Abstract：
:A major sensory organ for the detection of pheromones by animals is the vomeronasal organ (VNO). Although pheromones control the behaviors of various species, the effect of pheromones on human behavior has been controversial because the VNO is not functional in adults. However, recent genetic, biochemical, and electrophysiological data suggest that some pheromone-based behaviors, including male sexual behavior in mice, are mediated through the main olfactory epithelium (MOE) and are coupled to the type 3 adenylyl cyclase (AC3) and a cyclic nucleotide-gated (CNG) ion channel. These recent discoveries suggest the provocative hypothesis that human pheromones may signal through the MOE.
journal_name
Mol Neurobioljournal_title
Molecular neurobiologyauthors
Wang Z,Nudelman A,Storm DRdoi
10.1007/s12035-007-0014-1subject
Has Abstractpub_date
2007-06-01 00:00:00pages
317-23issue
3eissn
0893-7648issn
1559-1182pii
MN:35:3:317journal_volume
35pub_type
杂志文章,评审abstract：:Manganese (Mn) is widely regarded as a neurotoxic heavy metal that causes learning and memory deficits. Recently, it has been proved that the striatum is related to memory and learning ability. However, no previous study focused on the effect of Mn-induced learning and memory deficits on the striatum. This study aims ...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-015-9602-7
更新日期：2016-12-01 00:00:00
abstract：:The aim of this study was to examine if nicotine was able to improve cognition deficits in a mouse model of chronic mild stress. Twenty-four male C57BL/6 mice were divided into three groups: control, stress, and stress with nicotine treatment. The animal model was established by combining chronic unpredictable mild st...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-016-0012-2
更新日期：2017-08-01 00:00:00
abstract：:α-Synuclein aggregation contributes to the Parkinson's disease (PD) pathology in multiple ways-the two most important being the activation of neuroinflammation and mitochondrial dysfunction. Our recent studies have shown the beneficial effects of a heat shock protein (HSP) inducer, carbenoxolone (Cbx), in reducing the...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-014-8769-7
更新日期：2015-02-01 00:00:00
abstract：:OMI/HTRA2 (high-temperature requirement serine protease A2) is a mitochondrial serine protease involved in several cellular processes, including autophagy, chaperone activity, and apoptosis. Few studies on the role of OMI/HTRA2 in Alzheimer's disease (AD) are available, but none on its relationship with the cholinergi...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-018-1383-3
更新日期：2019-07-01 00:00:00
abstract：:Recent studies show that myostatin mRNA expression is found in some regions of the brain. However, the functional significance of this is currently unknown. We therefore investigated myostatin expression and function in the brain. In this study, we used immunohistochemistry, in situ hybridization, and RT-PCR analysis ...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-012-8342-1
更新日期：2013-02-01 00:00:00
abstract：:Endoplasmic reticulum (ER) stress induces a variety of neuronal cell death pathways that play a critical role in the pathophysiology of stroke. ER stress occurs when unfolded/misfolded proteins accumulate and the folding capacity of ER chaperones exceeds the capacity of ER lumen to facilitate their disposal. As a cons...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s12035-014-9029-6
更新日期：2016-01-01 00:00:00
abstract：:Accumulating evidence suggests that inflammatory processes in the central nervous system that are mediated by microglial activation play important roles in several neurodegenerative disorders. Therefore, development of methods for microglial inhibition is considered an important strategy in the search for neuroprotect...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-013-8474-y
更新日期：2013-12-01 00:00:00
abstract：:Zika virus (ZIKV) infection is associated with abnormal functions of neuronal cells causing neurological disorders such as microcephaly in the newborns and Guillain-Barré syndrome in the adults. Typically, healthy brain growth is associated with normal neural stem cell proliferation, differentiation, and maturation. T...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s12035-018-1263-x
更新日期：2019-04-01 00:00:00
abstract：:Insulin receptors in the brain are found in high densities in the hippocampus, a region that is fundamentally involved in the acquisition, consolidation, and recollection of new information. Using the intranasal method, which effectively bypasses the blood-brain barrier to deliver and target insulin directly from the ...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s12035-011-8229-6
更新日期：2012-08-01 00:00:00
abstract：:Spinal cord injury (SCI) is a traumatic event resulting in disturbances to normal sensory, motor, or autonomic functions, which ultimately impacts a patient's physical, psychological, and social well-being. Until now, no available therapy for SCI can effectively slow down or halt the disease progression. Compared to t...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s12035-015-9157-7
更新日期：2016-07-01 00:00:00
abstract：:Prion diseases are fatal neurodegenerative diseases in mammals with the unique characteristics of misfolding and aggregation of the cellular prion protein (PrPC) to the scrapie prion (PrPSc). Although neuroinflammation and neuronal loss feature within the disease process, the details of PrPC/PrPSc molecular transition...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-020-02112-z
更新日期：2021-01-01 00:00:00
abstract：:Angelman syndrome (AS) is a neurodevelopmental disorder largely caused by the loss of function of maternally inherited UBE3A. UBE3A-maternal deficient mice (AS mice) exhibit many typical features of AS including cognitive and motor deficits but the underlying mechanism of these behavioral abnormalities is poorly under...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-016-0080-3
更新日期：2017-09-01 00:00:00
abstract：:Adult neural progenitor cells (NPCs) induce post-ischemic long-term neuroprotection and brain remodeling by releasing of survival- and plasticity-promoting mediators. To evaluate whether secreted factors may mimic neuroprotective and restorative effects of NPCs, we exposed male C57BL6 mice to focal cerebral ischemia a...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-016-9748-y
更新日期：2017-03-01 00:00:00
abstract：:Multiple players are involved in motor and sensory dysfunctions after spinal cord injury (SCI). Therefore, therapeutic approaches targeting these various players in the damage cascade hold considerable promise for the treatment of traumatic spinal cord injury. Soluble epoxide hydrolase (sEH) is an endogenous key enzym...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-015-9118-1
更新日期：2016-04-01 00:00:00
abstract：:Diabetic peripheral neuropathy (DPN) is a microvascular complication of diabetes mellitus. The aim of this meta-analysis was to evaluate the effects of methylenetetrahydrofolate reductase (MTHFR) 677 C>T and ACE I/D polymorphisms in the development of DPN. We systematically reviewed published studies on MTHFR 677 C>T ...
journal_title：Molecular neurobiology
pub_type： 杂志文章,meta分析
doi：10.1007/s12035-016-9823-4
更新日期：2017-05-01 00:00:00
abstract：:Emerging researches point to a relevant role of postsynaptic density (PSD) proteins, such as PSD-95, Homer, Shank, and DISC-1, in the pathophysiology of schizophrenia and autism spectrum disorders. The PSD is a thickness, detectable at electronic microscopy, localized at the postsynaptic membrane of glutamatergic syna...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s12035-013-8534-3
更新日期：2014-02-01 00:00:00
abstract：:The Peruvian plant Lepidium meyenii (Maca) has been shown to possess neuroprotective activity both in vitro and in vivo. Previous studies have also demonstrated the activity of the pentane extract and its macamides, the most representative lipophilic constituents of Maca, in the endocannabinoid system as fatty acid am...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-013-8499-2
更新日期：2013-10-01 00:00:00
abstract：:Genetic disruptions of spindle/centrosome-associated WD40-repeat protein 62 (WDR62) are causative for autosomal recessive primary microcephaly (MCPH) and a broader range of cortical malformations. Since the identification of WDR62 as encoded by the MCPH2 locus in 2010, recent studies that have deleted/depleted WDR62 i...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s12035-017-0778-x
更新日期：2018-07-01 00:00:00
abstract：:GLI2 is a key mediator of the sonic hedgehog (Shh) signaling pathway and plays an important role in neural tube development during vertebrate embryogenesis; however, the role of gli2 in human folate-related neural tube defects remains unclear. In this study, we compared methylation status and polymorphisms of gli2 bet...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-015-9447-0
更新日期：2016-10-01 00:00:00
abstract：:Abnormal hippocampal neurogenesis is a prominent feature of temporal lobe epilepsy (TLE) models, which is thought to contribute to abnormal brain activity. Stromal cell-derived factor-1 (SDF-1) and its specific receptor CXCR4 play important roles in adult neurogenesis. We investigated whether treatment with the CXCR4 ...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-015-9102-9
更新日期：2016-04-01 00:00:00
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journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/BF02936609
更新日期：1987-10-01 00:00:00
abstract：:Copper is an essential nutrient that plays a fundamental role in the biochemistry of the central nervous system, as evidenced by patients with Menkes disease, a fatal neurodegenerative disorder of childhood resulting from the loss-of-function of a copper-transporting P-type adenosine triphosphatase (ATPase). Despite c...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1385/MN:33:2:81
更新日期：2006-04-01 00:00:00
abstract：:Antiretroviral therapy (ART) restricts human immunodeficiency virus type one (HIV-1) replication and by so doing, improves the quality and longevity of life for infected people. Nonetheless, treatment can also lead to adverse clinical outcomes such as drug resistance and systemic adverse events. Both could be affected...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-018-1273-8
更新日期：2019-04-01 00:00:00
abstract：:Neuroinflammation is the primary response by immune cells in the nervous system to protect against infection. Chronic and uncontrolled neuroinflammation triggers neuronal injury and neuronal death resulting in a variety of neurodegenerative disorders. Therefore, fine tuning of the immune response in the nervous system...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s12035-020-02066-2
更新日期：2020-11-01 00:00:00
abstract：:Timely thrombolytic treatment is paramount after acute ischemic stroke (AIS); however, a large proportion of patients experience substantial delays in presentation to hospital. This study evaluates the prevalence and risk factors in pre-hospital delays after AIS in central urban China. AIS patients from 66 hospitals i...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-016-9750-4
更新日期：2017-05-01 00:00:00
abstract：:Expression changes for long non-coding RNAs (lncRNAs) have been identified in adult glioblastoma multiforme (GBM) and in a mixture of adult and pediatric astrocytoma. Since adult and pediatric astrocytomas are molecularly different, the mixture of both could mask specific features in each. We determined the global exp...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-016-0123-9
更新日期：2017-10-01 00:00:00
abstract：:Inhibition of potassium channels is possibly the first step in the sequence of biochemical events leading to memory formation. These channels appear to be regulated directly or indirectly by GTP-binding proteins (G proteins), which may themselves be affected by phosphorylation and dephosphorylation in response to elev...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/BF02935554
更新日期：1991-01-01 00:00:00
abstract：:Amyotrophic lateral sclerosis (ALS) is the most frequent adult-onset motor neuron disease characterized by degeneration of upper and lower motor neurons (MNs), generalized weakness and muscle atrophy. The "neurocentric" view of ALS assumes that the disease primarily affects motor neurons, while muscle alterations only...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s12035-013-8578-4
更新日期：2014-04-01 00:00:00
abstract：:Long-chain omega-3 polyunsaturated fatty acids (LC-O3PUFAs) exhibit therapeutic potential for the treatment and prevention of the neurological deficits associated with spinal cord injury (SCI). However, the mechanisms implicated in these protective responses remain unclear. The objective of the present functional meta...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-014-8701-1
更新日期：2014-08-01 00:00:00
abstract：:The complications caused by overweight, obesity and type 2 diabetes are one of the main problems that increase morbidity and mortality in developed countries. Hypothalamic metabolic sensors play an important role in the control of feeding and energy homeostasis. PAS kinase (PASK) is a nutrient sensor proposed as a reg...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-013-8630-4
更新日期：2014-10-01 00:00:00
