Docosahexaenoic fatty acid reduces the pro-inflammatory response induced by IL-1β in astrocytes through inhibition of NF-κB and AP-1 transcription factor activation.

abstract：BACKGROUND:Ample evidence suggests a substantial contribution of cellular and molecular changes in the spinal cord to the induction and persistence of chronic neuropathic pain conditions. While for a long time, proteases were mainly considered as protein degrading enzymes, they are now receiving growing interest as sig...

journal_title：BMC neuroscience

authors： Leichsenring A,Bäcker I,Wendt W,Andriske M,Schmitz B,Stichel CC,Lübbert H

更新日期：2008-08-12 00:00:00

abstract：BACKGROUND:The olfactory neuroepithelium lines the upper nasal cavity and is in direct contact with the external environment and the olfactory bulbs. The ability to self-renew throughout life and the reproducible recovery after injury, make it a model tissue to study mechanisms underlying neurogenesis. In this study, X...

journal_title：BMC neuroscience

authors： Cunha C,Hort Y,Shine J,Doyle KL

更新日期：2012-10-31 00:00:00

abstract：BACKGROUND:Evoked potentials have been proposed to result from phase-locking of electroencephalographic (EEG) activities within specific frequency bands. However, the respective contribution of phasic activity and phase resetting of ongoing EEG oscillation remains largely debated. We here applied the EEGlab procedure i...

journal_title：BMC neuroscience

authors： Cheron G,Cebolla AM,De Saedeleer C,Bengoetxea A,Leurs F,Leroy A,Dan B

更新日期：2007-09-18 00:00:00

abstract：BACKGROUND:One of the most promising options for treatment of stroke using adult stem cells are human umbilical cord blood (HUCB) cells that were already approved for therapeutic efficacy in vivo. However, complexity of animal models has thus far limited the understanding of beneficial cellular mechanisms. To address t...

journal_title：BMC neuroscience

authors： Hau S,Reich DM,Scholz M,Naumann W,Emmrich F,Kamprad M,Boltze J

更新日期：2008-02-29 00:00:00

abstract：BACKGROUND:CNS injury including stroke, infection, and tumor growth lead to astrogliosis, a process that involves upregulation of glial fibrillary acidic protein (GFAP) in astrocytes. However, the kinetics of astrogliosis that is related to these insults (i.e. tumor) is largely unknown. RESULTS:Using transgenic mice e...

journal_title：BMC neuroscience

authors： Lee J,Borboa AK,Baird A,Eliceiri BP

更新日期：2011-01-19 00:00:00

abstract：BACKGROUND:Recently a hyperthermic rat hippocampal slice model system has been used to investigate febrile seizure pathophysiology. Our previous data indicates that heating immature rat hippocampal slices from 34 to 41 degrees C in an interface chamber induced epileptiform-like population spikes accompanied by a spread...

journal_title：BMC neuroscience

authors： Wu J,Javedan SP,Ellsworth K,Smith K,Fisher RS

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Parkinson's disease (PD) is a neurological disorder characterized by the degeneration of nigrostriatal dopaminergic systems. Free radicals induced by oxidative stress are involved in the mechanisms of cell death in PD. This study clarifies the neuroprotective effects of edaravone (MCI-186, 3-methyl-1-phenyl-...

journal_title：BMC neuroscience

authors： Yuan WJ,Yasuhara T,Shingo T,Muraoka K,Agari T,Kameda M,Uozumi T,Tajiri N,Morimoto T,Jing M,Baba T,Wang F,Leung H,Matsui T,Miyoshi Y,Date I

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND:Tone languages such as Thai and Mandarin Chinese use differences in fundamental frequency (F0, pitch) to distinguish lexical meaning. Previous behavioral studies have shown that native speakers of a non-tone language have difficulty discriminating among tone contrasts and are sensitive to different F0 dimens...

journal_title：BMC neuroscience

authors： Kaan E,Barkley CM,Bao M,Wayland R

更新日期：2008-06-23 00:00:00

abstract：BACKGROUND:To determine whether early imitative responses fade out following the maturation of attentional mechanisms, the relationship between primitive imitation behaviors and the development of attention was examined in 4-month-old infants. They were divided into high and low imitators, based on an index of imitatio...

journal_title：BMC neuroscience

authors： Nakagawa A,Sukigara M,Benga O

更新日期：2003-12-24 00:00:00

abstract：BACKGROUND:Oxidative stress has shown to contribute in the mechanisms underlying apoptotic cell death occurring in AIDS-dementia complex. Here we investigated the role of peroxynitrite in apoptosis occurring in astroglial cells incubated with supernatants of HIV-infected human primary macrophages (M/M). RESULTS:Flow c...

journal_title：BMC neuroscience

authors： Muscoli C,Salvemini D,Paolino D,Iannone M,Palma E,Cufari A,Rotiroti D,Perno CF,Aquaro S,Mollace V

更新日期：2002-09-16 00:00:00

abstract：BACKGROUND:To date, functional imaging studies of treatment-induced recovery from chronic aphasia only assessed short-term treatment effects after intensive language training. In the present study, we show with functional magnetic resonance imaging (fMRI), that different brain regions may be involved in immediate versu...

journal_title：BMC neuroscience

authors： Menke R,Meinzer M,Kugel H,Deppe M,Baumgärtner A,Schiffbauer H,Thomas M,Kramer K,Lohmann H,Flöel A,Knecht S,Breitenstein C

更新日期：2009-09-22 00:00:00

abstract：BACKGROUND:Adult neurogenesis continuously adds new neurons to the dentate gyrus and the olfactory bulb. It involves the proliferation and subsequent differentiation of neuronal progenitors, and is thus closely linked to the cell cycle machinery. Cell cycle progression is governed by the successive expression, activati...

journal_title：BMC neuroscience

authors： Ansorg A,Witte OW,Urbach A

更新日期：2012-05-07 00:00:00

abstract：BACKGROUND:Recovery following stroke depends on cellular plasticity in the perilesional zone (PZ). Doublecortin (DCX), a protein mainly labeling immature neurons in neurogenic niches is also highly expressed in the vicinity of focal cortical infarcts. Notably, the number of DCX+ cells positively correlates with the rec...

journal_title：BMC neuroscience

authors： Kunze A,Achilles A,Keiner S,Witte OW,Redecker C

更新日期：2015-04-15 00:00:00

abstract：BACKGROUND:HIV Associated Dementia (HAD) is a common complication of human immunodeficiency virus (HIV) infection that erodes the quality of life for patients and burdens health care providers. Intravenous drug use is a major route of HIV transmission, and drug use is associated with increased HAD. Specific proteins re...

journal_title：BMC neuroscience

authors： Kendall SL,Anderson CF,Nath A,Turchan-Cholewo J,Land CL,Mactutus CF,Booze RM

更新日期：2005-06-08 00:00:00

abstract：BACKGROUND:The properties of Ca2+ signaling mediated by purinergic receptors are intrinsically linked with functional activity of astrocytes. At present little is known concerning Ca2+-dependent purinergic responses in adult human astrocytes. This work has examined effects of purinergic stimulation to alter levels of i...

journal_title：BMC neuroscience

authors： Hashioka S,Wang YF,Little JP,Choi HB,Klegeris A,McGeer PL,McLarnon JG

更新日期：2014-01-22 00:00:00

abstract：BACKGROUND:Following partial injury to the central nervous system, cells beyond the initial injury site undergo secondary degeneration, exacerbating loss of neurons, compact myelin and function. Changes in Ca2+ flux are associated with metabolic and structural changes, but it is not yet clear how flux through specific ...

journal_title：BMC neuroscience

authors： O'Hare Doig RL,Chiha W,Giacci MK,Yates NJ,Bartlett CA,Smith NM,Hodgetts SI,Harvey AR,Fitzgerald M

更新日期：2017-08-14 00:00:00

abstract：BACKGROUND:An ever growing body of evidences is emerging concerning metabolism hormones, neurotransmitters or stress-related biomarkers as effective modulators of eating behavior and body weight in mammals. The present study sought at examining the density and affinity of two proteins related to neurotransmission and c...

journal_title：BMC neuroscience

authors： Giannaccini G,Betti L,Palego L,Pirone A,Schmid L,Lanza M,Fabbrini L,Pelosini C,Maffei M,Santini F,Pinchera A,Lucacchini A

更新日期：2011-02-07 00:00:00

abstract：BACKGROUND:Enhanced activity of trigeminal ganglion neurons is thought to underlie neuronal sensitization facilitating the onset of chronic pain attacks, including migraine. Recurrent headache attacks might establish a chronic neuroinflammatory ganglion profile contributing to the hypersensitive phenotype. Since it is ...

journal_title：BMC neuroscience

authors： Franceschini A,Nair A,Bele T,van den Maagdenberg AM,Nistri A,Fabbretti E

更新日期：2012-11-21 00:00:00

abstract：BACKGROUND:The function of synaptotagmins (syt) in Ca2+-dependent transmitter release has been attributed primarily to Ca2+-dependent isoforms such as syt I. Recently, syt IV, an inducible Ca2+-independent isoform has been implicated in transmitter release. We postulated that the effects of syt IV on transmitter releas...

journal_title：BMC neuroscience

authors： Moore-Dotson JM,Papke JB,Harkins AB

更新日期：2010-08-24 00:00:00

abstract：BACKGROUND:Synaptic degeneration and accumulation of amyloid β-peptides (Aβ) are hallmarks of the Alzheimer diseased brain. Aβ is synaptotoxic and produced by sequential cleavage of the amyloid precursor protein (APP) by the β-secretase BACE1 and by γ-secretase. If APP is instead cleaved by the α-secretase ADAM10, Aβ w...

journal_title：BMC neuroscience

authors： Lundgren JL,Vandermeulen L,Sandebring-Matton A,Ahmed S,Winblad B,Di Luca M,Tjernberg LO,Marcello E,Frykman S

更新日期：2020-02-04 00:00:00

abstract：BACKGROUND:Recent alleged attacks with nerve agent sarin on civilians in Syria indicate their potential threat to both civilian and military population. Acute nerve agent exposure can cause rapid death or leads to multiple and long term neurological effects. The biochemical changes that occur following nerve agent expo...

journal_title：BMC neuroscience

authors： RamaRao G,Afley P,Acharya J,Bhattacharya BK

更新日期：2014-04-04 00:00:00

abstract：BACKGROUND:SLC10A4 belongs to the solute carrier family SLC10 whose founding members are the Na(+)/taurocholate co-transporting polypeptide (NTCP, SLC10A1) and the apical sodium-dependent bile acid transporter (ASBT, SLC10A2). These carriers maintain the enterohepatic circulation of bile acids between the liver and the...

journal_title：BMC neuroscience

authors： Schmidt S,Moncada M,Burger S,Geyer J

更新日期：2015-06-19 00:00:00

abstract：BACKGROUND:Myzus persicae is a globally important aphid pest with a history of developing resistance to insecticides. Unusually, neonicotinoids have remained highly effective as control agents despite nearly two decades of steadily increasing use. In this study, a clone of M. persicae collected from southern France was...

journal_title：BMC neuroscience

authors： Bass C,Puinean AM,Andrews M,Cutler P,Daniels M,Elias J,Paul VL,Crossthwaite AJ,Denholm I,Field LM,Foster SP,Lind R,Williamson MS,Slater R

更新日期：2011-05-31 00:00:00

abstract：BACKGROUND:Transcranial focused ultrasound (tFUS) is a new non-invasive neuromodulation technique that uses mechanical energy to modulate neuronal excitability with high spatial precision. tFUS has been shown to be capable of modulating EEG brain activity in humans that is spatially restricted, and here, we use 7T MRI ...

journal_title：BMC neuroscience

authors： Ai L,Bansal P,Mueller JK,Legon W

更新日期：2018-09-14 00:00:00

abstract：BACKGROUND:Low-intensity pulsed ultrasound stimulation (LIPUS) has been proven to be a noninvasive method with high spatial resolution and deep penetration. Previous studies have qualitatively demonstrated that the electromyographic response caused by LIPUS in the mouse motor cortex is affected by the anesthetic state ...

journal_title：BMC neuroscience

authors： Yuan Y,Wang X,Yan J,Li X

更新日期：2018-12-03 00:00:00

abstract：BACKGROUND:Hyperbaric oxygen therapy (HBOT) is a known adjuvant for treating ischemia-related inner ear diseases. Controversies still exist in the role of HBOT in cochlear diseases. Few studies to date have investigated the cellular changes that occur in inner ears after HBOT. Nitric oxide, which is synthesized by nitr...

journal_title：BMC neuroscience

authors： Lin CD,Wei IH,Lai CH,Hsia TC,Kao MC,Tsai MH,Wu CH,Tsai MH

更新日期：2011-02-22 00:00:00

abstract：BACKGROUND:The aim of this study was to assess the distribution of key SNARE proteins in glutamatergic and GABAergic synapses of the adult rat cerebellar cortex using light microscopy immunohistochemical techniques. Analysis was made of co-localizations of vGluT-1 and vGluT-2, vesicular transporters of glutamate and ma...

journal_title：BMC neuroscience

authors： Benagiano V,Lorusso L,Flace P,Girolamo F,Rizzi A,Bosco L,Cagiano R,Nico B,Ribatti D,Ambrosi G

更新日期：2011-11-17 00:00:00

abstract：BACKGROUND:Intracranial Self-Stimulation (ICSS) of the medial forebrain bundle (MFB) is a deep brain stimulation procedure, which has a powerful enhancement effect on explicit and implicit memory. However, the downstream synaptic plasticity events of MFB-ICSS in memory related areas have not been described thoroughly. ...

journal_title：BMC neuroscience

authors： Kádár E,Varela EV,Aldavert-Vera L,Huguet G,Morgado-Bernal I,Segura-Torres P

更新日期：2018-08-08 00:00:00

abstract：BACKGROUND:Huntington's disease (HD) is a neurodegenerative disorder predominantly affecting the cerebral cortex and striatum. Transgenic mice (R6/1 line), expressing a CAG repeat encoding an expanded polyglutamine tract in the N-terminus of the huntingtin protein, closely model HD. We have previously shown that enviro...

journal_title：BMC neuroscience

authors： van Dellen A,Cordery PM,Spires TL,Blakemore C,Hannan AJ

更新日期：2008-04-01 00:00:00

abstract：BACKGROUND:Histone deacetylases (HDACs) are enzymes that modulate gene expression and cellular processes by deacetylating histones and non-histone proteins. While small molecule inhibitors of HDAC activity (HDACi) are used clinically in the treatment of cancer, pre-clinical treatment models suggest they also exert neur...

journal_title：BMC neuroscience

authors： Zhou Q,Dalgard CL,Wynder C,Doughty ML

更新日期：2011-05-26 00:00:00