Relationship between ambient light and glucose metabolism in healthy subjects.

abstract：BACKGROUND:Protein aggregation plays important roles in several neurodegenerative disorders. For instance, insoluble aggregates of phosphorylated tau and of Aβ peptides are cornerstones in the pathology of Alzheimer's disease. Soluble protein aggregates are therefore potential diagnostic and prognostic biomarkers for t...

journal_title：BMC neuroscience

authors： Kamali-Moghaddam M,Pettersson FE,Wu D,Englund H,Darmanis S,Lord A,Tavoosidana G,Sehlin D,Gustafsdottir S,Nilsson LN,Lannfelt L,Landegren U

更新日期：2010-10-05 00:00:00

abstract：BACKGROUND:After unilateral cervical cord lesion at the C7/C8 border interrupting the dorsolateral funiculus in adult monkeys, neutralization of Nogo-A using a specific monoclonal antibody promoted sprouting of corticospinal (CS) axons rostral and caudal to the lesion and, in parallel, improved functional recovery. In ...

journal_title：BMC neuroscience

authors： Beaud ML,Schmidlin E,Wannier T,Freund P,Bloch J,Mir A,Schwab ME,Rouiller EM

更新日期：2008-01-14 00:00:00

abstract：BACKGROUND:To identify mechanisms of cortical plasticity of the visual cortex and to quantify their significance, sensitive parameters are warranted. In this context, multifocal visual evoked potentials (mfVEPs) can make a valuable contribution as they are not associated with cancellation artifacts and include also the...

journal_title：BMC neuroscience

authors： Kolbe R,Aytulun A,Müller AK,Ringelstein M,Aktas O,Schnitzler A,Hartung HP,Groiss SJ,Albrecht P

更新日期：2020-11-23 00:00:00

abstract：BACKGROUND:Inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, known as statins, are commonly used as cholesterol-lowering drugs. During the past decade, evidence has emerged that statins also have neuroprotective effects. Research in the retina has shown that simvastatin, a commonly used statin, increases A...

journal_title：BMC neuroscience

authors： Brand Y,Setz C,Levano S,Listyo A,Chavez E,Pak K,Sung M,Radojevic V,Ryan AF,Bodmer D

更新日期：2011-11-14 00:00:00

abstract：BACKGROUND:Odorant stimuli can access the olfactory epithelium either orthonasally, by inhalation through the external nares, or retronasally by reverse airflow from the oral cavity. There is evidence that odors perceived through these two routes can differ in quality and intensity. We were curious whether such differe...

journal_title：BMC neuroscience

authors： Furudono Y,Cruz G,Lowe G

更新日期：2013-04-08 00:00:00

abstract：BACKGROUND:Understanding the underlying causes of nicotine addiction will require a multidisciplinary approach examining the key molecular, cellular and neuronal circuit functional changes that drive escalating levels of nicotine self-administration. In this study, we examined whether mice pretreated with chronic nicot...

journal_title：BMC neuroscience

authors： Renda A,Nashmi R

更新日期：2014-07-19 00:00:00

abstract：BACKGROUND:Post-stroke hyperglycemia appears to be associated with poor outcome from stroke, greater mortality, and reduced functional recovery. Focal cerebral ischemia data support that neural stem cells (NSCs) play an important role in post-ischemic repair. Here we sought to evaluate the negative effects of hyperglyc...

journal_title：BMC neuroscience

authors： Chen J,Guo Y,Cheng W,Chen R,Liu T,Chen Z,Tan S

更新日期：2013-03-04 00:00:00

abstract：BACKGROUND:Post-traumatic stress disorder (PTSD) is an anxious disorder associated with low levels of corticosterone and enhanced negative feedback of the hypothalamic-pituitary-adrenal (HPA) axis. Previous studies showed that the amygdala not only has an excitatory effect on the HPA axis but also plays a key role in f...

journal_title：BMC neuroscience

authors： Han F,Ding J,Shi Y

更新日期：2014-06-19 00:00:00

abstract：BACKGROUND:Acute subdural hemorrhage (ASDH) is a severe consequence of traumatic brain injury. The occurrence of subdural blood increases the lethality of these patients independent of the amount of blood or elevated intracranial pressure. Thrombin is one of the potential harmful blood components. Possible harmful effe...

journal_title：BMC neuroscience

authors： Krämer TJ,Sakas W,Jussen D,Krenzlin H,Kempski O,Alessandri B

更新日期：2018-12-27 00:00:00

abstract：BACKGROUND:Earlier functional imaging studies on visually induced self-motion perception (vection) disclosed a bilateral network of activations within primary and secondary visual cortex areas which was combined with signal decreases, i.e., deactivations, in multisensory vestibular cortex areas. This finding led to the...

journal_title：BMC neuroscience

authors： Becker-Bense S,Buchholz HG,zu Eulenburg P,Best C,Bartenstein P,Schreckenberger M,Dieterich M

更新日期：2012-07-16 00:00:00

abstract：BACKGROUND:Synaptic degeneration and accumulation of amyloid β-peptides (Aβ) are hallmarks of the Alzheimer diseased brain. Aβ is synaptotoxic and produced by sequential cleavage of the amyloid precursor protein (APP) by the β-secretase BACE1 and by γ-secretase. If APP is instead cleaved by the α-secretase ADAM10, Aβ w...

journal_title：BMC neuroscience

authors： Lundgren JL,Vandermeulen L,Sandebring-Matton A,Ahmed S,Winblad B,Di Luca M,Tjernberg LO,Marcello E,Frykman S

更新日期：2020-02-04 00:00:00

abstract：BACKGROUND:Acetylcholine receptors become aggregated at the developing neuromuscular synapse shortly after contact by a motorneuron in one of the earliest manifestations of synaptic development. While a major physiological signal for receptor aggregation (agrin) is known, the mechanism(s) by which muscle cells respond ...

journal_title：BMC neuroscience

authors： Kunkel DD,Lee LK,Stollberg J

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Multi-sensor technologies such as EEG, MEG, and ECoG result in high-dimensional data sets. Given the high temporal resolution of such techniques, scientific questions very often focus on the time-course of an experimental effect. In many studies, researchers focus on a single sensor or the average over a sub...

journal_title：BMC neuroscience

authors： Schurger A,Marti S,Dehaene S

更新日期：2013-10-14 00:00:00

abstract：BACKGROUND:Previous studies associate lipid peroxidation with long-term memory (LTM) failure in a gastropod model (Lymnaea stagnalis) of associative learning and memory. This process involves activation of Phospholipase A2 (PLA2), an enzyme mediating the release of fatty acids such as arachidonic acid that form the pre...

journal_title：BMC neuroscience

authors： Hermann PM,Park D,Beaulieu E,Wildering WC

更新日期：2013-08-06 00:00:00

abstract：BACKGROUND:Growing evidence shows that, in vivo, the precursor of Nerve Growth Factor (NGF), proNGF, displays biological activities different from those of its mature NGF counterpart, mediated by distinct, and somewhat complementary, receptor binding properties. NGF and proNGF induce distinct transcriptional signatures...

journal_title：BMC neuroscience

authors： Arisi I,D'Onofrio M,Brandi R,Malerba F,Paoletti F,Storti AE,Florenzano F,Fasulo L,Cattaneo A

更新日期：2014-04-08 00:00:00

abstract：BACKGROUND:In the absence of overt stimuli, the brain shows correlated fluctuations in functionally related brain regions. Approximately ten largely independent resting state networks (RSNs) showing this behaviour have been documented to date. Recent studies have reported the existence of an RSN in the basal ganglia - ...

journal_title：BMC neuroscience

authors： Robinson S,Basso G,Soldati N,Sailer U,Jovicich J,Bruzzone L,Kryspin-Exner I,Bauer H,Moser E

更新日期：2009-11-23 00:00:00

abstract：BACKGROUND:Errorless learning has advantages over errorful learning. The erroneous items produced during errorful learning compete with correct items at retrieval resulting in decreased memory performance. This interference is associated with an increased demand on executive monitoring processes. Event-related function...

journal_title：BMC neuroscience

authors： Hammer A,Tempelmann C,Münte TF

更新日期：2013-03-13 00:00:00

abstract：BACKGROUND:The human inferior frontal junction area (IFJ) is critically involved in three main component processes of cognitive control (working memory, task switching and inhibitory control). As it overlaps with several areas in established anatomical labeling schemes, it is considered to be underreported as a functio...

journal_title：BMC neuroscience

authors： Sundermann B,Pfleiderer B

更新日期：2012-10-03 00:00:00

abstract：BACKGROUND:Functional magnetic resonance imaging (fMRI) in white matter has long been considered controversial. Recently, this viewpoint has been challenged by an emerging body of evidence demonstrating white matter activation in the corpus callosum. The current study aimed to determine whether white matter activation ...

journal_title：BMC neuroscience

authors： Gawryluk JR,Mazerolle EL,Brewer KD,Beyea SD,D'Arcy RC

更新日期：2011-06-14 00:00:00

abstract：BACKGROUND:The human KALRN gene, which encodes a complex, multifunctional Rho GDP/GTP exchange factor, has been linked to cardiovascular disease, psychiatric disorders and neurodegeneration. Examination of existing Kalrn knockout mouse models has focused only on neuronal phenotypes. However, Kalirin was first identifie...

journal_title：BMC neuroscience

authors： Mandela P,Yankova M,Conti LH,Ma XM,Grady J,Eipper BA,Mains RE

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Cholecystokinin octapeptide (CCK-8), the most potent endogenous anti-opioid peptide, has been shown to regulate the processes of morphine dependence. In our previous study, we found that exogenous CCK-8 attenuated naloxone induced withdrawal symptoms. To investigate the precise effect of exogenous CCK-8 and ...

journal_title：BMC neuroscience

authors： Wen D,Ma CL,Zhang YJ,Meng YX,Ni ZY,Li SJ,Cong B

更新日期：2012-06-08 00:00:00

abstract：BACKGROUND:Early stages in the excitation cascade of Limulus photoreceptors are mediated by activation of Gq by rhodopsin, generation of inositol-1,4,5-trisphosphate by phospholipase-C and the release of Ca2+. At the end of the cascade, cGMP-gated channels open and generate the depolarizing receptor potential. A major ...

journal_title：BMC neuroscience

authors： Garger AV,Richard EA,Lisman JE

更新日期：2004-02-26 00:00:00

abstract：BACKGROUND:Major depressive disorder is a prevalent disease that is inadequately treated with currently available interventions. Stress increases susceptibility to depression in patients and rodent models. Depression is also associated with aberrant activation of inflammation, such as increases in circulating levels of...

journal_title：BMC neuroscience

authors： Cheng Y,Jope RS,Beurel E

更新日期：2015-05-07 00:00:00

abstract：BACKGROUND:HIV Associated Dementia (HAD) is a common complication of human immunodeficiency virus (HIV) infection that erodes the quality of life for patients and burdens health care providers. Intravenous drug use is a major route of HIV transmission, and drug use is associated with increased HAD. Specific proteins re...

journal_title：BMC neuroscience

authors： Kendall SL,Anderson CF,Nath A,Turchan-Cholewo J,Land CL,Mactutus CF,Booze RM

更新日期：2005-06-08 00:00:00

abstract：BACKGROUND:The properties of Ca2+ signaling mediated by purinergic receptors are intrinsically linked with functional activity of astrocytes. At present little is known concerning Ca2+-dependent purinergic responses in adult human astrocytes. This work has examined effects of purinergic stimulation to alter levels of i...

journal_title：BMC neuroscience

authors： Hashioka S,Wang YF,Little JP,Choi HB,Klegeris A,McGeer PL,McLarnon JG

更新日期：2014-01-22 00:00:00

abstract：BACKGROUND:Histone deacetylases (HDACs) are enzymes that modulate gene expression and cellular processes by deacetylating histones and non-histone proteins. While small molecule inhibitors of HDAC activity (HDACi) are used clinically in the treatment of cancer, pre-clinical treatment models suggest they also exert neur...

journal_title：BMC neuroscience

authors： Zhou Q,Dalgard CL,Wynder C,Doughty ML

更新日期：2011-05-26 00:00:00

abstract：BACKGROUND:Yawning is a stereotyped behavior that enhances blood flow to the skull, and the resulting counterflow has been hypothesized as a mechanism for brain cooling. Studies have shown that yawns are strongly associated with physiological and pathological conditions that increase brain temperature, and that they ar...

journal_title：BMC neuroscience

authors： Eguibar JR,Uribe CA,Cortes C,Bautista A,Gallup AC

更新日期：2017-01-03 00:00:00

abstract：BACKGROUND:The integration of EEG and fMRI is attractive because of their complementary precision regarding time and space. But the relationship between the indirect hemodynamic fMRI signal and the more direct EEG signal is uncertain. Event-related EEG responses can be analyzed in two different ways, reflecting two dif...

journal_title：BMC neuroscience

authors： Foucher JR,Otzenberger H,Gounot D

更新日期：2003-09-19 00:00:00

abstract：BACKGROUND:The megencephaly mouse, mceph/mceph, is epileptic and displays a dramatically increased brain volume and neuronal count. The responsible mutation was recently revealed to be an eleven base pair deletion, leading to a frame shift, in the gene encoding the potassium channel Kv1.1. The predicted MCEPH protein i...

journal_title：BMC neuroscience

authors： Persson AS,Klement G,Almgren M,Sahlholm K,Nilsson J,Petersson S,Arhem P,Schalling M,Lavebratt C

更新日期：2005-11-23 00:00:00

abstract：BACKGROUND:Magnetoencephalography (MEG) has become an increasingly popular technique for non-invasively characterizing neuromagnetic field changes in the brain at a high temporal resolution. To examine the reliability of the MEG signal, we compared magnetic and electrophysiological responses to complex natural stimuli ...

journal_title：BMC neuroscience

authors： Zhu Z,Zumer JM,Lowenthal ME,Padberg J,Recanzone GH,Krubitzer LA,Nagarajan SS,Disbrow EA

更新日期：2009-01-15 00:00:00