On the matching of top-down knowledge with sensory input in the perception of ambiguous speech.

abstract：BACKGROUND:The human KALRN gene, which encodes a complex, multifunctional Rho GDP/GTP exchange factor, has been linked to cardiovascular disease, psychiatric disorders and neurodegeneration. Examination of existing Kalrn knockout mouse models has focused only on neuronal phenotypes. However, Kalirin was first identifie...

journal_title：BMC neuroscience

authors： Mandela P,Yankova M,Conti LH,Ma XM,Grady J,Eipper BA,Mains RE

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Gap junction proteins, connexins, are expressed in most endocrine and exocrine glands in the body and are at least in some glands crucial for the hormonal secretion. To what extent connexins are expressed in neurons releasing hormones or neuropeptides from or within the central nervous system is, however, un...

journal_title：BMC neuroscience

authors： Westberg L,Sawa E,Wang AY,Gunaydin LA,Ribeiro AC,Pfaff DW

更新日期：2009-04-30 00:00:00

abstract：BACKGROUND:Huntington's disease (HD) is a progressive neurodegenerative disorder caused by a CAG repeat expansion mutation in the coding region of a novel gene. The mechanism of HD is unknown. Most data suggest that polyglutamine-mediated aggregation associated with expression of mutant huntingtin protein (mhtt) contri...

journal_title：BMC neuroscience

authors： Trushina E,Rana S,McMurray CT,Hua DH

更新日期：2009-07-08 00:00:00

abstract：BACKGROUND:Acupuncture has been applied to aid in the recovery of post-stroke patients, but its mechanism is unclear. This study aims to analyze the relationship between acupuncture and glucose metabolism in cerebral functional regions in post-stroke patients using (18)FDG PET-CT techniques. Forty-three ischemic stroke...

journal_title：BMC neuroscience

authors： Huang Y,Tang C,Wang S,Lu Y,Shen W,Yang J,Chen J,Lin R,Cui S,Xiao H,Qu S,Lai X,Shan B

更新日期：2012-06-27 00:00:00

abstract：BACKGROUND:Stress involves alterations of brain functioning that may precipitate to mood disorders. The neurotrophin Brain Derived Neurotrophic Factor (BDNF) has recently been involved in stress-induced adaptation. BDNF is a key regulator of neuronal plasticity and adaptive processes. Regulation of BDNF is complex and ...

journal_title：BMC neuroscience

authors： Tognoli C,Rossi F,Di Cola F,Baj G,Tongiorgi E,Terova G,Saroglia M,Bernardini G,Gornati R

更新日期：2010-01-14 00:00:00

abstract：INTRODUCTION:NAP (Asn-Ala-Pro-Val-Ser-Ile-Pro-Gln, single amino acid letter code, NAPVSIPQ), an eight amino acid neuroprotective peptide derived from activity-dependent neuroprotective protein (ADNP), exhibits some structural similarity to activity-dependent neurotropic factor-9 (ADNF-9; Ser-Alal-Leu-Leu-Arg-Ser-Ile-Pr...

journal_title：BMC neuroscience

authors： Gozes I,Divinski I,Piltzer I

更新日期：2008-12-10 00:00:00

abstract：BACKGROUND:Efficient multisensory integration is of vital importance for adequate interaction with the environment. In addition to basic binding cues like temporal and spatial coherence, meaningful multisensory information is also bound together by content-based associations. Many functional Magnetic Resonance Imaging ...

journal_title：BMC neuroscience

authors： van Atteveldt NM,Blau VC,Blomert L,Goebel R

更新日期：2010-02-02 00:00:00

abstract：BACKGROUND:Post-traumatic stress disorder (PTSD) is an anxious disorder associated with low levels of corticosterone and enhanced negative feedback of the hypothalamic-pituitary-adrenal (HPA) axis. Previous studies showed that the amygdala not only has an excitatory effect on the HPA axis but also plays a key role in f...

journal_title：BMC neuroscience

authors： Han F,Ding J,Shi Y

更新日期：2014-06-19 00:00:00

abstract：BACKGROUND:Fetal asphyctic (FA) preconditioning is effective in attenuating brain damage incurred by a subsequent perinatal asphyctic insult. Unraveling mechanisms of this endogenous neuroprotection, activated by FA preconditioning, is an important step towards new clinical strategies for asphyctic neonates. Genomic re...

journal_title：BMC neuroscience

authors： Cox-Limpens KE,Vles JS,Schlechter J,Zimmermann LJ,Strackx E,Gavilanes AW

更新日期：2013-06-22 00:00:00

abstract：BACKGROUND:The properties of Ca2+ signaling mediated by purinergic receptors are intrinsically linked with functional activity of astrocytes. At present little is known concerning Ca2+-dependent purinergic responses in adult human astrocytes. This work has examined effects of purinergic stimulation to alter levels of i...

journal_title：BMC neuroscience

authors： Hashioka S,Wang YF,Little JP,Choi HB,Klegeris A,McGeer PL,McLarnon JG

更新日期：2014-01-22 00:00:00

abstract：BACKGROUND:Astrocytes are responsible for a broad range of functions that maintain homeostasis in the brain. However, their response to the pro-inflammatory cytokines released by activated microglia in various neurological pathologies may exacerbate neurodegenerative processes. Accumulating evidence suggests that omega...

journal_title：BMC neuroscience

authors： Zgórzyńska E,Stulczewski D,Dziedzic B,Su KP,Walczewska A

更新日期：2021-01-27 00:00:00

abstract：BACKGROUND:The Pde6brd1 (Rd1) mouse is widely used as a murine model for human retinitis pigmentosa. Understanding the spatio-temporal patterns of cone degeneration is important for evaluating potential treatments. In the present study we performed a systematic characterization of the spatio-temporal patterns of S- and...

journal_title：BMC neuroscience

authors： Narayan DS,Ao J,Wood JPM,Casson RJ,Chidlow G

更新日期：2019-09-03 00:00:00

abstract：BACKGROUND:Enhanced activity of trigeminal ganglion neurons is thought to underlie neuronal sensitization facilitating the onset of chronic pain attacks, including migraine. Recurrent headache attacks might establish a chronic neuroinflammatory ganglion profile contributing to the hypersensitive phenotype. Since it is ...

journal_title：BMC neuroscience

authors： Franceschini A,Nair A,Bele T,van den Maagdenberg AM,Nistri A,Fabbretti E

更新日期：2012-11-21 00:00:00

abstract：BACKGROUND:10 Hz electroencephalographic (EEG) alpha rhythms correlate with memory performance. Alpha and memory decline in older people. We wished to test if alpha-like EEG activity contributes to memory formation. Flicker can elicit alpha-like EEG activity. We tested if alpha-frequency flicker enhances memory in olde...

journal_title：BMC neuroscience

authors： Williams J,Ramaswamy D,Oulhaj A

更新日期：2006-03-05 00:00:00

abstract：BACKGROUND:Growing evidence shows that, in vivo, the precursor of Nerve Growth Factor (NGF), proNGF, displays biological activities different from those of its mature NGF counterpart, mediated by distinct, and somewhat complementary, receptor binding properties. NGF and proNGF induce distinct transcriptional signatures...

journal_title：BMC neuroscience

authors： Arisi I,D'Onofrio M,Brandi R,Malerba F,Paoletti F,Storti AE,Florenzano F,Fasulo L,Cattaneo A

更新日期：2014-04-08 00:00:00

abstract：BACKGROUND:Polymorphisms in the gene for phosphatidylinositol binding clathrin assembly protein (PICALM), an endocytic-related protein, are associated with a small, increased risk of developing Alzheimer's disease (AD), strongly suggesting that changes in endocytosis are involved in the aetiology of the disease. We hav...

journal_title：BMC neuroscience

authors： Thomas RS,Henson A,Gerrish A,Jones L,Williams J,Kidd EJ

更新日期：2016-07-18 00:00:00

abstract：BACKGROUND:Recently a hyperthermic rat hippocampal slice model system has been used to investigate febrile seizure pathophysiology. Our previous data indicates that heating immature rat hippocampal slices from 34 to 41 degrees C in an interface chamber induced epileptiform-like population spikes accompanied by a spread...

journal_title：BMC neuroscience

authors： Wu J,Javedan SP,Ellsworth K,Smith K,Fisher RS

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Functional magnetic resonance imaging (fMRI) in white matter has long been considered controversial. Recently, this viewpoint has been challenged by an emerging body of evidence demonstrating white matter activation in the corpus callosum. The current study aimed to determine whether white matter activation ...

journal_title：BMC neuroscience

authors： Gawryluk JR,Mazerolle EL,Brewer KD,Beyea SD,D'Arcy RC

更新日期：2011-06-14 00:00:00

abstract：BACKGROUND:Immunization with neural derived peptides (INDP) as well as scar removal-separately-have shown to induce morphological and functional improvement after spinal cord injury (SCI). In the present study, we compared the effect of INDP alone versus INDP with scar removal on motor recovery, regeneration-associated...

journal_title：BMC neuroscience

authors： Rodríguez-Barrera R,Flores-Romero A,Fernández-Presas AM,García-Vences E,Silva-García R,Konigsberg M,Blancas-Espinoza L,Buzoianu-Anguiano V,Soria-Zavala K,Suárez-Meade P,Ibarra A

更新日期：2017-01-05 00:00:00

abstract：BACKGROUND:Glutamate, a major excitatory amino acid neurotransmitter, causes apoptotic neuronal cell death at high concentrations. Our previous studies have shown that depending on the neuronal cell type, glutamate-induced apoptotic cell death was associated with regulation of genes such as Bcl-2, Bax, and/or caspase-3...

journal_title：BMC neuroscience

authors： Zhang Y,Bhavnani BR

更新日期：2006-06-15 00:00:00

abstract：BACKGROUND:An ever growing body of evidences is emerging concerning metabolism hormones, neurotransmitters or stress-related biomarkers as effective modulators of eating behavior and body weight in mammals. The present study sought at examining the density and affinity of two proteins related to neurotransmission and c...

journal_title：BMC neuroscience

authors： Giannaccini G,Betti L,Palego L,Pirone A,Schmid L,Lanza M,Fabbrini L,Pelosini C,Maffei M,Santini F,Pinchera A,Lucacchini A

更新日期：2011-02-07 00:00:00

abstract：BACKGROUND:Recent studies have shown that the human right-hemispheric auditory cortex is particularly sensitive to reduction in sound quality, with an increase in distortion resulting in an amplification of the auditory N1m response measured in the magnetoencephalography (MEG). Here, we examined whether this sensitivit...

journal_title：BMC neuroscience

authors： Miettinen I,Tiitinen H,Alku P,May PJ

更新日期：2010-02-22 00:00:00

abstract：BACKGROUND:The neurological complications of HIV infection remain poorly understood. Clinically, in vivo 1H magnetic resonance spectroscopy (MRS) demonstrates brain injury caused by HIV infection even when the MRI is normal. Our goal was to undertsand the dynamics of cerebral injury by performing a longitudinal in vivo...

journal_title：BMC neuroscience

authors： Fuller RA,Westmoreland SV,Ratai E,Greco JB,Kim JP,Lentz MR,He J,Sehgal PK,Masliah E,Halpern E,Lackner AA,González RG

更新日期：2004-03-05 00:00:00

abstract：BACKGROUND:Given the reported inverse association between light and depressive mood, ambient light may also be associated with some of the brain regions in healthy subjects. The present study aims to investigate the effects of ambient light on glucose metabolism in the brain. We used the data of 28 healthy participants...

journal_title：BMC neuroscience

authors： Hirakawa H,Terao T,Hatano K,Kohno K,Ishii N

更新日期：2018-07-24 00:00:00

abstract：BACKGROUND:Glutamergic excitotoxicity has been shown to play a deleterious role in the pathophysiology of spinal cord injury (SCI). The aim of this study was to investigate the neuroprotective effect of dizocilpine maleate, MK801 (2 mg/Kg, 30 min and 6 hours after injury) in a mice model of SCI. The spinal cord trauma ...

journal_title：BMC neuroscience

authors： Esposito E,Paterniti I,Mazzon E,Genovese T,Galuppo M,Meli R,Bramanti P,Cuzzocrea S

更新日期：2011-04-14 00:00:00

abstract：BACKGROUND:The function of synaptotagmins (syt) in Ca2+-dependent transmitter release has been attributed primarily to Ca2+-dependent isoforms such as syt I. Recently, syt IV, an inducible Ca2+-independent isoform has been implicated in transmitter release. We postulated that the effects of syt IV on transmitter releas...

journal_title：BMC neuroscience

authors： Moore-Dotson JM,Papke JB,Harkins AB

更新日期：2010-08-24 00:00:00

abstract：BACKGROUND:Protein aggregation plays important roles in several neurodegenerative disorders. For instance, insoluble aggregates of phosphorylated tau and of Aβ peptides are cornerstones in the pathology of Alzheimer's disease. Soluble protein aggregates are therefore potential diagnostic and prognostic biomarkers for t...

journal_title：BMC neuroscience

authors： Kamali-Moghaddam M,Pettersson FE,Wu D,Englund H,Darmanis S,Lord A,Tavoosidana G,Sehlin D,Gustafsdottir S,Nilsson LN,Lannfelt L,Landegren U

更新日期：2010-10-05 00:00:00

abstract：BACKGROUND:Imprinting behavior is one form of learning and memory in precocial birds. With the aim of elucidating of the neural basis for visual imprinting, we focused on visual information processing. RESULTS:A lesion in the visual wulst, which is similar functionally to the mammalian visual cortex, caused anterograd...

journal_title：BMC neuroscience

authors： Maekawa F,Komine O,Sato K,Kanamatsu T,Uchimura M,Tanaka K,Ohki-Hamazaki H

更新日期：2006-11-14 00:00:00

abstract：BACKGROUND:The mechanisms of steroids actions in the brain mainly involve the binding and nuclear translocation of specific cytoplasmic receptors. These receptors can act as transcription factors and regulate gene expression. However, steroid-dependent transcriptional regulation in different types of neural cells is no...

journal_title：BMC neuroscience

authors： Piechota M,Korostynski M,Golda S,Ficek J,Jantas D,Barbara Z,Przewlocki R

更新日期：2017-04-05 00:00:00

abstract：BACKGROUND:Acetylcholine receptors become aggregated at the developing neuromuscular synapse shortly after contact by a motorneuron in one of the earliest manifestations of synaptic development. While a major physiological signal for receptor aggregation (agrin) is known, the mechanism(s) by which muscle cells respond ...

journal_title：BMC neuroscience

authors： Kunkel DD,Lee LK,Stollberg J

更新日期：2001-01-01 00:00:00