Abstract:
:Protein aggregation is involved in a variety of diseases. Alteration of the aggregation pathway, either to produce less toxic structures or to increase aggregate clearance, is a promising therapeutic route. Both active and passive immunization has been used for this purpose. However, the mechanism of action of antibodies on protein aggregates is not completely clear especially given poor ability of antibodies to cross blood-brain barrier. Here, we have shown that antibodies can interfere with protein aggregation at substoichiometric concentrations (as low as 1:1000 antibody to protein ratio). This is an indication that antibodies interact with aggregation intermediates in chaperone-like manner altering the aggregation pathways at very low antibody levels. This observation supports earlier suggestions that antibodies can inhibit aggregation by interaction with low abundance aggregation intermediates.
journal_name
Mol Neurobioljournal_title
Molecular neurobiologyauthors
Breydo L,Morgan D,Uversky VNdoi
10.1007/s12035-015-9148-8subject
Has Abstractpub_date
2016-04-01 00:00:00pages
1949-1958issue
3eissn
0893-7648issn
1559-1182pii
10.1007/s12035-015-9148-8journal_volume
53pub_type
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