Estrogen-astrocyte interactions: implications for neuroprotection.

abstract：BACKGROUND:Huntington's disease (HD) is a neurodegenerative disorder predominantly affecting the cerebral cortex and striatum. Transgenic mice (R6/1 line), expressing a CAG repeat encoding an expanded polyglutamine tract in the N-terminus of the huntingtin protein, closely model HD. We have previously shown that enviro...

journal_title：BMC neuroscience

authors： van Dellen A,Cordery PM,Spires TL,Blakemore C,Hannan AJ

更新日期：2008-04-01 00:00:00

abstract：BACKGROUND:One of the most basic human traits is language. Linguistic ability, and disability, have been shown to have a strong genetic component in family and twin studies, but molecular genetic studies of language phenotypes are scarce, relative to studies of other cognitive traits and neurodevelopmental phenotypes. ...

journal_title：BMC neuroscience

authors： Nudel R,Christiani CAJ,Ohland J,Uddin MJ,Hemager N,Ellersgaard D,Spang KS,Burton BK,Greve AN,Gantriis DL,Bybjerg-Grauholm J,Jepsen JRM,Thorup AAE,Mors O,Werge T,Nordentoft M

更新日期：2020-07-07 00:00:00

abstract：BACKGROUND:Anticipatory planning, the ability to anticipate future perceptual-motor demands of a goal-oriented action sequence, is essential for flexible, purposeful behavior. Once an action goal has been defined, movement details necessary to achieve that goal can be selected. Here, we investigate if anticipatory plan...

journal_title：BMC neuroscience

authors： Marangon M,Bucchioni G,Massacesi S,Castiello U

更新日期：2013-08-28 00:00:00

abstract：BACKGROUND:Sonic hedgehog (Shh)/Gli pathway plays an important regulatory role on the neuroepithelial cells (NEc) proliferation in the dorsal regions of the developing vertebrate Central Nervous System. The aim of this paper was to analyze the effect of the Shh/Gli signaling pathway activation on the proliferation dyna...

journal_title：BMC neuroscience

authors： Rapacioli M,Botelho J,Cerda G,Duarte S,Elliot M,Palma V,Flores V

更新日期：2012-10-02 00:00:00

abstract：BACKGROUND:It has been hypothesized that alterations of the serotonergic system contribute to neuropsychiatric symptoms in Alzheimer disease (AD). Cellular expressions of the two serotonergic receptors 5-HT2A and 5-HT6 have therefore been determined by immunohistochemistry in the prefrontal cortex of patients with AD (...

journal_title：BMC neuroscience

authors： Lorke DE,Lu G,Cho E,Yew DT

更新日期：2006-04-27 00:00:00

abstract：BACKGROUND:After unilateral cervical cord lesion at the C7/C8 border interrupting the dorsolateral funiculus in adult monkeys, neutralization of Nogo-A using a specific monoclonal antibody promoted sprouting of corticospinal (CS) axons rostral and caudal to the lesion and, in parallel, improved functional recovery. In ...

journal_title：BMC neuroscience

authors： Beaud ML,Schmidlin E,Wannier T,Freund P,Bloch J,Mir A,Schwab ME,Rouiller EM

更新日期：2008-01-14 00:00:00

abstract：BACKGROUND:Gap junction proteins, connexins, are expressed in most endocrine and exocrine glands in the body and are at least in some glands crucial for the hormonal secretion. To what extent connexins are expressed in neurons releasing hormones or neuropeptides from or within the central nervous system is, however, un...

journal_title：BMC neuroscience

authors： Westberg L,Sawa E,Wang AY,Gunaydin LA,Ribeiro AC,Pfaff DW

更新日期：2009-04-30 00:00:00

abstract：BACKGROUND:To determine whether early imitative responses fade out following the maturation of attentional mechanisms, the relationship between primitive imitation behaviors and the development of attention was examined in 4-month-old infants. They were divided into high and low imitators, based on an index of imitatio...

journal_title：BMC neuroscience

authors： Nakagawa A,Sukigara M,Benga O

更新日期：2003-12-24 00:00:00

abstract：:Many studies have highlighted the pathological involvement of iron accumulation and iron-related oxidative stress (OS) in Alzheimer's disease (AD). Iron was further demonstrated to modulate expression of the Alzheimer's amyloid precursor holo-protein (APP) by a mechanism similar to that of regulation of ferritin-L and...

journal_title：BMC neuroscience

authors： Avramovich-Tirosh Y,Amit T,Bar-Am O,Weinreb O,Youdim MB

更新日期：2008-12-03 00:00:00

abstract：BACKGROUND:This work examines the central nervous system distribution of virus-labeled neurons from the rat urinary bladder and the prostate simultaneously within the same tissue sections. Two immunohistochemically distinct pseudorabies virus strains were simultaneously injected into male Sprague Dawley rats (approxima...

journal_title：BMC neuroscience

authors： Nadelhaft I,Miranda-Sousa AJ,Vera PL

更新日期：2002-07-12 00:00:00

abstract：BACKGROUND:The human inferior frontal junction area (IFJ) is critically involved in three main component processes of cognitive control (working memory, task switching and inhibitory control). As it overlaps with several areas in established anatomical labeling schemes, it is considered to be underreported as a functio...

journal_title：BMC neuroscience

authors： Sundermann B,Pfleiderer B

更新日期：2012-10-03 00:00:00

abstract：BACKGROUND:Human brain microvascular endothelial cells (hBMVECs) are integral part of the blood brain barrier. Post-translational modifications of adherens junction proteins regulate the permeability of human brain microvascular endothelial cells. Pro-inflammatory signals can induce tyrosine phosphorylation of adherens...

journal_title：BMC neuroscience

authors： Mishra R,Singh SK

更新日期：2014-06-26 00:00:00

abstract：BACKGROUND:Traumatic brain injury (TBI) initiates a complex sequence of destructive and neuroprotective cellular responses. The initial mechanical injury is followed by an extended time period of secondary brain damage. Due to the complicated pathological picture a better understanding of the molecular events occurring...

journal_title：BMC neuroscience

authors： von Gertten C,Flores Morales A,Holmin S,Mathiesen T,Nordqvist AC

更新日期：2005-11-30 00:00:00

abstract：BACKGROUND:Multi-sensor technologies such as EEG, MEG, and ECoG result in high-dimensional data sets. Given the high temporal resolution of such techniques, scientific questions very often focus on the time-course of an experimental effect. In many studies, researchers focus on a single sensor or the average over a sub...

journal_title：BMC neuroscience

authors： Schurger A,Marti S,Dehaene S

更新日期：2013-10-14 00:00:00

abstract：BACKGROUND:Numerous electrophysiological, ultrastructural, and immunocytochemical studies on rodent taste buds have been carried out on rat taste buds. In recent years, however, the mouse has become the species of choice for molecular and other studies on sensory transduction in taste buds. Do rat and mouse taste buds ...

journal_title：BMC neuroscience

authors： Ma H,Yang R,Thomas SM,Kinnamon JC

更新日期：2007-01-05 00:00:00

abstract：BACKGROUND:Rett syndrome (RTT, MIM #312750) is a severe neurological disorder caused by mutations in the X-linked methyl-CpG binding protein 2 (MECP2) gene. Female patients are affected with an incidence of 1/15000 live births and develop normally from birth to 6-18 months of age before the onset of deficits in autonom...

journal_title：BMC neuroscience

authors： Panayotis N,Ghata A,Villard L,Roux JC

更新日期：2011-05-24 00:00:00

abstract：BACKGROUND:Recent evidence has suggested that Alzheimer's disease (AD)-associated neuronal loss may occur via the caspase-independent route of programmed cell death (PCD) in addition to caspase-dependent mechanisms. However, the brain region specificity of caspase-independent PCD in AD-associated neurodegeneration is u...

journal_title：BMC neuroscience

authors： Yu W,Bonnet M,Farso M,Ma K,Chabot JG,Martin E,Torriglia A,Guan Z,McLaurin J,Quirion R,Krantic S

更新日期：2014-06-10 00:00:00

abstract：BACKGROUND:The mechanisms of steroids actions in the brain mainly involve the binding and nuclear translocation of specific cytoplasmic receptors. These receptors can act as transcription factors and regulate gene expression. However, steroid-dependent transcriptional regulation in different types of neural cells is no...

journal_title：BMC neuroscience

authors： Piechota M,Korostynski M,Golda S,Ficek J,Jantas D,Barbara Z,Przewlocki R

更新日期：2017-04-05 00:00:00

abstract：BACKGROUND:Huntington's disease (HD) is a progressive neurodegenerative disorder caused by a CAG repeat expansion mutation in the coding region of a novel gene. The mechanism of HD is unknown. Most data suggest that polyglutamine-mediated aggregation associated with expression of mutant huntingtin protein (mhtt) contri...

journal_title：BMC neuroscience

authors： Trushina E,Rana S,McMurray CT,Hua DH

更新日期：2009-07-08 00:00:00

abstract：BACKGROUND:Polymorphisms in the gene for phosphatidylinositol binding clathrin assembly protein (PICALM), an endocytic-related protein, are associated with a small, increased risk of developing Alzheimer's disease (AD), strongly suggesting that changes in endocytosis are involved in the aetiology of the disease. We hav...

journal_title：BMC neuroscience

authors： Thomas RS,Henson A,Gerrish A,Jones L,Williams J,Kidd EJ

更新日期：2016-07-18 00:00:00

abstract：BACKGROUND:Agmatine is an endogenous polyamine formed by the decarboxylation of L-arginine. We investigated the protective effects of agmatine against hypoxia-induced apoptosis of immortalized rat retinal ganglion cells (RGC-5). RGC-5 cells were cultured in a closed hypoxic chamber (5% O2) with or without agmatine. Cel...

journal_title：BMC neuroscience

authors： Hong S,Lee JE,Kim CY,Seong GJ

更新日期：2007-10-02 00:00:00

abstract：BACKGROUND:The anesthetic drug ketamine (KT) has been reported to be an abused drug and fatal cases have been observed in polydrug users. In the present study, considering the possibility of KT-enhanced toxic effects of other drugs, and KT-induced promotion of an overdose without making the subject aware of the danger ...

journal_title：BMC neuroscience

authors： Hayase T,Yamamoto Y,Yamamoto K

更新日期：2006-03-16 00:00:00

abstract：BACKGROUND:Tone languages such as Thai and Mandarin Chinese use differences in fundamental frequency (F0, pitch) to distinguish lexical meaning. Previous behavioral studies have shown that native speakers of a non-tone language have difficulty discriminating among tone contrasts and are sensitive to different F0 dimens...

journal_title：BMC neuroscience

authors： Kaan E,Barkley CM,Bao M,Wayland R

更新日期：2008-06-23 00:00:00

abstract：BACKGROUND:CRISPR/Cas9 system is a powerful method to investigate the role of genes by introducing a mutation selectively and efficiently to specific genome positions in cell and animal lines. However, in primary neuron cultures, this method is affected by the issue that the effectiveness of CRISPR/Cas9 is different in...

journal_title：BMC neuroscience

authors： Tsunematsu H,Uyeda A,Yamamoto N,Sugo N

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Hyperbaric oxygen therapy (HBOT) is a known adjuvant for treating ischemia-related inner ear diseases. Controversies still exist in the role of HBOT in cochlear diseases. Few studies to date have investigated the cellular changes that occur in inner ears after HBOT. Nitric oxide, which is synthesized by nitr...

journal_title：BMC neuroscience

authors： Lin CD,Wei IH,Lai CH,Hsia TC,Kao MC,Tsai MH,Wu CH,Tsai MH

更新日期：2011-02-22 00:00:00

abstract：BACKGROUND:The use of induced pluripotent stem cells (iPSCs) for the functional replacement of damaged neurons and in vitro disease modeling is of great clinical relevance. Unfortunately, the capacity of iPSC lines to differentiate into neurons is highly variable, prompting the need for a reliable means of assessing th...

journal_title：BMC neuroscience

authors： Koehler KR,Tropel P,Theile JW,Kondo T,Cummins TR,Viville S,Hashino E

更新日期：2011-08-10 00:00:00

abstract：BACKGROUND:Previous studies showed that anodal transcranial DC stimulation (tDCS) applied to the primary motor cortex of the affected hemisphere (M1affected hemisphere) after subcortical stroke transiently improves performance of complex tasks that mimic activities of daily living (ADL). It is not known if relatively s...

journal_title：BMC neuroscience

authors： Hummel FC,Voller B,Celnik P,Floel A,Giraux P,Gerloff C,Cohen LG

更新日期：2006-11-03 00:00:00

abstract：BACKGROUND:Receptor-interacting protein 3 (RIP3), a member of RIP family proteins, has been shown to participate in programmed necrosis or necroptosis in cell biology studies. Evidence suggests that necroptosis may be a mode of neuronal death in the retina. RESULTS:In the present study we determined the expression of ...

journal_title：BMC neuroscience

authors： Huang JF,Shang L,Zhang MQ,Wang H,Chen D,Tong JB,Huang H,Yan XX,Zeng LP,Xiong K

更新日期：2013-02-02 00:00:00

abstract：BACKGROUND:A delay in surgical nerve repair results in impaired nerve function in humans, but mechanisms behind the weakened nerve regeneration are not known. Activating transcription factor 3 (ATF3) increases the intrinsic growth state of injured neurons early after injury, but the role of long-term changes and their ...

journal_title：BMC neuroscience

authors： Saito H,Dahlin LB

更新日期：2008-09-18 00:00:00

abstract：BACKGROUND:How does the brain repair obliterated speech and cope with acoustically ambivalent situations? A widely discussed possibility is to use top-down information for solving the ambiguity problem. In the case of speech, this may lead to a match of bottom-up sensory input with lexical expectations resulting in res...

journal_title：BMC neuroscience

authors： Eulitz C,Hannemann R

更新日期：2010-06-02 00:00:00