SNAP25 ameliorates sensory deficit in rats with spinal cord transection.

abstract：:A disintegrin and metalloproteinase 10 (ADAM10) is a synaptic enzyme that has been previously shown to limit amyloid-β1-42 (Aβ1-42) peptide formation in Alzheimer's disease (AD). Furthermore, ADAM10 participates to spine shaping through the cleavage of adhesion molecules and its activity is under the control of synapt...

journal_title：Molecular neurobiology

authors： Marcello E,Musardo S,Vandermeulen L,Pelucchi S,Gardoni F,Santo N,Antonucci F,Di Luca M

更新日期：2019-10-01 00:00:00

abstract：:Alpha synuclein (α-synuclein) is a neuronal protein found predominately in presynaptic terminals. While the pathological effect of α-synuclein aggregates has been a topic of intense study in several neurodegenerative conditions, less attention has been placed on changes in monomeric α-synuclein and related physiologic...

journal_title：Molecular neurobiology

authors： Carlson SW,Yan HQ,Li Y,Henchir J,Ma X,Young MS,Ikonomovic MD,Dixon CE

更新日期：2021-01-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease manifested by the progressive loss of upper and lower motoneurons. The pathomechanism of ALS is complex and not yet fully understood. Neuroinflammation is believed to significantly contribute to disease progression. Inflammasome activation was re...

journal_title：Molecular neurobiology

authors： Heitzer M,Kaiser S,Kanagaratnam M,Zendedel A,Hartmann P,Beyer C,Johann S

更新日期：2017-12-01 00:00:00

abstract：:This review describes the modulation of the GABAa receptor by steroid hormones and barbiturates and proposes guidelines for further research. Having examined the complex organization of the GABAa receptor complex and the multiple allosteric interactions between its drug and transmitter/modulator binding sites, the pos...

journal_title：Molecular neurobiology

authors： Schumacher M,McEwen BS

更新日期：1989-01-01 00:00:00

abstract：:Human telomerase reverse transcriptase (hTERT), a ribonucleoprotein, is reported as an important complex, which is required for stability of DNA molecular structure at the rear of the chromosome. Until now, hTERT has been linked to cell immortalization and tumorigenesis. A couple of articles have been published about ...

journal_title：Molecular neurobiology

authors： Li J,Li H,Liu J,Feng B,Feng M,Lv B,Cheng S,Yang X

更新日期：2016-07-01 00:00:00

abstract：:Evidence indicates that neural stem cells (NSCs) can ameliorate cerebral ischemia in animal models. In this study, we investigated the mechanism underlying one of the neuroprotective effects of NSCs: tunneling nanotube (TNT) formation. We addressed whether the control of cell-to-cell communication processes between NS...

journal_title：Molecular neurobiology

authors： Wang X,Yu X,Xie C,Tan Z,Tian Q,Zhu D,Liu M,Guan Y

更新日期：2016-05-01 00:00:00

abstract：:The functions of chloride channels in preconditioning-induced cell protection remain unclear. In this report, we show that the volume-activated chloride channels play a key role in hydrogen peroxide (H2O2) preconditioning-induced cell protection in pheochromocytoma PC12 cells. The preconditioning with 100 μM H2O2 for ...

journal_title：Molecular neurobiology

authors： Zhu L,Zuo W,Yang H,Zhang H,Luo H,Ye D,Lin X,Mao J,Feng J,Chen L,Wang L

更新日期：2013-08-01 00:00:00

abstract：:Emerging evidence has demonstrated the involvement of stromal cell-derived factor 1 (SDF1, also known as CXCL12)-CXCR4 signaling in a variety of pain state. However, the underlying mechanisms of SDF1-CXCR4 signaling leading to the maintenance of chronic pain states are poorly understood. In the present study, we sough...

journal_title：Molecular neurobiology

authors： Yang F,Sun W,Luo WJ,Yang Y,Yang F,Wang XL,Chen J

更新日期：2017-05-01 00:00:00

abstract：:Autism and epilepsy are diseases which have complex genetic inheritance. Genome-wide association and other genetic studies have implicated at least 500+ genes associated with the occurrence of autism spectrum disorders (ASD) including the human semaphorin 3F (Sema 3F) and neuropilin 2 (NRP2) genes. However, the geneti...

journal_title：Molecular neurobiology

authors： Li Z,Jagadapillai R,Gozal E,Barnes G

更新日期：2019-08-01 00:00:00

abstract：:Lafora progressive myoclonus epilepsy (Lafora disease, LD) is a fatal rare autosomal recessive neurodegenerative disorder characterized by the accumulation of insoluble ubiquitinated polyglucosan inclusions in the cytoplasm of neurons, which is most commonly associated with mutations in two genes: EPM2A, encoding the ...

journal_title：Molecular neurobiology

authors： López-González I,Viana R,Sanz P,Ferrer I

更新日期：2017-07-01 00:00:00

abstract：:The drastic increase in the consumption of fructose encouraged the research to focus on its effects on brain physio-pathology. Although young and adults differ largely by their metabolic and physiological profiles, most of the previous studies investigated brain disturbances induced by long-term fructose feeding in ad...

journal_title：Molecular neurobiology

authors： Cigliano L,Spagnuolo MS,Crescenzo R,Cancelliere R,Iannotta L,Mazzoli A,Liverini G,Iossa S

更新日期：2018-04-01 00:00:00

abstract：:Ascorbate, the reduced form of vitamin C, is highly concentrated in the central nervous system (CNS), including the retina, where it plays important physiological functions. In the CNS, the plasma membrane transporter sodium vitamin C co-transporter 2 (SVCT2) is responsible for ascorbate transport in neurons. The neur...

journal_title：Molecular neurobiology

authors： da Encarnação TG,Portugal CC,Nogueira CE,Santiago FN,Socodato R,Paes-de-Carvalho R

更新日期：2018-10-01 00:00:00

abstract：:Based on a multimodal drug design strategy for age-related neurodegenerative diseases, we have synthesized a multifunctional nontoxic, brain-permeable iron-chelating compound, M30, possessing the neuroprotective N-propargyl moiety of the anti-Parkinsonian drug, monoamine oxidase-B inhibitor, rasagiline and the antioxi...

journal_title：Molecular neurobiology

authors： Kupershmidt L,Amit T,Bar-Am O,Weinreb O,Youdim MB

更新日期：2012-08-01 00:00:00

abstract：:The neural crest is a transient embryonic structure that gives rise to a multitude of different cell types in the vertebrate. As such, it is an ideal model to study the processes of vertebrate differentiation and development. This review focuses on two major questions related to neural crest development. The first que...

journal_title：Molecular neurobiology

authors： Murphy M,Bartlett PF

更新日期：1993-07-01 00:00:00

abstract：:c-Jun N-terminal kinases (JNKs), which belong to a mitogen-activated protein kinase (MAPK) family, are involved in the regulation of several physiological functions in mammals and act as mediators of apoptosis, obesity, and memory storage in the brain, including the processes of neuronal de- and regeneration. JNK subf...

journal_title：Molecular neurobiology

authors： Petrov D,Luque M,Pedrós I,Ettcheto M,Abad S,Pallàs M,Verdaguer E,Auladell C,Folch J,Camins A

更新日期：2016-11-01 00:00:00

abstract：:Lambert-Eaton myasthenic syndrome (LEMS) is an autoimmune disease that disrupts the normally reliable neurotransmission at the neuromuscular junction (NMJ). This disruption is thought to result from an autoantibody-mediated removal of a subset of the P/Q-type Ca(2+) channels involved with neurotransmitter release. Wit...

journal_title：Molecular neurobiology

authors： Tarr TB,Wipf P,Meriney SD

更新日期：2015-08-01 00:00:00

abstract：:Paclitaxel is a chemotherapeutic agent used to treat solid tumours. However, it causes an acute and neuropathic pain syndrome that limits its use. Among the mechanisms involved in neuropathic pain caused by paclitaxel is activation of kinin receptors. Angiotensin converting enzyme (ACE) inhibitors can enhance kinin re...

journal_title：Molecular neurobiology

authors： Brusco I,Silva CR,Trevisan G,de Campos Velho Gewehr C,Rigo FK,La Rocca Tamiozzo L,Rossato MF,Tonello R,Dalmolin GD,de Almeida Cabrini D,Gomez MV,Ferreira J,Oliveira SM

更新日期：2017-12-01 00:00:00

abstract：:HIV infection and drugs of abuse induce oxidative stress and redox imbalance, which cause neurodegeneration. The mechanisms by which HIV infection and cocaine consumption affect astrocyte energy metabolism, and how this leads to neurodegenerative dysfunction, remain poorly understood. Presently, we investigated how ox...

journal_title：Molecular neurobiology

authors： Sivalingam K,Cirino TJ,McLaughlin JP,Samikkannu T

更新日期：2021-02-01 00:00:00

abstract：:Cerebral ischemia is a cerebrovascular episode that generates a high incidence of death and physical and mental disabilities worldwide. Excitotoxicity, release of free radicals, and exacerbated immune response cause serious complications in motor and cognitive areas during both short and long time frames post-ischemia...

journal_title：Molecular neurobiology

authors： Becerra-Calixto A,Cardona-Gómez GP

更新日期：2017-11-01 00:00:00

abstract：:Studies have shown that neurofibromin (NF1) restricts GABA release at inhibitory synapses and regulates dendritic spine formation, which may play an important role in temporal lobe epilepsy (TLE). NF1 expression was detected by double-label immunofluorescence, immunohistochemistry, and western blot analysis in the bra...

journal_title：Molecular neurobiology

authors： Ren M,Li K,Wang D,Guo J,Li J,Yang G,Long X,Shen W,Hu R,Wang X,Zeng K

更新日期：2016-11-01 00:00:00

abstract：:Neuronal differentiation plays a key role during embryogenesis. However, based on the capacity of neuronal stem cells to either generate or regenerate neurons and because differentiation stops aberrant neuroblasts proliferation, neuronal differentiation is crucial during neuropathological conditions. Although phosphat...

journal_title：Molecular neurobiology

authors： Paoletti L,Domizi P,Marcucci H,Montaner A,Krapf D,Salvador G,Banchio C

更新日期：2016-11-01 00:00:00

abstract：:Cultured hippocampal neurons represent the most widely used experimental substrate for in vitro electrophysiological studies. Nevertheless, in most cases, the nature of neuron under study is not identified as excitatory or inhibitory, or even worse, recorded neurons are considered as excitatory because of the paucity ...

journal_title：Molecular neurobiology

authors： Prestigio C,Ferrante D,Valente P,Casagrande S,Albanesi E,Yanagawa Y,Benfenati F,Baldelli P

更新日期：2019-09-01 00:00:00

abstract：:Reelin is an extracellular glycoprotein involved in key cellular processes in developing and adult nervous system, including regulation of neuronal migration, synapse formation, and plasticity. Most of these roles are mediated by the intracellular phosphorylation of disabled-1 (Dab1), an intracellular adaptor molecule...

journal_title：Molecular neurobiology

authors： Mata A,Urrea L,Vilches S,Llorens F,Thüne K,Espinosa JC,Andréoletti O,Sevillano AM,Torres JM,Requena JR,Zerr I,Ferrer I,Gavín R,Del Río JA

更新日期：2017-10-01 00:00:00

abstract：:The epidermal growth factor (EGF) family of polypeptides is regulators for tissue development and repair, and is characterized by the fact that their mature forms are proteolytically derived from their integral membrane precursors. This article reviews roles of the prominent members of the EGF family (EGF, transformin...

journal_title：Molecular neurobiology

authors： Xian CJ,Zhou XF

更新日期：1999-10-01 00:00:00

abstract：:Voltage-dependent Ca2+ channels are important in the regulation of neuronal structure and function, and as a result, they have received considerable attention. Recent studies have begun to characterize the diversity of their properties and the relationship of this diversity to their various cellular functions. In part...

journal_title：Molecular neurobiology

authors： Lnenicka GA,Hong SJ

更新日期：1997-02-01 00:00:00

abstract：:The vertebrate retina is a "genuine neural center" (Ramón y Cajal), in which glutamate is a major excitatory neurotransmitter. Both N-methyl-D-aspartate (NMDA) and non-NMDA receptors are expressed in the retina. Although non-NMDA receptors and/or metabotropic glutamate receptors are generally thought to be responsible...

journal_title：Molecular neurobiology

authors： Shen Y,Liu XL,Yang XL

更新日期：2006-12-01 00:00:00

abstract：:Human hGDH2 arose via duplication in the apes and driven by positive selection acquired enhanced catalytic ability under conditions inhibitory to its precursor hGDH1 (common to all mammals). To explore the biological advantage provided by the novel enzyme, we studied, by immunohistochemistry (IHC) and immunofluorescen...

journal_title：Molecular neurobiology

authors： Spanaki C,Kotzamani D,Kleopa K,Plaitakis A

更新日期：2016-10-01 00:00:00

abstract：:A major sensory organ for the detection of pheromones by animals is the vomeronasal organ (VNO). Although pheromones control the behaviors of various species, the effect of pheromones on human behavior has been controversial because the VNO is not functional in adults. However, recent genetic, biochemical, and electro...

journal_title：Molecular neurobiology

authors： Wang Z,Nudelman A,Storm DR

更新日期：2007-06-01 00:00:00

abstract：:Alzheimer's disease (AD) is characterized by intracellular and extracellular protein aggregates, including microtubule-associated protein tau and cleavage product of amyloid precursor protein, β-amyloid (Aβ). Tissue transglutaminase (tTG) is a calcium-dependent enzyme that cross-links proteins forming a γ-glutamyl-ε-l...

journal_title：Molecular neurobiology

authors： Zhang J,Wang S,Huang W,Bennett DA,Dickson DW,Wang D,Wang R

更新日期：2016-10-01 00:00:00

abstract：:Docosahexaenoic acid (DHA) is enriched in membrane phospholipids of the central nervous system (CNS) and has a role in aging and neuropsychiatric disorders. DHA is metabolized by the enzyme Alox15 to 17S-hydroxy-DHA, which is then converted to 7S-hydroperoxy,17S-hydroxy-DHA by a 5-lipoxygenase, and thence via epoxy in...

journal_title：Molecular neurobiology

authors： Shalini SM,Ho CF,Ng YK,Tong JX,Ong ES,Herr DR,Dawe GS,Ong WY

更新日期：2018-02-01 00:00:00