Abstract:
BACKGROUND:Recent studies have shown that the human right-hemispheric auditory cortex is particularly sensitive to reduction in sound quality, with an increase in distortion resulting in an amplification of the auditory N1m response measured in the magnetoencephalography (MEG). Here, we examined whether this sensitivity is specific to the processing of acoustic properties of speech or whether it can be observed also in the processing of sounds with a simple spectral structure. We degraded speech stimuli (vowel /a/), complex non-speech stimuli (a composite of five sinusoidals), and sinusoidal tones by decreasing the amplitude resolution of the signal waveform. The amplitude resolution was impoverished by reducing the number of bits to represent the signal samples. Auditory evoked magnetic fields (AEFs) were measured in the left and right hemisphere of sixteen healthy subjects. RESULTS:We found that the AEF amplitudes increased significantly with stimulus distortion for all stimulus types, which indicates that the right-hemispheric N1m sensitivity is not related exclusively to degradation of acoustic properties of speech. In addition, the P1m and P2m responses were amplified with increasing distortion similarly in both hemispheres. The AEF latencies were not systematically affected by the distortion. CONCLUSIONS:We propose that the increased activity of AEFs reflects cortical processing of acoustic properties common to both speech and non-speech stimuli. More specifically, the enhancement is most likely caused by spectral changes brought about by the decrease of amplitude resolution, in particular the introduction of periodic, signal-dependent distortion to the original sound. Converging evidence suggests that the observed AEF amplification could reflect cortical sensitivity to periodic sounds.
journal_name
BMC Neuroscijournal_title
BMC neuroscienceauthors
Miettinen I,Tiitinen H,Alku P,May PJdoi
10.1186/1471-2202-11-24subject
Has Abstractpub_date
2010-02-22 00:00:00pages
24issn
1471-2202pii
1471-2202-11-24journal_volume
11pub_type
杂志文章相关文献
BMC NEUROSCIENCE文献大全abstract:BACKGROUND:Circadian clocks are endogenous biochemical oscillators that control daily behavioral rhythms in all living organisms. In fruit fly, the circadian rhythms are typically studied using power spectra of multiday behavioral recordings. Despite decades of study, a quantitative understanding of the temporal shape ...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-016-0248-9
更新日期:2016-04-18 00:00:00
abstract:BACKGROUND:Astaxanthin (ATX) is a carotenoid pigment with pleiotropic pharmacological properties that is seen as a possible drug for treating cerebral ischemic injury and subarachnoid hemorrhage. Na+-K+-2Cl- co-transporter-1 (NKCC1), an intrinsic membrane protein expressed by many cell types, is activated by various in...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-017-0358-z
更新日期:2017-05-10 00:00:00
abstract:BACKGROUND:Given the reported inverse association between light and depressive mood, ambient light may also be associated with some of the brain regions in healthy subjects. The present study aims to investigate the effects of ambient light on glucose metabolism in the brain. We used the data of 28 healthy participants...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-018-0444-x
更新日期:2018-07-24 00:00:00
abstract:BACKGROUND:Alzheimer's Disease (AD) is the most common of the conformational neurodegenerative disorders characterized by the conversion of a normal biological protein into a β-sheet-rich pathological isoform. In AD the normal soluble Aβ (sAβ) forms oligomers and fibrils which assemble into neuritic plaques. The most t...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-11-130
更新日期:2010-10-14 00:00:00
abstract:BACKGROUND:GABAA receptor-mediated neurotransmission is greatly influenced by cation-chloride cotransporter activity during developmental stages. In embryonic neurons Na-K-2Cl (NKCC1) cotransporters mediate active chloride uptake, thus increasing the intracellular chloride concentration associated with GABA-induced dep...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-015-0180-4
更新日期:2015-07-14 00:00:00
abstract:BACKGROUND:The properties of Ca2+ signaling mediated by purinergic receptors are intrinsically linked with functional activity of astrocytes. At present little is known concerning Ca2+-dependent purinergic responses in adult human astrocytes. This work has examined effects of purinergic stimulation to alter levels of i...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-15-18
更新日期:2014-01-22 00:00:00
abstract:BACKGROUND:Receptor-interacting protein 3 (RIP3), a member of RIP family proteins, has been shown to participate in programmed necrosis or necroptosis in cell biology studies. Evidence suggests that necroptosis may be a mode of neuronal death in the retina. RESULTS:In the present study we determined the expression of ...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-14-16
更新日期:2013-02-02 00:00:00
abstract:BACKGROUND:Low-intensity pulsed ultrasound stimulation (LIPUS) has been proven to be a noninvasive method with high spatial resolution and deep penetration. Previous studies have qualitatively demonstrated that the electromyographic response caused by LIPUS in the mouse motor cortex is affected by the anesthetic state ...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-018-0476-2
更新日期:2018-12-03 00:00:00
abstract:BACKGROUND:Niemann-Pick type C1 (NPC1) disease is an inherited lysosomal storage disease caused by mutation of the Npc1 gene, resulting in a progressive accumulation of unesterified cholesterol and glycolipids in lysosomes of multiple tissues and leading to neurodegeneration and other disease. In Npc1 mutant mice, reti...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-014-0126-2
更新日期:2014-11-29 00:00:00
abstract:BACKGROUND:To determine whether early imitative responses fade out following the maturation of attentional mechanisms, the relationship between primitive imitation behaviors and the development of attention was examined in 4-month-old infants. They were divided into high and low imitators, based on an index of imitatio...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-4-33
更新日期:2003-12-24 00:00:00
abstract:BACKGROUND:Parkinson disease (PD) is a movement disorder affecting 1 % of people over the age of 60. The etiology of the disease is unknown; however, accumulating evidence suggests that mitochondrial defects, oxidative stress, and neuroinflammation play important roles in developing the disease. Current medications for...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-016-0293-4
更新日期:2016-08-22 00:00:00
abstract:BACKGROUND:The olfactory neuroepithelium lines the upper nasal cavity and is in direct contact with the external environment and the olfactory bulbs. The ability to self-renew throughout life and the reproducible recovery after injury, make it a model tissue to study mechanisms underlying neurogenesis. In this study, X...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-13-134
更新日期:2012-10-31 00:00:00
abstract:BACKGROUND:Anticipatory planning, the ability to anticipate future perceptual-motor demands of a goal-oriented action sequence, is essential for flexible, purposeful behavior. Once an action goal has been defined, movement details necessary to achieve that goal can be selected. Here, we investigate if anticipatory plan...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-14-91
更新日期:2013-08-28 00:00:00
abstract:BACKGROUND:How living neural networks retain information is still incompletely understood. Two prominent ideas on this topic have developed in parallel, but have remained somewhat unconnected. The first of these, the "synaptic hypothesis," holds that information can be retained in synaptic connection strengths, or weig...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-11-3
更新日期:2010-01-06 00:00:00
abstract:BACKGROUND:Stress involves alterations of brain functioning that may precipitate to mood disorders. The neurotrophin Brain Derived Neurotrophic Factor (BDNF) has recently been involved in stress-induced adaptation. BDNF is a key regulator of neuronal plasticity and adaptive processes. Regulation of BDNF is complex and ...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-11-4
更新日期:2010-01-14 00:00:00
abstract:BACKGROUND:Trigeminal nerve is a major source of the sensory input of the face, and trigeminal neuropathology models have been reported in rodents with injury to branches of the maxillary or mandibular division of the trigeminal nerve. Non-human primates are neuroanatomically more closely related to human than rodents;...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-13-150
更新日期:2012-12-13 00:00:00
abstract:BACKGROUND:Recovery following stroke depends on cellular plasticity in the perilesional zone (PZ). Doublecortin (DCX), a protein mainly labeling immature neurons in neurogenic niches is also highly expressed in the vicinity of focal cortical infarcts. Notably, the number of DCX+ cells positively correlates with the rec...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-015-0160-8
更新日期:2015-04-15 00:00:00
abstract:BACKGROUND:Empathy refers to the ability to recognise and share emotions with others. Several research groups have recognised observational fear in mice as a useful behavioural model for assessing their ability to empathise. However, in these observation systems, it remains unclear whether the observer mouse truly reco...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-020-00566-4
更新日期:2020-05-01 00:00:00
abstract:BACKGROUND:HIV Associated Dementia (HAD) is a common complication of human immunodeficiency virus (HIV) infection that erodes the quality of life for patients and burdens health care providers. Intravenous drug use is a major route of HIV transmission, and drug use is associated with increased HAD. Specific proteins re...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-6-40
更新日期:2005-06-08 00:00:00
abstract:BACKGROUND:Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the selective loss of motor neurons (MN) in the brain stem and spinal cord. Intracellular disruptions of cytosolic and mitochondrial calcium have been associated with selective MN degeneration, but the underlying mecha...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-10-64
更新日期:2009-06-22 00:00:00
abstract:BACKGROUND:Alzheimer's Disease (AD) and Fronto temporal lobar dementia (FTLD) are common causes of dementia in the aging population for which limited therapeutical options are available. These disorders are associated with Tau accumulation. We have previously shown that Cerebrolysin™ (CBL), a neuropeptide mixture with ...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-15-90
更新日期:2014-07-21 00:00:00
abstract:BACKGROUND:An individual's ability to recognise and pay attention to others is crucial in order to behave appropriately in various social situations. Studies in humans have shown a sex bias in sociability as well as social memory, indicating that females have better face memory and gaze more at the eyes of others, but ...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-015-0221-z
更新日期:2015-11-25 00:00:00
abstract:BACKGROUND:CNS injury including stroke, infection, and tumor growth lead to astrogliosis, a process that involves upregulation of glial fibrillary acidic protein (GFAP) in astrocytes. However, the kinetics of astrogliosis that is related to these insults (i.e. tumor) is largely unknown. RESULTS:Using transgenic mice e...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-12-9
更新日期:2011-01-19 00:00:00
abstract:BACKGROUND:Enhanced activity of trigeminal ganglion neurons is thought to underlie neuronal sensitization facilitating the onset of chronic pain attacks, including migraine. Recurrent headache attacks might establish a chronic neuroinflammatory ganglion profile contributing to the hypersensitive phenotype. Since it is ...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-13-143
更新日期:2012-11-21 00:00:00
abstract:BACKGROUND:One of the most basic human traits is language. Linguistic ability, and disability, have been shown to have a strong genetic component in family and twin studies, but molecular genetic studies of language phenotypes are scarce, relative to studies of other cognitive traits and neurodevelopmental phenotypes. ...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-020-00581-5
更新日期:2020-07-07 00:00:00
abstract:BACKGROUND:Efficient multisensory integration is of vital importance for adequate interaction with the environment. In addition to basic binding cues like temporal and spatial coherence, meaningful multisensory information is also bound together by content-based associations. Many functional Magnetic Resonance Imaging ...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-11-11
更新日期:2010-02-02 00:00:00
abstract:BACKGROUND:Cigarette smoking enhances the risk of stroke. However, the underlying molecular mechanisms are largely unknown. The present study established an in vivo rat secondhand cigarette smoking (SHS) model and examined the hypothesis that SHS upregulates endothelin receptors with increased cerebrovascular contracti...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-12-109
更新日期:2011-11-01 00:00:00
abstract:BACKGROUND:Astaxanthin is a carotenoid pigment that possesses potent antioxidative, anti-inflammatory, antitumor, and immunomodulatory activities. Previous studies have demonstrated that astaxanthin displays potential neuroprotective properties for the treatment of central nervous system diseases, such as ischemic brai...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-016-0295-2
更新日期:2016-08-31 00:00:00
abstract:BACKGROUND:Overexpression and abnormal accumulation of aggregated alpha-synuclein (alphaS) have been linked to Parkinson's disease (PD) and other synucleinopathies. alphaS can misfold and adopt a variety of morphologies but recent studies implicate oligomeric forms as the most cytotoxic species. Both genetic mutations ...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-11-57
更新日期:2010-04-30 00:00:00
abstract:BACKGROUND:Microglia, the resident immune cells of the central nervous system (CNS), have two distinct phenotypes in the developing brain: amoeboid form, known to be amoeboid microglial cells (AMC) and ramified form, known to be ramified microglial cells (RMC). The AMC are characterized by being proliferative, phagocyt...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-13-64
更新日期:2012-06-14 00:00:00