Abstract：
:Preconditioning with volatile anesthetics can create an ischemia tolerance against cerebral ischemia-reperfusion injury. We investigated whether ubiquitin conjugase 9 (Ubc9), the E2 conjugase for SUMOylation, is associated with neuroprotection induced by isoflurane preconditioning (IsoPC). In vitro, Ubc9 protein expression was evaluated at 4 and 24 h after reoxygenation. The role of Ubc9 in the neuroprotective effect was assessed in the presence or absence of Ubc9 small interfering RNA (siRNA). In vivo, rats were preconditionally exposed for 1 h to 2% isoflurane for five consecutive days followed by middle cerebral artery occlusion. Neurobehavioral scores and infarction volume were determined at different times after reperfusion. The role of Ubc9 in ischemic tolerance was evaluated by intracerebroventricular microinjection with the Ubc9 siRNA. We showed that isoflurane preconditioning improved the cell viability of the SH-SY5Y cells that were challenged by oxygen-glucose deprivation. It also reduced brain infarct volumes and improved neurologic outcomes in the focal cerebral ischemic rat. The expression of Ubc9 was upregulated by isoflurane preconditioning. Knockdown of Ubc9 significantly attenuated the isoflurane preconditioning-induced neuroprotective effects. Isoflurane preconditioning-induced neuroprotection against ischemic injuries is mediated by Ubc9. These results suggest a novel mechanism for isoflurane preconditioning-induced tolerance to cerebral ischemia.
journal_name
Mol Neurobioljournal_title
Molecular neurobiologyauthors
Tong L,Wu Z,Ran M,Chen Y,Yang L,Zhang H,Zhang L,Dong H,Xiong Ldoi
10.1007/s12035-014-8797-3subject
Has Abstractpub_date
2015-01-01 00:00:00pages
1221-31issue
3eissn
0893-7648issn
1559-1182journal_volume
51pub_type
杂志文章abstract：:Cell fate reprogramming makes possible the generation of new cell types from healthy adult cells to replace those lost or damaged in disease. Additionally, reprogramming patient cells into specific cell types allows for drug screening and the development of new therapeutic tools. Generation of new neurons is of partic...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s12035-012-8277-6
更新日期：2012-06-01 00:00:00
abstract：:In Alzheimer's disease, the accumulation of amyloid-beta (Aβ) in the brain occurs in the parenchyma and cerebrovasculature. Several evidences support that the neuronal demise is potentiated by vascular alterations in the early stages of the disease, but the mechanisms responsible for the dysfunction of brain endotheli...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-014-8740-7
更新日期：2015-04-01 00:00:00
abstract：:The exocyst, an octameric protein complex consisting of Exoc1 through Exoc8, was first determined to regulate exocytosis by targeting vesicles to the plasma membrane in yeast to mice. In addition to this fundamental role, the exocyst complex has been implicated in other cellular processes. In this study, we investigat...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-017-0857-z
更新日期：2018-08-01 00:00:00
abstract：:Adenine nucleotides through P2Y1 receptor stimulation are known to control retinal progenitor cell (RPC) proliferation by modulating expression of the p57KIP2, a cell cycle regulator. However, the role of Gi protein-coupled P2Y12 and P2Y13 receptors also activated by adenine nucleotides in RPC proliferation is still u...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-018-1012-1
更新日期：2018-11-01 00:00:00
abstract：:Endozepine has recently been isolated from various steroid-forming organs. The following article explores the role of endozepine in the regulation of steroid synthesis. Steroid hormone synthesis from cholesterol begins in the inner mitochondrial membrane, where cytochrome P450 converts cholesterol to pregnenolone. Sci...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/BF02740835
更新日期：1995-02-01 00:00:00
abstract：:In the present study, we demonstrate that molecular chaperone Hsp70 and Hsc70 is essential for normal organization and development of ommatidial cells in Drosophila melanogaster eye. An exogenously expressed dominant negative mutant of Hsp70 (K71E) and Hsc70.4 (K71S and D206S) in an eye-specific manner resulted in eye...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-017-0650-z
更新日期：2018-05-01 00:00:00
abstract：:Human telomerase reverse transcriptase (hTERT), a ribonucleoprotein, is reported as an important complex, which is required for stability of DNA molecular structure at the rear of the chromosome. Until now, hTERT has been linked to cell immortalization and tumorigenesis. A couple of articles have been published about ...
journal_title：Molecular neurobiology
pub_type： 杂志文章,收录出版
doi：10.1007/s12035-015-9170-x
更新日期：2016-07-01 00:00:00
abstract：:Removal of the Bax gene from mice completely protects the somas of retinal ganglion cells (RGCs) from apoptosis following optic nerve injury. This makes BAX a promising therapeutic target to prevent neurodegeneration. In this study, Bax+/- mice were used to test the hypothesis that lowering the quantity of BAX in RGCs...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-019-01783-7
更新日期：2020-02-01 00:00:00
abstract：:Human T-lymphotropic virus type 1 (HTLV-I) is a pathogenic retrovirus associated with a chronic progressive myelopathy, termed HTLV-I-associated myelopathy (HAM)/tropical spastic paraparesis (TSP), as well as adult T-cell leukemia (ATL). A chronic inflammatory process has been implicated in HAM/TSP by a pathological s...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/BF02780664
更新日期：1994-04-01 00:00:00
abstract：:HIV infection and drugs of abuse induce oxidative stress and redox imbalance, which cause neurodegeneration. The mechanisms by which HIV infection and cocaine consumption affect astrocyte energy metabolism, and how this leads to neurodegenerative dysfunction, remain poorly understood. Presently, we investigated how ox...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-020-02131-w
更新日期：2021-02-01 00:00:00
abstract：:Adult neural progenitor cells (NPCs) induce post-ischemic long-term neuroprotection and brain remodeling by releasing of survival- and plasticity-promoting mediators. To evaluate whether secreted factors may mimic neuroprotective and restorative effects of NPCs, we exposed male C57BL6 mice to focal cerebral ischemia a...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-016-9748-y
更新日期：2017-03-01 00:00:00
abstract：:Fatty acid-binding proteins (FABPs) bind and internalize long-chain fatty acids, controlling lipid dynamics. Recent studies have proposed the involvement of FABPs, particularly FABP7, in lipid droplet (LD) formation in glioma, but the physiological significance of LDs is poorly understood. In this study, we sought to ...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-019-1489-2
更新日期：2019-08-01 00:00:00
abstract：:The epidermal growth factor (EGF) family of polypeptides is regulators for tissue development and repair, and is characterized by the fact that their mature forms are proteolytically derived from their integral membrane precursors. This article reviews roles of the prominent members of the EGF family (EGF, transformin...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/BF02742440
更新日期：1999-10-01 00:00:00
abstract：:Although the use, and misuse, of methylphenidate is increasing in childhood and adolescence, there is little information about the consequences of this psychostimulant chronic use on brain and behavior during development. The aim of the present study was to investigate hippocampus biochemical, histochemical, and behav...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-016-9987-y
更新日期：2017-08-01 00:00:00
abstract：:Rett syndrome is a complex neurodevelopmental disorder that is mainly caused by mutations in MECP2. However, mutations in FOXG1 cause a less frequent form of atypical Rett syndrome, called FOXG1 syndrome. FOXG1 is a key transcription factor crucial for forebrain development, where it maintains the balance between prog...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-018-1444-7
更新日期：2019-07-01 00:00:00
abstract：:Retrograde signaling is defined as the signaling events leading from the plastids to the nucleus in plants and across the chemical synapse, from the postsynaptic neuron to the presynaptic neuron in animals. The discovery of various retrograde messengers has opened many avenues and clouds of thoughts as to the role of ...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s12035-015-9280-5
更新日期：2016-05-01 00:00:00
abstract：:Microglial activation is a pathological feature of many neurodegenerative diseases and the role of cellular lipids in these diseases is mostly unknown. It was known that the special ether lipid plasmalogens (Pls) were reduced in the brain and blood samples of Alzheimer's disease (AD) patients. It has recently been rep...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-018-1307-2
更新日期：2019-05-01 00:00:00
abstract：:Nicotine, the main component of tobacco smoke, exerts influence on mood, and contributes to physical and psychological dependence. Taking into account frequent concomitance of nicotine abuse and stress, we aimed to research behavioral and biochemical effects associated with nicotine administration in combination with ...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-016-9701-0
更新日期：2017-03-01 00:00:00
abstract：:The escalating burden of type 2 diabetes (T2D) and its related complications has become a major public health challenge worldwide. Substantial evidence indicates that T2D is one of the culprits for the high prevalence of Alzheimer's disease (AD) in diabetic subjects. This study aimed to investigate the possible mitoch...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-020-02142-7
更新日期：2021-02-01 00:00:00
abstract：:The characteristic functions of tissues and organs result from the integrated activity of individual cells. Nowhere is this more evident than in the nervous system, where the activities of single neurons communicating via electrical and chemical signals mediate complex functions, such as learning and memory. The past ...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/BF02740623
更新日期：1996-12-01 00:00:00
abstract：:Alzheimer's disease (AD) is the most common cause of dementia among elderly people. Despite enormous efforts, the pathogenesis of AD still remains unclear and no drug has yet been proved to be disease-modifying. As the basis of learning and memory, the plasticity of synapse and dendritic spine has been impaired during...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-020-02183-y
更新日期：2020-11-03 00:00:00
abstract：:Huntington's disease (HD) is a devastating neurodegenerative disease caused by cytosine-adenine-guanine trinucleotide repeat expansion in the huntingtin gene. Growing evidence supports the regulatory functions of long noncoding RNAs (lncRNAs) in the disease process, but little is known about the association between ln...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-016-9928-9
更新日期：2017-03-01 00:00:00
abstract：:Pharmacological and genetic tools targeting the 5-hydroxytryptamine (5-HT)7 receptor in preclinical animal models have implicated this receptor in diverse (patho)physiological processes of the central nervous system (CNS). Some data obtained with 5-HT7 receptor knockout mice, selective antagonists, and, to a lesser ex...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s12035-011-8175-3
更新日期：2011-06-01 00:00:00
abstract：:Ketamine is used as a general anesthetic, and recent data suggest that anesthetics can cause neuronal damage when exposure occurs during development. The precise mechanisms are not completely understood. To evaluate the degree of ketamine-induced neuronal toxicity, neural stem cells were isolated from gestational day ...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-015-9248-5
更新日期：2015-10-01 00:00:00
abstract：:The association between Alzheimer's disease and uric acid levels had gained great interest in recent years, but there was still lack of definite evidence. A systematic review and meta-analysis of relevant studies was performed to comprehensively estimate the association. Relevant studies published before October 26, 2...
journal_title：Molecular neurobiology
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s12035-015-9271-6
更新日期：2016-05-01 00:00:00
abstract：:Depression is the leading cause of disability worldwide with global distribution of 322 million people suffering from the disease. While much is understood about depression, the underlying pathophysiology is yet to be fully characterized. Recently, the unfolded protein response (UPR) has been shown to be involved in r...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-019-01687-6
更新日期：2019-12-01 00:00:00
abstract：:Alzheimer's disease (AD) is a neurodegenerative disease which is characterized by progressive memory loss, the accumulation of β-amyloid peptide (Aβ) (mainly Aβ1-42), and more recently, by neuroinflammation, which has been highlighted as playing a central role in the development and progress of AD. This study utilized...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-018-1211-9
更新日期：2019-04-01 00:00:00
abstract：:Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder characterized by involuntary body movement, cognitive impairment and psychiatric disturbance. A polyglutamine expansion in the amino-terminal region of the huntingtin (htt) protein is the genetic cause of HD. Htt protein interacts with a wid...
journal_title：Molecular neurobiology
pub_type： 杂志文章,评审
doi：10.1007/s12035-010-8153-1
更新日期：2011-02-01 00:00:00
abstract：:Findings from observational and experimental studies suggest that maternal inflammation during pregnancy is associated with autism spectrum disorder (ASD). We report the first study in humans to examine this association in a large prospective birth cohort. We studied 788 mother-child pairs from the Seychelles Child De...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-018-1424-y
更新日期：2019-07-01 00:00:00
abstract：:Neuropsin (NP) is a serine protease, implicated in synaptic plasticity and memory acquisition through cleavage of synaptic adhesion molecule, L1CAM. However, NP has not been explored during brain aging that entails drastic deterioration of plasticity and memory with selective regional vulnerability. Therefore, we have...
journal_title：Molecular neurobiology
pub_type： 杂志文章
doi：10.1007/s12035-014-8780-z
更新日期：2015-01-01 00:00:00
