Do Human Endogenous Retroviruses Contribute to Multiple Sclerosis, and if So, How?

abstract：:Stroke is considered as the second leading cause of death worldwide. The survivors of stroke experience different levels of impairment in brain function resulting in debilitating disabilities. Current therapies for stroke are primarily palliative and may be effective in only a small population of stroke patients. In t...

journal_title：Molecular neurobiology

authors： Hou B,Ma J,Guo X,Ju F,Gao J,Wang D,Liu J,Li X,Zhang S,Ren H

更新日期：2017-03-01 00:00:00

abstract：:Neurogenesis is a developmental process that involves fine-tuned coordination between self-renewal, proliferation, and differentiation of neural stem cells (NSCs) into neurons. However, early-life assault with environmental toxicants interferes with the regular function of genes, proteins, and other molecules that bui...

journal_title：Molecular neurobiology

authors： Yadav A,Tandon A,Seth B,Goyal S,Singh SJ,Tiwari SK,Agarwal S,Nair S,Chaturvedi RK

更新日期：2021-01-01 00:00:00

abstract：:Fatty acid-binding proteins (FABPs) bind and internalize long-chain fatty acids, controlling lipid dynamics. Recent studies have proposed the involvement of FABPs, particularly FABP7, in lipid droplet (LD) formation in glioma, but the physiological significance of LDs is poorly understood. In this study, we sought to ...

journal_title：Molecular neurobiology

authors： Islam A,Kagawa Y,Miyazaki H,Shil SK,Umaru BA,Yasumoto Y,Yamamoto Y,Owada Y

更新日期：2019-08-01 00:00:00

abstract：:Since melamine was illegally added to raw milk for increasing the apparent protein content, such a scandal has not been quite blown out. Previous studies showed that melamine induced apoptosis and oxidative damage in both in vivo and in vitro experiments. It is well known that autophagy is closely related to oxidative...

journal_title：Molecular neurobiology

authors： Wang H,Gao N,Li Z,Yang Z,Zhang T

更新日期：2016-04-01 00:00:00

abstract：:Multiple sclerosis (MS) is an autoimmune, inflammatory disease of the central nervous system (CNS). We have measured the levels of over 20 non-esterified sterols in plasma and cerebrospinal fluid (CSF) from patients suffering from MS, inflammatory CNS disease, neurodegenerative disease and control patients. Analysis w...

journal_title：Molecular neurobiology

authors： Crick PJ,Griffiths WJ,Zhang J,Beibel M,Abdel-Khalik J,Kuhle J,Sailer AW,Wang Y

更新日期：2017-12-01 00:00:00

abstract：:Bisphenol A (BPA) is a ubiquitous compound emerging as a possible toxicant during embryonic development. Human embryonic stem cell (hESC) promises a valuable model for evaluating the effects of environmental chemicals on human prenatal development. In our study, 1 μM BPA were applied to hESC-derived embryoid bodies (h...

journal_title：Molecular neurobiology

authors： Huang B,Ning S,Zhang Q,Chen A,Jiang C,Cui Y,Hu J,Li H,Fan G,Qin L,Liu J

更新日期：2017-07-01 00:00:00

abstract：:Although the use, and misuse, of methylphenidate is increasing in childhood and adolescence, there is little information about the consequences of this psychostimulant chronic use on brain and behavior during development. The aim of the present study was to investigate hippocampus biochemical, histochemical, and behav...

journal_title：Molecular neurobiology

authors： Schmitz F,Pierozan P,Rodrigues AF,Biasibetti H,Grunevald M,Pettenuzzo LF,Scaini G,Streck EL,Netto CA,Wyse ATS

更新日期：2017-08-01 00:00:00

abstract：:Tenascin-C (TNC), a matricellular protein, is upregulated in brain parenchyma after experimental subarachnoid hemorrhage (SAH). Recent studies emphasize that early brain injury (EBI) should be overcome to improve post-SAH outcomes. The aim of this study was to investigate effects of TNC knockout (TNKO) on neuronal apo...

journal_title：Molecular neurobiology

authors： Liu L,Fujimoto M,Nakano F,Nishikawa H,Okada T,Kawakita F,Imanaka-Yoshida K,Yoshida T,Suzuki H

更新日期：2018-11-01 00:00:00

abstract：:TREK-1, a two-pore-domain K+ channel, is highly expressed in the central nervous system. Although aberrant expression of TREK-1 is implicated in cognitive impairment, the cellular and functional mechanism underlying this channelopathy is poorly understood. Here we examined TREK-1 contribution to neuronal morphology, e...

journal_title：Molecular neurobiology

authors： Wang W,Kiyoshi CM,Du Y,Taylor AT,Sheehan ER,Wu X,Zhou M

更新日期：2020-03-01 00:00:00

abstract：:Agmatine, an endogenous neuromodulator, is a potential candidate to constitute an adjuvant/monotherapy for the management of depression. A recent study by our group demonstrated that agmatine induces Nrf2 and protects against corticosterone effects in a hippocampal neuronal cell line. The present study is an extension...

journal_title：Molecular neurobiology

authors： Freitas AE,Egea J,Buendia I,Gómez-Rangel V,Parada E,Navarro E,Casas AI,Wojnicz A,Ortiz JA,Cuadrado A,Ruiz-Nuño A,Rodrigues ALS,Lopez MG

更新日期：2016-07-01 00:00:00

abstract：:Impaired glucose metabolism and mitochondrial decay greatly increase with age, when cognitive decline becomes rampant. No pharmacological or dietary intervention has proven effective, but proper diet and lifestyle do postpone the onset of neurodegeneration and some nutrients are being investigated. We studied insulin ...

journal_title：Molecular neurobiology

authors： Tomé-Carneiro J,Carmen Crespo M,Burgos-Ramos E,Tomas-Zapico C,García-Serrano A,Castro-Gómez P,Venero C,Pereda-Pérez I,Baliyan S,Valencia A,Fontecha J,Dávalos A,Visioli F

更新日期：2018-09-01 00:00:00

abstract：:Activated autophagy/mitophagy has been intensively observed in ischemic brain, but its roles remain controversial. Peroxynitrite (ONOO-), as a representative of reactive nitrogen species, is considered as a critical neurotoxic factor in mediating cerebral ischemia-reperfusion (I/R) injury, but its roles in autophagy/m...

journal_title：Molecular neurobiology

authors： Feng J,Chen X,Guan B,Li C,Qiu J,Shen J

更新日期：2018-08-01 00:00:00

abstract：:Occurrence of stroke cases displays a time-of-day variation in human. However, the mechanism linking circadian rhythm to the internal response mechanisms against pathophysiological events after ischemic stroke remained largely unknown. To this end, temporal changes in the susceptibility to ischemia/reperfusion (I/R) i...

journal_title：Molecular neurobiology

authors： Beker MC,Caglayan B,Yalcin E,Caglayan AB,Turkseven S,Gurel B,Kelestemur T,Sertel E,Sahin Z,Kutlu S,Kilic U,Baykal AT,Kilic E

更新日期：2018-03-01 00:00:00

abstract：:The mechanisms by which inflammation affects the different emotional moods are only partially known. Previous works have pointed to stress hormones like glucocorticoids plus the vascular factor endothelin-1 as key factors evoking stressful states especially in relation to endothelial dysfunctions. With this work, it w...

journal_title：Molecular neurobiology

authors： Avolio E,Fazzari G,Mele M,Alò R,Zizza M,Jiao W,Di Vito A,Barni T,Mandalà M,Canonaco M

更新日期：2017-10-01 00:00:00

abstract：:GLI2 is a key mediator of the sonic hedgehog (Shh) signaling pathway and plays an important role in neural tube development during vertebrate embryogenesis; however, the role of gli2 in human folate-related neural tube defects remains unclear. In this study, we compared methylation status and polymorphisms of gli2 bet...

journal_title：Molecular neurobiology

authors： Lu XL,Wang L,Chang SY,Shangguan SF,Wang Z,Wu LH,Zou JZ,Xiao P,Li R,Bao YH,Qiu ZY,Zhang T

更新日期：2016-10-01 00:00:00

abstract：:Inhalational general anesthetics, such as sevoflurane and isoflurane, modulate a subset of brain Kv1 potassium channels. However, the Kv1.2 channel is resistant to propofol, a commonly used intravenous alkylphenol anesthetic. We hypothesize that propofol binds to a presumed pocket involving the channel's S4-S5 linker,...

journal_title：Molecular neurobiology

authors： Bu W,Liang Q,Zhi L,Maciunas L,Loll PJ,Eckenhoff RG,Covarrubias M

更新日期：2018-02-01 00:00:00

abstract：:Alzheimer's disease is a chronic neurodegenerative disorder characterized by neuronal loss, cerebrovascular inflammation, and accumulation of senile plaques in the brain parenchyma and cerebral blood vessels. Amyloid-beta peptide (Abeta), a major component of senile plaques, has been shown to exert multiple toxic effe...

journal_title：Molecular neurobiology

authors： Yang X,Askarova S,Lee JC

更新日期：2010-06-01 00:00:00

abstract：:Fenpropathrin is one of the widely used pyrethroids in agriculture and household and also reported to have neurotoxic effects in rodent models. In our Parkinson's disease (PD) clinic, there was a unique patient with a history of daily exposure to fenpropathrin for 6 months prior to developing Parkinsonian symptoms pro...

journal_title：Molecular neurobiology

authors： Xiong J,Zhang X,Huang J,Chen C,Chen Z,Liu L,Zhang G,Yang J,Zhang Z,Zhang Z,Lin Z,Xiong N,Wang T

更新日期：2016-03-01 00:00:00

abstract：:Astrogliosis and microgliosis in hippocampal sclerosis (HS) are widespread and are postulated to contribute to the pro-excitatory neuropathological environment. This study aimed to establish if seizure burden at the time of surgery or post-surgical outcome were correlated with the extent of gliosis in HS. As a seconda...

journal_title：Molecular neurobiology

authors： Johnson AM,Sugo E,Barreto D,Hiew CC,Lawson JA,Connolly AM,Somerville E,Hasic E,Bye AM,Cunningham AM

更新日期：2016-10-01 00:00:00

abstract：:Tonic GABAA receptors are a subpopulation of receptors that generate long-lasting inhibition and thereby control network excitability. In recent years, these receptors have been implicated in various neurological and psychiatric disorders, including Parkinson's disease, schizophrenia, and epilepsy. Their distinct subu...

journal_title：Molecular neurobiology

authors： Schipper S,Aalbers MW,Rijkers K,Swijsen A,Rigo JM,Hoogland G,Vles JS

更新日期：2016-10-01 00:00:00

abstract：:L-DOPA is the main pharmacological therapy for Parkinson's disease. However, long-term exposure to L-DOPA induces involuntary movements termed dyskinesia. Clinical trials show that dyskinesia is attenuated by metabotropic glutamate receptor type 5 (mGluR5) antagonists. Further, the onset of dyskinesia is delayed by ni...

journal_title：Molecular neurobiology

authors： García-Montes JR,Solís O,Enríquez-Traba J,Ruiz-DeDiego I,Drucker-Colín R,Moratalla R

更新日期：2019-06-01 00:00:00

abstract：:Inflammation plays a crucial role in the pathogenesis of stroke. This study aims to determine lipoprotein (a) [Lp(a)] levels in serum and to investigate their associations with stroke recurrence events in a 3-month follow-up study in patients with acute ischemic stroke (AIS). Serum Lp(a) levels were determined in 203 ...

journal_title：Molecular neurobiology

authors： Hong XW,Wu DM,Lu J,Zheng YL,Tu WJ,Yan J

更新日期：2018-01-01 00:00:00

abstract：:PCDH19-Clustering Epilepsy (PCDH19-CE) is an infantile onset disorder caused by mutation of the X-linked PCDH19 gene. Intriguingly, heterozygous females are affected while hemizygous males are not. While there is compelling evidence that this disorder stems from the coexistence of WT and PCDH19-null cells, the cellula...

journal_title：Molecular neurobiology

authors： Mincheva-Tasheva S,Nieto Guil AF,Homan CC,Gecz J,Thomas PQ

更新日期：2021-01-07 00:00:00

abstract：:The vertebrate retina is a "genuine neural center" (Ramón y Cajal), in which glutamate is a major excitatory neurotransmitter. Both N-methyl-D-aspartate (NMDA) and non-NMDA receptors are expressed in the retina. Although non-NMDA receptors and/or metabotropic glutamate receptors are generally thought to be responsible...

journal_title：Molecular neurobiology

authors： Shen Y,Liu XL,Yang XL

更新日期：2006-12-01 00:00:00

abstract：:Multiple players are involved in motor and sensory dysfunctions after spinal cord injury (SCI). Therefore, therapeutic approaches targeting these various players in the damage cascade hold considerable promise for the treatment of traumatic spinal cord injury. Soluble epoxide hydrolase (sEH) is an endogenous key enzym...

journal_title：Molecular neurobiology

authors： Chen X,Chen X,Huang X,Qin C,Fang Y,Liu Y,Zhang G,Pan D,Wang W,Xie M

更新日期：2016-04-01 00:00:00

abstract：:Dimebon (latrepirdine) is an anti-histaminergic agent which belongs to a fast-growing group of "old" medicines suggested to be of therapeutic utility for pathological conditions different from their original design ("repositioning"). Here, we overview the most recent studies on Dimebon directed to pathological process...

journal_title：Molecular neurobiology

authors： Ustyugov A,Shevtsova E,Bachurin S

更新日期：2015-10-01 00:00:00

abstract：:Activation of RhoA/Rho kinase leads to growth cone collapse and neurite retraction. Although RhoA/Rho kinase inhibition has been shown to improve axon regeneration, remyelination and functional recovery, its role in neuronal cell death remains unclear. To determine whether RhoA/Rho kinase played a role in neuronal dea...

journal_title：Molecular neurobiology

authors： Wu X,Walker CL,Lu Q,Wu W,Eddelman DB,Parish JM,Xu XM

更新日期：2017-11-01 00:00:00

abstract：:We prepared and grafted tropomyosin receptor kinase B (TrkB) gene-transfected mesenchymal stem cells (TrkB-MSCs) into the ischemic penumbra and investigated whether electroacupuncture (EA) treatment could promote functional recovery from ischemic stroke. For the behavioral test, TrkB-MSCs+EA resulted in significantly ...

journal_title：Molecular neurobiology

authors： Ahn SM,Kim YR,Shin YI,Ha KT,Lee SY,Shin HK,Choi BT

更新日期：2019-01-01 00:00:00

abstract：:Recent evidence suggests that hypoxia preconditioning can alter the microRNA (miRNA) profile of extracellular vesicles (EVs) and has better neuroprotective effects when enriched miRs are delivered to recipients. However, the roles of exosomal miRNAs in regulating ischaemia-reperfusion (IR)-induced pain hypersensitivit...

journal_title：Molecular neurobiology

authors： Wang H,Chen FS,Zhang ZL,Zhou HX,Ma H,Li XQ

更新日期：2021-02-01 00:00:00

abstract：:Previous studies have provided evidence for axon-to-myelin transfer of intact lipids and lipid precursors for reutilization by myelin enzymes. Several of the lipid constituents of myelin showed significant contralateral/ipsilateral ratios of incorporated radioactivity, indicative of axonal origin, whereas proteins and...

journal_title：Molecular neurobiology

authors： Ledeen RW,Golly F,Haley JE

更新日期：1992-07-01 00:00:00