Behavioral and Biochemical Impact of Chronic Unpredictable Mild Stress on the Acquisition of Nicotine Conditioned Place Preference in Rats.

abstract：:Rhodopsin is a G protein-coupled receptor essential for vision and rod photoreceptor viability. Disease-associated rhodopsin mutations, such as P23H rhodopsin, cause rhodopsin protein misfolding and trigger endoplasmic reticulum (ER) stress, activating the unfolded protein response (UPR). The pathophysiologic effects ...

journal_title：Molecular neurobiology

authors： Chiang WC,Kroeger H,Sakami S,Messah C,Yasumura D,Matthes MT,Coppinger JA,Palczewski K,LaVail MM,Lin JH

更新日期：2015-08-01 00:00:00

abstract：:Neuronal differentiation plays a key role during embryogenesis. However, based on the capacity of neuronal stem cells to either generate or regenerate neurons and because differentiation stops aberrant neuroblasts proliferation, neuronal differentiation is crucial during neuropathological conditions. Although phosphat...

journal_title：Molecular neurobiology

authors： Paoletti L,Domizi P,Marcucci H,Montaner A,Krapf D,Salvador G,Banchio C

更新日期：2016-11-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most prevalent form of dementia in the world. The neuropathological characteristics of AD patients are the accumulation of extracellular plaques of β-amyloid (Aβ) and intracellular hyperphosphorylated tau protein. Transthyretin (TTR) may alleviate AD symptom by reducing Aβ concentration...

journal_title：Molecular neurobiology

authors： Xiang Q,Bi R,Xu M,Zhang DF,Tan L,Zhang C,Fang Y,Yao YG

更新日期：2017-09-01 00:00:00

abstract：:For more than a century dendritic spines have been a source of fascination and speculation. The long-held belief that these anatomical structures are involved in learning and memory are addressed. Specifically, two lines of evidence that support this claim are reviewed. In the first, we review evidence that experiment...

journal_title：Molecular neurobiology

authors： Leuner B,Shors TJ

更新日期：2004-04-01 00:00:00

abstract：:Nicotine has a broad impact on both the central and peripheral nervous systems. Over the past decades, an increasing number of genes potentially involved in nicotine addiction have been identified by different technical approaches. However, the molecular mechanisms underlying nicotine addiction remain largely unknown....

journal_title：Molecular neurobiology

authors： Liu X,Liu M,Li X,Zhang L,Fan R,Wang J

更新日期：2015-08-01 00:00:00

abstract：:The neural crest is a transient embryonic structure that gives rise to a multitude of different cell types in the vertebrate. As such, it is an ideal model to study the processes of vertebrate differentiation and development. This review focuses on two major questions related to neural crest development. The first que...

journal_title：Molecular neurobiology

authors： Murphy M,Bartlett PF

更新日期：1993-07-01 00:00:00

abstract：:The characteristic functions of tissues and organs result from the integrated activity of individual cells. Nowhere is this more evident than in the nervous system, where the activities of single neurons communicating via electrical and chemical signals mediate complex functions, such as learning and memory. The past ...

journal_title：Molecular neurobiology

authors： O'Dowd DK,Smith MA

更新日期：1996-12-01 00:00:00

abstract：:Among five members of the K+-dependent Na+/Ca2+ exchanger (NCKX) family (NCKX1-5), only NCKX2 is highly expressed in mouse brain. NCKX2 in plasma membranes mediates cytosolic calcium excretion through electrogenic exchange of 4 Na+ for 1 Ca2+ and 1 K+. Here, we observed significantly decreased levels of NCKX2 protein ...

journal_title：Molecular neurobiology

authors： Moriguchi S,Kita S,Yabuki Y,Inagaki R,Izumi H,Sasaki Y,Tagashira H,Horie K,Takeda J,Iwamoto T,Fukunaga K

更新日期：2018-05-01 00:00:00

abstract：:Matrix metalloproteinase-9 (MMP-9) plays a crucial role in pathological processes of brain inflammation, injury, and neurodegeneration. Thrombin has been known as a regulator of MMP-9 expression and cells migration. However, the mechanisms underlying thrombin-induced MMP-9 expression in rat brain astrocytes (RBA-1 cel...

journal_title：Molecular neurobiology

authors： Lin CC,Lee IT,Wu WB,Liu CJ,Hsieh HL,Hsiao LD,Yang CC,Yang CM

更新日期：2013-12-01 00:00:00

abstract：:We prepared and grafted tropomyosin receptor kinase B (TrkB) gene-transfected mesenchymal stem cells (TrkB-MSCs) into the ischemic penumbra and investigated whether electroacupuncture (EA) treatment could promote functional recovery from ischemic stroke. For the behavioral test, TrkB-MSCs+EA resulted in significantly ...

journal_title：Molecular neurobiology

authors： Ahn SM,Kim YR,Shin YI,Ha KT,Lee SY,Shin HK,Choi BT

更新日期：2019-01-01 00:00:00

abstract：:Ketamine is used as a general anesthetic, and recent data suggest that anesthetics can cause neuronal damage when exposure occurs during development. The precise mechanisms are not completely understood. To evaluate the degree of ketamine-induced neuronal toxicity, neural stem cells were isolated from gestational day ...

journal_title：Molecular neurobiology

authors： Slikker W Jr,Liu F,Rainosek SW,Patterson TA,Sadovova N,Hanig JP,Paule MG,Wang C

更新日期：2015-10-01 00:00:00

abstract：:Oxidative stress-induced damage is a major mechanism in the pathophysiology of amyotrophic lateral sclerosis (ALS). A recent human clinical trial showed that the combination of nicotinamide riboside (NR) and pterostilbene (PT), molecules with potential to interfere in that mechanism, was efficacious in ALS patients. W...

journal_title：Molecular neurobiology

authors： Obrador E,Salvador R,Marchio P,López-Blanch R,Jihad-Jebbar A,Rivera P,Vallés SL,Banacloche S,Alcácer J,Colomer N,Coronado JA,Alandes S,Drehmer E,Benlloch M,Estrela JM

更新日期：2020-11-10 00:00:00

abstract：:Neurodegenerative foldopathies are characterized by aberrant folding of diseased modified proteins, which are major constituents of the intracellular and extracellular lesions. These lesions correlate with the cognitive and/or motor impairment seen in these diseases. The majority of the disease modified proteins in ne...

journal_title：Molecular neurobiology

authors： Jadhav S,Zilka N,Novak M

更新日期：2013-12-01 00:00:00

abstract：:In human glioma tumours, heme oxygenase-1 (HO-1) is overexpressed when compared with normal brain tissues and during oligodendroglioma progression. However, the molecular mechanisms mediated by HO-1 to promote glioblastoma remain unknown. We therefore aimed at investigating the effect of HO-1 expression and its select...

journal_title：Molecular neurobiology

authors： Castruccio Castracani C,Longhitano L,Distefano A,Di Rosa M,Pittalà V,Lupo G,Caruso M,Corona D,Tibullo D,Li Volti G

更新日期：2020-05-01 00:00:00

abstract：:Docosahexaenoic acid (DHA) is enriched in membrane phospholipids of the central nervous system (CNS) and has a role in aging and neuropsychiatric disorders. DHA is metabolized by the enzyme Alox15 to 17S-hydroxy-DHA, which is then converted to 7S-hydroperoxy,17S-hydroxy-DHA by a 5-lipoxygenase, and thence via epoxy in...

journal_title：Molecular neurobiology

authors： Shalini SM,Ho CF,Ng YK,Tong JX,Ong ES,Herr DR,Dawe GS,Ong WY

更新日期：2018-02-01 00:00:00

abstract：:Traumatic spinal cord injury (SCI) causes neuron death and axonal damage resulting in functional motor and sensory loss, showing limited regeneration because of adverse microenvironment such as neuroinflammation and glial scarring. Currently, there is no effective therapy to treat SCI in clinical practice. Bone marrow...

journal_title：Molecular neurobiology

authors： Zhao H,Cheng L,Du X,Hou Y,Liu Y,Cui Z,Nie L

更新日期：2016-01-01 00:00:00

abstract：:OMI/HTRA2 (high-temperature requirement serine protease A2) is a mitochondrial serine protease involved in several cellular processes, including autophagy, chaperone activity, and apoptosis. Few studies on the role of OMI/HTRA2 in Alzheimer's disease (AD) are available, but none on its relationship with the cholinergi...

journal_title：Molecular neurobiology

authors： Darreh-Shori T,Rezaeianyazdi S,Lana E,Mitra S,Gellerbring A,Karami A,Bogdanovic N,Lithner CU,Winblad B,Behbahani H

更新日期：2019-07-01 00:00:00

abstract：:Tonic GABAA receptors are a subpopulation of receptors that generate long-lasting inhibition and thereby control network excitability. In recent years, these receptors have been implicated in various neurological and psychiatric disorders, including Parkinson's disease, schizophrenia, and epilepsy. Their distinct subu...

journal_title：Molecular neurobiology

authors： Schipper S,Aalbers MW,Rijkers K,Swijsen A,Rigo JM,Hoogland G,Vles JS

更新日期：2016-10-01 00:00:00

abstract：:Up to now, survivin has been recommended as a prognostic and diagnostic indicator in glioma patients. However, there are still many controversies. Here, a meta-analysis was conducted to draw a more definitive conclusion on the correlation of survivin with overall survival (OS), age, gender, and WHO grade. Eligible stu...

journal_title：Molecular neurobiology

authors： Lv S,Dai C,Liu Y,Shi R,Tang Z,Han M,Bian R,Sun B,Wang R

更新日期：2015-01-01 00:00:00

abstract：:An increasing number of circulating micro-ribonucleic acids (microRNAs, miRNAs) have been discovered its potential as biomarkers to diagnose neurodegenerative diseases (NDs) by many researchers. However, there were obvious inconsistencies among previous studies, and thus we performed this meta-analysis to evaluate whe...

journal_title：Molecular neurobiology

authors： Zi Y,Yin Z,Xiao W,Liu X,Gao Z,Jiao L,Deng L

更新日期：2015-12-01 00:00:00

abstract：:Involvement of membrane mineralocorticoid (MC) and glucocorticoid (GC) receptors in synaptic Zn2+ dynamics remains unclear. Here, we tested whether synaptic plasticity is affected by rapid intracellular Zn2+ dysregulation via membrane MC and GC receptor activation, in comparison with intracellular Ca2+ dysregulation. ...

journal_title：Molecular neurobiology

authors： Suzuki M,Sato Y,Tamura K,Tamano H,Takeda A

更新日期：2019-02-01 00:00:00

abstract：:Our previous study has proved that the up-regulation of glial glutamate transporter 1 (GLT-1) played an important role in the acquisition of brain ischemic tolerance after cerebral ischemic preconditioning (CIP) in rats. However, little is known about the mechanism involved in the up-regulation of GLT-1 in the process...

journal_title：Molecular neurobiology

authors： Zhang M,Gong JX,Wang JL,Jiang MY,Li L,Hu YY,Qi J,Zhang LY,Zhao H,Cui X,Xian XH,Li WB

更新日期：2017-01-01 00:00:00

abstract：:Military personnel are often subjected to sleep deprivation (SD) during combat operations. Since SD is a severe stress and alters neurochemical metabolism in the brain, a possibility exists that acute or long-term SD will influence blood-brain barrier (BBB) function and brain pathology. This hypothesis was examined in...

journal_title：Molecular neurobiology

authors： Sharma A,Muresanu DF,Lafuente JV,Patnaik R,Tian ZR,Buzoianu AD,Sharma HS

更新日期：2015-10-01 00:00:00

abstract：:The administration of the anorexigenic drug d,l-fenfluramine (Ponderax) to laboratory animals results in a dose-dependent reduction in presynaptically located serotonergic reuptake transporter protein. This long-term effect may represent an altered mechanism of synthesis of the transporter (downregulation). Alternativ...

journal_title：Molecular neurobiology

authors： Westphalen RI,Dodd PR

更新日期：1995-08-01 00:00:00

abstract：:Five-prime repressor element under dual repression binding protein-1 (Freud-1)/CC2D1A is genetically linked to intellectual disability and implicated in neuronal development. Freud-1 represses the serotonin-1A (5-HT1A) receptor gene HTR1A by histone deacetylase (HDAC)-dependent or HDAC-independent mechanisms in 5-HT1A...

journal_title：Molecular neurobiology

authors： Souslova T,Mirédin K,Millar AM,Albert PR

更新日期：2017-12-01 00:00:00

abstract：:A major sensory organ for the detection of pheromones by animals is the vomeronasal organ (VNO). Although pheromones control the behaviors of various species, the effect of pheromones on human behavior has been controversial because the VNO is not functional in adults. However, recent genetic, biochemical, and electro...

journal_title：Molecular neurobiology

authors： Wang Z,Nudelman A,Storm DR

更新日期：2007-06-01 00:00:00

abstract：:Most survivors of ischemic stroke remain physically disabled and require prolonged rehabilitation. However, some stroke victims achieve a full neurological recovery suggesting that the human brain can defend itself against ischemic injury, but the protective mechanisms are unknown. This study used selective pharmacolo...

journal_title：Molecular neurobiology

authors： Sun F,Johnson SR,Jin K,Uteshev VV

更新日期：2017-04-01 00:00:00

abstract：:Impaired glucose metabolism and mitochondrial decay greatly increase with age, when cognitive decline becomes rampant. No pharmacological or dietary intervention has proven effective, but proper diet and lifestyle do postpone the onset of neurodegeneration and some nutrients are being investigated. We studied insulin ...

journal_title：Molecular neurobiology

authors： Tomé-Carneiro J,Carmen Crespo M,Burgos-Ramos E,Tomas-Zapico C,García-Serrano A,Castro-Gómez P,Venero C,Pereda-Pérez I,Baliyan S,Valencia A,Fontecha J,Dávalos A,Visioli F

更新日期：2018-09-01 00:00:00

abstract：:Neurons are highly polarized cells displaying an elaborate architectural morphology. The design of their dendritic arborization and the distribution of their synapses contribute importantly to information processing in the brain. The growth and complexity of dendritic arbors are driven by the formation of synapses alo...

journal_title：Molecular neurobiology

authors： Lira M,Arancibia D,Orrego PR,Montenegro-Venegas C,Cruz Y,García J,Leal-Ortiz S,Godoy JA,Gundelfinger ED,Inestrosa NC,Garner CC,Zamorano P,Torres VI

更新日期：2019-07-01 00:00:00

abstract：:Cholinergic system is very important for many higher brain functions, including learning and memory. Cholinergic neurons, especially those in the basal forebrain, are specifically susceptible in some neurodegenerative diseases, such as in Alzheimer's disease (AD). Here, we studied the cholinergic system lesion effects...

journal_title：Molecular neurobiology

authors： Yan H,Pang P,Chen W,Zhu H,Henok K A,Li H,Wu Z,Ke X,Wu J,Zhang T,Pan K,Pei L,Han Y,Lu Y

更新日期：2018-05-01 00:00:00