Persistent changes in spinal cord gene expression after recovery from inflammatory hyperalgesia: a preliminary study on pain memory.

abstract：BACKGROUND:Oxidative stress has shown to contribute in the mechanisms underlying apoptotic cell death occurring in AIDS-dementia complex. Here we investigated the role of peroxynitrite in apoptosis occurring in astroglial cells incubated with supernatants of HIV-infected human primary macrophages (M/M). RESULTS:Flow c...

journal_title：BMC neuroscience

authors： Muscoli C,Salvemini D,Paolino D,Iannone M,Palma E,Cufari A,Rotiroti D,Perno CF,Aquaro S,Mollace V

更新日期：2002-09-16 00:00:00

abstract：BACKGROUND:After unilateral cervical cord lesion at the C7/C8 border interrupting the dorsolateral funiculus in adult monkeys, neutralization of Nogo-A using a specific monoclonal antibody promoted sprouting of corticospinal (CS) axons rostral and caudal to the lesion and, in parallel, improved functional recovery. In ...

journal_title：BMC neuroscience

authors： Beaud ML,Schmidlin E,Wannier T,Freund P,Bloch J,Mir A,Schwab ME,Rouiller EM

更新日期：2008-01-14 00:00:00

abstract：BACKGROUND:The neurological complications of HIV infection remain poorly understood. Clinically, in vivo 1H magnetic resonance spectroscopy (MRS) demonstrates brain injury caused by HIV infection even when the MRI is normal. Our goal was to undertsand the dynamics of cerebral injury by performing a longitudinal in vivo...

journal_title：BMC neuroscience

authors： Fuller RA,Westmoreland SV,Ratai E,Greco JB,Kim JP,Lentz MR,He J,Sehgal PK,Masliah E,Halpern E,Lackner AA,González RG

更新日期：2004-03-05 00:00:00

abstract：BACKGROUND:Gap junction proteins, connexins, are expressed in most endocrine and exocrine glands in the body and are at least in some glands crucial for the hormonal secretion. To what extent connexins are expressed in neurons releasing hormones or neuropeptides from or within the central nervous system is, however, un...

journal_title：BMC neuroscience

authors： Westberg L,Sawa E,Wang AY,Gunaydin LA,Ribeiro AC,Pfaff DW

更新日期：2009-04-30 00:00:00

abstract：BACKGROUND:Inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, known as statins, are commonly used as cholesterol-lowering drugs. During the past decade, evidence has emerged that statins also have neuroprotective effects. Research in the retina has shown that simvastatin, a commonly used statin, increases A...

journal_title：BMC neuroscience

authors： Brand Y,Setz C,Levano S,Listyo A,Chavez E,Pak K,Sung M,Radojevic V,Ryan AF,Bodmer D

更新日期：2011-11-14 00:00:00

abstract：:Many studies have highlighted the pathological involvement of iron accumulation and iron-related oxidative stress (OS) in Alzheimer's disease (AD). Iron was further demonstrated to modulate expression of the Alzheimer's amyloid precursor holo-protein (APP) by a mechanism similar to that of regulation of ferritin-L and...

journal_title：BMC neuroscience

authors： Avramovich-Tirosh Y,Amit T,Bar-Am O,Weinreb O,Youdim MB

更新日期：2008-12-03 00:00:00

abstract：BACKGROUND:During development the switch from a depolarizing to a hyperpolarizing action of GABA is a consequence of a decrease of the Na+-K+-2Cl- co-transporter (NKCC1, Cl--uptake) and increase of the K+-Cl- co-transporter (KCC2, Cl--extrusion) expression. However albino visual cortex neurons don't show a correspondin...

journal_title：BMC neuroscience

authors： Diykov D,Turchinovich A,Zoidl G,Hoffmann KP

更新日期：2008-06-30 00:00:00

abstract：BACKGROUND:Granulocyte-macrophage colony stimulating factor (GM-CSF) is a hematopoietic growth factor involved in the generation of granulocytes, macrophages, and dendritic cells from hematopoietic progenitor cells. We have recently demonstrated that GM-CSF has anti-apoptotic functions on neurons, and is neuroprotectiv...

journal_title：BMC neuroscience

authors： Krüger C,Laage R,Pitzer C,Schäbitz WR,Schneider A

更新日期：2007-10-22 00:00:00

abstract：BACKGROUND:A delay in surgical nerve repair results in impaired nerve function in humans, but mechanisms behind the weakened nerve regeneration are not known. Activating transcription factor 3 (ATF3) increases the intrinsic growth state of injured neurons early after injury, but the role of long-term changes and their ...

journal_title：BMC neuroscience

authors： Saito H,Dahlin LB

更新日期：2008-09-18 00:00:00

abstract：BACKGROUND:Acupuncture has been applied to aid in the recovery of post-stroke patients, but its mechanism is unclear. This study aims to analyze the relationship between acupuncture and glucose metabolism in cerebral functional regions in post-stroke patients using (18)FDG PET-CT techniques. Forty-three ischemic stroke...

journal_title：BMC neuroscience

authors： Huang Y,Tang C,Wang S,Lu Y,Shen W,Yang J,Chen J,Lin R,Cui S,Xiao H,Qu S,Lai X,Shan B

更新日期：2012-06-27 00:00:00

abstract：BACKGROUND:Functional magnetic resonance imaging (fMRI) in white matter has long been considered controversial. Recently, this viewpoint has been challenged by an emerging body of evidence demonstrating white matter activation in the corpus callosum. The current study aimed to determine whether white matter activation ...

journal_title：BMC neuroscience

authors： Gawryluk JR,Mazerolle EL,Brewer KD,Beyea SD,D'Arcy RC

更新日期：2011-06-14 00:00:00

abstract：:Numerous molecular factors orchestrate the development of the peripheral taste system. The unique anatomy/function of the taste system makes this system ideal for understanding the mechanisms by which these factors function; yet the taste system is underutilized for this role. This review focuses on some of the many f...

journal_title：BMC neuroscience

authors： Krimm RF

更新日期：2007-09-18 00:00:00

abstract：BACKGROUND:Glutamergic excitotoxicity has been shown to play a deleterious role in the pathophysiology of spinal cord injury (SCI). The aim of this study was to investigate the neuroprotective effect of dizocilpine maleate, MK801 (2 mg/Kg, 30 min and 6 hours after injury) in a mice model of SCI. The spinal cord trauma ...

journal_title：BMC neuroscience

authors： Esposito E,Paterniti I,Mazzon E,Genovese T,Galuppo M,Meli R,Bramanti P,Cuzzocrea S

更新日期：2011-04-14 00:00:00

abstract：BACKGROUND:Synaptic degeneration and accumulation of amyloid β-peptides (Aβ) are hallmarks of the Alzheimer diseased brain. Aβ is synaptotoxic and produced by sequential cleavage of the amyloid precursor protein (APP) by the β-secretase BACE1 and by γ-secretase. If APP is instead cleaved by the α-secretase ADAM10, Aβ w...

journal_title：BMC neuroscience

authors： Lundgren JL,Vandermeulen L,Sandebring-Matton A,Ahmed S,Winblad B,Di Luca M,Tjernberg LO,Marcello E,Frykman S

更新日期：2020-02-04 00:00:00

abstract：BACKGROUND:Anticipatory planning, the ability to anticipate future perceptual-motor demands of a goal-oriented action sequence, is essential for flexible, purposeful behavior. Once an action goal has been defined, movement details necessary to achieve that goal can be selected. Here, we investigate if anticipatory plan...

journal_title：BMC neuroscience

authors： Marangon M,Bucchioni G,Massacesi S,Castiello U

更新日期：2013-08-28 00:00:00

abstract：BACKGROUND:Errorless learning has advantages over errorful learning. The erroneous items produced during errorful learning compete with correct items at retrieval resulting in decreased memory performance. This interference is associated with an increased demand on executive monitoring processes. Event-related function...

journal_title：BMC neuroscience

authors： Hammer A,Tempelmann C,Münte TF

更新日期：2013-03-13 00:00:00

abstract：BACKGROUND:The zitter (zi/zi) rat, a loss-of-function mutant of the glycosylated transmembrane protein attractin (atrn), exhibits widespread age-dependent spongiform degeneration, hypomyelination, and abnormal metabolism of reactive oxygen species (ROS) in the brain. To date, the mechanisms underlying these phenotypes ...

journal_title：BMC neuroscience

authors： Sakakibara S,Nakadate K,Ookawara S,Ueda S

更新日期：2008-04-05 00:00:00

abstract：BACKGROUND:Myzus persicae is a globally important aphid pest with a history of developing resistance to insecticides. Unusually, neonicotinoids have remained highly effective as control agents despite nearly two decades of steadily increasing use. In this study, a clone of M. persicae collected from southern France was...

journal_title：BMC neuroscience

authors： Bass C,Puinean AM,Andrews M,Cutler P,Daniels M,Elias J,Paul VL,Crossthwaite AJ,Denholm I,Field LM,Foster SP,Lind R,Williamson MS,Slater R

更新日期：2011-05-31 00:00:00

abstract：BACKGROUND:In this study, we examined the effects of cyclophosphamide, methothrexate, and 5-Fluorouracil (CMF) drug combination on various aspects of learning and memory. We also examined the effects of CMF on cell proliferation and chromatin remodeling as possible underlying mechanisms to explain chemotherapy-associat...

journal_title：BMC neuroscience

authors： Briones TL,Woods J

更新日期：2011-12-09 00:00:00

abstract：BACKGROUND:Auditory perceptual learning persistently modifies neural networks in the central nervous system. Central auditory processing comprises a hierarchy of sound analysis and integration, which transforms an acoustical signal into a meaningful object for perception. Based on latencies and source locations of audi...

journal_title：BMC neuroscience

authors： Ross B,Jamali S,Tremblay KL

更新日期：2013-12-05 00:00:00

abstract：BACKGROUND:Knock-in (KI) mouse models of Alzheimer's disease (AD) that endogenously overproduce Aβ without non-physiological overexpression of amyloid precursor protein (APP) provide important insights into the pathogenic mechanisms of AD. Previously, we reported that AppNL-G-F mice, which harbor three familial AD muta...

journal_title：BMC neuroscience

authors： Sakakibara Y,Sekiya M,Saito T,Saido TC,Iijima KM

更新日期：2019-03-20 00:00:00

abstract：BACKGROUND:To measure the impact of masticatory reduction on learning and memory, previous studies have produced experimental masticatory reduction by modified diet or molar removal. Here we induced spatial learning impairment in mice by reducing masticatory activity and then tested the effect of a combination of envir...

journal_title：BMC neuroscience

authors： Mendes Fde C,de Almeida MN,Felício AP,Fadel AC,Silva Dde J,Borralho TG,da Silva RP,Bento-Torres J,Vasconcelos PF,Perry VH,Ramos EM,Picanço-Diniz CW,Sosthenes MC

更新日期：2013-06-28 00:00:00

abstract：BACKGROUND:Parkinson's disease (PD) is a neurological disorder characterized by the degeneration of nigrostriatal dopaminergic systems. Free radicals induced by oxidative stress are involved in the mechanisms of cell death in PD. This study clarifies the neuroprotective effects of edaravone (MCI-186, 3-methyl-1-phenyl-...

journal_title：BMC neuroscience

authors： Yuan WJ,Yasuhara T,Shingo T,Muraoka K,Agari T,Kameda M,Uozumi T,Tajiri N,Morimoto T,Jing M,Baba T,Wang F,Leung H,Matsui T,Miyoshi Y,Date I

更新日期：2008-08-01 00:00:00

abstract：:Recent research has demonstrated the suitability of adult zebrafish to model some aspects of complex behaviour. Studies of reward behaviour, learning and memory, aggression, anxiety and sleep strongly suggest that conserved regulatory processes underlie behaviour in zebrafish and mammals. The isolation and molecular a...

journal_title：BMC neuroscience

authors： Norton W,Bally-Cuif L

更新日期：2010-08-02 00:00:00

abstract：BACKGROUND:Astrocytes are responsible for a broad range of functions that maintain homeostasis in the brain. However, their response to the pro-inflammatory cytokines released by activated microglia in various neurological pathologies may exacerbate neurodegenerative processes. Accumulating evidence suggests that omega...

journal_title：BMC neuroscience

authors： Zgórzyńska E,Stulczewski D,Dziedzic B,Su KP,Walczewska A

更新日期：2021-01-27 00:00:00

abstract：BACKGROUND:Major depressive disorder is a prevalent disease that is inadequately treated with currently available interventions. Stress increases susceptibility to depression in patients and rodent models. Depression is also associated with aberrant activation of inflammation, such as increases in circulating levels of...

journal_title：BMC neuroscience

authors： Cheng Y,Jope RS,Beurel E

更新日期：2015-05-07 00:00:00

abstract：BACKGROUND:Glutamate, a major excitatory amino acid neurotransmitter, causes apoptotic neuronal cell death at high concentrations. Our previous studies have shown that depending on the neuronal cell type, glutamate-induced apoptotic cell death was associated with regulation of genes such as Bcl-2, Bax, and/or caspase-3...

journal_title：BMC neuroscience

authors： Zhang Y,Bhavnani BR

更新日期：2006-06-15 00:00:00

abstract：BACKGROUND:It has been hypothesized that alterations of the serotonergic system contribute to neuropsychiatric symptoms in Alzheimer disease (AD). Cellular expressions of the two serotonergic receptors 5-HT2A and 5-HT6 have therefore been determined by immunohistochemistry in the prefrontal cortex of patients with AD (...

journal_title：BMC neuroscience

authors： Lorke DE,Lu G,Cho E,Yew DT

更新日期：2006-04-27 00:00:00

abstract：BACKGROUND:The integration of EEG and fMRI is attractive because of their complementary precision regarding time and space. But the relationship between the indirect hemodynamic fMRI signal and the more direct EEG signal is uncertain. Event-related EEG responses can be analyzed in two different ways, reflecting two dif...

journal_title：BMC neuroscience

authors： Foucher JR,Otzenberger H,Gounot D

更新日期：2003-09-19 00:00:00

abstract：BACKGROUND:Berberine is the major alkaloidal component of Rhizoma coptidis, and has multiple pharmacological effects including inhibiting acetylcholinesterase, reducing cholesterol and glucose, lowering mortality in patients with chronic congestive heart failure and anti-inflammation etc. Thus berberine is a promising ...

journal_title：BMC neuroscience

authors： Zhu F,Qian C

更新日期：2006-12-01 00:00:00