Jung KH,Ban JJ,Im WS,Jo HY,Park JH,Lim JY,Shin JW,Moon J,Lee SK,Kim M,Roh JK

更新日期：2015-02-01 00:00:00

abstract：:Maternal hypothyroxinemia can induce neurodevelopmental impairments in the developing fetus. We here review recent studies on the epidemiology and molecular mechanisms associated with this important public health issue. In 2011, the American Thyroid Association defined maternal hypothyroxinemia as low serum free thyro...

journal_title：Molecular neurobiology

authors： Min H,Dong J,Wang Y,Wang Y,Teng W,Xi Q,Chen J

更新日期：2016-04-01 00:00:00

abstract：:Methylmercury (MeHg) is an extremely dangerous environmental pollutant that induces severe toxic effects in the central nervous system. Neuronal damage plays critical roles mediating MeHg-induced loss of brain function and neurotoxicity. The molecular mechanisms of MeHg neurotoxicity are incompletely understood. The o...

journal_title：Molecular neurobiology

authors： Liu W,Xu Z,Yang T,Xu B,Deng Y,Feng S

更新日期：2017-09-01 00:00:00

abstract：:Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental condition with unknown etiology. Recent experimental evidences suggest the contribution of non-coding RNAs (ncRNAs) in the pathophysiology of ASD. In this work, we aimed to investigate the expression profile of the ncRNA class of circular RNAs (circR...

journal_title：Molecular neurobiology

authors： Gasparini S,Del Vecchio G,Gioiosa S,Flati T,Castrignano T,Legnini I,Licursi V,Ricceri L,Scattoni ML,Rinaldi A,Presutti C,Mannironi C

更新日期：2020-05-01 00:00:00

abstract：:Stress, unaccompanied by signs of post-traumatic stress disorder, is known to decrease grey matter volume (GMV) in the anterior cingulate cortex (ACC) and hippocampus but not the amygdala in humans. We sought to determine if this was the case in stressed mice using high-resolution magnetic resonance imaging (MRI) and ...

journal_title：Molecular neurobiology

authors： Kassem MS,Lagopoulos J,Stait-Gardner T,Price WS,Chohan TW,Arnold JC,Hatton SN,Bennett MR

更新日期：2013-04-01 00:00:00

abstract：:Melanocortins are peptides with well-recognized antiinflammatory and neuroprotective activity. No data are currently available on melanocortin receptor-4 (MC4R) gene polymorphisms and tumors, including glioblastomas (GBMs), or their relationship with radiotherapy or chemotherapy. The aim of this study was to evaluate ...

journal_title：Molecular neurobiology

authors： Pasqualetti F,Orlandi P,Simeon V,Cantarella M,Giuliani D,Di Desidero T,Gonnelli A,Delishaj D,Lombardi G,Sechi A,Sanson M,Zagonel V,Paiar F,Danesi R,Guarini S,Bocci G

更新日期：2018-02-01 00:00:00

abstract：:Linoleic acid (LA, 18:2n-6) is a precursor to arachidonic acid (AA, 20:4n-6), which can be converted by brain lipoxygenase and cyclooxygenase (COX) enzymes into various lipid mediators involved in the regulation of brain immunity. Brain AA metabolism is activated in rodents by the bacterial endotoxin, lipopolysacchari...

journal_title：Molecular neurobiology

authors： Taha AY,Blanchard HC,Cheon Y,Ramadan E,Chen M,Chang L,Rapoport SI

更新日期：2017-08-01 00:00:00

abstract：:The complement component (3b/4b) receptor 1 gene (CR1) is considered as one of the most important genetic susceptibility loci in Alzheimer's disease (AD). However, to date, few studies were performed to discover the possible effect of CR1 genetic variants on AD pathology in the brain. Here, we evaluated the potential ...

journal_title：Molecular neurobiology

authors： Zhu XC,Wang HF,Jiang T,Lu H,Tan MS,Tan CC,Tan L,Tan L,Yu JT,Alzheimer’s Disease Neuroimaging Initiative.

更新日期：2017-01-01 00:00:00

abstract：:Microglia, the resident macrophages of the central nervous system, rapidly activate in nearly all kinds of neurological diseases. These activated microglia become highly motile, secreting inflammatory cytokines, migrating to the lesion area, and phagocytosing cell debris or damaged neurons. During the past decades, th...

journal_title：Molecular neurobiology

authors： Fu R,Shen Q,Xu P,Luo JJ,Tang Y

更新日期：2014-06-01 00:00:00

abstract：:Neuronal differentiation plays a key role during embryogenesis. However, based on the capacity of neuronal stem cells to either generate or regenerate neurons and because differentiation stops aberrant neuroblasts proliferation, neuronal differentiation is crucial during neuropathological conditions. Although phosphat...

journal_title：Molecular neurobiology

authors： Paoletti L,Domizi P,Marcucci H,Montaner A,Krapf D,Salvador G,Banchio C

更新日期：2016-11-01 00:00:00

abstract：:Nuclear factor erythroid 2-related factor 2 (Nrf2) is a neuroprotective transcription factor that has recently attracted increased attention. Stroke, a common and serious neurological disease, is currently a leading cause of death in the USA so far. It is therefore of vital importance to explore how Nrf2 behaves in st...

journal_title：Molecular neurobiology

authors： Jiang S,Deng C,Lv J,Fan C,Hu W,Di S,Yan X,Ma Z,Liang Z,Yang Y

更新日期：2017-03-01 00:00:00

abstract：:Glycine is a major inhibitory neurotransmitter in the spinal cord and brainstem of vertebrates. Glycine is accumulated into synaptic vesicles by a proton-coupled transport system and released to the synaptic cleft after depolarization of the presynaptic terminal. The inhibitory action of glycine is mediated by pentame...

journal_title：Molecular neurobiology

authors： Zafra F,Aragón C,Giménez C

更新日期：1997-06-01 00:00:00

abstract：:Hyperpalatable diets (HP) impair brain metabolism, and regular physical exercise has an apparent opposite effect. Here, we combined a prior long-term exposure to HP diet followed by physical exercise and evaluated the impact on some neuroenergetic components and on cognitive performance. We assessed the extracellular ...

journal_title：Molecular neurobiology

authors： Portela LV,Brochier AW,Haas CB,de Carvalho AK,Gnoato JA,Zimmer ER,Kalinine E,Pellerin L,Muller AP

更新日期：2017-10-01 00:00:00

abstract：:Lafora progressive myoclonus epilepsy (Lafora disease, LD) is a fatal rare autosomal recessive neurodegenerative disorder characterized by the accumulation of insoluble ubiquitinated polyglucosan inclusions in the cytoplasm of neurons, which is most commonly associated with mutations in two genes: EPM2A, encoding the ...

journal_title：Molecular neurobiology

authors： López-González I,Viana R,Sanz P,Ferrer I

更新日期：2017-07-01 00:00:00

abstract：:The global trend of the phenomenon of population ageing has dramatic consequences on public health and the incidence of neurodegenerative diseases. Physiological changes that occur during normal ageing of the brain may exacerbate and initiate pathological processes that may lead to neurodegenerative disorders, especia...

journal_title：Molecular neurobiology

authors： Schaffer S,Asseburg H,Kuntz S,Muller WE,Eckert GP

更新日期：2012-08-01 00:00:00

abstract：:Neural stem cells (NSCs) are hitherto regarded as perspective candidates for cell transplantation in clinical therapies for multilevel spinal cord injury and function restoration. However, the extreme drawbacks of NSCs available for injury transplantation still represent a significant bottleneck in neural regeneration...

journal_title：Molecular neurobiology

authors： Yang H,Liu C,Chen B,An J,Zhang R,Zhang Q,Zhao J,He B,Hao DJ

更新日期：2017-01-01 00:00:00

abstract：:Rotenone, a pesticide, causes neurotoxicity via the mitochondrial complex-I inhibition. The present study was conducted to evaluate the role of endoplasmic reticulum (ER) stress in rotenone-induced neuronal death. Cell viability, cytotoxicity, reactive oxygen species (ROS) generation, nitrite level, mitochondrial memb...

journal_title：Molecular neurobiology

authors： Goswami P,Gupta S,Biswas J,Joshi N,Swarnkar S,Nath C,Singh S

更新日期：2016-01-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most common cause of dementia among elderly people. Despite enormous efforts, the pathogenesis of AD still remains unclear and no drug has yet been proved to be disease-modifying. As the basis of learning and memory, the plasticity of synapse and dendritic spine has been impaired during...

journal_title：Molecular neurobiology

authors： Huang L,Lan J,Tang J,Kang Y,Feng X,Wu L,Peng Y

更新日期：2020-11-03 00:00:00

abstract：:It is important to understand the molecular mechanisms of barrier disruption in the central nervous system (CNS) of patients with multiple sclerosis (MS). The purpose of the present study was to clarify whether claudin-11 is involved in the disruption of two endothelial barriers (blood-brain barrier (BBB) and blood-sp...

journal_title：Molecular neurobiology

authors： Uchida Y,Sumiya T,Tachikawa M,Yamakawa T,Murata S,Yagi Y,Sato K,Stephan A,Ito K,Ohtsuki S,Couraud PO,Suzuki T,Terasaki T

更新日期：2019-03-01 00:00:00

abstract：:Evidence indicates that adverse experiences in early life may be a factor for immune disturbances leading to the depression in adulthood. Recently, a pivotal role in the pathogenesis of depression has been assigned to the activation of the brain Nod-like receptor pyrin-containing 3 (NLRP3) inflammasome. We investigate...

journal_title：Molecular neurobiology

authors： Trojan E,Chamera K,Bryniarska N,Kotarska K,Leśkiewicz M,Regulska M,Basta-Kaim A

更新日期：2019-08-01 00:00:00

abstract：:Iodine deficiency (ID) during development results in dysfunction of the central nervous system (CNS) and affects psychomotor and motor function. It is worth noting that maternal mild and marginal ID tends to be the most common reason of preventable neurodevelopmental impairment, via a mechanism that has not been eluci...

journal_title：Molecular neurobiology

authors： Dong J,Lei X,Wang Y,Wang Y,Song H,Li M,Min H,Yu Y,Xi Q,Teng W,Chen J

更新日期：2016-09-01 00:00:00

abstract：:Dehydroepiandrosterone sulfate (DHEAS), one of the most important neuroactive steroids, is produced in the adrenals and the brain. DHEAS is believed to play a critical role in modulating different forms of cellular control, including processes associated with human neural systems. Its production rate and level in seru...

journal_title：Molecular neurobiology

authors： Liou CJ,Yang CM,Lee TH,Liu PS,Hsieh HL

更新日期：2019-01-01 00:00:00

abstract：:Major depressive disorder (MDD) is a prevalent psychiatric disorder associated with varied prognosis, chronic course, and duration of illness with reduced quality of life. One factor that significantly contributes to the relevant disease burden of MDD is the heterogeneous treatment response patients experience with cu...

journal_title：Molecular neurobiology

authors： Ignácio ZM,da Silva RS,Plissari ME,Quevedo J,Réus GZ

更新日期：2019-12-01 00:00:00

abstract：:Peripheral inflammatory stimuli may activate a brain neuroinflammatory processes with consequences in brain function. The present study investigated if anthocyanins (ANT) consumption was able to prevent the memory loss, the neuronal damage, and the neuroinflammatory processes triggered by the intraperitoneal lipopolys...

journal_title：Molecular neurobiology

authors： Carvalho FB,Gutierres JM,Bueno A,Agostinho P,Zago AM,Vieira J,Frühauf P,Cechella JL,Nogueira CW,Oliveira SM,Rizzi C,Spanevello RM,Duarte MMF,Duarte T,Dellagostin OA,Andrade CM

更新日期：2017-07-01 00:00:00

abstract：:Huntington's disease (HD) is a devastating neurodegenerative disease caused by cytosine-adenine-guanine trinucleotide repeat expansion in the huntingtin gene. Growing evidence supports the regulatory functions of long noncoding RNAs (lncRNAs) in the disease process, but little is known about the association between ln...

journal_title：Molecular neurobiology

authors： Sunwoo JS,Lee ST,Im W,Lee M,Byun JI,Jung KH,Park KI,Jung KY,Lee SK,Chu K,Kim M

更新日期：2017-03-01 00:00:00

abstract：:The purpose of this study was to investigate the effects of brain-derived neurotrophic factor (BDNF)-transfected bone marrow mesenchymal stem cells (BMSCs) on neural functional recovery and synaptophysin expression in rats with cerebral infarction (CI). A total of 120 healthy Sprague Dawley rats were randomly divided ...

journal_title：Molecular neurobiology

authors： Zhang Y,Qiu B,Wang J,Yao Y,Wang C,Liu J

更新日期：2017-07-01 00:00:00

abstract：:The ability of pluripotent stem cells (PSCs) to differentiate into retinal tissue has led to many attempts to direct this process to yield specific retinal cell types. The ability to do so would greatly impact both the study of normal retina development in model systems that can be precisely controlled and the generat...

journal_title：Molecular neurobiology

authors： Lu AQ,Barnstable CJ

更新日期：2019-09-01 00:00:00

abstract：:Spinal cord injury causes sensory loss below the level of lesion. Synaptosomal-associated protein 25 (SNAP25) is a t-SNARE protein essential for exocytosis and neurotransmitter release, but its role in sensory functional recovery has not been determined. The aim of the present study is therefore to investigate whether...

journal_title：Molecular neurobiology

authors： Wang W,Wang F,Liu J,Zhao W,Zhao Q,He M,Qian BJ,Xu Y,Liu R,Liu SJ,Liu W,Liu J,Zhou XF,Wang TH

更新日期：2014-10-01 00:00:00

abstract：:(-)-Epigallocatechin-3‑gallate (EGCG), the predominant constituent of green tea, has been demonstrated to be neuroprotective against acute ischemic stroke. However, the long-term actions of EGCG on neurogenesis and functional recovery after ischemic stroke have not been identified. In this study, C57BL/6 mice underwen...

journal_title：Molecular neurobiology

authors： Zhang JC,Xu H,Yuan Y,Chen JY,Zhang YJ,Lin Y,Yuan SY

更新日期：2017-07-01 00:00:00