Abstract:
BACKGROUND:To date, functional imaging studies of treatment-induced recovery from chronic aphasia only assessed short-term treatment effects after intensive language training. In the present study, we show with functional magnetic resonance imaging (fMRI), that different brain regions may be involved in immediate versus long-term success of intensive language training in chronic post-stroke aphasia patients. RESULTS:Eight patients were trained daily for three hours over a period of two weeks in naming of concrete objects. Prior to, immediately after, and eight months after training, patients overtly named trained and untrained objects during event-related fMRI. On average the patients improved from zero (at baseline) to 64.4% correct naming responses immediately after training, and treatment success remained highly stable at follow-up. Regression analyses showed that the degree of short-term treatment success was predicted by increased activity (compared to the pretraining scan) bilaterally in the hippocampal formation, the right precuneus and cingulate gyrus, and bilaterally in the fusiform gyri. A different picture emerged for long-term training success, which was best predicted by activity increases in the right-sided Wernicke's homologue and to a lesser degree in perilesional temporal areas. CONCLUSION:The results show for the first time that treatment-induced language recovery in the chronic stage after stroke is a dynamic process. Initially, brain regions involved in memory encoding, attention, and multimodal integration mediated treatment success. In contrast, long-term treatment success was predicted mainly by activity increases in the so-called 'classical' language regions. The results suggest that besides perilesional and homologue language-associated regions, functional integrity of domain-unspecific memory structures may be a prerequisite for successful (intensive) language interventions.
journal_name
BMC Neuroscijournal_title
BMC neuroscienceauthors
Menke R,Meinzer M,Kugel H,Deppe M,Baumgärtner A,Schiffbauer H,Thomas M,Kramer K,Lohmann H,Flöel A,Knecht S,Breitenstein Cdoi
10.1186/1471-2202-10-118subject
Has Abstractpub_date
2009-09-22 00:00:00pages
118issn
1471-2202pii
1471-2202-10-118journal_volume
10pub_type
杂志文章相关文献
BMC NEUROSCIENCE文献大全abstract:BACKGROUND:Reuptake of synaptic norepinephrine (NE) via the antidepressant-sensitive NE transporter (NET) supports efficient noradrenergic signaling and presynaptic NE homeostasis. Limited, and somewhat contradictory, information currently describes the axonal transport and localization of NET in neurons. RESULTS:We e...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-10-65
更新日期:2009-06-23 00:00:00
abstract:BACKGROUND:Functional magnetic resonance imaging (fMRI) in white matter has long been considered controversial. Recently, this viewpoint has been challenged by an emerging body of evidence demonstrating white matter activation in the corpus callosum. The current study aimed to determine whether white matter activation ...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-12-56
更新日期:2011-06-14 00:00:00
abstract:BACKGROUND:Acupuncture has been applied to aid in the recovery of post-stroke patients, but its mechanism is unclear. This study aims to analyze the relationship between acupuncture and glucose metabolism in cerebral functional regions in post-stroke patients using (18)FDG PET-CT techniques. Forty-three ischemic stroke...
journal_title:BMC neuroscience
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-2202-13-75
更新日期:2012-06-27 00:00:00
abstract:BACKGROUND:Noise exposure (NE) is a severe modern health hazard that induces hearing impairment. However, the noise-induced ultrastructural changes of blood-labyrinth barrier (BLB) and the potential involvements of tight junction proteins (TJP) remain inconclusive. We investigated the effects of NE on not only the ultr...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-014-0136-0
更新日期:2014-12-24 00:00:00
abstract:BACKGROUND:Earlier functional imaging studies on visually induced self-motion perception (vection) disclosed a bilateral network of activations within primary and secondary visual cortex areas which was combined with signal decreases, i.e., deactivations, in multisensory vestibular cortex areas. This finding led to the...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-13-81
更新日期:2012-07-16 00:00:00
abstract:BACKGROUND:Human brain microvascular endothelial cells (hBMVECs) are integral part of the blood brain barrier. Post-translational modifications of adherens junction proteins regulate the permeability of human brain microvascular endothelial cells. Pro-inflammatory signals can induce tyrosine phosphorylation of adherens...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-15-80
更新日期:2014-06-26 00:00:00
abstract:BACKGROUND:Microglia, the resident immune cells of the central nervous system (CNS), have two distinct phenotypes in the developing brain: amoeboid form, known to be amoeboid microglial cells (AMC) and ramified form, known to be ramified microglial cells (RMC). The AMC are characterized by being proliferative, phagocyt...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-13-64
更新日期:2012-06-14 00:00:00
abstract:BACKGROUND:Cholecystokinin octapeptide (CCK-8), the most potent endogenous anti-opioid peptide, has been shown to regulate the processes of morphine dependence. In our previous study, we found that exogenous CCK-8 attenuated naloxone induced withdrawal symptoms. To investigate the precise effect of exogenous CCK-8 and ...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-13-63
更新日期:2012-06-08 00:00:00
abstract:BACKGROUND:How does the brain repair obliterated speech and cope with acoustically ambivalent situations? A widely discussed possibility is to use top-down information for solving the ambiguity problem. In the case of speech, this may lead to a match of bottom-up sensory input with lexical expectations resulting in res...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-11-67
更新日期:2010-06-02 00:00:00
abstract:BACKGROUND:Excitotoxicity (the toxic overstimulation of neurons by the excitatory transmitter Glutamate) is a central process in widespread neurodegenerative conditions such as brain ischemia and chronic neurological diseases. Many mechanisms have been suggested to mediate excitotoxicity, but their significance across ...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-015-0158-2
更新日期:2015-04-23 00:00:00
abstract:BACKGROUND:Following partial injury to the central nervous system, cells beyond the initial injury site undergo secondary degeneration, exacerbating loss of neurons, compact myelin and function. Changes in Ca2+ flux are associated with metabolic and structural changes, but it is not yet clear how flux through specific ...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-017-0380-1
更新日期:2017-08-14 00:00:00
abstract:BACKGROUND:Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative fatal disease that can affect the neurons of brain and spinal cord. ALS genetics has identified various genes to be associated with disease pathology. Oxidative stress induced bunina and lewy bodies formation can be regulated through the ...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-020-00591-3
更新日期:2020-10-09 00:00:00
abstract:BACKGROUND:Gap junction proteins, connexins, are expressed in most endocrine and exocrine glands in the body and are at least in some glands crucial for the hormonal secretion. To what extent connexins are expressed in neurons releasing hormones or neuropeptides from or within the central nervous system is, however, un...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-10-41
更新日期:2009-04-30 00:00:00
abstract:BACKGROUND:White matter hyperintensities (WMH) can lead to dementia but the underlying physiological mechanisms are unclear. We compared relative oscillatory power from electroencephalographic studies (EEGs) of 17 patients with subcortical ischemic vascular dementia, based on extensive white matter hyperintensities (SI...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-13-85
更新日期:2012-07-24 00:00:00
abstract:BACKGROUND:Immunization with neural derived peptides (INDP) as well as scar removal-separately-have shown to induce morphological and functional improvement after spinal cord injury (SCI). In the present study, we compared the effect of INDP alone versus INDP with scar removal on motor recovery, regeneration-associated...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-016-0331-2
更新日期:2017-01-05 00:00:00
abstract:BACKGROUND:The olfactory neuroepithelium lines the upper nasal cavity and is in direct contact with the external environment and the olfactory bulbs. The ability to self-renew throughout life and the reproducible recovery after injury, make it a model tissue to study mechanisms underlying neurogenesis. In this study, X...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-13-134
更新日期:2012-10-31 00:00:00
abstract:BACKGROUND:To reach and grasp an object in space on the basis of its image cast on the retina requires different coordinate transformations that take into account gaze and limb positioning. Eye position in the orbit influences the image's conversion from retinotopic (eye-centered) coordinates to an egocentric frame nec...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-5-35
更新日期:2004-09-19 00:00:00
abstract:BACKGROUND:CRISPR/Cas9 system is a powerful method to investigate the role of genes by introducing a mutation selectively and efficiently to specific genome positions in cell and animal lines. However, in primary neuron cultures, this method is affected by the issue that the effectiveness of CRISPR/Cas9 is different in...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-017-0377-9
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:Stress involves alterations of brain functioning that may precipitate to mood disorders. The neurotrophin Brain Derived Neurotrophic Factor (BDNF) has recently been involved in stress-induced adaptation. BDNF is a key regulator of neuronal plasticity and adaptive processes. Regulation of BDNF is complex and ...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-11-4
更新日期:2010-01-14 00:00:00
abstract:BACKGROUND:This study examined the relationship of the arithmetic mismatch negativity (AMN) and the semantic evaluation of numerical magnitude. The first question was whether the AMN was sensitive to the incongruity in numerical information per se, or rather, to the violation of strategic expectations. The second quest...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-12-83
更新日期:2011-08-11 00:00:00
abstract:BACKGROUND:Subjective tinnitus is characterized by an auditory phantom perception in the absence of any physical sound source. Consequently, in a quiet environment, tinnitus patients differ from control participants because they constantly perceive a sound whereas controls do not. We hypothesized that this difference i...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-10-11
更新日期:2009-02-19 00:00:00
abstract:BACKGROUND:Low-intensity pulsed ultrasound stimulation (LIPUS) has been proven to be a noninvasive method with high spatial resolution and deep penetration. Previous studies have qualitatively demonstrated that the electromyographic response caused by LIPUS in the mouse motor cortex is affected by the anesthetic state ...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-018-0476-2
更新日期:2018-12-03 00:00:00
abstract:BACKGROUND:Precise control of developmental and cell-specific expression of the brain-derived neurotrophic factor (BDNF) gene is essential for normal neuronal development and the diverse functions of BDNF in the adult organism. We previously showed that the zebrafish BDNF gene has multiple promoters. The complexity of ...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-5-19
更新日期:2004-05-21 00:00:00
abstract:BACKGROUND:CNS injury including stroke, infection, and tumor growth lead to astrogliosis, a process that involves upregulation of glial fibrillary acidic protein (GFAP) in astrocytes. However, the kinetics of astrogliosis that is related to these insults (i.e. tumor) is largely unknown. RESULTS:Using transgenic mice e...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-12-9
更新日期:2011-01-19 00:00:00
abstract:BACKGROUND:The effects of negative emotion on different processing periods in spatial and verbal working memory (WM) and the possible brain mechanism of the interaction between negative emotion and WM were explored using a high-time resolution event-related potential (ERP) technique and time-locked delayed matching-to-...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-11-60
更新日期:2010-05-07 00:00:00
abstract:BACKGROUND:Inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, known as statins, are commonly used as cholesterol-lowering drugs. During the past decade, evidence has emerged that statins also have neuroprotective effects. Research in the retina has shown that simvastatin, a commonly used statin, increases A...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-12-114
更新日期:2011-11-14 00:00:00
abstract:BACKGROUND:The human KALRN gene, which encodes a complex, multifunctional Rho GDP/GTP exchange factor, has been linked to cardiovascular disease, psychiatric disorders and neurodegeneration. Examination of existing Kalrn knockout mouse models has focused only on neuronal phenotypes. However, Kalirin was first identifie...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-13-136
更新日期:2012-11-01 00:00:00
abstract:BACKGROUND:Opioid agonist drugs produce analgesia. However, long-term exposure to opioid agonists may lead to opioid dependence. The analgesic and addictive properties of opioid agonist drugs are mediated primarily via the mu-opioid receptor (MOR). Opioid agonists appear to alter neuronal morphology in key brain region...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-11-33
更新日期:2010-03-09 00:00:00
abstract:BACKGROUND:To identify mechanisms of cortical plasticity of the visual cortex and to quantify their significance, sensitive parameters are warranted. In this context, multifocal visual evoked potentials (mfVEPs) can make a valuable contribution as they are not associated with cancellation artifacts and include also the...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-020-00600-5
更新日期:2020-11-23 00:00:00
abstract:BACKGROUND:To measure the impact of masticatory reduction on learning and memory, previous studies have produced experimental masticatory reduction by modified diet or molar removal. Here we induced spatial learning impairment in mice by reducing masticatory activity and then tested the effect of a combination of envir...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-14-63
更新日期:2013-06-28 00:00:00