解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:Astrocytes are responsible for a broad range of functions that maintain homeostasis in the brain. However, their response to the pro-inflammatory cytokines released by activated microglia in various neurological pathologies may exacerbate neurodegenerative processes. Accumulating evidence suggests that omega...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-021-00611-w
更新日期:2021-01-27 00:00:00
abstract:BACKGROUND:To identify mechanisms of cortical plasticity of the visual cortex and to quantify their significance, sensitive parameters are warranted. In this context, multifocal visual evoked potentials (mfVEPs) can make a valuable contribution as they are not associated with cancellation artifacts and include also the...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-020-00600-5
更新日期:2020-11-23 00:00:00
abstract:BACKGROUND:Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative fatal disease that can affect the neurons of brain and spinal cord. ALS genetics has identified various genes to be associated with disease pathology. Oxidative stress induced bunina and lewy bodies formation can be regulated through the ...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-020-00591-3
更新日期:2020-10-09 00:00:00
abstract:BACKGROUND:Alzheimer's disease (AD) is a progressive neuro-degenerative disease with a major manifestation of dementia. MicroRNAs were reported to regulate the transcript expression in patients with Alzheimer's disease (AD). In this study, we investigated the roles of miR-138, a brain-enriched miRNA, in the AD cell mod...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-020-00579-z
更新日期:2020-07-31 00:00:00
abstract:BACKGROUND:Recent research has revealed that the community of microorganisms inhabiting the gut affects brain development, function and behaviour. In particular, disruption of the gut microbiome during critical developmental windows can have lasting effects on host physiology. Both antibiotic exposure and germ-free con...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-020-00583-3
更新日期:2020-07-22 00:00:00
abstract:BACKGROUND:One of the most basic human traits is language. Linguistic ability, and disability, have been shown to have a strong genetic component in family and twin studies, but molecular genetic studies of language phenotypes are scarce, relative to studies of other cognitive traits and neurodevelopmental phenotypes. ...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-020-00581-5
更新日期:2020-07-07 00:00:00
abstract:BACKGROUND:Empathy refers to the ability to recognise and share emotions with others. Several research groups have recognised observational fear in mice as a useful behavioural model for assessing their ability to empathise. However, in these observation systems, it remains unclear whether the observer mouse truly reco...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-020-00566-4
更新日期:2020-05-01 00:00:00
abstract::Following the publication of this article [1], it has been noted by the authors that an image of the same cell nuclei has been used in error twice, in Fig. 8, parts A and B. These images are redundant in this figure as the images in parts D and E show Wnt3a treated and control cells stained with both Hoechst 33342 (as...
journal_title:BMC neuroscience
pub_type: 杂志文章,已发布勘误
doi:10.1186/s12868-020-0558-9
更新日期:2020-03-06 00:00:00
abstract:BACKGROUND:Synaptic degeneration and accumulation of amyloid β-peptides (Aβ) are hallmarks of the Alzheimer diseased brain. Aβ is synaptotoxic and produced by sequential cleavage of the amyloid precursor protein (APP) by the β-secretase BACE1 and by γ-secretase. If APP is instead cleaved by the α-secretase ADAM10, Aβ w...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-020-0554-0
更新日期:2020-02-04 00:00:00
abstract:BACKGROUND:The Pde6brd1 (Rd1) mouse is widely used as a murine model for human retinitis pigmentosa. Understanding the spatio-temporal patterns of cone degeneration is important for evaluating potential treatments. In the present study we performed a systematic characterization of the spatio-temporal patterns of S- and...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-019-0528-2
更新日期:2019-09-03 00:00:00
abstract:BACKGROUND:Distinctive patterns of functional connectivity (FC) abnormalities in neural circuitry has been reported in patients with bipolar depression (BD) and unipolar depression (UD). However, it is unclear that whether this distinct functional connectivity patterns are diagnosis specific between BD and UD. This stu...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-019-0508-6
更新日期:2019-06-17 00:00:00
abstract:BACKGROUND:Knock-in (KI) mouse models of Alzheimer's disease (AD) that endogenously overproduce Aβ without non-physiological overexpression of amyloid precursor protein (APP) provide important insights into the pathogenic mechanisms of AD. Previously, we reported that AppNL-G-F mice, which harbor three familial AD muta...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-019-0496-6
更新日期:2019-03-20 00:00:00
abstract:BACKGROUND:Acute subdural hemorrhage (ASDH) is a severe consequence of traumatic brain injury. The occurrence of subdural blood increases the lethality of these patients independent of the amount of blood or elevated intracranial pressure. Thrombin is one of the potential harmful blood components. Possible harmful effe...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-018-0481-5
更新日期:2018-12-27 00:00:00
abstract:BACKGROUND:Low-intensity pulsed ultrasound stimulation (LIPUS) has been proven to be a noninvasive method with high spatial resolution and deep penetration. Previous studies have qualitatively demonstrated that the electromyographic response caused by LIPUS in the mouse motor cortex is affected by the anesthetic state ...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-018-0476-2
更新日期:2018-12-03 00:00:00
abstract:BACKGROUND:Transcranial focused ultrasound (tFUS) is a new non-invasive neuromodulation technique that uses mechanical energy to modulate neuronal excitability with high spatial precision. tFUS has been shown to be capable of modulating EEG brain activity in humans that is spatially restricted, and here, we use 7T MRI ...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-018-0456-6
更新日期:2018-09-14 00:00:00
abstract:BACKGROUND:Cys-loop receptors play important roles in fast neuronal signal transmission. Functional receptors are pentamers, with each subunit having an extracellular, transmembrane (TM) and intracellular domain. Each TM domain contains 4 α-helices (M1-M4) joined by loops of varying lengths. Many of the amino acid resi...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-018-0454-8
更新日期:2018-09-06 00:00:00
abstract:BACKGROUND:Intracranial Self-Stimulation (ICSS) of the medial forebrain bundle (MFB) is a deep brain stimulation procedure, which has a powerful enhancement effect on explicit and implicit memory. However, the downstream synaptic plasticity events of MFB-ICSS in memory related areas have not been described thoroughly. ...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-018-0449-5
更新日期:2018-08-08 00:00:00
abstract:BACKGROUND:Given the reported inverse association between light and depressive mood, ambient light may also be associated with some of the brain regions in healthy subjects. The present study aims to investigate the effects of ambient light on glucose metabolism in the brain. We used the data of 28 healthy participants...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-018-0444-x
更新日期:2018-07-24 00:00:00
abstract:BACKGROUND:Alzheimer's disease (AD) is the most prevalent form of dementia and represents one of the highest unmet requirements in medicine today. There is shortage of novel molecules entering into market because of poor pharmacokinetic properties and safety issues. Drug repurposing offers an opportunity to reinvigorat...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-017-0394-8
更新日期:2017-10-27 00:00:00
abstract:BACKGROUND:Following partial injury to the central nervous system, cells beyond the initial injury site undergo secondary degeneration, exacerbating loss of neurons, compact myelin and function. Changes in Ca2+ flux are associated with metabolic and structural changes, but it is not yet clear how flux through specific ...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-017-0380-1
更新日期:2017-08-14 00:00:00
abstract:BACKGROUND:CRISPR/Cas9 system is a powerful method to investigate the role of genes by introducing a mutation selectively and efficiently to specific genome positions in cell and animal lines. However, in primary neuron cultures, this method is affected by the issue that the effectiveness of CRISPR/Cas9 is different in...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-017-0377-9
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:Astaxanthin (ATX) is a carotenoid pigment with pleiotropic pharmacological properties that is seen as a possible drug for treating cerebral ischemic injury and subarachnoid hemorrhage. Na+-K+-2Cl- co-transporter-1 (NKCC1), an intrinsic membrane protein expressed by many cell types, is activated by various in...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-017-0358-z
更新日期:2017-05-10 00:00:00
abstract:BACKGROUND:The mechanisms of steroids actions in the brain mainly involve the binding and nuclear translocation of specific cytoplasmic receptors. These receptors can act as transcription factors and regulate gene expression. However, steroid-dependent transcriptional regulation in different types of neural cells is no...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-017-0352-5
更新日期:2017-04-05 00:00:00
abstract:BACKGROUND:Immunization with neural derived peptides (INDP) as well as scar removal-separately-have shown to induce morphological and functional improvement after spinal cord injury (SCI). In the present study, we compared the effect of INDP alone versus INDP with scar removal on motor recovery, regeneration-associated...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-016-0331-2
更新日期:2017-01-05 00:00:00
abstract:BACKGROUND:Yawning is a stereotyped behavior that enhances blood flow to the skull, and the resulting counterflow has been hypothesized as a mechanism for brain cooling. Studies have shown that yawns are strongly associated with physiological and pathological conditions that increase brain temperature, and that they ar...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-016-0330-3
更新日期:2017-01-03 00:00:00
abstract:BACKGROUND:The neuropeptide arginine vasopressin (Avp) modulates social behaviors via its two centrally expressed receptors, the Avp 1a receptor and the Avp 1b receptor (Avpr1b). Recent work suggests that, at least in mice, Avp signaling through Avpr1b within the CA2 region of the hippocampus is critical for normal agg...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-016-0310-7
更新日期:2016-11-24 00:00:00
abstract:BACKGROUND:Astaxanthin is a carotenoid pigment that possesses potent antioxidative, anti-inflammatory, antitumor, and immunomodulatory activities. Previous studies have demonstrated that astaxanthin displays potential neuroprotective properties for the treatment of central nervous system diseases, such as ischemic brai...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-016-0295-2
更新日期:2016-08-31 00:00:00
abstract:BACKGROUND:Parkinson disease (PD) is a movement disorder affecting 1 % of people over the age of 60. The etiology of the disease is unknown; however, accumulating evidence suggests that mitochondrial defects, oxidative stress, and neuroinflammation play important roles in developing the disease. Current medications for...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-016-0293-4
更新日期:2016-08-22 00:00:00
abstract:BACKGROUND:Polymorphisms in the gene for phosphatidylinositol binding clathrin assembly protein (PICALM), an endocytic-related protein, are associated with a small, increased risk of developing Alzheimer's disease (AD), strongly suggesting that changes in endocytosis are involved in the aetiology of the disease. We hav...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-016-0288-1
更新日期:2016-07-18 00:00:00
abstract:BACKGROUND:Perivascular stromal cells (PSCs) are a recently identified cell type that comprises a small percentage of the platelet derived growth factor receptor-β+ cells within the CNS perivascular space. PSCs are activated following injury to the brain or spinal cord, expand in number and contribute to fibrotic scar ...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-016-0284-5
更新日期:2016-07-15 00:00:00
abstract:BACKGROUND:The potential adverse effect of mobile phone radiation is currently an area of great concern in the field of public health. In the present study, we aimed to investigate the effect of mobile phone radiation (900 MHz radiofrequency) during hatching on postnatal social behaviors in chicks, as well as the effec...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-016-0266-7
更新日期:2016-06-10 00:00:00
abstract:BACKGROUND:Circadian clocks are endogenous biochemical oscillators that control daily behavioral rhythms in all living organisms. In fruit fly, the circadian rhythms are typically studied using power spectra of multiday behavioral recordings. Despite decades of study, a quantitative understanding of the temporal shape ...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-016-0248-9
更新日期:2016-04-18 00:00:00
abstract:BACKGROUND:An individual's ability to recognise and pay attention to others is crucial in order to behave appropriately in various social situations. Studies in humans have shown a sex bias in sociability as well as social memory, indicating that females have better face memory and gaze more at the eyes of others, but ...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-015-0221-z
更新日期:2015-11-25 00:00:00
abstract:BACKGROUND:Obesity has deleterious effects on the brain, and metabolic dysfunction may exacerbate the outcomes of seizures and brain injuries. However, it is unclear whether obesity affects excitotoxicity-induced neuronal cell death. The purpose of this study was to investigate the effects of a high-fat diet (HFD) on n...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-015-0202-2
更新日期:2015-10-30 00:00:00
abstract:BACKGROUND:The topological structure of the wiring of the mammalian brain cortex plays an important role in shaping the functional dynamics of large-scale neural activity. Due to their central embedding in the network, high degree hub regions and their connections (often referred to as the 'rich club') have been hypoth...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-015-0193-z
更新日期:2015-09-02 00:00:00
abstract:BACKGROUND:GABAA receptor-mediated neurotransmission is greatly influenced by cation-chloride cotransporter activity during developmental stages. In embryonic neurons Na-K-2Cl (NKCC1) cotransporters mediate active chloride uptake, thus increasing the intracellular chloride concentration associated with GABA-induced dep...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-015-0180-4
更新日期:2015-07-14 00:00:00
abstract:BACKGROUND:SLC10A4 belongs to the solute carrier family SLC10 whose founding members are the Na(+)/taurocholate co-transporting polypeptide (NTCP, SLC10A1) and the apical sodium-dependent bile acid transporter (ASBT, SLC10A2). These carriers maintain the enterohepatic circulation of bile acids between the liver and the...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-015-0174-2
更新日期:2015-06-19 00:00:00
abstract:BACKGROUND:Major depressive disorder is a prevalent disease that is inadequately treated with currently available interventions. Stress increases susceptibility to depression in patients and rodent models. Depression is also associated with aberrant activation of inflammation, such as increases in circulating levels of...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-015-0169-z
更新日期:2015-05-07 00:00:00
abstract:BACKGROUND:Excitotoxicity (the toxic overstimulation of neurons by the excitatory transmitter Glutamate) is a central process in widespread neurodegenerative conditions such as brain ischemia and chronic neurological diseases. Many mechanisms have been suggested to mediate excitotoxicity, but their significance across ...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-015-0158-2
更新日期:2015-04-23 00:00:00
abstract:BACKGROUND:Recovery following stroke depends on cellular plasticity in the perilesional zone (PZ). Doublecortin (DCX), a protein mainly labeling immature neurons in neurogenic niches is also highly expressed in the vicinity of focal cortical infarcts. Notably, the number of DCX+ cells positively correlates with the rec...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-015-0160-8
更新日期:2015-04-15 00:00:00