Peroxynitrite decomposition catalyst prevents apoptotic cell death in a human astrocytoma cell line incubated with supernatants of HIV-infected macrophages.

Abstract:

BACKGROUND:Oxidative stress has shown to contribute in the mechanisms underlying apoptotic cell death occurring in AIDS-dementia complex. Here we investigated the role of peroxynitrite in apoptosis occurring in astroglial cells incubated with supernatants of HIV-infected human primary macrophages (M/M). RESULTS:Flow cytometric analysis (FACS) of human cultured astrocytes shortly incubated with HIV-1-infected M/M supernatants showed apoptotic cell death, an effect accompanied by pronounced staining for nitrotyrosine (footprint of peroxynitrite) and by abnormal formation of malondialdehyde (MDA). Pretreatment of astrocytes with the peroxynitrite decomposition catalyst FeTMPS antagonized HIV-related astrocytic apoptosis, MDA formation and nitrotyrosine staining. CONCLUSIONS:Taken together, our results suggest that inhibition of peroxynitrite leads to protection against peroxidative stress accompanying HIV-related apoptosis of astrocytes. Overall results support the role of peroxynitrite in HIV-related programmed death of astrocytes and suggest the use of peroxynitrite decomposition catalyst to counteract HIV-1-related neurological disorders.

journal_name

BMC Neurosci

journal_title

BMC neuroscience

authors

Muscoli C,Salvemini D,Paolino D,Iannone M,Palma E,Cufari A,Rotiroti D,Perno CF,Aquaro S,Mollace V

doi

10.1186/1471-2202-3-13

keywords:

subject

Has Abstract

pub_date

2002-09-16 00:00:00

pages

13

issn

1471-2202

journal_volume

3

pub_type

杂志文章
  • Non-invasive quantification of brain tumor-induced astrogliosis.

    abstract:BACKGROUND:CNS injury including stroke, infection, and tumor growth lead to astrogliosis, a process that involves upregulation of glial fibrillary acidic protein (GFAP) in astrocytes. However, the kinetics of astrogliosis that is related to these insults (i.e. tumor) is largely unknown. RESULTS:Using transgenic mice e...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-12-9

    authors: Lee J,Borboa AK,Baird A,Eliceiri BP

    更新日期:2011-01-19 00:00:00

  • Interaction of the mu-opioid receptor with GPR177 (Wntless) inhibits Wnt secretion: potential implications for opioid dependence.

    abstract:BACKGROUND:Opioid agonist drugs produce analgesia. However, long-term exposure to opioid agonists may lead to opioid dependence. The analgesic and addictive properties of opioid agonist drugs are mediated primarily via the mu-opioid receptor (MOR). Opioid agonists appear to alter neuronal morphology in key brain region...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-11-33

    authors: Jin J,Kittanakom S,Wong V,Reyes BA,Van Bockstaele EJ,Stagljar I,Berrettini W,Levenson R

    更新日期:2010-03-09 00:00:00

  • Agmatine protects retinal ganglion cells from hypoxia-induced apoptosis in transformed rat retinal ganglion cell line.

    abstract:BACKGROUND:Agmatine is an endogenous polyamine formed by the decarboxylation of L-arginine. We investigated the protective effects of agmatine against hypoxia-induced apoptosis of immortalized rat retinal ganglion cells (RGC-5). RGC-5 cells were cultured in a closed hypoxic chamber (5% O2) with or without agmatine. Cel...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-8-81

    authors: Hong S,Lee JE,Kim CY,Seong GJ

    更新日期:2007-10-02 00:00:00

  • Separate urinary bladder and prostate neurons in the central nervous system of the rat: simultaneous labeling with two immunohistochemically distinguishable pseudorabies viruses.

    abstract:BACKGROUND:This work examines the central nervous system distribution of virus-labeled neurons from the rat urinary bladder and the prostate simultaneously within the same tissue sections. Two immunohistochemically distinct pseudorabies virus strains were simultaneously injected into male Sprague Dawley rats (approxima...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-3-8

    authors: Nadelhaft I,Miranda-Sousa AJ,Vera PL

    更新日期:2002-07-12 00:00:00

  • Hyperbaric oxygen upregulates cochlear constitutive nitric oxide synthase.

    abstract:BACKGROUND:Hyperbaric oxygen therapy (HBOT) is a known adjuvant for treating ischemia-related inner ear diseases. Controversies still exist in the role of HBOT in cochlear diseases. Few studies to date have investigated the cellular changes that occur in inner ears after HBOT. Nitric oxide, which is synthesized by nitr...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-12-21

    authors: Lin CD,Wei IH,Lai CH,Hsia TC,Kao MC,Tsai MH,Wu CH,Tsai MH

    更新日期:2011-02-22 00:00:00

  • Cholecystokinin receptor-1 mediates the inhibitory effects of exogenous cholecystokinin octapeptide on cellular morphine dependence.

    abstract:BACKGROUND:Cholecystokinin octapeptide (CCK-8), the most potent endogenous anti-opioid peptide, has been shown to regulate the processes of morphine dependence. In our previous study, we found that exogenous CCK-8 attenuated naloxone induced withdrawal symptoms. To investigate the precise effect of exogenous CCK-8 and ...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-13-63

    authors: Wen D,Ma CL,Zhang YJ,Meng YX,Ni ZY,Li SJ,Cong B

    更新日期:2012-06-08 00:00:00

  • Correction to: Wnt3a induces exosome secretion from primary cultured rat microglia.

    abstract::Following the publication of this article [1], it has been noted by the authors that an image of the same cell nuclei has been used in error twice, in Fig. 8, parts A and B. These images are redundant in this figure as the images in parts D and E show Wnt3a treated and control cells stained with both Hoechst 33342 (as...

    journal_title:BMC neuroscience

    pub_type: 杂志文章,已发布勘误

    doi:10.1186/s12868-020-0558-9

    authors: Hooper C,Sainz-Fuertes R,Lynham S,Hye A,Killick R,Warley A,Bolondi C,Pocock J,Lovestone S

    更新日期:2020-03-06 00:00:00

  • Expressed sequence tag analysis of adult human optic nerve for NEIBank: identification of cell type and tissue markers.

    abstract:BACKGROUND:The optic nerve is a pure white matter central nervous system (CNS) tract with an isolated blood supply, and is widely used in physiological studies of white matter response to various insults. We examined the gene expression profile of human optic nerve (ON) and, through the NEIBANK online resource, to prov...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-10-121

    authors: Bernstein SL,Guo Y,Peterson K,Wistow G

    更新日期:2009-09-24 00:00:00

  • VAMP-2, SNAP-25A/B and syntaxin-1 in glutamatergic and GABAergic synapses of the rat cerebellar cortex.

    abstract:BACKGROUND:The aim of this study was to assess the distribution of key SNARE proteins in glutamatergic and GABAergic synapses of the adult rat cerebellar cortex using light microscopy immunohistochemical techniques. Analysis was made of co-localizations of vGluT-1 and vGluT-2, vesicular transporters of glutamate and ma...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-12-118

    authors: Benagiano V,Lorusso L,Flace P,Girolamo F,Rizzi A,Bosco L,Cagiano R,Nico B,Ribatti D,Ambrosi G

    更新日期:2011-11-17 00:00:00

  • Culture but not gender modulates amygdala activation during explicit emotion recognition.

    abstract:BACKGROUND:Mounting evidence indicates that humans have significant difficulties in understanding emotional expressions from individuals of different ethnic backgrounds, leading to reduced recognition accuracy and stronger amygdala activation. However, the impact of gender on the behavioral and neural reactions during ...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-13-54

    authors: Derntl B,Habel U,Robinson S,Windischberger C,Kryspin-Exner I,Gur RC,Moser E

    更新日期:2012-05-29 00:00:00

  • Behavioral effects of ketamine and toxic interactions with psychostimulants.

    abstract:BACKGROUND:The anesthetic drug ketamine (KT) has been reported to be an abused drug and fatal cases have been observed in polydrug users. In the present study, considering the possibility of KT-enhanced toxic effects of other drugs, and KT-induced promotion of an overdose without making the subject aware of the danger ...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-7-25

    authors: Hayase T,Yamamoto Y,Yamamoto K

    更新日期:2006-03-16 00:00:00

  • Neuroprotective effect of nerolidol against neuroinflammation and oxidative stress induced by rotenone.

    abstract:BACKGROUND:Parkinson disease (PD) is a movement disorder affecting 1 % of people over the age of 60. The etiology of the disease is unknown; however, accumulating evidence suggests that mitochondrial defects, oxidative stress, and neuroinflammation play important roles in developing the disease. Current medications for...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/s12868-016-0293-4

    authors: Javed H,Azimullah S,Abul Khair SB,Ojha S,Haque ME

    更新日期:2016-08-22 00:00:00

  • Laminin enhances the growth of human neural stem cells in defined culture media.

    abstract:BACKGROUND:Human neural stem cells (hNSC) have the potential to provide novel cell-based therapies for neurodegenerative conditions such as multiple sclerosis and Parkinson's disease. In order to realise this goal, protocols need to be developed that allow for large quantities of hNSC to be cultured efficiently. As suc...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-9-71

    authors: Hall PE,Lathia JD,Caldwell MA,Ffrench-Constant C

    更新日期:2008-07-23 00:00:00

  • Qualitative and quantitative differences between taste buds of the rat and mouse.

    abstract:BACKGROUND:Numerous electrophysiological, ultrastructural, and immunocytochemical studies on rodent taste buds have been carried out on rat taste buds. In recent years, however, the mouse has become the species of choice for molecular and other studies on sensory transduction in taste buds. Do rat and mouse taste buds ...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-8-5

    authors: Ma H,Yang R,Thomas SM,Kinnamon JC

    更新日期:2007-01-05 00:00:00

  • Thai lexical tone perception in native speakers of Thai, English and Mandarin Chinese: an event-related potentials training study.

    abstract:BACKGROUND:Tone languages such as Thai and Mandarin Chinese use differences in fundamental frequency (F0, pitch) to distinguish lexical meaning. Previous behavioral studies have shown that native speakers of a non-tone language have difficulty discriminating among tone contrasts and are sensitive to different F0 dimens...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-9-53

    authors: Kaan E,Barkley CM,Bao M,Wayland R

    更新日期:2008-06-23 00:00:00

  • Inhibition of apoptosis in neuronal cells infected with Chlamydophila (Chlamydia) pneumoniae.

    abstract:BACKGROUND:Chlamydophila (Chlamydia) pneumoniae is an intracellular bacterium that has been identified within cells in areas of neuropathology found in Alzheimer disease (AD), including endothelia, glia, and neurons. Depending on the cell type of the host, infection by C. pneumoniae has been shown to influence apoptoti...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-9-13

    authors: Appelt DM,Roupas MR,Way DS,Bell MG,Albert EV,Hammond CJ,Balin BJ

    更新日期:2008-01-24 00:00:00

  • Long-lasting anxiolytic effect of neural precursor cells freshly prepared but not neurosphere-derived cell transplantation in newborn rats.

    abstract:BACKGROUND:The GABAergic system plays an important role in modulating levels of anxiety. When transplanted into the brain, precursor cells from the medial ganglionic eminence (MGE) have the ability to differentiate into GABAergic interneurons and modify the inhibitory tone in the host brain. Currently, two methods have...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-15-94

    authors: Romariz SA,Paiva Dde S,Valente MF,Barnabé GF,Frussa-Filho R,Barbosa-Silva RC,Calcagnotto ME,Longo BM

    更新日期:2014-08-02 00:00:00

  • Simvastatin protects auditory hair cells from gentamicin-induced toxicity and activates Akt signaling in vitro.

    abstract:BACKGROUND:Inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, known as statins, are commonly used as cholesterol-lowering drugs. During the past decade, evidence has emerged that statins also have neuroprotective effects. Research in the retina has shown that simvastatin, a commonly used statin, increases A...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-12-114

    authors: Brand Y,Setz C,Levano S,Listyo A,Chavez E,Pak K,Sung M,Radojevic V,Ryan AF,Bodmer D

    更新日期:2011-11-14 00:00:00

  • Sensitive detection of Aβ protofibrils by proximity ligation--relevance for Alzheimer's disease.

    abstract:BACKGROUND:Protein aggregation plays important roles in several neurodegenerative disorders. For instance, insoluble aggregates of phosphorylated tau and of Aβ peptides are cornerstones in the pathology of Alzheimer's disease. Soluble protein aggregates are therefore potential diagnostic and prognostic biomarkers for t...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-11-124

    authors: Kamali-Moghaddam M,Pettersson FE,Wu D,Englund H,Darmanis S,Lord A,Tavoosidana G,Sehlin D,Gustafsdottir S,Nilsson LN,Lannfelt L,Landegren U

    更新日期:2010-10-05 00:00:00

  • Effects of sex and gonadectomy on social investigation and social recognition in mice.

    abstract:BACKGROUND:An individual's ability to recognise and pay attention to others is crucial in order to behave appropriately in various social situations. Studies in humans have shown a sex bias in sociability as well as social memory, indicating that females have better face memory and gaze more at the eyes of others, but ...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/s12868-015-0221-z

    authors: Karlsson SA,Haziri K,Hansson E,Kettunen P,Westberg L

    更新日期:2015-11-25 00:00:00

  • Anti-Nogo-A antibody treatment does not prevent cell body shrinkage in the motor cortex in adult monkeys subjected to unilateral cervical cord lesion.

    abstract:BACKGROUND:After unilateral cervical cord lesion at the C7/C8 border interrupting the dorsolateral funiculus in adult monkeys, neutralization of Nogo-A using a specific monoclonal antibody promoted sprouting of corticospinal (CS) axons rostral and caudal to the lesion and, in parallel, improved functional recovery. In ...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-9-5

    authors: Beaud ML,Schmidlin E,Wannier T,Freund P,Bloch J,Mir A,Schwab ME,Rouiller EM

    更新日期:2008-01-14 00:00:00

  • Recognition of face-name associations after errorless and errorful learning: an fMRI study.

    abstract:BACKGROUND:Errorless learning has advantages over errorful learning. The erroneous items produced during errorful learning compete with correct items at retrieval resulting in decreased memory performance. This interference is associated with an increased demand on executive monitoring processes. Event-related function...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-14-30

    authors: Hammer A,Tempelmann C,Münte TF

    更新日期:2013-03-13 00:00:00

  • Specific ion channels contribute to key elements of pathology during secondary degeneration following neurotrauma.

    abstract:BACKGROUND:Following partial injury to the central nervous system, cells beyond the initial injury site undergo secondary degeneration, exacerbating loss of neurons, compact myelin and function. Changes in Ca2+ flux are associated with metabolic and structural changes, but it is not yet clear how flux through specific ...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/s12868-017-0380-1

    authors: O'Hare Doig RL,Chiha W,Giacci MK,Yates NJ,Bartlett CA,Smith NM,Hodgetts SI,Harvey AR,Fitzgerald M

    更新日期:2017-08-14 00:00:00

  • Neurotrophins regulate ApoER2 proteolysis through activation of the Trk signaling pathway.

    abstract:BACKGROUND:ApoER2 and the neurotrophin receptors Trk and p75(NTR) are expressed in the CNS and regulate key functional aspects of neurons, including development, survival, and neuronal function. It is known that both ApoER2 and p75(NTR) are processed by metalloproteinases, followed by regulated intramembrane proteolysi...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-15-108

    authors: Larios JA,Jausoro I,Benitez ML,Bronfman FC,Marzolo MP

    更新日期:2014-09-19 00:00:00

  • Both 5' and 3' flanks regulate Zebrafish brain-derived neurotrophic factor gene expression.

    abstract:BACKGROUND:Precise control of developmental and cell-specific expression of the brain-derived neurotrophic factor (BDNF) gene is essential for normal neuronal development and the diverse functions of BDNF in the adult organism. We previously showed that the zebrafish BDNF gene has multiple promoters. The complexity of ...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-5-19

    authors: Heinrich G,Pagtakhan CJ

    更新日期:2004-05-21 00:00:00

  • Apoptosis of supraoptic AVP neurons is involved in the development of central diabetes insipidus after hypophysectomy in rats.

    abstract:BACKGROUND:It has been reported that various types of axonal injury of hypothalamo-neurohypophyseal tract can result in degeneration of the magnocellular neurons (MCNs) in hypothalamus and development of central diabetes insipidus (CDI). However, the mechanism of the degeneration and death of MCNs after hypophysectomy ...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-9-54

    authors: Wang Y,Zhao C,Wang Z,Wang C,Feng W,Huang L,Zhang J,Qi S

    更新日期:2008-06-25 00:00:00

  • Maxillary nerve compression in cynomolgus monkey Macaca fascicularis: altered somatic sensation and peripheral nerve firing.

    abstract:BACKGROUND:Trigeminal nerve is a major source of the sensory input of the face, and trigeminal neuropathology models have been reported in rodents with injury to branches of the maxillary or mandibular division of the trigeminal nerve. Non-human primates are neuroanatomically more closely related to human than rodents;...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-13-150

    authors: Guo N,Gu X,Zhao J,Zhao G,Jin M,Zou H,Zhang Y,Zhao Z,Jin GJ,Yu L

    更新日期:2012-12-13 00:00:00

  • proNGF/NGF mixtures induce gene expression changes in PC12 cells that neither singly produces.

    abstract:BACKGROUND:Growing evidence shows that, in vivo, the precursor of Nerve Growth Factor (NGF), proNGF, displays biological activities different from those of its mature NGF counterpart, mediated by distinct, and somewhat complementary, receptor binding properties. NGF and proNGF induce distinct transcriptional signatures...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-15-48

    authors: Arisi I,D'Onofrio M,Brandi R,Malerba F,Paoletti F,Storti AE,Florenzano F,Fasulo L,Cattaneo A

    更新日期:2014-04-08 00:00:00

  • Effects of brain polarization on reaction times and pinch force in chronic stroke.

    abstract:BACKGROUND:Previous studies showed that anodal transcranial DC stimulation (tDCS) applied to the primary motor cortex of the affected hemisphere (M1affected hemisphere) after subcortical stroke transiently improves performance of complex tasks that mimic activities of daily living (ADL). It is not known if relatively s...

    journal_title:BMC neuroscience

    pub_type: 临床试验,杂志文章

    doi:10.1186/1471-2202-7-73

    authors: Hummel FC,Voller B,Celnik P,Floel A,Giraux P,Gerloff C,Cohen LG

    更新日期:2006-11-03 00:00:00

  • Disturbed oscillatory brain dynamics in subcortical ischemic vascular dementia.

    abstract:BACKGROUND:White matter hyperintensities (WMH) can lead to dementia but the underlying physiological mechanisms are unclear. We compared relative oscillatory power from electroencephalographic studies (EEGs) of 17 patients with subcortical ischemic vascular dementia, based on extensive white matter hyperintensities (SI...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-13-85

    authors: van Straaten EC,de Haan W,de Waal H,Scheltens P,van der Flier WM,Barkhof F,Koene T,Stam CJ

    更新日期:2012-07-24 00:00:00