Abstract:
:Parkinson's disease (PD) is a major neurodegenerative chronic disease, most likely caused by a complex interplay of genetic and environmental factors. Information on various aspects of PD pathogenesis is rapidly increasing and needs to be efficiently organized, so that the resulting data is available for exploration and analysis. Here we introduce a computationally tractable, comprehensive molecular interaction map of PD. This map integrates pathways implicated in PD pathogenesis such as synaptic and mitochondrial dysfunction, impaired protein degradation, alpha-synuclein pathobiology and neuroinflammation. We also present bioinformatics tools for the analysis, enrichment and annotation of the map, allowing the research community to open new avenues in PD research. The PD map is accessible at http://minerva.uni.lu/pd_map .
journal_name
Mol Neurobioljournal_title
Molecular neurobiologyauthors
Fujita KA,Ostaszewski M,Matsuoka Y,Ghosh S,Glaab E,Trefois C,Crespo I,Perumal TM,Jurkowski W,Antony PM,Diederich N,Buttini M,Kodama A,Satagopam VP,Eifes S,Del Sol A,Schneider R,Kitano H,Balling Rdoi
10.1007/s12035-013-8489-4subject
Has Abstractpub_date
2014-02-01 00:00:00pages
88-102issue
1eissn
0893-7648issn
1559-1182journal_volume
49pub_type
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pub_type: 已发布勘误
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