Abnormal resting-state cerebral-limbic functional connectivity in bipolar depression and unipolar depression.

abstract：BACKGROUND:Understanding the underlying causes of nicotine addiction will require a multidisciplinary approach examining the key molecular, cellular and neuronal circuit functional changes that drive escalating levels of nicotine self-administration. In this study, we examined whether mice pretreated with chronic nicot...

journal_title：BMC neuroscience

authors： Renda A,Nashmi R

更新日期：2014-07-19 00:00:00

abstract：BACKGROUND:Several studies have shown that Stroop interference is stronger in children than in adults. However, in a standard Stroop paradigm, stimulus interference and response interference are confounded. The purpose of the present study was to determine whether interference at the stimulus level and the response lev...

journal_title：BMC neuroscience

authors： Jongen EM,Jonkman LM

更新日期：2008-09-05 00:00:00

abstract：BACKGROUND:Microglia, the resident immune cells of the central nervous system (CNS), have two distinct phenotypes in the developing brain: amoeboid form, known to be amoeboid microglial cells (AMC) and ramified form, known to be ramified microglial cells (RMC). The AMC are characterized by being proliferative, phagocyt...

journal_title：BMC neuroscience

authors： Parakalan R,Jiang B,Nimmi B,Janani M,Jayapal M,Lu J,Tay SS,Ling EA,Dheen ST

更新日期：2012-06-14 00:00:00

abstract：BACKGROUND:Polymorphisms in the gene for phosphatidylinositol binding clathrin assembly protein (PICALM), an endocytic-related protein, are associated with a small, increased risk of developing Alzheimer's disease (AD), strongly suggesting that changes in endocytosis are involved in the aetiology of the disease. We hav...

journal_title：BMC neuroscience

authors： Thomas RS,Henson A,Gerrish A,Jones L,Williams J,Kidd EJ

更新日期：2016-07-18 00:00:00

abstract：BACKGROUND:Subjective tinnitus is characterized by an auditory phantom perception in the absence of any physical sound source. Consequently, in a quiet environment, tinnitus patients differ from control participants because they constantly perceive a sound whereas controls do not. We hypothesized that this difference i...

journal_title：BMC neuroscience

authors： Schlee W,Hartmann T,Langguth B,Weisz N

更新日期：2009-02-19 00:00:00

abstract：BACKGROUND:Ample evidence suggests a substantial contribution of cellular and molecular changes in the spinal cord to the induction and persistence of chronic neuropathic pain conditions. While for a long time, proteases were mainly considered as protein degrading enzymes, they are now receiving growing interest as sig...

journal_title：BMC neuroscience

authors： Leichsenring A,Bäcker I,Wendt W,Andriske M,Schmitz B,Stichel CC,Lübbert H

更新日期：2008-08-12 00:00:00

abstract：BACKGROUND:Numerous electrophysiological, ultrastructural, and immunocytochemical studies on rodent taste buds have been carried out on rat taste buds. In recent years, however, the mouse has become the species of choice for molecular and other studies on sensory transduction in taste buds. Do rat and mouse taste buds ...

journal_title：BMC neuroscience

authors： Ma H,Yang R,Thomas SM,Kinnamon JC

更新日期：2007-01-05 00:00:00

abstract：BACKGROUND:Recent work has suggested that the ovarian steroid 17beta-estradiol, at physiological concentrations, may exert protective effects in neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease and acute ischemic stroke. While physiological concentrations of estrogen have consistently been s...

journal_title：BMC neuroscience

authors： Dhandapani KM,Brann DW

更新日期：2002-06-07 00:00:00

abstract：BACKGROUND:Alzheimer's Disease (AD) and Fronto temporal lobar dementia (FTLD) are common causes of dementia in the aging population for which limited therapeutical options are available. These disorders are associated with Tau accumulation. We have previously shown that Cerebrolysin™ (CBL), a neuropeptide mixture with ...

journal_title：BMC neuroscience

authors： Rockenstein E,Ubhi K,Trejo M,Mante M,Patrick C,Adame A,Novak P,Jech M,Doppler E,Moessler H,Masliah E

更新日期：2014-07-21 00:00:00

abstract：BACKGROUND:The anesthetic drug ketamine (KT) has been reported to be an abused drug and fatal cases have been observed in polydrug users. In the present study, considering the possibility of KT-enhanced toxic effects of other drugs, and KT-induced promotion of an overdose without making the subject aware of the danger ...

journal_title：BMC neuroscience

authors： Hayase T,Yamamoto Y,Yamamoto K

更新日期：2006-03-16 00:00:00

abstract：BACKGROUND:Glutamate gated postsynaptic receptors in the central nervous system (CNS) are essential for environmentally stimulated behaviours including learning and memory in both invertebrates and vertebrates. Though their genetics, biochemistry, physiology, and role in behaviour have been intensely studied in vitro a...

journal_title：BMC neuroscience

authors： Ryan TJ,Emes RD,Grant SG,Komiyama NH

更新日期：2008-01-15 00:00:00

abstract：BACKGROUND:The neuropeptide arginine vasopressin (Avp) modulates social behaviors via its two centrally expressed receptors, the Avp 1a receptor and the Avp 1b receptor (Avpr1b). Recent work suggests that, at least in mice, Avp signaling through Avpr1b within the CA2 region of the hippocampus is critical for normal agg...

journal_title：BMC neuroscience

authors： Witchey SK,Stevenson EL,Caldwell HK

更新日期：2016-11-24 00:00:00

abstract：BACKGROUND:It has been hypothesized that alterations of the serotonergic system contribute to neuropsychiatric symptoms in Alzheimer disease (AD). Cellular expressions of the two serotonergic receptors 5-HT2A and 5-HT6 have therefore been determined by immunohistochemistry in the prefrontal cortex of patients with AD (...

journal_title：BMC neuroscience

authors： Lorke DE,Lu G,Cho E,Yew DT

更新日期：2006-04-27 00:00:00

abstract：BACKGROUND:One of the most basic human traits is language. Linguistic ability, and disability, have been shown to have a strong genetic component in family and twin studies, but molecular genetic studies of language phenotypes are scarce, relative to studies of other cognitive traits and neurodevelopmental phenotypes. ...

journal_title：BMC neuroscience

authors： Nudel R,Christiani CAJ,Ohland J,Uddin MJ,Hemager N,Ellersgaard D,Spang KS,Burton BK,Greve AN,Gantriis DL,Bybjerg-Grauholm J,Jepsen JRM,Thorup AAE,Mors O,Werge T,Nordentoft M

更新日期：2020-07-07 00:00:00

abstract：BACKGROUND:Parkinson's disease (PD) is a neurological disorder characterized by the degeneration of nigrostriatal dopaminergic systems. Free radicals induced by oxidative stress are involved in the mechanisms of cell death in PD. This study clarifies the neuroprotective effects of edaravone (MCI-186, 3-methyl-1-phenyl-...

journal_title：BMC neuroscience

authors： Yuan WJ,Yasuhara T,Shingo T,Muraoka K,Agari T,Kameda M,Uozumi T,Tajiri N,Morimoto T,Jing M,Baba T,Wang F,Leung H,Matsui T,Miyoshi Y,Date I

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND:Chlamydophila (Chlamydia) pneumoniae is an intracellular bacterium that has been identified within cells in areas of neuropathology found in Alzheimer disease (AD), including endothelia, glia, and neurons. Depending on the cell type of the host, infection by C. pneumoniae has been shown to influence apoptoti...

journal_title：BMC neuroscience

authors： Appelt DM,Roupas MR,Way DS,Bell MG,Albert EV,Hammond CJ,Balin BJ

更新日期：2008-01-24 00:00:00

abstract：BACKGROUND:How living neural networks retain information is still incompletely understood. Two prominent ideas on this topic have developed in parallel, but have remained somewhat unconnected. The first of these, the "synaptic hypothesis," holds that information can be retained in synaptic connection strengths, or weig...

journal_title：BMC neuroscience

authors： Chen W,Hobbs JP,Tang A,Beggs JM

更新日期：2010-01-06 00:00:00

abstract：BACKGROUND:To examine which language function depends on early experience, the present study compared deaf native signers, deaf non-native signers and hearing German native speakers while processing German sentences. The participants watched simple written sentences while event-related potentials (ERPs) were recorded. ...

journal_title：BMC neuroscience

authors： Skotara N,Salden U,Kügow M,Hänel-Faulhaber B,Röder B

更新日期：2012-05-03 00:00:00

abstract：BACKGROUND:Myzus persicae is a globally important aphid pest with a history of developing resistance to insecticides. Unusually, neonicotinoids have remained highly effective as control agents despite nearly two decades of steadily increasing use. In this study, a clone of M. persicae collected from southern France was...

journal_title：BMC neuroscience

authors： Bass C,Puinean AM,Andrews M,Cutler P,Daniels M,Elias J,Paul VL,Crossthwaite AJ,Denholm I,Field LM,Foster SP,Lind R,Williamson MS,Slater R

更新日期：2011-05-31 00:00:00

abstract：BACKGROUND:Noise exposure (NE) is a severe modern health hazard that induces hearing impairment. However, the noise-induced ultrastructural changes of blood-labyrinth barrier (BLB) and the potential involvements of tight junction proteins (TJP) remain inconclusive. We investigated the effects of NE on not only the ultr...

journal_title：BMC neuroscience

authors： Wu YX,Zhu GX,Liu XQ,Sun F,Zhou K,Wang S,Wang CM,Jia JW,Song JT,Lu LJ

更新日期：2014-12-24 00:00:00

abstract：BACKGROUND:Synaptic degeneration and accumulation of amyloid β-peptides (Aβ) are hallmarks of the Alzheimer diseased brain. Aβ is synaptotoxic and produced by sequential cleavage of the amyloid precursor protein (APP) by the β-secretase BACE1 and by γ-secretase. If APP is instead cleaved by the α-secretase ADAM10, Aβ w...

journal_title：BMC neuroscience

authors： Lundgren JL,Vandermeulen L,Sandebring-Matton A,Ahmed S,Winblad B,Di Luca M,Tjernberg LO,Marcello E,Frykman S

更新日期：2020-02-04 00:00:00

abstract：BACKGROUND:To reach and grasp an object in space on the basis of its image cast on the retina requires different coordinate transformations that take into account gaze and limb positioning. Eye position in the orbit influences the image's conversion from retinotopic (eye-centered) coordinates to an egocentric frame nec...

journal_title：BMC neuroscience

authors： Andersson F,Etard O,Denise P,Petit L

更新日期：2004-09-19 00:00:00

abstract：BACKGROUND:Human neural stem cells (hNSC) have the potential to provide novel cell-based therapies for neurodegenerative conditions such as multiple sclerosis and Parkinson's disease. In order to realise this goal, protocols need to be developed that allow for large quantities of hNSC to be cultured efficiently. As suc...

journal_title：BMC neuroscience

authors： Hall PE,Lathia JD,Caldwell MA,Ffrench-Constant C

更新日期：2008-07-23 00:00:00

abstract：BACKGROUND:The effects induced by administering the anticonvulsant lamotrigine, the preferential inhibitor of neuronal nitric oxide synthase 7-nitroindazole and the precursor of NO synthesis L-arginine, alone or in combination, on an experimental model of partial complex seizures (maximal dentate gyrus activation) were...

journal_title：BMC neuroscience

authors： Sardo P,Ferraro G

更新日期：2007-07-03 00:00:00

abstract：BACKGROUND:Recent alleged attacks with nerve agent sarin on civilians in Syria indicate their potential threat to both civilian and military population. Acute nerve agent exposure can cause rapid death or leads to multiple and long term neurological effects. The biochemical changes that occur following nerve agent expo...

journal_title：BMC neuroscience

authors： RamaRao G,Afley P,Acharya J,Bhattacharya BK

更新日期：2014-04-04 00:00:00

abstract：BACKGROUND:Immunization with neural derived peptides (INDP) as well as scar removal-separately-have shown to induce morphological and functional improvement after spinal cord injury (SCI). In the present study, we compared the effect of INDP alone versus INDP with scar removal on motor recovery, regeneration-associated...

journal_title：BMC neuroscience

authors： Rodríguez-Barrera R,Flores-Romero A,Fernández-Presas AM,García-Vences E,Silva-García R,Konigsberg M,Blancas-Espinoza L,Buzoianu-Anguiano V,Soria-Zavala K,Suárez-Meade P,Ibarra A

更新日期：2017-01-05 00:00:00

abstract：BACKGROUND:The neurological complications of HIV infection remain poorly understood. Clinically, in vivo 1H magnetic resonance spectroscopy (MRS) demonstrates brain injury caused by HIV infection even when the MRI is normal. Our goal was to undertsand the dynamics of cerebral injury by performing a longitudinal in vivo...

journal_title：BMC neuroscience

authors： Fuller RA,Westmoreland SV,Ratai E,Greco JB,Kim JP,Lentz MR,He J,Sehgal PK,Masliah E,Halpern E,Lackner AA,González RG

更新日期：2004-03-05 00:00:00

abstract：BACKGROUND:Functional magnetic resonance imaging (fMRI) in white matter has long been considered controversial. Recently, this viewpoint has been challenged by an emerging body of evidence demonstrating white matter activation in the corpus callosum. The current study aimed to determine whether white matter activation ...

journal_title：BMC neuroscience

authors： Gawryluk JR,Mazerolle EL,Brewer KD,Beyea SD,D'Arcy RC

更新日期：2011-06-14 00:00:00

abstract：BACKGROUND:Parkinson disease (PD) is a movement disorder affecting 1 % of people over the age of 60. The etiology of the disease is unknown; however, accumulating evidence suggests that mitochondrial defects, oxidative stress, and neuroinflammation play important roles in developing the disease. Current medications for...

journal_title：BMC neuroscience

authors： Javed H,Azimullah S,Abul Khair SB,Ojha S,Haque ME

更新日期：2016-08-22 00:00:00

abstract：BACKGROUND:Previous studies showed that anodal transcranial DC stimulation (tDCS) applied to the primary motor cortex of the affected hemisphere (M1affected hemisphere) after subcortical stroke transiently improves performance of complex tasks that mimic activities of daily living (ADL). It is not known if relatively s...

journal_title：BMC neuroscience

authors： Hummel FC,Voller B,Celnik P,Floel A,Giraux P,Gerloff C,Cohen LG

更新日期：2006-11-03 00:00:00