Morphological and behavioural changes occur following the X-ray irradiation of the adult mouse olfactory neuroepithelium.

abstract：BACKGROUND:HIV Associated Dementia (HAD) is a common complication of human immunodeficiency virus (HIV) infection that erodes the quality of life for patients and burdens health care providers. Intravenous drug use is a major route of HIV transmission, and drug use is associated with increased HAD. Specific proteins re...

journal_title：BMC neuroscience

authors： Kendall SL,Anderson CF,Nath A,Turchan-Cholewo J,Land CL,Mactutus CF,Booze RM

更新日期：2005-06-08 00:00:00

abstract：BACKGROUND:Recent work has suggested that the ovarian steroid 17beta-estradiol, at physiological concentrations, may exert protective effects in neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease and acute ischemic stroke. While physiological concentrations of estrogen have consistently been s...

journal_title：BMC neuroscience

authors： Dhandapani KM,Brann DW

更新日期：2002-06-07 00:00:00

abstract：BACKGROUND:Mounting evidence indicates that humans have significant difficulties in understanding emotional expressions from individuals of different ethnic backgrounds, leading to reduced recognition accuracy and stronger amygdala activation. However, the impact of gender on the behavioral and neural reactions during ...

journal_title：BMC neuroscience

authors： Derntl B,Habel U,Robinson S,Windischberger C,Kryspin-Exner I,Gur RC,Moser E

更新日期：2012-05-29 00:00:00

abstract：BACKGROUND:Subjective tinnitus is characterized by an auditory phantom perception in the absence of any physical sound source. Consequently, in a quiet environment, tinnitus patients differ from control participants because they constantly perceive a sound whereas controls do not. We hypothesized that this difference i...

journal_title：BMC neuroscience

authors： Schlee W,Hartmann T,Langguth B,Weisz N

更新日期：2009-02-19 00:00:00

abstract：BACKGROUND:Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative fatal disease that can affect the neurons of brain and spinal cord. ALS genetics has identified various genes to be associated with disease pathology. Oxidative stress induced bunina and lewy bodies formation can be regulated through the ...

journal_title：BMC neuroscience

authors： Pal S,Tiwari A,Sharma K,Sharma SK

更新日期：2020-10-09 00:00:00

abstract：BACKGROUND:Alzheimer's Disease (AD) and Fronto temporal lobar dementia (FTLD) are common causes of dementia in the aging population for which limited therapeutical options are available. These disorders are associated with Tau accumulation. We have previously shown that Cerebrolysin™ (CBL), a neuropeptide mixture with ...

journal_title：BMC neuroscience

authors： Rockenstein E,Ubhi K,Trejo M,Mante M,Patrick C,Adame A,Novak P,Jech M,Doppler E,Moessler H,Masliah E

更新日期：2014-07-21 00:00:00

abstract：BACKGROUND:Auditory perceptual learning persistently modifies neural networks in the central nervous system. Central auditory processing comprises a hierarchy of sound analysis and integration, which transforms an acoustical signal into a meaningful object for perception. Based on latencies and source locations of audi...

journal_title：BMC neuroscience

authors： Ross B,Jamali S,Tremblay KL

更新日期：2013-12-05 00:00:00

abstract：BACKGROUND:Errorless learning has advantages over errorful learning. The erroneous items produced during errorful learning compete with correct items at retrieval resulting in decreased memory performance. This interference is associated with an increased demand on executive monitoring processes. Event-related function...

journal_title：BMC neuroscience

authors： Hammer A,Tempelmann C,Münte TF

更新日期：2013-03-13 00:00:00

abstract：BACKGROUND:Astrocytes are responsible for a broad range of functions that maintain homeostasis in the brain. However, their response to the pro-inflammatory cytokines released by activated microglia in various neurological pathologies may exacerbate neurodegenerative processes. Accumulating evidence suggests that omega...

journal_title：BMC neuroscience

authors： Zgórzyńska E,Stulczewski D,Dziedzic B,Su KP,Walczewska A

更新日期：2021-01-27 00:00:00

abstract：BACKGROUND:The use of induced pluripotent stem cells (iPSCs) for the functional replacement of damaged neurons and in vitro disease modeling is of great clinical relevance. Unfortunately, the capacity of iPSC lines to differentiate into neurons is highly variable, prompting the need for a reliable means of assessing th...

journal_title：BMC neuroscience

authors： Koehler KR,Tropel P,Theile JW,Kondo T,Cummins TR,Viville S,Hashino E

更新日期：2011-08-10 00:00:00

abstract：BACKGROUND:Ample evidence suggests a substantial contribution of cellular and molecular changes in the spinal cord to the induction and persistence of chronic neuropathic pain conditions. While for a long time, proteases were mainly considered as protein degrading enzymes, they are now receiving growing interest as sig...

journal_title：BMC neuroscience

authors： Leichsenring A,Bäcker I,Wendt W,Andriske M,Schmitz B,Stichel CC,Lübbert H

更新日期：2008-08-12 00:00:00

abstract：BACKGROUND:A delay in surgical nerve repair results in impaired nerve function in humans, but mechanisms behind the weakened nerve regeneration are not known. Activating transcription factor 3 (ATF3) increases the intrinsic growth state of injured neurons early after injury, but the role of long-term changes and their ...

journal_title：BMC neuroscience

authors： Saito H,Dahlin LB

更新日期：2008-09-18 00:00:00

abstract：BACKGROUND:The lateral premotor cortex plays a crucial role in visually guided limb movements. It is divided into two main regions, the dorsal (PMd) and ventral (PMv) areas, which are in turn subdivided into functionally and anatomically distinct rostral (PMd-r and PMv-r) and caudal (PMd-c and PMv-c) sub-regions. We an...

journal_title：BMC neuroscience

authors： Boussaoud D,Tanné-Gariépy J,Wannier T,Rouiller EM

更新日期：2005-11-25 00:00:00

abstract：BACKGROUND:In this study, we examined the effects of cyclophosphamide, methothrexate, and 5-Fluorouracil (CMF) drug combination on various aspects of learning and memory. We also examined the effects of CMF on cell proliferation and chromatin remodeling as possible underlying mechanisms to explain chemotherapy-associat...

journal_title：BMC neuroscience

authors： Briones TL,Woods J

更新日期：2011-12-09 00:00:00

abstract：BACKGROUND:10 Hz electroencephalographic (EEG) alpha rhythms correlate with memory performance. Alpha and memory decline in older people. We wished to test if alpha-like EEG activity contributes to memory formation. Flicker can elicit alpha-like EEG activity. We tested if alpha-frequency flicker enhances memory in olde...

journal_title：BMC neuroscience

authors： Williams J,Ramaswamy D,Oulhaj A

更新日期：2006-03-05 00:00:00

abstract：BACKGROUND:The human KALRN gene, which encodes a complex, multifunctional Rho GDP/GTP exchange factor, has been linked to cardiovascular disease, psychiatric disorders and neurodegeneration. Examination of existing Kalrn knockout mouse models has focused only on neuronal phenotypes. However, Kalirin was first identifie...

journal_title：BMC neuroscience

authors： Mandela P,Yankova M,Conti LH,Ma XM,Grady J,Eipper BA,Mains RE

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Lateralized processing of speech is a well studied phenomenon in humans. Both anatomical and neurophysiological studies support the view that nonhuman primates and other animal species also reveal hemispheric differences in areas involved in sound processing. In recent years, an increasing number of studies ...

journal_title：BMC neuroscience

authors： Fischer J,Teufel C,Drolet M,Patzelt A,Rübsamen R,von Cramon DY,Schubotz RI

更新日期：2009-02-24 00:00:00

abstract：BACKGROUND:Obesity has deleterious effects on the brain, and metabolic dysfunction may exacerbate the outcomes of seizures and brain injuries. However, it is unclear whether obesity affects excitotoxicity-induced neuronal cell death. The purpose of this study was to investigate the effects of a high-fat diet (HFD) on n...

journal_title：BMC neuroscience

authors： Kang DH,Heo RW,Yi CO,Kim H,Choi CH,Roh GS

更新日期：2015-10-30 00:00:00

abstract：BACKGROUND:The "inverse" problem is related to the determination of unknown causes on the bases of the observation of their effects. This is the opposite of the corresponding "direct" problem, which relates to the prediction of the effects generated by a complete description of some agencies. The solution of an inverse...

journal_title：BMC neuroscience

authors： Arisi I,Cattaneo A,Rosato V

更新日期：2006-10-30 00:00:00

abstract：BACKGROUND:Knock-in (KI) mouse models of Alzheimer's disease (AD) that endogenously overproduce Aβ without non-physiological overexpression of amyloid precursor protein (APP) provide important insights into the pathogenic mechanisms of AD. Previously, we reported that AppNL-G-F mice, which harbor three familial AD muta...

journal_title：BMC neuroscience

authors： Sakakibara Y,Sekiya M,Saito T,Saido TC,Iijima KM

更新日期：2019-03-20 00:00:00

abstract：BACKGROUND:Cigarette smoking enhances the risk of stroke. However, the underlying molecular mechanisms are largely unknown. The present study established an in vivo rat secondhand cigarette smoking (SHS) model and examined the hypothesis that SHS upregulates endothelin receptors with increased cerebrovascular contracti...

journal_title：BMC neuroscience

authors： Cao L,Xu CB,Zhang Y,Cao YX,Edvinsson L

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:Acupuncture has been applied to aid in the recovery of post-stroke patients, but its mechanism is unclear. This study aims to analyze the relationship between acupuncture and glucose metabolism in cerebral functional regions in post-stroke patients using (18)FDG PET-CT techniques. Forty-three ischemic stroke...

journal_title：BMC neuroscience

authors： Huang Y,Tang C,Wang S,Lu Y,Shen W,Yang J,Chen J,Lin R,Cui S,Xiao H,Qu S,Lai X,Shan B

更新日期：2012-06-27 00:00:00

abstract：BACKGROUND:Myzus persicae is a globally important aphid pest with a history of developing resistance to insecticides. Unusually, neonicotinoids have remained highly effective as control agents despite nearly two decades of steadily increasing use. In this study, a clone of M. persicae collected from southern France was...

journal_title：BMC neuroscience

authors： Bass C,Puinean AM,Andrews M,Cutler P,Daniels M,Elias J,Paul VL,Crossthwaite AJ,Denholm I,Field LM,Foster SP,Lind R,Williamson MS,Slater R

更新日期：2011-05-31 00:00:00

abstract：BACKGROUND:To examine which language function depends on early experience, the present study compared deaf native signers, deaf non-native signers and hearing German native speakers while processing German sentences. The participants watched simple written sentences while event-related potentials (ERPs) were recorded. ...

journal_title：BMC neuroscience

authors： Skotara N,Salden U,Kügow M,Hänel-Faulhaber B,Röder B

更新日期：2012-05-03 00:00:00

abstract：BACKGROUND:Emotional stimuli are preferentially processed compared to neutral ones. Measuring the magnetic resonance blood-oxygen level dependent (BOLD) response or EEG event-related potentials, this has also been demonstrated for emotional versus neutral words. However, it is currently unclear whether emotion effects ...

journal_title：BMC neuroscience

authors： Koban L,Ninck M,Li J,Gisler T,Kissler J

更新日期：2010-07-27 00:00:00

abstract：BACKGROUND:Berberine is the major alkaloidal component of Rhizoma coptidis, and has multiple pharmacological effects including inhibiting acetylcholinesterase, reducing cholesterol and glucose, lowering mortality in patients with chronic congestive heart failure and anti-inflammation etc. Thus berberine is a promising ...

journal_title：BMC neuroscience

authors： Zhu F,Qian C

更新日期：2006-12-01 00:00:00

abstract：BACKGROUND:Parkinson's disease (PD) is a neurological disorder characterized by the degeneration of nigrostriatal dopaminergic systems. Free radicals induced by oxidative stress are involved in the mechanisms of cell death in PD. This study clarifies the neuroprotective effects of edaravone (MCI-186, 3-methyl-1-phenyl-...

journal_title：BMC neuroscience

authors： Yuan WJ,Yasuhara T,Shingo T,Muraoka K,Agari T,Kameda M,Uozumi T,Tajiri N,Morimoto T,Jing M,Baba T,Wang F,Leung H,Matsui T,Miyoshi Y,Date I

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND:Empathy refers to the ability to recognise and share emotions with others. Several research groups have recognised observational fear in mice as a useful behavioural model for assessing their ability to empathise. However, in these observation systems, it remains unclear whether the observer mouse truly reco...

journal_title：BMC neuroscience

authors： Ueno H,Suemitsu S,Murakami S,Kitamura N,Wani K,Takahashi Y,Matsumoto Y,Okamoto M,Ishihara T

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the selective loss of motor neurons (MN) in the brain stem and spinal cord. Intracellular disruptions of cytosolic and mitochondrial calcium have been associated with selective MN degeneration, but the underlying mecha...

journal_title：BMC neuroscience

authors： Jaiswal MK,Zech WD,Goos M,Leutbecher C,Ferri A,Zippelius A,Carrì MT,Nau R,Keller BU

更新日期：2009-06-22 00:00:00

abstract：BACKGROUND:Neurogenesis continues to occur throughout life but dramatically decreases with increasing age. This decrease is mostly related to a decline in proliferative activity as a result of an impoverishment of the microenvironment of the aged brain, including a reduction in trophic factors and increased inflammatio...

journal_title：BMC neuroscience

authors： Bachstetter AD,Pabon MM,Cole MJ,Hudson CE,Sanberg PR,Willing AE,Bickford PC,Gemma C

更新日期：2008-02-14 00:00:00