Elevated intracellular chloride level in albino visual cortex neurons is mediated by Na-K-Cl co-transporter.

abstract：BACKGROUND:Cholecystokinin octapeptide (CCK-8), the most potent endogenous anti-opioid peptide, has been shown to regulate the processes of morphine dependence. In our previous study, we found that exogenous CCK-8 attenuated naloxone induced withdrawal symptoms. To investigate the precise effect of exogenous CCK-8 and ...

journal_title：BMC neuroscience

authors： Wen D,Ma CL,Zhang YJ,Meng YX,Ni ZY,Li SJ,Cong B

更新日期：2012-06-08 00:00:00

abstract：BACKGROUND:CNS injury including stroke, infection, and tumor growth lead to astrogliosis, a process that involves upregulation of glial fibrillary acidic protein (GFAP) in astrocytes. However, the kinetics of astrogliosis that is related to these insults (i.e. tumor) is largely unknown. RESULTS:Using transgenic mice e...

journal_title：BMC neuroscience

authors： Lee J,Borboa AK,Baird A,Eliceiri BP

更新日期：2011-01-19 00:00:00

abstract：BACKGROUND:The Pde6brd1 (Rd1) mouse is widely used as a murine model for human retinitis pigmentosa. Understanding the spatio-temporal patterns of cone degeneration is important for evaluating potential treatments. In the present study we performed a systematic characterization of the spatio-temporal patterns of S- and...

journal_title：BMC neuroscience

authors： Narayan DS,Ao J,Wood JPM,Casson RJ,Chidlow G

更新日期：2019-09-03 00:00:00

abstract：BACKGROUND:Errorless learning has advantages over errorful learning. The erroneous items produced during errorful learning compete with correct items at retrieval resulting in decreased memory performance. This interference is associated with an increased demand on executive monitoring processes. Event-related function...

journal_title：BMC neuroscience

authors： Hammer A,Tempelmann C,Münte TF

更新日期：2013-03-13 00:00:00

abstract：BACKGROUND:Protein aggregation plays important roles in several neurodegenerative disorders. For instance, insoluble aggregates of phosphorylated tau and of Aβ peptides are cornerstones in the pathology of Alzheimer's disease. Soluble protein aggregates are therefore potential diagnostic and prognostic biomarkers for t...

journal_title：BMC neuroscience

authors： Kamali-Moghaddam M,Pettersson FE,Wu D,Englund H,Darmanis S,Lord A,Tavoosidana G,Sehlin D,Gustafsdottir S,Nilsson LN,Lannfelt L,Landegren U

更新日期：2010-10-05 00:00:00

abstract：BACKGROUND:Nitric oxide (NO) is a multifunctional molecule synthesized by three isozymes of the NO synthase (NOSs) acting as a messenger/modulator and/or a potential neurotoxin. In rodents, the role of NOSs in sleep processes and throughout aging is now well established. For example, sleep parameters are highly deterio...

journal_title：BMC neuroscience

authors： Colas D,Gharib A,Bezin L,Morales A,Guidon G,Cespuglio R,Sarda N

更新日期：2006-12-21 00:00:00

abstract：BACKGROUND:Mitochondrial DNA (mtDNA) mutations, which are present in all mitochondria-containing cells, paradoxically cause tissue-specific disease. For example, Leber's hereditary optic neuropathy (LHON) results from one of three point mutations mtDNA coding for complex I components, but is only manifested in retinal ...

journal_title：BMC neuroscience

authors： Hoegger MJ,Lieven CJ,Levin LA

更新日期：2008-01-08 00:00:00

abstract：BACKGROUND:Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the selective loss of motor neurons (MN) in the brain stem and spinal cord. Intracellular disruptions of cytosolic and mitochondrial calcium have been associated with selective MN degeneration, but the underlying mecha...

journal_title：BMC neuroscience

authors： Jaiswal MK,Zech WD,Goos M,Leutbecher C,Ferri A,Zippelius A,Carrì MT,Nau R,Keller BU

更新日期：2009-06-22 00:00:00

abstract：BACKGROUND:Accumulating evidence suggests that glial signalling is activated by different brain functions. However, knowledge regarding molecular mechanisms of activation or their relation to neuronal activity is limited. The purpose of the present study is to identify the characteristics of ATP-evoked glial signalling...

journal_title：BMC neuroscience

authors： Molnár T,Dobolyi A,Nyitrai G,Barabás P,Héja L,Emri Z,Palkovits M,Kardos J

更新日期：2011-10-03 00:00:00

abstract：BACKGROUND:Alzheimer's disease (AD) is a progressive neuro-degenerative disease with a major manifestation of dementia. MicroRNAs were reported to regulate the transcript expression in patients with Alzheimer's disease (AD). In this study, we investigated the roles of miR-138, a brain-enriched miRNA, in the AD cell mod...

journal_title：BMC neuroscience

authors： Miao J,Jing J,Shao Y,Sun H

更新日期：2020-07-31 00:00:00

abstract：BACKGROUND:Impaired speech perception is one of the major sequelae of aging. In addition to peripheral hearing loss, central deficits of auditory processing are supposed to contribute to the deterioration of speech perception in older individuals. To test the hypothesis that auditory temporal processing is compromised ...

journal_title：BMC neuroscience

authors： Sörös P,Teismann IK,Manemann E,Lütkenhöner B

更新日期：2009-04-07 00:00:00

abstract：BACKGROUND:In rodents, dietary Na+ deprivation reduces gustatory responses of primary taste fibers and central taste neurons to lingual Na+ stimulation. However, in the rat taste bud cells Na+ deprivation increases the number of amiloride sensitive epithelial Na+ channels (ENaC), which are considered as the "receptor" ...

journal_title：BMC neuroscience

authors： Huang T,Stähler F

更新日期：2009-03-12 00:00:00

abstract：BACKGROUND:Alzheimer's disease (AD) is the most prevalent form of dementia and represents one of the highest unmet requirements in medicine today. There is shortage of novel molecules entering into market because of poor pharmacokinetic properties and safety issues. Drug repurposing offers an opportunity to reinvigorat...

journal_title：BMC neuroscience

authors： Kumar S,Chowdhury S,Kumar S

更新日期：2017-10-27 00:00:00

abstract：BACKGROUND:Yawning is a stereotyped behavior that enhances blood flow to the skull, and the resulting counterflow has been hypothesized as a mechanism for brain cooling. Studies have shown that yawns are strongly associated with physiological and pathological conditions that increase brain temperature, and that they ar...

journal_title：BMC neuroscience

authors： Eguibar JR,Uribe CA,Cortes C,Bautista A,Gallup AC

更新日期：2017-01-03 00:00:00

abstract：BACKGROUND:Neurogenesis continues to occur throughout life but dramatically decreases with increasing age. This decrease is mostly related to a decline in proliferative activity as a result of an impoverishment of the microenvironment of the aged brain, including a reduction in trophic factors and increased inflammatio...

journal_title：BMC neuroscience

authors： Bachstetter AD,Pabon MM,Cole MJ,Hudson CE,Sanberg PR,Willing AE,Bickford PC,Gemma C

更新日期：2008-02-14 00:00:00

abstract：BACKGROUND:Rett syndrome (RTT, MIM #312750) is a severe neurological disorder caused by mutations in the X-linked methyl-CpG binding protein 2 (MECP2) gene. Female patients are affected with an incidence of 1/15000 live births and develop normally from birth to 6-18 months of age before the onset of deficits in autonom...

journal_title：BMC neuroscience

authors： Panayotis N,Ghata A,Villard L,Roux JC

更新日期：2011-05-24 00:00:00

abstract：BACKGROUND:How living neural networks retain information is still incompletely understood. Two prominent ideas on this topic have developed in parallel, but have remained somewhat unconnected. The first of these, the "synaptic hypothesis," holds that information can be retained in synaptic connection strengths, or weig...

journal_title：BMC neuroscience

authors： Chen W,Hobbs JP,Tang A,Beggs JM

更新日期：2010-01-06 00:00:00

abstract：BACKGROUND:Recent discoveries suggest that arealization of the mammalian cortical sheet develops in a manner consonant with principles established for embryonic patterning of the body. Signaling centers release morphogens that determine regional growth and tissue identity by regulating regional expression of transcript...

journal_title：BMC neuroscience

authors： Airey DC,Robbins AI,Enzinger KM,Wu F,Collins CE

更新日期：2005-03-17 00:00:00

abstract：BACKGROUND:Functional magnetic resonance imaging (fMRI) in white matter has long been considered controversial. Recently, this viewpoint has been challenged by an emerging body of evidence demonstrating white matter activation in the corpus callosum. The current study aimed to determine whether white matter activation ...

journal_title：BMC neuroscience

authors： Gawryluk JR,Mazerolle EL,Brewer KD,Beyea SD,D'Arcy RC

更新日期：2011-06-14 00:00:00

abstract：BACKGROUND:The megencephaly mouse, mceph/mceph, is epileptic and displays a dramatically increased brain volume and neuronal count. The responsible mutation was recently revealed to be an eleven base pair deletion, leading to a frame shift, in the gene encoding the potassium channel Kv1.1. The predicted MCEPH protein i...

journal_title：BMC neuroscience

authors： Persson AS,Klement G,Almgren M,Sahlholm K,Nilsson J,Petersson S,Arhem P,Schalling M,Lavebratt C

更新日期：2005-11-23 00:00:00

abstract：BACKGROUND:Human neural stem cells (hNSC) have the potential to provide novel cell-based therapies for neurodegenerative conditions such as multiple sclerosis and Parkinson's disease. In order to realise this goal, protocols need to be developed that allow for large quantities of hNSC to be cultured efficiently. As suc...

journal_title：BMC neuroscience

authors： Hall PE,Lathia JD,Caldwell MA,Ffrench-Constant C

更新日期：2008-07-23 00:00:00

abstract：BACKGROUND:Gap junction proteins, connexins, are expressed in most endocrine and exocrine glands in the body and are at least in some glands crucial for the hormonal secretion. To what extent connexins are expressed in neurons releasing hormones or neuropeptides from or within the central nervous system is, however, un...

journal_title：BMC neuroscience

authors： Westberg L,Sawa E,Wang AY,Gunaydin LA,Ribeiro AC,Pfaff DW

更新日期：2009-04-30 00:00:00

abstract：BACKGROUND:Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative fatal disease that can affect the neurons of brain and spinal cord. ALS genetics has identified various genes to be associated with disease pathology. Oxidative stress induced bunina and lewy bodies formation can be regulated through the ...

journal_title：BMC neuroscience

authors： Pal S,Tiwari A,Sharma K,Sharma SK

更新日期：2020-10-09 00:00:00

abstract：BACKGROUND:Synaptic degeneration and accumulation of amyloid β-peptides (Aβ) are hallmarks of the Alzheimer diseased brain. Aβ is synaptotoxic and produced by sequential cleavage of the amyloid precursor protein (APP) by the β-secretase BACE1 and by γ-secretase. If APP is instead cleaved by the α-secretase ADAM10, Aβ w...

journal_title：BMC neuroscience

authors： Lundgren JL,Vandermeulen L,Sandebring-Matton A,Ahmed S,Winblad B,Di Luca M,Tjernberg LO,Marcello E,Frykman S

更新日期：2020-02-04 00:00:00

abstract：BACKGROUND:Glutamate gated postsynaptic receptors in the central nervous system (CNS) are essential for environmentally stimulated behaviours including learning and memory in both invertebrates and vertebrates. Though their genetics, biochemistry, physiology, and role in behaviour have been intensely studied in vitro a...

journal_title：BMC neuroscience

authors： Ryan TJ,Emes RD,Grant SG,Komiyama NH

更新日期：2008-01-15 00:00:00

abstract：BACKGROUND:Post-stroke hyperglycemia appears to be associated with poor outcome from stroke, greater mortality, and reduced functional recovery. Focal cerebral ischemia data support that neural stem cells (NSCs) play an important role in post-ischemic repair. Here we sought to evaluate the negative effects of hyperglyc...

journal_title：BMC neuroscience

authors： Chen J,Guo Y,Cheng W,Chen R,Liu T,Chen Z,Tan S

更新日期：2013-03-04 00:00:00

abstract：BACKGROUND:Better treatments for schizophrenia are urgently needed. The therapeutic use of the nitric oxide (NO)-donor sodium nitroprusside (SNP) in patients with schizophrenia has shown promising results. The role of NO in schizophrenia is still unclear, and NO modulation is unexplored in ketamine (KET) animal models ...

journal_title：BMC neuroscience

authors： Kandratavicius L,Balista PA,Wolf DC,Abrao J,Evora PR,Rodrigues AJ,Chaves C,Maia-de-Oliveira JP,Leite JP,Dursun SM,Baker GB,Guimaraes FS,Hallak JE

更新日期：2015-03-07 00:00:00

abstract：BACKGROUND:Glutamergic excitotoxicity has been shown to play a deleterious role in the pathophysiology of spinal cord injury (SCI). The aim of this study was to investigate the neuroprotective effect of dizocilpine maleate, MK801 (2 mg/Kg, 30 min and 6 hours after injury) in a mice model of SCI. The spinal cord trauma ...

journal_title：BMC neuroscience

authors： Esposito E,Paterniti I,Mazzon E,Genovese T,Galuppo M,Meli R,Bramanti P,Cuzzocrea S

更新日期：2011-04-14 00:00:00

abstract：BACKGROUND:The human inferior frontal junction area (IFJ) is critically involved in three main component processes of cognitive control (working memory, task switching and inhibitory control). As it overlaps with several areas in established anatomical labeling schemes, it is considered to be underreported as a functio...

journal_title：BMC neuroscience

authors： Sundermann B,Pfleiderer B

更新日期：2012-10-03 00:00:00

abstract：BACKGROUND:Several studies have shown that Stroop interference is stronger in children than in adults. However, in a standard Stroop paradigm, stimulus interference and response interference are confounded. The purpose of the present study was to determine whether interference at the stimulus level and the response lev...

journal_title：BMC neuroscience

authors： Jongen EM,Jonkman LM

更新日期：2008-09-05 00:00:00