Enriched environment and masticatory activity rehabilitation recover spatial memory decline in aged mice.

Abstract:

BACKGROUND:To measure the impact of masticatory reduction on learning and memory, previous studies have produced experimental masticatory reduction by modified diet or molar removal. Here we induced spatial learning impairment in mice by reducing masticatory activity and then tested the effect of a combination of environmental enrichment and masticatory rehabilitation in recovering spatial learning at adulthood and in later life. For 6 months (6M) or 18 months (18M), we fed three groups of mice from postnatal day 21 respectively with a hard diet (HD) of pellets; pellets followed by a powdered, soft diet (HD/SD, divided into equal periods); or pellets followed by powder, followed by pellets again (HD/SD/HD, divided into equal periods). To mimic sedentary or active lifestyles, half of the animals from each group were raised from weaning in standard cages (impoverished environment; IE) and the other half in enriched cages (enriched environment; EE). To evaluate spatial learning, we used the Morris water maze. RESULTS:IE6M-HD/SD mice showed lower learning rates compared with control (IE6M-HD) or masticatory rehabilitated (IE6MHD/SD/HD) animals. Similarly, EE-HD/SD mice independent of age showed lower performance than controls (EE-HD) or rehabilitated mice (EE-HD/SD/HD). However, combined rehabilitation and EE in aged mice improved learning rate up to control levels. Learning rates did not correlate with swim speed. CONCLUSIONS:Reduction in masticatory activity imposed on mice previously fed a hard diet (HD/SD) impaired spatial learning in the Morris water maze. In adults, masticatory rehabilitation recovered spatial abilities in both sedentary and active mice, and rehabilitation of masticatory activity combined with EE recovered these losses in aged mice.

journal_name

BMC Neurosci

journal_title

BMC neuroscience

authors

Mendes Fde C,de Almeida MN,Felício AP,Fadel AC,Silva Dde J,Borralho TG,da Silva RP,Bento-Torres J,Vasconcelos PF,Perry VH,Ramos EM,Picanço-Diniz CW,Sosthenes MC

doi

10.1186/1471-2202-14-63

subject

Has Abstract

pub_date

2013-06-28 00:00:00

pages

63

issn

1471-2202

pii

1471-2202-14-63

journal_volume

14

pub_type

杂志文章
  • Behavioral effects of ketamine and toxic interactions with psychostimulants.

    abstract:BACKGROUND:The anesthetic drug ketamine (KT) has been reported to be an abused drug and fatal cases have been observed in polydrug users. In the present study, considering the possibility of KT-enhanced toxic effects of other drugs, and KT-induced promotion of an overdose without making the subject aware of the danger ...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-7-25

    authors: Hayase T,Yamamoto Y,Yamamoto K

    更新日期:2006-03-16 00:00:00

  • Parameter estimate of signal transduction pathways.

    abstract:BACKGROUND:The "inverse" problem is related to the determination of unknown causes on the bases of the observation of their effects. This is the opposite of the corresponding "direct" problem, which relates to the prediction of the effects generated by a complete description of some agencies. The solution of an inverse...

    journal_title:BMC neuroscience

    pub_type: 杂志文章,评审

    doi:10.1186/1471-2202-7-S1-S6

    authors: Arisi I,Cattaneo A,Rosato V

    更新日期:2006-10-30 00:00:00

  • Regional age-related changes in neuronal nitric oxide synthase (nNOS), messenger RNA levels and activity in SAMP8 brain.

    abstract:BACKGROUND:Nitric oxide (NO) is a multifunctional molecule synthesized by three isozymes of the NO synthase (NOSs) acting as a messenger/modulator and/or a potential neurotoxin. In rodents, the role of NOSs in sleep processes and throughout aging is now well established. For example, sleep parameters are highly deterio...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-7-81

    authors: Colas D,Gharib A,Bezin L,Morales A,Guidon G,Cespuglio R,Sarda N

    更新日期:2006-12-21 00:00:00

  • Effects of brain polarization on reaction times and pinch force in chronic stroke.

    abstract:BACKGROUND:Previous studies showed that anodal transcranial DC stimulation (tDCS) applied to the primary motor cortex of the affected hemisphere (M1affected hemisphere) after subcortical stroke transiently improves performance of complex tasks that mimic activities of daily living (ADL). It is not known if relatively s...

    journal_title:BMC neuroscience

    pub_type: 临床试验,杂志文章

    doi:10.1186/1471-2202-7-73

    authors: Hummel FC,Voller B,Celnik P,Floel A,Giraux P,Gerloff C,Cohen LG

    更新日期:2006-11-03 00:00:00

  • Amygdalar glutamatergic neuronal systems play a key role on the hibernating state of hamsters.

    abstract:BACKGROUND:Excitatory transmitting mechanisms are proving to play a critical role on neuronal homeostasis conditions of facultative hibernators such as the Syrian golden hamster. Indeed works have shown that the glutamatergic system of the main olfactory brain station (amygdala) is capable of controlling thermoregulato...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-12-10

    authors: Alò R,Avolio E,Carelli A,Facciolo RM,Canonaco M

    更新日期:2011-01-20 00:00:00

  • Specific ion channels contribute to key elements of pathology during secondary degeneration following neurotrauma.

    abstract:BACKGROUND:Following partial injury to the central nervous system, cells beyond the initial injury site undergo secondary degeneration, exacerbating loss of neurons, compact myelin and function. Changes in Ca2+ flux are associated with metabolic and structural changes, but it is not yet clear how flux through specific ...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/s12868-017-0380-1

    authors: O'Hare Doig RL,Chiha W,Giacci MK,Yates NJ,Bartlett CA,Smith NM,Hodgetts SI,Harvey AR,Fitzgerald M

    更新日期:2017-08-14 00:00:00

  • Modulatory effects of nitric oxide-active drugs on the anticonvulsant activity of lamotrigine in an experimental model of partial complex epilepsy in the rat.

    abstract:BACKGROUND:The effects induced by administering the anticonvulsant lamotrigine, the preferential inhibitor of neuronal nitric oxide synthase 7-nitroindazole and the precursor of NO synthesis L-arginine, alone or in combination, on an experimental model of partial complex seizures (maximal dentate gyrus activation) were...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-8-47

    authors: Sardo P,Ferraro G

    更新日期:2007-07-03 00:00:00

  • Acupuncture regulates the glucose metabolism in cerebral functional regions in chronic stage ischemic stroke patients--a PET-CT cerebral functional imaging study.

    abstract:BACKGROUND:Acupuncture has been applied to aid in the recovery of post-stroke patients, but its mechanism is unclear. This study aims to analyze the relationship between acupuncture and glucose metabolism in cerebral functional regions in post-stroke patients using (18)FDG PET-CT techniques. Forty-three ischemic stroke...

    journal_title:BMC neuroscience

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/1471-2202-13-75

    authors: Huang Y,Tang C,Wang S,Lu Y,Shen W,Yang J,Chen J,Lin R,Cui S,Xiao H,Qu S,Lai X,Shan B

    更新日期:2012-06-27 00:00:00

  • Transcriptional signatures of steroid hormones in the striatal neurons and astrocytes.

    abstract:BACKGROUND:The mechanisms of steroids actions in the brain mainly involve the binding and nuclear translocation of specific cytoplasmic receptors. These receptors can act as transcription factors and regulate gene expression. However, steroid-dependent transcriptional regulation in different types of neural cells is no...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/s12868-017-0352-5

    authors: Piechota M,Korostynski M,Golda S,Ficek J,Jantas D,Barbara Z,Przewlocki R

    更新日期:2017-04-05 00:00:00

  • Effects of nitric oxide-related compounds in the acute ketamine animal model of schizophrenia.

    abstract:BACKGROUND:Better treatments for schizophrenia are urgently needed. The therapeutic use of the nitric oxide (NO)-donor sodium nitroprusside (SNP) in patients with schizophrenia has shown promising results. The role of NO in schizophrenia is still unclear, and NO modulation is unexplored in ketamine (KET) animal models ...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/s12868-015-0149-3

    authors: Kandratavicius L,Balista PA,Wolf DC,Abrao J,Evora PR,Rodrigues AJ,Chaves C,Maia-de-Oliveira JP,Leite JP,Dursun SM,Baker GB,Guimaraes FS,Hallak JE

    更新日期:2015-03-07 00:00:00

  • The effect of anesthetic dose on the motor response induced by low-intensity pulsed ultrasound stimulation.

    abstract:BACKGROUND:Low-intensity pulsed ultrasound stimulation (LIPUS) has been proven to be a noninvasive method with high spatial resolution and deep penetration. Previous studies have qualitatively demonstrated that the electromyographic response caused by LIPUS in the mouse motor cortex is affected by the anesthetic state ...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/s12868-018-0476-2

    authors: Yuan Y,Wang X,Yan J,Li X

    更新日期:2018-12-03 00:00:00

  • Immunocytochemistry and fluorescence imaging efficiently identify individual neurons with CRISPR/Cas9-mediated gene disruption in primary cortical cultures.

    abstract:BACKGROUND:CRISPR/Cas9 system is a powerful method to investigate the role of genes by introducing a mutation selectively and efficiently to specific genome positions in cell and animal lines. However, in primary neuron cultures, this method is affected by the issue that the effectiveness of CRISPR/Cas9 is different in...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/s12868-017-0377-9

    authors: Tsunematsu H,Uyeda A,Yamamoto N,Sugo N

    更新日期:2017-08-01 00:00:00

  • Plasticity in neuromagnetic cortical responses suggests enhanced auditory object representation.

    abstract:BACKGROUND:Auditory perceptual learning persistently modifies neural networks in the central nervous system. Central auditory processing comprises a hierarchy of sound analysis and integration, which transforms an acoustical signal into a meaningful object for perception. Based on latencies and source locations of audi...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-14-151

    authors: Ross B,Jamali S,Tremblay KL

    更新日期:2013-12-05 00:00:00

  • Peripheral injection of human umbilical cord blood stimulates neurogenesis in the aged rat brain.

    abstract:BACKGROUND:Neurogenesis continues to occur throughout life but dramatically decreases with increasing age. This decrease is mostly related to a decline in proliferative activity as a result of an impoverishment of the microenvironment of the aged brain, including a reduction in trophic factors and increased inflammatio...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-9-22

    authors: Bachstetter AD,Pabon MM,Cole MJ,Hudson CE,Sanberg PR,Willing AE,Bickford PC,Gemma C

    更新日期:2008-02-14 00:00:00

  • Investigation of fMRI activation in the internal capsule.

    abstract:BACKGROUND:Functional magnetic resonance imaging (fMRI) in white matter has long been considered controversial. Recently, this viewpoint has been challenged by an emerging body of evidence demonstrating white matter activation in the corpus callosum. The current study aimed to determine whether white matter activation ...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-12-56

    authors: Gawryluk JR,Mazerolle EL,Brewer KD,Beyea SD,D'Arcy RC

    更新日期:2011-06-14 00:00:00

  • Effects of sex and gonadectomy on social investigation and social recognition in mice.

    abstract:BACKGROUND:An individual's ability to recognise and pay attention to others is crucial in order to behave appropriately in various social situations. Studies in humans have shown a sex bias in sociability as well as social memory, indicating that females have better face memory and gaze more at the eyes of others, but ...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/s12868-015-0221-z

    authors: Karlsson SA,Haziri K,Hansson E,Kettunen P,Westberg L

    更新日期:2015-11-25 00:00:00

  • Evidence for inflammation-mediated memory dysfunction in gastropods: putative PLA2 and COX inhibitors abolish long-term memory failure induced by systemic immune challenges.

    abstract:BACKGROUND:Previous studies associate lipid peroxidation with long-term memory (LTM) failure in a gastropod model (Lymnaea stagnalis) of associative learning and memory. This process involves activation of Phospholipase A2 (PLA2), an enzyme mediating the release of fatty acids such as arachidonic acid that form the pre...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-14-83

    authors: Hermann PM,Park D,Beaulieu E,Wildering WC

    更新日期:2013-08-06 00:00:00

  • Amyloid-β plaque formation and reactive gliosis are required for induction of cognitive deficits in App knock-in mouse models of Alzheimer's disease.

    abstract:BACKGROUND:Knock-in (KI) mouse models of Alzheimer's disease (AD) that endogenously overproduce Aβ without non-physiological overexpression of amyloid precursor protein (APP) provide important insights into the pathogenic mechanisms of AD. Previously, we reported that AppNL-G-F mice, which harbor three familial AD muta...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/s12868-019-0496-6

    authors: Sakakibara Y,Sekiya M,Saito T,Saido TC,Iijima KM

    更新日期:2019-03-20 00:00:00

  • Spatial encoding in spinal sensorimotor circuits differs in different wild type mice strains.

    abstract:BACKGROUND:Previous studies in the rat have shown that the spatial organisation of the receptive fields of nociceptive withdrawal reflex (NWR) system are functionally adapted through experience dependent mechanisms, termed somatosensory imprinting, during postnatal development. Here we wanted to clarify 1) if mice exhi...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-9-45

    authors: Thelin J,Schouenborg J

    更新日期:2008-05-21 00:00:00

  • Differential expression of Cathepsin S and X in the spinal cord of a rat neuropathic pain model.

    abstract:BACKGROUND:Ample evidence suggests a substantial contribution of cellular and molecular changes in the spinal cord to the induction and persistence of chronic neuropathic pain conditions. While for a long time, proteases were mainly considered as protein degrading enzymes, they are now receiving growing interest as sig...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-9-80

    authors: Leichsenring A,Bäcker I,Wendt W,Andriske M,Schmitz B,Stichel CC,Lübbert H

    更新日期:2008-08-12 00:00:00

  • Non-invasive quantification of brain tumor-induced astrogliosis.

    abstract:BACKGROUND:CNS injury including stroke, infection, and tumor growth lead to astrogliosis, a process that involves upregulation of glial fibrillary acidic protein (GFAP) in astrocytes. However, the kinetics of astrogliosis that is related to these insults (i.e. tumor) is largely unknown. RESULTS:Using transgenic mice e...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-12-9

    authors: Lee J,Borboa AK,Baird A,Eliceiri BP

    更新日期:2011-01-19 00:00:00

  • Cholecystokinin receptor-1 mediates the inhibitory effects of exogenous cholecystokinin octapeptide on cellular morphine dependence.

    abstract:BACKGROUND:Cholecystokinin octapeptide (CCK-8), the most potent endogenous anti-opioid peptide, has been shown to regulate the processes of morphine dependence. In our previous study, we found that exogenous CCK-8 attenuated naloxone induced withdrawal symptoms. To investigate the precise effect of exogenous CCK-8 and ...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-13-63

    authors: Wen D,Ma CL,Zhang YJ,Meng YX,Ni ZY,Li SJ,Cong B

    更新日期:2012-06-08 00:00:00

  • Neuroprotective effects of edaravone-administration on 6-OHDA-treated dopaminergic neurons.

    abstract:BACKGROUND:Parkinson's disease (PD) is a neurological disorder characterized by the degeneration of nigrostriatal dopaminergic systems. Free radicals induced by oxidative stress are involved in the mechanisms of cell death in PD. This study clarifies the neuroprotective effects of edaravone (MCI-186, 3-methyl-1-phenyl-...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-9-75

    authors: Yuan WJ,Yasuhara T,Shingo T,Muraoka K,Agari T,Kameda M,Uozumi T,Tajiri N,Morimoto T,Jing M,Baba T,Wang F,Leung H,Matsui T,Miyoshi Y,Date I

    更新日期:2008-08-01 00:00:00

  • Differential production of superoxide by neuronal mitochondria.

    abstract:BACKGROUND:Mitochondrial DNA (mtDNA) mutations, which are present in all mitochondria-containing cells, paradoxically cause tissue-specific disease. For example, Leber's hereditary optic neuropathy (LHON) results from one of three point mutations mtDNA coding for complex I components, but is only manifested in retinal ...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-9-4

    authors: Hoegger MJ,Lieven CJ,Levin LA

    更新日期:2008-01-08 00:00:00

  • Quantitative genome-wide association analyses of receptive language in the Danish High Risk and Resilience Study.

    abstract:BACKGROUND:One of the most basic human traits is language. Linguistic ability, and disability, have been shown to have a strong genetic component in family and twin studies, but molecular genetic studies of language phenotypes are scarce, relative to studies of other cognitive traits and neurodevelopmental phenotypes. ...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/s12868-020-00581-5

    authors: Nudel R,Christiani CAJ,Ohland J,Uddin MJ,Hemager N,Ellersgaard D,Spang KS,Burton BK,Greve AN,Gantriis DL,Bybjerg-Grauholm J,Jepsen JRM,Thorup AAE,Mors O,Werge T,Nordentoft M

    更新日期:2020-07-07 00:00:00

  • Culture but not gender modulates amygdala activation during explicit emotion recognition.

    abstract:BACKGROUND:Mounting evidence indicates that humans have significant difficulties in understanding emotional expressions from individuals of different ethnic backgrounds, leading to reduced recognition accuracy and stronger amygdala activation. However, the impact of gender on the behavioral and neural reactions during ...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-13-54

    authors: Derntl B,Habel U,Robinson S,Windischberger C,Kryspin-Exner I,Gur RC,Moser E

    更新日期:2012-05-29 00:00:00

  • Anticipating the course of an action: evidence from corticospinal excitability.

    abstract:BACKGROUND:Anticipatory planning, the ability to anticipate future perceptual-motor demands of a goal-oriented action sequence, is essential for flexible, purposeful behavior. Once an action goal has been defined, movement details necessary to achieve that goal can be selected. Here, we investigate if anticipatory plan...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-14-91

    authors: Marangon M,Bucchioni G,Massacesi S,Castiello U

    更新日期:2013-08-28 00:00:00

  • Long-lasting anxiolytic effect of neural precursor cells freshly prepared but not neurosphere-derived cell transplantation in newborn rats.

    abstract:BACKGROUND:The GABAergic system plays an important role in modulating levels of anxiety. When transplanted into the brain, precursor cells from the medial ganglionic eminence (MGE) have the ability to differentiate into GABAergic interneurons and modify the inhibitory tone in the host brain. Currently, two methods have...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-15-94

    authors: Romariz SA,Paiva Dde S,Valente MF,Barnabé GF,Frussa-Filho R,Barbosa-Silva RC,Calcagnotto ME,Longo BM

    更新日期:2014-08-02 00:00:00

  • Qualitative and quantitative differences between taste buds of the rat and mouse.

    abstract:BACKGROUND:Numerous electrophysiological, ultrastructural, and immunocytochemical studies on rodent taste buds have been carried out on rat taste buds. In recent years, however, the mouse has become the species of choice for molecular and other studies on sensory transduction in taste buds. Do rat and mouse taste buds ...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-8-5

    authors: Ma H,Yang R,Thomas SM,Kinnamon JC

    更新日期:2007-01-05 00:00:00

  • Effects of transcranial focused ultrasound on human primary motor cortex using 7T fMRI: a pilot study.

    abstract:BACKGROUND:Transcranial focused ultrasound (tFUS) is a new non-invasive neuromodulation technique that uses mechanical energy to modulate neuronal excitability with high spatial precision. tFUS has been shown to be capable of modulating EEG brain activity in humans that is spatially restricted, and here, we use 7T MRI ...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/s12868-018-0456-6

    authors: Ai L,Bansal P,Mueller JK,Legon W

    更新日期:2018-09-14 00:00:00