Effects of nitric oxide-related compounds in the acute ketamine animal model of schizophrenia.

abstract：BACKGROUND:Emotional stimuli are preferentially processed compared to neutral ones. Measuring the magnetic resonance blood-oxygen level dependent (BOLD) response or EEG event-related potentials, this has also been demonstrated for emotional versus neutral words. However, it is currently unclear whether emotion effects ...

journal_title：BMC neuroscience

authors： Koban L,Ninck M,Li J,Gisler T,Kissler J

更新日期：2010-07-27 00:00:00

abstract：BACKGROUND:Cholecystokinin octapeptide (CCK-8), the most potent endogenous anti-opioid peptide, has been shown to regulate the processes of morphine dependence. In our previous study, we found that exogenous CCK-8 attenuated naloxone induced withdrawal symptoms. To investigate the precise effect of exogenous CCK-8 and ...

journal_title：BMC neuroscience

authors： Wen D,Ma CL,Zhang YJ,Meng YX,Ni ZY,Li SJ,Cong B

更新日期：2012-06-08 00:00:00

abstract：BACKGROUND:Early stages in the excitation cascade of Limulus photoreceptors are mediated by activation of Gq by rhodopsin, generation of inositol-1,4,5-trisphosphate by phospholipase-C and the release of Ca2+. At the end of the cascade, cGMP-gated channels open and generate the depolarizing receptor potential. A major ...

journal_title：BMC neuroscience

authors： Garger AV,Richard EA,Lisman JE

更新日期：2004-02-26 00:00:00

abstract：BACKGROUND:Glutamergic excitotoxicity has been shown to play a deleterious role in the pathophysiology of spinal cord injury (SCI). The aim of this study was to investigate the neuroprotective effect of dizocilpine maleate, MK801 (2 mg/Kg, 30 min and 6 hours after injury) in a mice model of SCI. The spinal cord trauma ...

journal_title：BMC neuroscience

authors： Esposito E,Paterniti I,Mazzon E,Genovese T,Galuppo M,Meli R,Bramanti P,Cuzzocrea S

更新日期：2011-04-14 00:00:00

abstract：BACKGROUND:One of the most promising options for treatment of stroke using adult stem cells are human umbilical cord blood (HUCB) cells that were already approved for therapeutic efficacy in vivo. However, complexity of animal models has thus far limited the understanding of beneficial cellular mechanisms. To address t...

journal_title：BMC neuroscience

authors： Hau S,Reich DM,Scholz M,Naumann W,Emmrich F,Kamprad M,Boltze J

更新日期：2008-02-29 00:00:00

abstract：BACKGROUND:Microglia, the resident immune cells of the central nervous system (CNS), have two distinct phenotypes in the developing brain: amoeboid form, known to be amoeboid microglial cells (AMC) and ramified form, known to be ramified microglial cells (RMC). The AMC are characterized by being proliferative, phagocyt...

journal_title：BMC neuroscience

authors： Parakalan R,Jiang B,Nimmi B,Janani M,Jayapal M,Lu J,Tay SS,Ling EA,Dheen ST

更新日期：2012-06-14 00:00:00

abstract：BACKGROUND:Granulocyte-macrophage colony stimulating factor (GM-CSF) is a hematopoietic growth factor involved in the generation of granulocytes, macrophages, and dendritic cells from hematopoietic progenitor cells. We have recently demonstrated that GM-CSF has anti-apoptotic functions on neurons, and is neuroprotectiv...

journal_title：BMC neuroscience

authors： Krüger C,Laage R,Pitzer C,Schäbitz WR,Schneider A

更新日期：2007-10-22 00:00:00

abstract：BACKGROUND:The human KALRN gene, which encodes a complex, multifunctional Rho GDP/GTP exchange factor, has been linked to cardiovascular disease, psychiatric disorders and neurodegeneration. Examination of existing Kalrn knockout mouse models has focused only on neuronal phenotypes. However, Kalirin was first identifie...

journal_title：BMC neuroscience

authors： Mandela P,Yankova M,Conti LH,Ma XM,Grady J,Eipper BA,Mains RE

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Cigarette smoking enhances the risk of stroke. However, the underlying molecular mechanisms are largely unknown. The present study established an in vivo rat secondhand cigarette smoking (SHS) model and examined the hypothesis that SHS upregulates endothelin receptors with increased cerebrovascular contracti...

journal_title：BMC neuroscience

authors： Cao L,Xu CB,Zhang Y,Cao YX,Edvinsson L

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:Huntington's disease (HD) is a neurodegenerative disorder predominantly affecting the cerebral cortex and striatum. Transgenic mice (R6/1 line), expressing a CAG repeat encoding an expanded polyglutamine tract in the N-terminus of the huntingtin protein, closely model HD. We have previously shown that enviro...

journal_title：BMC neuroscience

authors： van Dellen A,Cordery PM,Spires TL,Blakemore C,Hannan AJ

更新日期：2008-04-01 00:00:00

abstract：BACKGROUND:A delay in surgical nerve repair results in impaired nerve function in humans, but mechanisms behind the weakened nerve regeneration are not known. Activating transcription factor 3 (ATF3) increases the intrinsic growth state of injured neurons early after injury, but the role of long-term changes and their ...

journal_title：BMC neuroscience

authors： Saito H,Dahlin LB

更新日期：2008-09-18 00:00:00

abstract：BACKGROUND:Multi-sensory integration is necessary for organisms to discriminate different environmental stimuli and thus determine behavior. Caenorhabditis elegans has 12 pairs of amphid sensory neurons, which are involved in generating behaviors such as thermotaxis toward cultivation temperature, and chemotaxis toward...

journal_title：BMC neuroscience

authors： Adachi R,Osada H,Shingai R

更新日期：2008-11-01 00:00:00

abstract：BACKGROUND:Major depressive disorder is a prevalent disease that is inadequately treated with currently available interventions. Stress increases susceptibility to depression in patients and rodent models. Depression is also associated with aberrant activation of inflammation, such as increases in circulating levels of...

journal_title：BMC neuroscience

authors： Cheng Y,Jope RS,Beurel E

更新日期：2015-05-07 00:00:00

abstract：BACKGROUND:Trigeminal nerve is a major source of the sensory input of the face, and trigeminal neuropathology models have been reported in rodents with injury to branches of the maxillary or mandibular division of the trigeminal nerve. Non-human primates are neuroanatomically more closely related to human than rodents;...

journal_title：BMC neuroscience

authors： Guo N,Gu X,Zhao J,Zhao G,Jin M,Zou H,Zhang Y,Zhao Z,Jin GJ,Yu L

更新日期：2012-12-13 00:00:00

abstract：BACKGROUND:Subjective tinnitus is characterized by an auditory phantom perception in the absence of any physical sound source. Consequently, in a quiet environment, tinnitus patients differ from control participants because they constantly perceive a sound whereas controls do not. We hypothesized that this difference i...

journal_title：BMC neuroscience

authors： Schlee W,Hartmann T,Langguth B,Weisz N

更新日期：2009-02-19 00:00:00

abstract：BACKGROUND:Recent evidence has suggested that Alzheimer's disease (AD)-associated neuronal loss may occur via the caspase-independent route of programmed cell death (PCD) in addition to caspase-dependent mechanisms. However, the brain region specificity of caspase-independent PCD in AD-associated neurodegeneration is u...

journal_title：BMC neuroscience

authors： Yu W,Bonnet M,Farso M,Ma K,Chabot JG,Martin E,Torriglia A,Guan Z,McLaurin J,Quirion R,Krantic S

更新日期：2014-06-10 00:00:00

abstract：BACKGROUND:Acupuncture has been applied to aid in the recovery of post-stroke patients, but its mechanism is unclear. This study aims to analyze the relationship between acupuncture and glucose metabolism in cerebral functional regions in post-stroke patients using (18)FDG PET-CT techniques. Forty-three ischemic stroke...

journal_title：BMC neuroscience

authors： Huang Y,Tang C,Wang S,Lu Y,Shen W,Yang J,Chen J,Lin R,Cui S,Xiao H,Qu S,Lai X,Shan B

更新日期：2012-06-27 00:00:00

abstract：BACKGROUND:Alzheimer's disease (AD) is the most prevalent form of dementia and represents one of the highest unmet requirements in medicine today. There is shortage of novel molecules entering into market because of poor pharmacokinetic properties and safety issues. Drug repurposing offers an opportunity to reinvigorat...

journal_title：BMC neuroscience

authors： Kumar S,Chowdhury S,Kumar S

更新日期：2017-10-27 00:00:00

abstract：BACKGROUND:Post-traumatic stress disorder (PTSD) is an anxious disorder associated with low levels of corticosterone and enhanced negative feedback of the hypothalamic-pituitary-adrenal (HPA) axis. Previous studies showed that the amygdala not only has an excitatory effect on the HPA axis but also plays a key role in f...

journal_title：BMC neuroscience

authors： Han F,Ding J,Shi Y

更新日期：2014-06-19 00:00:00

abstract：BACKGROUND:Anticipatory planning, the ability to anticipate future perceptual-motor demands of a goal-oriented action sequence, is essential for flexible, purposeful behavior. Once an action goal has been defined, movement details necessary to achieve that goal can be selected. Here, we investigate if anticipatory plan...

journal_title：BMC neuroscience

authors： Marangon M,Bucchioni G,Massacesi S,Castiello U

更新日期：2013-08-28 00:00:00

abstract：BACKGROUND:To identify mechanisms of cortical plasticity of the visual cortex and to quantify their significance, sensitive parameters are warranted. In this context, multifocal visual evoked potentials (mfVEPs) can make a valuable contribution as they are not associated with cancellation artifacts and include also the...

journal_title：BMC neuroscience

authors： Kolbe R,Aytulun A,Müller AK,Ringelstein M,Aktas O,Schnitzler A,Hartung HP,Groiss SJ,Albrecht P

更新日期：2020-11-23 00:00:00

abstract：BACKGROUND:Berberine is the major alkaloidal component of Rhizoma coptidis, and has multiple pharmacological effects including inhibiting acetylcholinesterase, reducing cholesterol and glucose, lowering mortality in patients with chronic congestive heart failure and anti-inflammation etc. Thus berberine is a promising ...

journal_title：BMC neuroscience

authors： Zhu F,Qian C

更新日期：2006-12-01 00:00:00

abstract：BACKGROUND:Growing evidence shows that, in vivo, the precursor of Nerve Growth Factor (NGF), proNGF, displays biological activities different from those of its mature NGF counterpart, mediated by distinct, and somewhat complementary, receptor binding properties. NGF and proNGF induce distinct transcriptional signatures...

journal_title：BMC neuroscience

authors： Arisi I,D'Onofrio M,Brandi R,Malerba F,Paoletti F,Storti AE,Florenzano F,Fasulo L,Cattaneo A

更新日期：2014-04-08 00:00:00

abstract：:Numerous molecular factors orchestrate the development of the peripheral taste system. The unique anatomy/function of the taste system makes this system ideal for understanding the mechanisms by which these factors function; yet the taste system is underutilized for this role. This review focuses on some of the many f...

journal_title：BMC neuroscience

authors： Krimm RF

更新日期：2007-09-18 00:00:00

abstract：BACKGROUND:Recent discoveries suggest that arealization of the mammalian cortical sheet develops in a manner consonant with principles established for embryonic patterning of the body. Signaling centers release morphogens that determine regional growth and tissue identity by regulating regional expression of transcript...

journal_title：BMC neuroscience

authors： Airey DC,Robbins AI,Enzinger KM,Wu F,Collins CE

更新日期：2005-03-17 00:00:00

abstract：:Recent research has demonstrated the suitability of adult zebrafish to model some aspects of complex behaviour. Studies of reward behaviour, learning and memory, aggression, anxiety and sleep strongly suggest that conserved regulatory processes underlie behaviour in zebrafish and mammals. The isolation and molecular a...

journal_title：BMC neuroscience

authors： Norton W,Bally-Cuif L

更新日期：2010-08-02 00:00:00

abstract：BACKGROUND:Huntington's disease (HD) is a progressive neurodegenerative disorder caused by a CAG repeat expansion mutation in the coding region of a novel gene. The mechanism of HD is unknown. Most data suggest that polyglutamine-mediated aggregation associated with expression of mutant huntingtin protein (mhtt) contri...

journal_title：BMC neuroscience

authors： Trushina E,Rana S,McMurray CT,Hua DH

更新日期：2009-07-08 00:00:00

abstract：BACKGROUND:Inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, known as statins, are commonly used as cholesterol-lowering drugs. During the past decade, evidence has emerged that statins also have neuroprotective effects. Research in the retina has shown that simvastatin, a commonly used statin, increases A...

journal_title：BMC neuroscience

authors： Brand Y,Setz C,Levano S,Listyo A,Chavez E,Pak K,Sung M,Radojevic V,Ryan AF,Bodmer D

更新日期：2011-11-14 00:00:00

abstract：BACKGROUND:Amyloid precursor protein (APP) is enzymatically cleaved by gamma-secretase to form two peptide products, either Abeta40 or the more neurotoxic Abeta42. The Abeta42/40 ratio is increased in many cases of familial Alzheimer's disease (FAD). The transmembrane domain (TM) of APP contains the known dimerization ...

journal_title：BMC neuroscience

authors： Gorman PM,Kim S,Guo M,Melnyk RA,McLaurin J,Fraser PE,Bowie JU,Chakrabartty A

更新日期：2008-01-30 00:00:00

abstract：BACKGROUND:Astaxanthin (ATX) is a carotenoid pigment with pleiotropic pharmacological properties that is seen as a possible drug for treating cerebral ischemic injury and subarachnoid hemorrhage. Na+-K+-2Cl- co-transporter-1 (NKCC1), an intrinsic membrane protein expressed by many cell types, is activated by various in...

journal_title：BMC neuroscience

authors： Zhang M,Cui Z,Cui H,Wang Y,Zhong C

更新日期：2017-05-10 00:00:00