Both 5' and 3' flanks regulate Zebrafish brain-derived neurotrophic factor gene expression.

abstract：BACKGROUND:Major depressive disorder is a prevalent disease that is inadequately treated with currently available interventions. Stress increases susceptibility to depression in patients and rodent models. Depression is also associated with aberrant activation of inflammation, such as increases in circulating levels of...

journal_title：BMC neuroscience

authors： Cheng Y,Jope RS,Beurel E

更新日期：2015-05-07 00:00:00

abstract：BACKGROUND:The optic nerve is a pure white matter central nervous system (CNS) tract with an isolated blood supply, and is widely used in physiological studies of white matter response to various insults. We examined the gene expression profile of human optic nerve (ON) and, through the NEIBANK online resource, to prov...

journal_title：BMC neuroscience

authors： Bernstein SL,Guo Y,Peterson K,Wistow G

更新日期：2009-09-24 00:00:00

abstract：BACKGROUND:CNS injury including stroke, infection, and tumor growth lead to astrogliosis, a process that involves upregulation of glial fibrillary acidic protein (GFAP) in astrocytes. However, the kinetics of astrogliosis that is related to these insults (i.e. tumor) is largely unknown. RESULTS:Using transgenic mice e...

journal_title：BMC neuroscience

authors： Lee J,Borboa AK,Baird A,Eliceiri BP

更新日期：2011-01-19 00:00:00

abstract：BACKGROUND:Parkinson's disease (PD) is a neurological disorder characterized by the degeneration of nigrostriatal dopaminergic systems. Free radicals induced by oxidative stress are involved in the mechanisms of cell death in PD. This study clarifies the neuroprotective effects of edaravone (MCI-186, 3-methyl-1-phenyl-...

journal_title：BMC neuroscience

authors： Yuan WJ,Yasuhara T,Shingo T,Muraoka K,Agari T,Kameda M,Uozumi T,Tajiri N,Morimoto T,Jing M,Baba T,Wang F,Leung H,Matsui T,Miyoshi Y,Date I

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND:Evoked potentials have been proposed to result from phase-locking of electroencephalographic (EEG) activities within specific frequency bands. However, the respective contribution of phasic activity and phase resetting of ongoing EEG oscillation remains largely debated. We here applied the EEGlab procedure i...

journal_title：BMC neuroscience

authors： Cheron G,Cebolla AM,De Saedeleer C,Bengoetxea A,Leurs F,Leroy A,Dan B

更新日期：2007-09-18 00:00:00

abstract：BACKGROUND:Tone languages such as Thai and Mandarin Chinese use differences in fundamental frequency (F0, pitch) to distinguish lexical meaning. Previous behavioral studies have shown that native speakers of a non-tone language have difficulty discriminating among tone contrasts and are sensitive to different F0 dimens...

journal_title：BMC neuroscience

authors： Kaan E,Barkley CM,Bao M,Wayland R

更新日期：2008-06-23 00:00:00

abstract：BACKGROUND:Huntington's disease (HD) is a neurodegenerative disorder predominantly affecting the cerebral cortex and striatum. Transgenic mice (R6/1 line), expressing a CAG repeat encoding an expanded polyglutamine tract in the N-terminus of the huntingtin protein, closely model HD. We have previously shown that enviro...

journal_title：BMC neuroscience

authors： van Dellen A,Cordery PM,Spires TL,Blakemore C,Hannan AJ

更新日期：2008-04-01 00:00:00

abstract：BACKGROUND:The integration of EEG and fMRI is attractive because of their complementary precision regarding time and space. But the relationship between the indirect hemodynamic fMRI signal and the more direct EEG signal is uncertain. Event-related EEG responses can be analyzed in two different ways, reflecting two dif...

journal_title：BMC neuroscience

authors： Foucher JR,Otzenberger H,Gounot D

更新日期：2003-09-19 00:00:00

abstract：BACKGROUND:Earlier functional imaging studies on visually induced self-motion perception (vection) disclosed a bilateral network of activations within primary and secondary visual cortex areas which was combined with signal decreases, i.e., deactivations, in multisensory vestibular cortex areas. This finding led to the...

journal_title：BMC neuroscience

authors： Becker-Bense S,Buchholz HG,zu Eulenburg P,Best C,Bartenstein P,Schreckenberger M,Dieterich M

更新日期：2012-07-16 00:00:00

abstract：BACKGROUND:To determine whether early imitative responses fade out following the maturation of attentional mechanisms, the relationship between primitive imitation behaviors and the development of attention was examined in 4-month-old infants. They were divided into high and low imitators, based on an index of imitatio...

journal_title：BMC neuroscience

authors： Nakagawa A,Sukigara M,Benga O

更新日期：2003-12-24 00:00:00

abstract：BACKGROUND:Cys-loop receptors play important roles in fast neuronal signal transmission. Functional receptors are pentamers, with each subunit having an extracellular, transmembrane (TM) and intracellular domain. Each TM domain contains 4 α-helices (M1-M4) joined by loops of varying lengths. Many of the amino acid resi...

journal_title：BMC neuroscience

authors： Tang B,Lummis SCR

更新日期：2018-09-06 00:00:00

abstract：BACKGROUND:Cholecystokinin octapeptide (CCK-8), the most potent endogenous anti-opioid peptide, has been shown to regulate the processes of morphine dependence. In our previous study, we found that exogenous CCK-8 attenuated naloxone induced withdrawal symptoms. To investigate the precise effect of exogenous CCK-8 and ...

journal_title：BMC neuroscience

authors： Wen D,Ma CL,Zhang YJ,Meng YX,Ni ZY,Li SJ,Cong B

更新日期：2012-06-08 00:00:00

abstract：BACKGROUND:Recent discoveries suggest that arealization of the mammalian cortical sheet develops in a manner consonant with principles established for embryonic patterning of the body. Signaling centers release morphogens that determine regional growth and tissue identity by regulating regional expression of transcript...

journal_title：BMC neuroscience

authors： Airey DC,Robbins AI,Enzinger KM,Wu F,Collins CE

更新日期：2005-03-17 00:00:00

abstract：BACKGROUND:An individual's ability to recognise and pay attention to others is crucial in order to behave appropriately in various social situations. Studies in humans have shown a sex bias in sociability as well as social memory, indicating that females have better face memory and gaze more at the eyes of others, but ...

journal_title：BMC neuroscience

authors： Karlsson SA,Haziri K,Hansson E,Kettunen P,Westberg L

更新日期：2015-11-25 00:00:00

abstract：BACKGROUND:The megencephaly mouse, mceph/mceph, is epileptic and displays a dramatically increased brain volume and neuronal count. The responsible mutation was recently revealed to be an eleven base pair deletion, leading to a frame shift, in the gene encoding the potassium channel Kv1.1. The predicted MCEPH protein i...

journal_title：BMC neuroscience

authors： Persson AS,Klement G,Almgren M,Sahlholm K,Nilsson J,Petersson S,Arhem P,Schalling M,Lavebratt C

更新日期：2005-11-23 00:00:00

abstract：BACKGROUND:The human inferior frontal junction area (IFJ) is critically involved in three main component processes of cognitive control (working memory, task switching and inhibitory control). As it overlaps with several areas in established anatomical labeling schemes, it is considered to be underreported as a functio...

journal_title：BMC neuroscience

authors： Sundermann B,Pfleiderer B

更新日期：2012-10-03 00:00:00

abstract：BACKGROUND:Fetal asphyctic (FA) preconditioning is effective in attenuating brain damage incurred by a subsequent perinatal asphyctic insult. Unraveling mechanisms of this endogenous neuroprotection, activated by FA preconditioning, is an important step towards new clinical strategies for asphyctic neonates. Genomic re...

journal_title：BMC neuroscience

authors： Cox-Limpens KE,Vles JS,Schlechter J,Zimmermann LJ,Strackx E,Gavilanes AW

更新日期：2013-06-22 00:00:00

abstract：BACKGROUND:The human KALRN gene, which encodes a complex, multifunctional Rho GDP/GTP exchange factor, has been linked to cardiovascular disease, psychiatric disorders and neurodegeneration. Examination of existing Kalrn knockout mouse models has focused only on neuronal phenotypes. However, Kalirin was first identifie...

journal_title：BMC neuroscience

authors： Mandela P,Yankova M,Conti LH,Ma XM,Grady J,Eipper BA,Mains RE

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Reuptake of synaptic norepinephrine (NE) via the antidepressant-sensitive NE transporter (NET) supports efficient noradrenergic signaling and presynaptic NE homeostasis. Limited, and somewhat contradictory, information currently describes the axonal transport and localization of NET in neurons. RESULTS:We e...

journal_title：BMC neuroscience

authors： Matthies HJ,Han Q,Shields A,Wright J,Moore JL,Winder DG,Galli A,Blakely RD

更新日期：2009-06-23 00:00:00

abstract：BACKGROUND:Granulocyte-macrophage colony stimulating factor (GM-CSF) is a hematopoietic growth factor involved in the generation of granulocytes, macrophages, and dendritic cells from hematopoietic progenitor cells. We have recently demonstrated that GM-CSF has anti-apoptotic functions on neurons, and is neuroprotectiv...

journal_title：BMC neuroscience

authors： Krüger C,Laage R,Pitzer C,Schäbitz WR,Schneider A

更新日期：2007-10-22 00:00:00

abstract：BACKGROUND:Many studies of cerebral asymmetries in different species lead, on the one hand, to a better understanding of the functions of each cerebral hemisphere and, on the other hand, to develop an evolutionary history of hemispheric laterality. Our animal model is particularly interesting because of its original ev...

journal_title：BMC neuroscience

authors： Blois-Heulin C,Crével M,Böye M,Lemasson A

更新日期：2012-01-12 00:00:00

abstract：BACKGROUND:The mechanisms of steroids actions in the brain mainly involve the binding and nuclear translocation of specific cytoplasmic receptors. These receptors can act as transcription factors and regulate gene expression. However, steroid-dependent transcriptional regulation in different types of neural cells is no...

journal_title：BMC neuroscience

authors： Piechota M,Korostynski M,Golda S,Ficek J,Jantas D,Barbara Z,Przewlocki R

更新日期：2017-04-05 00:00:00

abstract：BACKGROUND:To date, functional imaging studies of treatment-induced recovery from chronic aphasia only assessed short-term treatment effects after intensive language training. In the present study, we show with functional magnetic resonance imaging (fMRI), that different brain regions may be involved in immediate versu...

journal_title：BMC neuroscience

authors： Menke R,Meinzer M,Kugel H,Deppe M,Baumgärtner A,Schiffbauer H,Thomas M,Kramer K,Lohmann H,Flöel A,Knecht S,Breitenstein C

更新日期：2009-09-22 00:00:00

abstract：BACKGROUND:Rett syndrome (RTT, MIM #312750) is a severe neurological disorder caused by mutations in the X-linked methyl-CpG binding protein 2 (MECP2) gene. Female patients are affected with an incidence of 1/15000 live births and develop normally from birth to 6-18 months of age before the onset of deficits in autonom...

journal_title：BMC neuroscience

authors： Panayotis N,Ghata A,Villard L,Roux JC

更新日期：2011-05-24 00:00:00

abstract：BACKGROUND:Given the reported inverse association between light and depressive mood, ambient light may also be associated with some of the brain regions in healthy subjects. The present study aims to investigate the effects of ambient light on glucose metabolism in the brain. We used the data of 28 healthy participants...

journal_title：BMC neuroscience

authors： Hirakawa H,Terao T,Hatano K,Kohno K,Ishii N

更新日期：2018-07-24 00:00:00

abstract：BACKGROUND:Noise exposure (NE) is a severe modern health hazard that induces hearing impairment. However, the noise-induced ultrastructural changes of blood-labyrinth barrier (BLB) and the potential involvements of tight junction proteins (TJP) remain inconclusive. We investigated the effects of NE on not only the ultr...

journal_title：BMC neuroscience

authors： Wu YX,Zhu GX,Liu XQ,Sun F,Zhou K,Wang S,Wang CM,Jia JW,Song JT,Lu LJ

更新日期：2014-12-24 00:00:00

abstract：BACKGROUND:Early stages in the excitation cascade of Limulus photoreceptors are mediated by activation of Gq by rhodopsin, generation of inositol-1,4,5-trisphosphate by phospholipase-C and the release of Ca2+. At the end of the cascade, cGMP-gated channels open and generate the depolarizing receptor potential. A major ...

journal_title：BMC neuroscience

authors： Garger AV,Richard EA,Lisman JE

更新日期：2004-02-26 00:00:00

abstract：BACKGROUND:Recent work has suggested that the ovarian steroid 17beta-estradiol, at physiological concentrations, may exert protective effects in neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease and acute ischemic stroke. While physiological concentrations of estrogen have consistently been s...

journal_title：BMC neuroscience

authors： Dhandapani KM,Brann DW

更新日期：2002-06-07 00:00:00

abstract：BACKGROUND:Yawning is a stereotyped behavior that enhances blood flow to the skull, and the resulting counterflow has been hypothesized as a mechanism for brain cooling. Studies have shown that yawns are strongly associated with physiological and pathological conditions that increase brain temperature, and that they ar...

journal_title：BMC neuroscience

authors： Eguibar JR,Uribe CA,Cortes C,Bautista A,Gallup AC

更新日期：2017-01-03 00:00:00

abstract：BACKGROUND:Mitochondrial DNA (mtDNA) mutations, which are present in all mitochondria-containing cells, paradoxically cause tissue-specific disease. For example, Leber's hereditary optic neuropathy (LHON) results from one of three point mutations mtDNA coding for complex I components, but is only manifested in retinal ...

journal_title：BMC neuroscience

authors： Hoegger MJ,Lieven CJ,Levin LA

更新日期：2008-01-08 00:00:00