Peroxynitrite decomposition catalyst prevents apoptotic cell death in a human astrocytoma cell line incubated with supernatants of HIV-infected macrophages.


BACKGROUND:Oxidative stress has shown to contribute in the mechanisms underlying apoptotic cell death occurring in AIDS-dementia complex. Here we investigated the role of peroxynitrite in apoptosis occurring in astroglial cells incubated with supernatants of HIV-infected human primary macrophages (M/M). RESULTS:Flow cytometric analysis (FACS) of human cultured astrocytes shortly incubated with HIV-1-infected M/M supernatants showed apoptotic cell death, an effect accompanied by pronounced staining for nitrotyrosine (footprint of peroxynitrite) and by abnormal formation of malondialdehyde (MDA). Pretreatment of astrocytes with the peroxynitrite decomposition catalyst FeTMPS antagonized HIV-related astrocytic apoptosis, MDA formation and nitrotyrosine staining. CONCLUSIONS:Taken together, our results suggest that inhibition of peroxynitrite leads to protection against peroxidative stress accompanying HIV-related apoptosis of astrocytes. Overall results support the role of peroxynitrite in HIV-related programmed death of astrocytes and suggest the use of peroxynitrite decomposition catalyst to counteract HIV-1-related neurological disorders.


BMC Neurosci


BMC neuroscience


Muscoli C,Salvemini D,Paolino D,Iannone M,Palma E,Cufari A,Rotiroti D,Perno CF,Aquaro S,Mollace V





Has Abstract


2002-09-16 00:00:00








  • Evolution of NMDA receptor cytoplasmic interaction domains: implications for organisation of synaptic signalling complexes.

    abstract:BACKGROUND:Glutamate gated postsynaptic receptors in the central nervous system (CNS) are essential for environmentally stimulated behaviours including learning and memory in both invertebrates and vertebrates. Though their genetics, biochemistry, physiology, and role in behaviour have been intensely studied in vitro a...

    journal_title:BMC neuroscience

    pub_type: 杂志文章


    authors: Ryan TJ,Emes RD,Grant SG,Komiyama NH

    更新日期:2008-01-15 00:00:00

  • Tricyclic pyrone compounds prevent aggregation and reverse cellular phenotypes caused by expression of mutant huntingtin protein in striatal neurons.

    abstract:BACKGROUND:Huntington's disease (HD) is a progressive neurodegenerative disorder caused by a CAG repeat expansion mutation in the coding region of a novel gene. The mechanism of HD is unknown. Most data suggest that polyglutamine-mediated aggregation associated with expression of mutant huntingtin protein (mhtt) contri...

    journal_title:BMC neuroscience

    pub_type: 杂志文章


    authors: Trushina E,Rana S,McMurray CT,Hua DH

    更新日期:2009-07-08 00:00:00

  • Inhibition of apoptosis in neuronal cells infected with Chlamydophila (Chlamydia) pneumoniae.

    abstract:BACKGROUND:Chlamydophila (Chlamydia) pneumoniae is an intracellular bacterium that has been identified within cells in areas of neuropathology found in Alzheimer disease (AD), including endothelia, glia, and neurons. Depending on the cell type of the host, infection by C. pneumoniae has been shown to influence apoptoti...

    journal_title:BMC neuroscience

    pub_type: 杂志文章


    authors: Appelt DM,Roupas MR,Way DS,Bell MG,Albert EV,Hammond CJ,Balin BJ

    更新日期:2008-01-24 00:00:00

  • Pure phase-locking of beta/gamma oscillation contributes to the N30 frontal component of somatosensory evoked potentials.

    abstract:BACKGROUND:Evoked potentials have been proposed to result from phase-locking of electroencephalographic (EEG) activities within specific frequency bands. However, the respective contribution of phasic activity and phase resetting of ongoing EEG oscillation remains largely debated. We here applied the EEGlab procedure i...

    journal_title:BMC neuroscience

    pub_type: 杂志文章


    authors: Cheron G,Cebolla AM,De Saedeleer C,Bengoetxea A,Leurs F,Leroy A,Dan B

    更新日期:2007-09-18 00:00:00

  • Extended passaging increases the efficiency of neural differentiation from induced pluripotent stem cells.

    abstract:BACKGROUND:The use of induced pluripotent stem cells (iPSCs) for the functional replacement of damaged neurons and in vitro disease modeling is of great clinical relevance. Unfortunately, the capacity of iPSC lines to differentiate into neurons is highly variable, prompting the need for a reliable means of assessing th...

    journal_title:BMC neuroscience

    pub_type: 杂志文章


    authors: Koehler KR,Tropel P,Theile JW,Kondo T,Cummins TR,Viville S,Hashino E

    更新日期:2011-08-10 00:00:00

  • Interaction of the mu-opioid receptor with GPR177 (Wntless) inhibits Wnt secretion: potential implications for opioid dependence.

    abstract:BACKGROUND:Opioid agonist drugs produce analgesia. However, long-term exposure to opioid agonists may lead to opioid dependence. The analgesic and addictive properties of opioid agonist drugs are mediated primarily via the mu-opioid receptor (MOR). Opioid agonists appear to alter neuronal morphology in key brain region...

    journal_title:BMC neuroscience

    pub_type: 杂志文章


    authors: Jin J,Kittanakom S,Wong V,Reyes BA,Van Bockstaele EJ,Stagljar I,Berrettini W,Levenson R

    更新日期:2010-03-09 00:00:00

  • Both 5' and 3' flanks regulate Zebrafish brain-derived neurotrophic factor gene expression.

    abstract:BACKGROUND:Precise control of developmental and cell-specific expression of the brain-derived neurotrophic factor (BDNF) gene is essential for normal neuronal development and the diverse functions of BDNF in the adult organism. We previously showed that the zebrafish BDNF gene has multiple promoters. The complexity of ...

    journal_title:BMC neuroscience

    pub_type: 杂志文章


    authors: Heinrich G,Pagtakhan CJ

    更新日期:2004-05-21 00:00:00

  • Callosal connections of dorsal versus ventral premotor areas in the macaque monkey: a multiple retrograde tracing study.

    abstract:BACKGROUND:The lateral premotor cortex plays a crucial role in visually guided limb movements. It is divided into two main regions, the dorsal (PMd) and ventral (PMv) areas, which are in turn subdivided into functionally and anatomically distinct rostral (PMd-r and PMv-r) and caudal (PMd-c and PMv-c) sub-regions. We an...

    journal_title:BMC neuroscience

    pub_type: 杂志文章


    authors: Boussaoud D,Tanné-Gariépy J,Wannier T,Rouiller EM

    更新日期:2005-11-25 00:00:00

  • Dimerization of the transmembrane domain of amyloid precursor proteins and familial Alzheimer's disease mutants.

    abstract:BACKGROUND:Amyloid precursor protein (APP) is enzymatically cleaved by gamma-secretase to form two peptide products, either Abeta40 or the more neurotoxic Abeta42. The Abeta42/40 ratio is increased in many cases of familial Alzheimer's disease (FAD). The transmembrane domain (TM) of APP contains the known dimerization ...

    journal_title:BMC neuroscience

    pub_type: 杂志文章


    authors: Gorman PM,Kim S,Guo M,Melnyk RA,McLaurin J,Fraser PE,Bowie JU,Chakrabartty A

    更新日期:2008-01-30 00:00:00

  • The type III neurofilament peripherin is expressed in the tuberomammillary neurons of the mouse.

    abstract:BACKGROUND:Peripherin, a type III neuronal intermediate filament, is widely expressed in neurons of the peripheral nervous system and in selected central nervous system hindbrain areas with projections towards peripheral structures, such as cranial nerves and spinal cord neurons. Peripherin appears to play a role in ne...

    journal_title:BMC neuroscience

    pub_type: 杂志文章


    authors: Eriksson KS,Zhang S,Lin L,Larivière RC,Julien JP,Mignot E

    更新日期:2008-02-24 00:00:00

  • Upregulation of synaptotagmin IV inhibits transmitter release in PC12 cells with targeted synaptotagmin I knockdown.

    abstract:BACKGROUND:The function of synaptotagmins (syt) in Ca2+-dependent transmitter release has been attributed primarily to Ca2+-dependent isoforms such as syt I. Recently, syt IV, an inducible Ca2+-independent isoform has been implicated in transmitter release. We postulated that the effects of syt IV on transmitter releas...

    journal_title:BMC neuroscience

    pub_type: 杂志文章


    authors: Moore-Dotson JM,Papke JB,Harkins AB

    更新日期:2010-08-24 00:00:00

  • Anticipating the course of an action: evidence from corticospinal excitability.

    abstract:BACKGROUND:Anticipatory planning, the ability to anticipate future perceptual-motor demands of a goal-oriented action sequence, is essential for flexible, purposeful behavior. Once an action goal has been defined, movement details necessary to achieve that goal can be selected. Here, we investigate if anticipatory plan...

    journal_title:BMC neuroscience

    pub_type: 杂志文章


    authors: Marangon M,Bucchioni G,Massacesi S,Castiello U

    更新日期:2013-08-28 00:00:00

  • Visual laterality in dolphins: importance of the familiarity of stimuli.

    abstract:BACKGROUND:Many studies of cerebral asymmetries in different species lead, on the one hand, to a better understanding of the functions of each cerebral hemisphere and, on the other hand, to develop an evolutionary history of hemispheric laterality. Our animal model is particularly interesting because of its original ev...

    journal_title:BMC neuroscience

    pub_type: 杂志文章


    authors: Blois-Heulin C,Crével M,Böye M,Lemasson A

    更新日期:2012-01-12 00:00:00

  • Two distinct populations of doublecortin-positive cells in the perilesional zone of cortical infarcts.

    abstract:BACKGROUND:Recovery following stroke depends on cellular plasticity in the perilesional zone (PZ). Doublecortin (DCX), a protein mainly labeling immature neurons in neurogenic niches is also highly expressed in the vicinity of focal cortical infarcts. Notably, the number of DCX+ cells positively correlates with the rec...

    journal_title:BMC neuroscience

    pub_type: 杂志文章


    authors: Kunze A,Achilles A,Keiner S,Witte OW,Redecker C

    更新日期:2015-04-15 00:00:00

  • Reducing multi-sensor data to a single time course that reveals experimental effects.

    abstract:BACKGROUND:Multi-sensor technologies such as EEG, MEG, and ECoG result in high-dimensional data sets. Given the high temporal resolution of such techniques, scientific questions very often focus on the time-course of an experimental effect. In many studies, researchers focus on a single sensor or the average over a sub...

    journal_title:BMC neuroscience

    pub_type: 杂志文章


    authors: Schurger A,Marti S,Dehaene S

    更新日期:2013-10-14 00:00:00

  • Glomerular input patterns in the mouse olfactory bulb evoked by retronasal odor stimuli.

    abstract:BACKGROUND:Odorant stimuli can access the olfactory epithelium either orthonasally, by inhalation through the external nares, or retronasally by reverse airflow from the oral cavity. There is evidence that odors perceived through these two routes can differ in quality and intensity. We were curious whether such differe...

    journal_title:BMC neuroscience

    pub_type: 杂志文章


    authors: Furudono Y,Cruz G,Lowe G

    更新日期:2013-04-08 00:00:00

  • Gonadal steroids differentially modulate neurotoxicity of HIV and cocaine: testosterone and ICI 182,780 sensitive mechanism.

    abstract:BACKGROUND:HIV Associated Dementia (HAD) is a common complication of human immunodeficiency virus (HIV) infection that erodes the quality of life for patients and burdens health care providers. Intravenous drug use is a major route of HIV transmission, and drug use is associated with increased HAD. Specific proteins re...

    journal_title:BMC neuroscience

    pub_type: 杂志文章


    authors: Kendall SL,Anderson CF,Nath A,Turchan-Cholewo J,Land CL,Mactutus CF,Booze RM

    更新日期:2005-06-08 00:00:00

  • Transcriptome analysis of amoeboid and ramified microglia isolated from the corpus callosum of rat brain.

    abstract:BACKGROUND:Microglia, the resident immune cells of the central nervous system (CNS), have two distinct phenotypes in the developing brain: amoeboid form, known to be amoeboid microglial cells (AMC) and ramified form, known to be ramified microglial cells (RMC). The AMC are characterized by being proliferative, phagocyt...

    journal_title:BMC neuroscience

    pub_type: 杂志文章


    authors: Parakalan R,Jiang B,Nimmi B,Janani M,Jayapal M,Lu J,Tay SS,Ling EA,Dheen ST

    更新日期:2012-06-14 00:00:00

  • Gamma oscillation underlies hyperthermia-induced epileptiform-like spikes in immature rat hippocampal slices.

    abstract:BACKGROUND:Recently a hyperthermic rat hippocampal slice model system has been used to investigate febrile seizure pathophysiology. Our previous data indicates that heating immature rat hippocampal slices from 34 to 41 degrees C in an interface chamber induced epileptiform-like population spikes accompanied by a spread...

    journal_title:BMC neuroscience

    pub_type: 杂志文章


    authors: Wu J,Javedan SP,Ellsworth K,Smith K,Fisher RS

    更新日期:2001-01-01 00:00:00

  • Arithmetic mismatch negativity and numerical magnitude processing in number matching.

    abstract:BACKGROUND:This study examined the relationship of the arithmetic mismatch negativity (AMN) and the semantic evaluation of numerical magnitude. The first question was whether the AMN was sensitive to the incongruity in numerical information per se, or rather, to the violation of strategic expectations. The second quest...

    journal_title:BMC neuroscience

    pub_type: 杂志文章


    authors: Hsu YF,Szücs D

    更新日期:2011-08-11 00:00:00

  • Chemotherapy-induced cognitive impairment is associated with decreases in cell proliferation and histone modifications.

    abstract:BACKGROUND:In this study, we examined the effects of cyclophosphamide, methothrexate, and 5-Fluorouracil (CMF) drug combination on various aspects of learning and memory. We also examined the effects of CMF on cell proliferation and chromatin remodeling as possible underlying mechanisms to explain chemotherapy-associat...

    journal_title:BMC neuroscience

    pub_type: 杂志文章


    authors: Briones TL,Woods J

    更新日期:2011-12-09 00:00:00

  • Behavioral effects of ketamine and toxic interactions with psychostimulants.

    abstract:BACKGROUND:The anesthetic drug ketamine (KT) has been reported to be an abused drug and fatal cases have been observed in polydrug users. In the present study, considering the possibility of KT-enhanced toxic effects of other drugs, and KT-induced promotion of an overdose without making the subject aware of the danger ...

    journal_title:BMC neuroscience

    pub_type: 杂志文章


    authors: Hayase T,Yamamoto Y,Yamamoto K

    更新日期:2006-03-16 00:00:00

  • Kuramoto model simulation of neural hubs and dynamic synchrony in the human cerebral connectome.

    abstract:BACKGROUND:The topological structure of the wiring of the mammalian brain cortex plays an important role in shaping the functional dynamics of large-scale neural activity. Due to their central embedding in the network, high degree hub regions and their connections (often referred to as the 'rich club') have been hypoth...

    journal_title:BMC neuroscience

    pub_type: 杂志文章


    authors: Schmidt R,LaFleur KJ,de Reus MA,van den Berg LH,van den Heuvel MP

    更新日期:2015-09-02 00:00:00

  • Acupuncture regulates the glucose metabolism in cerebral functional regions in chronic stage ischemic stroke patients--a PET-CT cerebral functional imaging study.

    abstract:BACKGROUND:Acupuncture has been applied to aid in the recovery of post-stroke patients, but its mechanism is unclear. This study aims to analyze the relationship between acupuncture and glucose metabolism in cerebral functional regions in post-stroke patients using (18)FDG PET-CT techniques. Forty-three ischemic stroke...

    journal_title:BMC neuroscience

    pub_type: 杂志文章,随机对照试验


    authors: Huang Y,Tang C,Wang S,Lu Y,Shen W,Yang J,Chen J,Lin R,Cui S,Xiao H,Qu S,Lai X,Shan B

    更新日期:2012-06-27 00:00:00

  • Stage effects of negative emotion on spatial and verbal working memory.

    abstract:BACKGROUND:The effects of negative emotion on different processing periods in spatial and verbal working memory (WM) and the possible brain mechanism of the interaction between negative emotion and WM were explored using a high-time resolution event-related potential (ERP) technique and time-locked delayed matching-to-...

    journal_title:BMC neuroscience

    pub_type: 杂志文章


    authors: Li X,Chan RC,Luo YJ

    更新日期:2010-05-07 00:00:00

  • NKCC1 downregulation induces hyperpolarizing shift of GABA responsiveness at near term fetal stages in rat cultured dorsal root ganglion neurons.

    abstract:BACKGROUND:GABAA receptor-mediated neurotransmission is greatly influenced by cation-chloride cotransporter activity during developmental stages. In embryonic neurons Na-K-2Cl (NKCC1) cotransporters mediate active chloride uptake, thus increasing the intracellular chloride concentration associated with GABA-induced dep...

    journal_title:BMC neuroscience

    pub_type: 杂志文章


    authors: Chabwine JN,Talavera K,Van Den Bosch L,Callewaert G

    更新日期:2015-07-14 00:00:00

  • proNGF/NGF mixtures induce gene expression changes in PC12 cells that neither singly produces.

    abstract:BACKGROUND:Growing evidence shows that, in vivo, the precursor of Nerve Growth Factor (NGF), proNGF, displays biological activities different from those of its mature NGF counterpart, mediated by distinct, and somewhat complementary, receptor binding properties. NGF and proNGF induce distinct transcriptional signatures...

    journal_title:BMC neuroscience

    pub_type: 杂志文章


    authors: Arisi I,D'Onofrio M,Brandi R,Malerba F,Paoletti F,Storti AE,Florenzano F,Fasulo L,Cattaneo A

    更新日期:2014-04-08 00:00:00

  • Spatial distribution of Na+-K+-ATPase in dendritic spines dissected by nanoscale superresolution STED microscopy.

    abstract:BACKGROUND:The Na+,K+-ATPase plays an important role for ion homeostasis in virtually all mammalian cells, including neurons. Despite this, there is as yet little known about the isoform specific distribution in neurons. RESULTS:With help of superresolving stimulated emission depletion microscopy the spatial distribut...

    journal_title:BMC neuroscience

    pub_type: 杂志文章


    authors: Blom H,Rönnlund D,Scott L,Spicarova Z,Widengren J,Bondar A,Aperia A,Brismar H

    更新日期:2011-01-27 00:00:00

  • Quantitative genome-wide association analyses of receptive language in the Danish High Risk and Resilience Study.

    abstract:BACKGROUND:One of the most basic human traits is language. Linguistic ability, and disability, have been shown to have a strong genetic component in family and twin studies, but molecular genetic studies of language phenotypes are scarce, relative to studies of other cognitive traits and neurodevelopmental phenotypes. ...

    journal_title:BMC neuroscience

    pub_type: 杂志文章


    authors: Nudel R,Christiani CAJ,Ohland J,Uddin MJ,Hemager N,Ellersgaard D,Spang KS,Burton BK,Greve AN,Gantriis DL,Bybjerg-Grauholm J,Jepsen JRM,Thorup AAE,Mors O,Werge T,Nordentoft M

    更新日期:2020-07-07 00:00:00

  • Maxillary nerve compression in cynomolgus monkey Macaca fascicularis: altered somatic sensation and peripheral nerve firing.

    abstract:BACKGROUND:Trigeminal nerve is a major source of the sensory input of the face, and trigeminal neuropathology models have been reported in rodents with injury to branches of the maxillary or mandibular division of the trigeminal nerve. Non-human primates are neuroanatomically more closely related to human than rodents;...

    journal_title:BMC neuroscience

    pub_type: 杂志文章


    authors: Guo N,Gu X,Zhao J,Zhao G,Jin M,Zou H,Zhang Y,Zhao Z,Jin GJ,Yu L

    更新日期:2012-12-13 00:00:00