Abstract:
BACKGROUND:Sonic hedgehog (Shh)/Gli pathway plays an important regulatory role on the neuroepithelial cells (NEc) proliferation in the dorsal regions of the developing vertebrate Central Nervous System. The aim of this paper was to analyze the effect of the Shh/Gli signaling pathway activation on the proliferation dynamics and/or the spatial organization of the NEc proliferation activity during early stages of the developing chick optic tectum (OT). In ovo pharmacological gain and loss of hedgehog function approaches were complemented with in vivo electroporation experiments in order to create ectopic sources of either Shh or Gli activator (GliA) proteins in the OT. NEc proliferating activity was analyzed at ED 4/4.5 by recording the spatial co-ordinates of the entire population of mitotic NEc (mNEc) located along OT dorsal-ventral sections. Several space signals (numerical sequences) were derived from the mNEc spatial co-ordinate records and analyzed by different standardized non-linear methods of signal analysis. RESULTS:In ovo pharmacologic treatment with cyclopamine resulted in dramatic failure in the OT expansion while the agonist purmorphamine produced the opposite result, a huge expansion of the OT vesicle. Besides, GliA and Shh misexpressions interfere with the formation of the intertectal fissure located along the dorsal midline. This morphogenetic alteration is accompanied by an increase in the mNEc density. There is a gradient in the response of NEcs to Shh and GliA: the increase in mNEc density is maximal near the dorsal regions and decrease towards the OT-tegmental boundary. Biomathematical analyses of the signals derived from the mNEc records show that both Shh and GliA electroporations change the proliferation dynamics and the spatial organization of the mNEc as revealed by the changes in the scaling index estimated by these methods. CONCLUSIONS:The present results show that the Shh/Gli signaling pathway plays a critical role in the OT expansion and modelling. This effect is probably mediated by a differential mitogenic effect that increases the NEc proliferation and modulates the spatial organization of the NEc proliferation activity.
journal_name
BMC Neuroscijournal_title
BMC neuroscienceauthors
Rapacioli M,Botelho J,Cerda G,Duarte S,Elliot M,Palma V,Flores Vdoi
10.1186/1471-2202-13-117subject
Has Abstractpub_date
2012-10-02 00:00:00pages
117issn
1471-2202pii
1471-2202-13-117journal_volume
13pub_type
杂志文章相关文献
BMC NEUROSCIENCE文献大全abstract:BACKGROUND:Protein aggregation plays important roles in several neurodegenerative disorders. For instance, insoluble aggregates of phosphorylated tau and of Aβ peptides are cornerstones in the pathology of Alzheimer's disease. Soluble protein aggregates are therefore potential diagnostic and prognostic biomarkers for t...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-11-124
更新日期:2010-10-05 00:00:00
abstract:BACKGROUND:Recently, there has been a strong emphasis on identifying an in vitro model for neurotoxicity research that combines the biological relevance of primary neurons with the scalability, reproducibility and genetic tractability of continuous cell lines. Derived neurons should be homotypic, exhibit neuron-specifi...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-13-127
更新日期:2012-10-24 00:00:00
abstract:BACKGROUND:To reach and grasp an object in space on the basis of its image cast on the retina requires different coordinate transformations that take into account gaze and limb positioning. Eye position in the orbit influences the image's conversion from retinotopic (eye-centered) coordinates to an egocentric frame nec...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-5-35
更新日期:2004-09-19 00:00:00
abstract:BACKGROUND:Errorless learning has advantages over errorful learning. The erroneous items produced during errorful learning compete with correct items at retrieval resulting in decreased memory performance. This interference is associated with an increased demand on executive monitoring processes. Event-related function...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-14-30
更新日期:2013-03-13 00:00:00
abstract:BACKGROUND:Glutamate gated postsynaptic receptors in the central nervous system (CNS) are essential for environmentally stimulated behaviours including learning and memory in both invertebrates and vertebrates. Though their genetics, biochemistry, physiology, and role in behaviour have been intensely studied in vitro a...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-9-6
更新日期:2008-01-15 00:00:00
abstract:BACKGROUND:Low-intensity pulsed ultrasound stimulation (LIPUS) has been proven to be a noninvasive method with high spatial resolution and deep penetration. Previous studies have qualitatively demonstrated that the electromyographic response caused by LIPUS in the mouse motor cortex is affected by the anesthetic state ...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-018-0476-2
更新日期:2018-12-03 00:00:00
abstract:BACKGROUND:Evoked potentials have been proposed to result from phase-locking of electroencephalographic (EEG) activities within specific frequency bands. However, the respective contribution of phasic activity and phase resetting of ongoing EEG oscillation remains largely debated. We here applied the EEGlab procedure i...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-8-75
更新日期:2007-09-18 00:00:00
abstract:BACKGROUND:Microglia, the resident immune cells of the central nervous system (CNS), have two distinct phenotypes in the developing brain: amoeboid form, known to be amoeboid microglial cells (AMC) and ramified form, known to be ramified microglial cells (RMC). The AMC are characterized by being proliferative, phagocyt...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-13-64
更新日期:2012-06-14 00:00:00
abstract:BACKGROUND:Magnetoencephalography (MEG) has become an increasingly popular technique for non-invasively characterizing neuromagnetic field changes in the brain at a high temporal resolution. To examine the reliability of the MEG signal, we compared magnetic and electrophysiological responses to complex natural stimuli ...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-10-4
更新日期:2009-01-15 00:00:00
abstract:BACKGROUND:Recovery following stroke depends on cellular plasticity in the perilesional zone (PZ). Doublecortin (DCX), a protein mainly labeling immature neurons in neurogenic niches is also highly expressed in the vicinity of focal cortical infarcts. Notably, the number of DCX+ cells positively correlates with the rec...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-015-0160-8
更新日期:2015-04-15 00:00:00
abstract:BACKGROUND:In the absence of overt stimuli, the brain shows correlated fluctuations in functionally related brain regions. Approximately ten largely independent resting state networks (RSNs) showing this behaviour have been documented to date. Recent studies have reported the existence of an RSN in the basal ganglia - ...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-10-137
更新日期:2009-11-23 00:00:00
abstract:BACKGROUND:Symptoms of schizophrenia are related to deficits in self-monitoring function, which may be a consequence of irregularity in aspects of the default mode network (DMN). Schizophrenia can also be characterized by a functional abnormality of the brain activity that is reflected in the resting state. Oscillatory...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-15-104
更新日期:2014-09-05 00:00:00
abstract:BACKGROUND:Growing evidence shows that, in vivo, the precursor of Nerve Growth Factor (NGF), proNGF, displays biological activities different from those of its mature NGF counterpart, mediated by distinct, and somewhat complementary, receptor binding properties. NGF and proNGF induce distinct transcriptional signatures...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-15-48
更新日期:2014-04-08 00:00:00
abstract:BACKGROUND:Following partial injury to the central nervous system, cells beyond the initial injury site undergo secondary degeneration, exacerbating loss of neurons, compact myelin and function. Changes in Ca2+ flux are associated with metabolic and structural changes, but it is not yet clear how flux through specific ...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-017-0380-1
更新日期:2017-08-14 00:00:00
abstract:BACKGROUND:Bone morphogenic proteins (BMPs) promote the survival of neurons, suggesting a therapeutic application of BMPs in the treatment of acute and chronic neurodegenerative disorders. However, the application of recombinant BMPs in vivo is limited by their short half-life. To provide a continuous supply for functi...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-15-38
更新日期:2014-03-11 00:00:00
abstract:BACKGROUND:Enhanced activity of trigeminal ganglion neurons is thought to underlie neuronal sensitization facilitating the onset of chronic pain attacks, including migraine. Recurrent headache attacks might establish a chronic neuroinflammatory ganglion profile contributing to the hypersensitive phenotype. Since it is ...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-13-143
更新日期:2012-11-21 00:00:00
abstract:BACKGROUND:Neurogenesis continues to occur throughout life but dramatically decreases with increasing age. This decrease is mostly related to a decline in proliferative activity as a result of an impoverishment of the microenvironment of the aged brain, including a reduction in trophic factors and increased inflammatio...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-9-22
更新日期:2008-02-14 00:00:00
abstract:BACKGROUND:The potential adverse effect of mobile phone radiation is currently an area of great concern in the field of public health. In the present study, we aimed to investigate the effect of mobile phone radiation (900 MHz radiofrequency) during hatching on postnatal social behaviors in chicks, as well as the effec...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-016-0266-7
更新日期:2016-06-10 00:00:00
abstract:BACKGROUND:Auditory perceptual learning persistently modifies neural networks in the central nervous system. Central auditory processing comprises a hierarchy of sound analysis and integration, which transforms an acoustical signal into a meaningful object for perception. Based on latencies and source locations of audi...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-14-151
更新日期:2013-12-05 00:00:00
abstract:BACKGROUND:Obesity has deleterious effects on the brain, and metabolic dysfunction may exacerbate the outcomes of seizures and brain injuries. However, it is unclear whether obesity affects excitotoxicity-induced neuronal cell death. The purpose of this study was to investigate the effects of a high-fat diet (HFD) on n...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-015-0202-2
更新日期:2015-10-30 00:00:00
abstract:BACKGROUND:To identify mechanisms of cortical plasticity of the visual cortex and to quantify their significance, sensitive parameters are warranted. In this context, multifocal visual evoked potentials (mfVEPs) can make a valuable contribution as they are not associated with cancellation artifacts and include also the...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-020-00600-5
更新日期:2020-11-23 00:00:00
abstract:BACKGROUND:Mounting evidence indicates that humans have significant difficulties in understanding emotional expressions from individuals of different ethnic backgrounds, leading to reduced recognition accuracy and stronger amygdala activation. However, the impact of gender on the behavioral and neural reactions during ...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-13-54
更新日期:2012-05-29 00:00:00
abstract:BACKGROUND:Berberine is the major alkaloidal component of Rhizoma coptidis, and has multiple pharmacological effects including inhibiting acetylcholinesterase, reducing cholesterol and glucose, lowering mortality in patients with chronic congestive heart failure and anti-inflammation etc. Thus berberine is a promising ...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-7-78
更新日期:2006-12-01 00:00:00
abstract:BACKGROUND:Receptor-interacting protein 3 (RIP3), a member of RIP family proteins, has been shown to participate in programmed necrosis or necroptosis in cell biology studies. Evidence suggests that necroptosis may be a mode of neuronal death in the retina. RESULTS:In the present study we determined the expression of ...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-14-16
更新日期:2013-02-02 00:00:00
abstract:BACKGROUND:Stress involves alterations of brain functioning that may precipitate to mood disorders. The neurotrophin Brain Derived Neurotrophic Factor (BDNF) has recently been involved in stress-induced adaptation. BDNF is a key regulator of neuronal plasticity and adaptive processes. Regulation of BDNF is complex and ...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-11-4
更新日期:2010-01-14 00:00:00
abstract:BACKGROUND:Early stages in the excitation cascade of Limulus photoreceptors are mediated by activation of Gq by rhodopsin, generation of inositol-1,4,5-trisphosphate by phospholipase-C and the release of Ca2+. At the end of the cascade, cGMP-gated channels open and generate the depolarizing receptor potential. A major ...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-5-7
更新日期:2004-02-26 00:00:00
abstract:BACKGROUND:Acupuncture has been applied to aid in the recovery of post-stroke patients, but its mechanism is unclear. This study aims to analyze the relationship between acupuncture and glucose metabolism in cerebral functional regions in post-stroke patients using (18)FDG PET-CT techniques. Forty-three ischemic stroke...
journal_title:BMC neuroscience
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-2202-13-75
更新日期:2012-06-27 00:00:00
abstract:BACKGROUND:The olfactory neuroepithelium lines the upper nasal cavity and is in direct contact with the external environment and the olfactory bulbs. The ability to self-renew throughout life and the reproducible recovery after injury, make it a model tissue to study mechanisms underlying neurogenesis. In this study, X...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-13-134
更新日期:2012-10-31 00:00:00
abstract:BACKGROUND:Glutamate, a major excitatory amino acid neurotransmitter, causes apoptotic neuronal cell death at high concentrations. Our previous studies have shown that depending on the neuronal cell type, glutamate-induced apoptotic cell death was associated with regulation of genes such as Bcl-2, Bax, and/or caspase-3...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-7-49
更新日期:2006-06-15 00:00:00
abstract:BACKGROUND:Efficient multisensory integration is of vital importance for adequate interaction with the environment. In addition to basic binding cues like temporal and spatial coherence, meaningful multisensory information is also bound together by content-based associations. Many functional Magnetic Resonance Imaging ...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-11-11
更新日期:2010-02-02 00:00:00