Abstract:
BACKGROUND:An individual's ability to recognise and pay attention to others is crucial in order to behave appropriately in various social situations. Studies in humans have shown a sex bias in sociability as well as social memory, indicating that females have better face memory and gaze more at the eyes of others, but information about the factors that underpin these differences is sparse. Our aim was therefore to investigate if sociability and social recognition differ between female and male mice, and if so, to what extent gonadal hormones may be involved. Intact and gonadectomised male and female mice were assessed for sociability and social recognition using the three-chambered sociability paradigm, as well as the social discrimination test. Furthermore, we conducted a novel object recognition test, a locomotor activity test and an odour habituation/dishabituation test. RESULTS:The present study showed that the ability to recognise other individuals is intact in males with and without gonads, as well as in intact females, whereas it is hampered in gonadectomised females. Additionally, intact male mice displayed more persistent investigatory behaviour compared to the other groups, although the intact females showed elevated basal locomotor activity. In addition, all groups had intact object memory and habituated to odours. CONCLUSIONS:Our results suggest that intact male mice investigate conspecifics more than females do, and these differences seem to depend upon circulating hormones released from the testis. As these results seem to contrast what is known from human studies, they should be taken into consideration when using the three-chambered apparatus, and similar paradigms as animal models of social deficits in e.g. autism. Other behavioural tests, and animal models, may be more suitable for translational studies between patients and experimental animals.
journal_name
BMC Neuroscijournal_title
BMC neuroscienceauthors
Karlsson SA,Haziri K,Hansson E,Kettunen P,Westberg Ldoi
10.1186/s12868-015-0221-zsubject
Has Abstractpub_date
2015-11-25 00:00:00pages
83issn
1471-2202pii
10.1186/s12868-015-0221-zjournal_volume
16pub_type
杂志文章相关文献
BMC NEUROSCIENCE文献大全abstract:BACKGROUND:Acupuncture has been applied to aid in the recovery of post-stroke patients, but its mechanism is unclear. This study aims to analyze the relationship between acupuncture and glucose metabolism in cerebral functional regions in post-stroke patients using (18)FDG PET-CT techniques. Forty-three ischemic stroke...
journal_title:BMC neuroscience
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-2202-13-75
更新日期:2012-06-27 00:00:00
abstract:BACKGROUND:Parkinson disease (PD) is a movement disorder affecting 1 % of people over the age of 60. The etiology of the disease is unknown; however, accumulating evidence suggests that mitochondrial defects, oxidative stress, and neuroinflammation play important roles in developing the disease. Current medications for...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-016-0293-4
更新日期:2016-08-22 00:00:00
abstract:BACKGROUND:The "inverse" problem is related to the determination of unknown causes on the bases of the observation of their effects. This is the opposite of the corresponding "direct" problem, which relates to the prediction of the effects generated by a complete description of some agencies. The solution of an inverse...
journal_title:BMC neuroscience
pub_type: 杂志文章,评审
doi:10.1186/1471-2202-7-S1-S6
更新日期:2006-10-30 00:00:00
abstract:BACKGROUND:Ample evidence suggests a substantial contribution of cellular and molecular changes in the spinal cord to the induction and persistence of chronic neuropathic pain conditions. While for a long time, proteases were mainly considered as protein degrading enzymes, they are now receiving growing interest as sig...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-9-80
更新日期:2008-08-12 00:00:00
abstract:BACKGROUND:Early stages in the excitation cascade of Limulus photoreceptors are mediated by activation of Gq by rhodopsin, generation of inositol-1,4,5-trisphosphate by phospholipase-C and the release of Ca2+. At the end of the cascade, cGMP-gated channels open and generate the depolarizing receptor potential. A major ...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-5-7
更新日期:2004-02-26 00:00:00
abstract:BACKGROUND:Rett syndrome (RTT, MIM #312750) is a severe neurological disorder caused by mutations in the X-linked methyl-CpG binding protein 2 (MECP2) gene. Female patients are affected with an incidence of 1/15000 live births and develop normally from birth to 6-18 months of age before the onset of deficits in autonom...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-12-47
更新日期:2011-05-24 00:00:00
abstract:BACKGROUND:The optic nerve is a pure white matter central nervous system (CNS) tract with an isolated blood supply, and is widely used in physiological studies of white matter response to various insults. We examined the gene expression profile of human optic nerve (ON) and, through the NEIBANK online resource, to prov...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-10-121
更新日期:2009-09-24 00:00:00
abstract:BACKGROUND:To determine whether early imitative responses fade out following the maturation of attentional mechanisms, the relationship between primitive imitation behaviors and the development of attention was examined in 4-month-old infants. They were divided into high and low imitators, based on an index of imitatio...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-4-33
更新日期:2003-12-24 00:00:00
abstract:BACKGROUND:Previous studies showed that anodal transcranial DC stimulation (tDCS) applied to the primary motor cortex of the affected hemisphere (M1affected hemisphere) after subcortical stroke transiently improves performance of complex tasks that mimic activities of daily living (ADL). It is not known if relatively s...
journal_title:BMC neuroscience
pub_type: 临床试验,杂志文章
doi:10.1186/1471-2202-7-73
更新日期:2006-11-03 00:00:00
abstract:BACKGROUND:ApoER2 and the neurotrophin receptors Trk and p75(NTR) are expressed in the CNS and regulate key functional aspects of neurons, including development, survival, and neuronal function. It is known that both ApoER2 and p75(NTR) are processed by metalloproteinases, followed by regulated intramembrane proteolysi...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-15-108
更新日期:2014-09-19 00:00:00
abstract:BACKGROUND:We have recorded responses from single neurons in murine visual cortex to determine the effectiveness of the input from the two murine cone photoreceptor mechanisms and whether there is any unique selectivity for cone inputs at this higher region of the visual system that would support the possibility of col...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-9-113
更新日期:2008-11-14 00:00:00
abstract:BACKGROUND:Cys-loop receptors play important roles in fast neuronal signal transmission. Functional receptors are pentamers, with each subunit having an extracellular, transmembrane (TM) and intracellular domain. Each TM domain contains 4 α-helices (M1-M4) joined by loops of varying lengths. Many of the amino acid resi...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-018-0454-8
更新日期:2018-09-06 00:00:00
abstract:BACKGROUND:Huntington's disease (HD) is a neurodegenerative disorder predominantly affecting the cerebral cortex and striatum. Transgenic mice (R6/1 line), expressing a CAG repeat encoding an expanded polyglutamine tract in the N-terminus of the huntingtin protein, closely model HD. We have previously shown that enviro...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-9-34
更新日期:2008-04-01 00:00:00
abstract:BACKGROUND:To measure the impact of masticatory reduction on learning and memory, previous studies have produced experimental masticatory reduction by modified diet or molar removal. Here we induced spatial learning impairment in mice by reducing masticatory activity and then tested the effect of a combination of envir...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-14-63
更新日期:2013-06-28 00:00:00
abstract:BACKGROUND:In this study, we examined the effects of cyclophosphamide, methothrexate, and 5-Fluorouracil (CMF) drug combination on various aspects of learning and memory. We also examined the effects of CMF on cell proliferation and chromatin remodeling as possible underlying mechanisms to explain chemotherapy-associat...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-12-124
更新日期:2011-12-09 00:00:00
abstract:BACKGROUND:Lateralized processing of speech is a well studied phenomenon in humans. Both anatomical and neurophysiological studies support the view that nonhuman primates and other animal species also reveal hemispheric differences in areas involved in sound processing. In recent years, an increasing number of studies ...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-10-14
更新日期:2009-02-24 00:00:00
abstract:BACKGROUND:Traumatic brain injury (TBI) initiates a complex sequence of destructive and neuroprotective cellular responses. The initial mechanical injury is followed by an extended time period of secondary brain damage. Due to the complicated pathological picture a better understanding of the molecular events occurring...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-6-69
更新日期:2005-11-30 00:00:00
abstract:BACKGROUND:Multi-sensor technologies such as EEG, MEG, and ECoG result in high-dimensional data sets. Given the high temporal resolution of such techniques, scientific questions very often focus on the time-course of an experimental effect. In many studies, researchers focus on a single sensor or the average over a sub...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-14-122
更新日期:2013-10-14 00:00:00
abstract:BACKGROUND:The function of synaptotagmins (syt) in Ca2+-dependent transmitter release has been attributed primarily to Ca2+-dependent isoforms such as syt I. Recently, syt IV, an inducible Ca2+-independent isoform has been implicated in transmitter release. We postulated that the effects of syt IV on transmitter releas...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-11-104
更新日期:2010-08-24 00:00:00
abstract:BACKGROUND:Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the selective loss of motor neurons (MN) in the brain stem and spinal cord. Intracellular disruptions of cytosolic and mitochondrial calcium have been associated with selective MN degeneration, but the underlying mecha...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-10-64
更新日期:2009-06-22 00:00:00
abstract:BACKGROUND:Amyloid precursor protein (APP) is enzymatically cleaved by gamma-secretase to form two peptide products, either Abeta40 or the more neurotoxic Abeta42. The Abeta42/40 ratio is increased in many cases of familial Alzheimer's disease (FAD). The transmembrane domain (TM) of APP contains the known dimerization ...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-9-17
更新日期:2008-01-30 00:00:00
abstract:BACKGROUND:Many studies of cerebral asymmetries in different species lead, on the one hand, to a better understanding of the functions of each cerebral hemisphere and, on the other hand, to develop an evolutionary history of hemispheric laterality. Our animal model is particularly interesting because of its original ev...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-13-9
更新日期:2012-01-12 00:00:00
abstract:BACKGROUND:Recent studies have shown that the human right-hemispheric auditory cortex is particularly sensitive to reduction in sound quality, with an increase in distortion resulting in an amplification of the auditory N1m response measured in the magnetoencephalography (MEG). Here, we examined whether this sensitivit...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-11-24
更新日期:2010-02-22 00:00:00
abstract:BACKGROUND:Sonic hedgehog (Shh)/Gli pathway plays an important regulatory role on the neuroepithelial cells (NEc) proliferation in the dorsal regions of the developing vertebrate Central Nervous System. The aim of this paper was to analyze the effect of the Shh/Gli signaling pathway activation on the proliferation dyna...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-13-117
更新日期:2012-10-02 00:00:00
abstract:BACKGROUND:Recent discoveries suggest that arealization of the mammalian cortical sheet develops in a manner consonant with principles established for embryonic patterning of the body. Signaling centers release morphogens that determine regional growth and tissue identity by regulating regional expression of transcript...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-6-18
更新日期:2005-03-17 00:00:00
abstract:BACKGROUND:Previous studies found that rats subjected to carrageenan injection develop hyperalgesia, and despite complete recovery in several days, they continue to have an enhanced hyperalgesic response to a new noxious challenge for more than 28d. The study's aim was to identify candidate genes that have a role in th...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-9-32
更新日期:2008-03-13 00:00:00
abstract:BACKGROUND:Fetal asphyctic (FA) preconditioning is effective in attenuating brain damage incurred by a subsequent perinatal asphyctic insult. Unraveling mechanisms of this endogenous neuroprotection, activated by FA preconditioning, is an important step towards new clinical strategies for asphyctic neonates. Genomic re...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-14-61
更新日期:2013-06-22 00:00:00
abstract:BACKGROUND:Efficient multisensory integration is of vital importance for adequate interaction with the environment. In addition to basic binding cues like temporal and spatial coherence, meaningful multisensory information is also bound together by content-based associations. Many functional Magnetic Resonance Imaging ...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-11-11
更新日期:2010-02-02 00:00:00
abstract:BACKGROUND:Noise exposure (NE) is a severe modern health hazard that induces hearing impairment. However, the noise-induced ultrastructural changes of blood-labyrinth barrier (BLB) and the potential involvements of tight junction proteins (TJP) remain inconclusive. We investigated the effects of NE on not only the ultr...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-014-0136-0
更新日期:2014-12-24 00:00:00
abstract:BACKGROUND:Opioid agonist drugs produce analgesia. However, long-term exposure to opioid agonists may lead to opioid dependence. The analgesic and addictive properties of opioid agonist drugs are mediated primarily via the mu-opioid receptor (MOR). Opioid agonists appear to alter neuronal morphology in key brain region...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-11-33
更新日期:2010-03-09 00:00:00