Abstract:
:Emerging evidence has demonstrated the involvement of stromal cell-derived factor 1 (SDF1, also known as CXCL12)-CXCR4 signaling in a variety of pain state. However, the underlying mechanisms of SDF1-CXCR4 signaling leading to the maintenance of chronic pain states are poorly understood. In the present study, we sought to explore the role of SDF1-CXCR4 signaling in the forming of neuroplasticity by applying a model of the transition from acute to chronic pain state, named as hyperalgesic priming. Utilizing intraplantar bee venom (BV) injection, we successfully established hyperalgesic priming state and found that peripheral treating with AMD3100, a CXCR4 antagonist, or knocking down CXCR4 by intraganglionar CXCR4 small interfering RNA (siRNA) injection could prevent BV-induced primary mechanical hyperalgesia and hyperalgesic priming. Moreover, we showed that single intraplantar active SDF1 protein injection is sufficient to induce acute mechanical hyperalgesia and hyperalgesic priming through CXC4. Intraplantar coinjection of ERK inhibitor, U0126, and PI3K inhibitor, LY294002, as well as two protein translation inhibitors, temsirolimus and cordycepin, prevented the development of SDF1-induced acute mechanical hyperalgesia and hyperalgesic priming. Finally, on the models of complete Freund's adjuvant (CFA)-induced chronic inflammatory pain and spared nerve injury (SNI)-induced chronic neuropathic pain, we observed that knock-down of CXCR4 could both prevent the development and reverse the maintenance of chronic pain state. In conclusion, our present data suggested that through regulating ERK and PI3K-AKT pathways-mediated protein translation SDF1-CXCR4 signaling mediates the transition from acute pain to chronic pain state and finally contributes to the development and maintenance of chronic pain.
journal_name
Mol Neurobioljournal_title
Molecular neurobiologyauthors
Yang F,Sun W,Luo WJ,Yang Y,Yang F,Wang XL,Chen Jdoi
10.1007/s12035-016-9875-5subject
Has Abstractpub_date
2017-05-01 00:00:00pages
2763-2775issue
4eissn
0893-7648issn
1559-1182pii
10.1007/s12035-016-9875-5journal_volume
54pub_type
杂志文章abstract::The protective and therapeutic mechanism of bee venom acupuncture (BVA) in neurodegenerative disorders is not clear. We investigated whether treatment with BVA (0.25 and 0.8 mg/kg) at the Zusanli (ST36) acupoints, located lateral from the anterior border of the tibia, has a beneficial effect in a myelin basic protein ...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-014-9012-2
更新日期:2016-04-01 00:00:00
abstract::Bronchopulmonary sensory neurons are derived from the vagal sensory ganglia and are essential for monitoring the physical and chemical environment of the airways and lungs. Subtypes are heterogenous in their responsiveness to stimuli, phenotype, and developmental origin, but they collectively serve to regulate normal ...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-019-01782-8
更新日期:2020-02-01 00:00:00
abstract::Polyglutamine [poly(Q)] disorders are a class of trinucleotide repeat expansion neurodegenerative disorders which are dominantly inherited and progressively acquired with age. This group of disorders entail the characteristic formation of protein aggregates leading to widespread loss of neurons in different regions of...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-018-1160-3
更新日期:2019-02-01 00:00:00
abstract::A major sensory organ for the detection of pheromones by animals is the vomeronasal organ (VNO). Although pheromones control the behaviors of various species, the effect of pheromones on human behavior has been controversial because the VNO is not functional in adults. However, recent genetic, biochemical, and electro...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/s12035-007-0014-1
更新日期:2007-06-01 00:00:00
abstract::NMDA receptor signaling is critical for the development of synaptic plasticity, learning, and memory, and dysregulation of NMDAR signaling is implicated in a number of neurological disorders including schizophrenia (SZ). Previous work has demonstrated that the STriatal-Enriched protein tyrosine Phosphatase 61 kDa (STE...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-017-0555-x
更新日期:2018-04-01 00:00:00
abstract::Bioluminescence imaging (BLI) takes advantage of the light-emitting properties of luciferase enzymes, which produce light upon oxidizing a substrate (i.e., D-luciferin) in the presence of molecular oxygen and energy. Photons emitted from living tissues can be detected and quantified by a highly sensitive charge-couple...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/s12035-012-8379-1
更新日期:2013-06-01 00:00:00
abstract::α-Lipoic acid-plus (LAP), an amine derivative of α-lipoic acid (LA), could protect cells against oxidant challenges via chelating intralysosomal iron. However, the application of LAP in experimental subarachnoid hemorrhage (SAH) is still not well known. This study was designed to evaluate the potential neuroprotection...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-014-8846-y
更新日期:2015-08-01 00:00:00
abstract::Autophagy is an intracellular catabolic mechanism for the degradation of cytoplasmic constituents in the autophagosomal-lysosomal pathway. This mechanism plays an important role in homeostasis and it is defective in certain diseases. Preceding studies have revealed that autophagy is developing as an important moderato...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-016-9827-0
更新日期:2017-05-01 00:00:00
abstract::Maternal separation (MS) causes long-lasting epigenetic changes in the brain and increases vulnerability to traumatic events in adulthood. Of interest, there may be sex-specific differences in these epigenetic changes. In this study, the extent of histone acetylation in the hippocampus (HIP) and the expression of BDNF...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-020-02224-6
更新日期:2020-11-27 00:00:00
abstract::Epigenetic and regulatory elements provide an additional layer of complexity to the heterogeneity of anxiety disorders. MicroRNAs (miRNAs) are a class of small, noncoding RNAs that have recently drawn interest as epigenetic modulators of gene expression in psychiatric disorders. miRNAs elicit their effects by binding ...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/s12035-012-8374-6
更新日期:2013-04-01 00:00:00
abstract::Lysine-specific demethylase 1 (LSD1/KDM1A) plays an important role in complex cellular processes such as differentiation, proliferation, apoptosis, and cell cycle progression. It has recently been demonstrated that during development, downregulation of LSD1 inhibits cell proliferation, modulates the expression of cell...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-015-9206-2
更新日期:2016-05-01 00:00:00
abstract::Although neurons in the adult mammalian CNS are inherently incapable of regeneration after injury, we previously showed that exogenous delivery of pigment epithelium-derived factor (PEDF), a 50-kDa neurotrophic factor (NTF), promoted adult retinal ganglion cell neuroprotection and axon regeneration. Here, we show that...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-019-1614-2
更新日期:2019-11-01 00:00:00
abstract::Modulation of αCaMKII expression and phosphorylation is a feature shared by drugs of abuse with different mechanisms of action. Accordingly, we investigated whether αCaMKII expression and activation could be altered by self-administration of ketamine, a non-competitive antagonist of the NMDA glutamate receptor, with a...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-017-0772-3
更新日期:2018-07-01 00:00:00
abstract::Preconditioning with volatile anesthetics can create an ischemia tolerance against cerebral ischemia-reperfusion injury. We investigated whether ubiquitin conjugase 9 (Ubc9), the E2 conjugase for SUMOylation, is associated with neuroprotection induced by isoflurane preconditioning (IsoPC). In vitro, Ubc9 protein expre...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-014-8797-3
更新日期:2015-01-01 00:00:00
abstract::Inhalational general anesthetics, such as sevoflurane and isoflurane, modulate a subset of brain Kv1 potassium channels. However, the Kv1.2 channel is resistant to propofol, a commonly used intravenous alkylphenol anesthetic. We hypothesize that propofol binds to a presumed pocket involving the channel's S4-S5 linker,...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-017-0437-2
更新日期:2018-02-01 00:00:00
abstract::Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder characterized by involuntary body movement, cognitive impairment and psychiatric disturbance. A polyglutamine expansion in the amino-terminal region of the huntingtin (htt) protein is the genetic cause of HD. Htt protein interacts with a wid...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/s12035-010-8153-1
更新日期:2011-02-01 00:00:00
abstract::The complement component (3b/4b) receptor 1 gene (CR1) is considered as one of the most important genetic susceptibility loci in Alzheimer's disease (AD). However, to date, few studies were performed to discover the possible effect of CR1 genetic variants on AD pathology in the brain. Here, we evaluated the potential ...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-015-9638-8
更新日期:2017-01-01 00:00:00
abstract::Infantile amnesia (IA) refers to the inability of adults to recall episodic memories from infancy or early childhood. While several hypotheses have been proposed to explain the occurrence of IA, the neurobiological and molecular bases for this accelerated forgetting phenomenon remain elusive. Using hippocampus-depende...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-018-1119-4
更新日期:2019-02-01 00:00:00
abstract::Smarcd1 is a component of an evolutionary conserved chromatin remodeling complex-SWI/SNF, which is involved in transcription factor recruitment, DNA replication, recombination, and repair. Suppression of the SWI/SNF complex required for cellular differentiation and gene regulation may be inducible for cell proliferati...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-020-02190-z
更新日期:2020-11-14 00:00:00
abstract::Based on current knowledge on the role of the CX3CL1/CX3CR1 axis in the regulation of microglial activation and on the involvement of activated microglia in damaging oligodendrocytes, we hypothesized that CX3CL1/CX3CR1 axis is associated with the development of ischemic oligodendrocyte and white matter injury. We inve...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-015-9339-3
更新日期:2016-08-01 00:00:00
abstract::(-)-Epigallocatechin-3‑gallate (EGCG), the predominant constituent of green tea, has been demonstrated to be neuroprotective against acute ischemic stroke. However, the long-term actions of EGCG on neurogenesis and functional recovery after ischemic stroke have not been identified. In this study, C57BL/6 mice underwen...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-016-9924-0
更新日期:2017-07-01 00:00:00
abstract::The human KCTD13 gene is located within the 16p11.2 locus and copy number variants of this locus are associated with a high risk for neuropsychiatric diseases including autism spectrum disorder and schizophrenia. Studies in zebrafish point to a role of KCTD13 in proliferation of neural precursor cells which may contri...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-019-01727-1
更新日期:2020-02-01 00:00:00
abstract::Prion diseases are transmissible neurodegenerative disorders of humans and animals, which are characterized by the aggregation of abnormal prion protein (PrPSc) in the central nervous system. Although several small compounds that bind to normal PrP (PrPC) have been shown to inhibit structural conversion of the protein...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-018-1088-7
更新日期:2019-01-01 00:00:00
abstract::α-Synuclein (α-syn) has been recognized to induce neuroinflammation and to disturb nerve repair process in Parkinson's disease. However, the potential mechanisms underlying α-syn-induced impairment of adult neurogenesis remain unclear. In the present study, A53T mutant α--synuclein transgenic (A53Ttg/tg) mice, caspase...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-015-9620-5
更新日期:2016-12-01 00:00:00
abstract::AD, a devastating neurodegenerative disorder, is the most common cause of dementia in the elderly. Patients with AD are characterized by three hallmarks of neuropathology including neuritic plaque deposition, neurofibrillary tangle formation, and neuronal loss. Growing evidences indicate that dysregulation of regulato...
journal_title:Molecular neurobiology
pub_type: 杂志文章,评审
doi:10.1007/s12035-014-8704-y
更新日期:2014-12-01 00:00:00
abstract::Neural stem cells (NSCs) are hitherto regarded as perspective candidates for cell transplantation in clinical therapies for multilevel spinal cord injury and function restoration. However, the extreme drawbacks of NSCs available for injury transplantation still represent a significant bottleneck in neural regeneration...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-016-0057-2
更新日期:2017-01-01 00:00:00
abstract::Protein aggregation is involved in a variety of diseases. Alteration of the aggregation pathway, either to produce less toxic structures or to increase aggregate clearance, is a promising therapeutic route. Both active and passive immunization has been used for this purpose. However, the mechanism of action of antibod...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-015-9148-8
更新日期:2016-04-01 00:00:00
abstract::Early brain injury (EBI), highlighted with inflammation and apoptosis, occurring within 72 h after subarachnoid hemorrhage (SAH), is associated with the prognosis of SAH. Recent studies have revealed that hydrogen-rich saline (HS) exerted multiple neuroprotective properties in many neurological diseases including SAH,...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-015-9242-y
更新日期:2016-07-01 00:00:00
abstract::Timely thrombolytic treatment is paramount after acute ischemic stroke (AIS); however, a large proportion of patients experience substantial delays in presentation to hospital. This study evaluates the prevalence and risk factors in pre-hospital delays after AIS in central urban China. AIS patients from 66 hospitals i...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-016-9750-4
更新日期:2017-05-01 00:00:00
abstract::The molecular mechanisms underlying cognitive impairment in Alzheimer's disease (AD) remain largely unclear. In the present study, we were aimed to identify the potential key molecules involved in spatial memory impairment in a triple transgenic (3xTg-AD) mouse model of AD. By employing two-dimensional fluorescence di...
journal_title:Molecular neurobiology
pub_type: 杂志文章
doi:10.1007/s12035-016-9959-2
更新日期:2017-07-01 00:00:00