Abstract：
:Angelman syndrome (AS) is a neurodevelopmental disorder largely caused by the loss of function of maternally inherited UBE3A. UBE3A-maternal deficient mice (AS mice) exhibit many typical features of AS including cognitive and motor deficits but the underlying mechanism of these behavioral abnormalities is poorly understood. Here, we demonstrate that rearing of AS mice in the enriched environment for prolonged period significantly improved their cognitive and motor dysfunction. Enriched environment also restored elevated serum corticosterone level and reduced anxiety-like behaviors in these mice. Biochemical analysis further revealed restoration of altered levels of brain-derived neurotrophic factor, glucocorticoid receptor, and phoshphorylated calcium/calmodulin-dependent protein kinase IIα in the hippocampus of AS mice maintained in the enriched environment. Enriched environment also significantly increased the number of parvalbumin-positive GABAergic interneuron in the hippocampus and basolateral amygdala of AS mice. These results indicate potential beneficial effect of enriched environment in the reversal of AS phenotype.
journal_name
Mol Neurobioljournal_title
Molecular neurobiologyauthors
Jamal I,Kumar V,Vatsa N,Singh BK,Shekhar S,Sharma A,Jana NRdoi
10.1007/s12035-016-0080-3subject
Has Abstractpub_date
2017-09-01 00:00:00pages
5319-5326issue
7eissn
0893-7648issn
1559-1182pii
10.1007/s12035-016-0080-3journal_volume
54pub_type
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