Abstract:
BACKGROUND:Multi-sensory integration is necessary for organisms to discriminate different environmental stimuli and thus determine behavior. Caenorhabditis elegans has 12 pairs of amphid sensory neurons, which are involved in generating behaviors such as thermotaxis toward cultivation temperature, and chemotaxis toward chemical stimuli. This arrangement of known sensory neurons and measurable behavioral output makes C. elegans suitable for addressing questions of multi-sensory integration in the nervous system. Previous studies have suggested that C. elegans can process different chemoattractants simultaneously. However, little is known about how these organisms can integrate information from stimuli of different modality, such as thermal and chemical stimuli. RESULTS:We studied the behavior of a population of C. elegans during simultaneous presentation of thermal and chemical stimuli. First, we examined thermotaxis within the radial temperature gradient produced by a feedback-controlled thermoregulator. Separately, we examined chemotaxis toward sodium chloride or isoamyl alcohol. Then, assays for simultaneous presentations of 15 degrees C (colder temperature than 20 degrees C room temperature) and chemoattractant were performed with 15 degrees C-cultivated wild-type worms. Unlike the sum of behavioral indices for each separate behavior, simultaneous presentation resulted in a biased migration to cold regions in the first 10 min of the assay, and sodium chloride-regions in the last 40 min. However, when sodium chloride was replaced with isoamyl alcohol in the simultaneous presentation, the behavioral index was very similar to the sum of separate single presentation indices. We then recorded tracks of single worms and analyzed their behavior. For behavior toward sodium chloride, frequencies of forward and backward movements in simultaneous presentation were significantly different from those in single presentation. Also, migration toward 15 degrees C in simultaneous presentation was faster than that in 15 degrees C-single presentation. CONCLUSION:We conclude that worms preferred temperature to chemoattractant at first, but preferred the chemoattractant sodium chloride thereafter. This preference was not seen for isoamyl alcohol presentation. We attribute this phase-dependent preference to the result of integration of thermosensory and chemosensory signals received by distinct sensory neurons.
journal_name
BMC Neuroscijournal_title
BMC neuroscienceauthors
Adachi R,Osada H,Shingai Rdoi
10.1186/1471-2202-9-106subject
Has Abstractpub_date
2008-11-01 00:00:00pages
106issn
1471-2202pii
1471-2202-9-106journal_volume
9pub_type
杂志文章相关文献
BMC NEUROSCIENCE文献大全abstract:BACKGROUND:Niemann-Pick type C1 (NPC1) disease is an inherited lysosomal storage disease caused by mutation of the Npc1 gene, resulting in a progressive accumulation of unesterified cholesterol and glycolipids in lysosomes of multiple tissues and leading to neurodegeneration and other disease. In Npc1 mutant mice, reti...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-014-0126-2
更新日期:2014-11-29 00:00:00
abstract:BACKGROUND:Histone deacetylases (HDACs) are enzymes that modulate gene expression and cellular processes by deacetylating histones and non-histone proteins. While small molecule inhibitors of HDAC activity (HDACi) are used clinically in the treatment of cancer, pre-clinical treatment models suggest they also exert neur...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-12-50
更新日期:2011-05-26 00:00:00
abstract:BACKGROUND:10 Hz electroencephalographic (EEG) alpha rhythms correlate with memory performance. Alpha and memory decline in older people. We wished to test if alpha-like EEG activity contributes to memory formation. Flicker can elicit alpha-like EEG activity. We tested if alpha-frequency flicker enhances memory in olde...
journal_title:BMC neuroscience
pub_type: 临床试验,杂志文章
doi:10.1186/1471-2202-7-21
更新日期:2006-03-05 00:00:00
abstract:BACKGROUND:We have recorded responses from single neurons in murine visual cortex to determine the effectiveness of the input from the two murine cone photoreceptor mechanisms and whether there is any unique selectivity for cone inputs at this higher region of the visual system that would support the possibility of col...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-9-113
更新日期:2008-11-14 00:00:00
abstract:BACKGROUND:The Na+,K+-ATPase plays an important role for ion homeostasis in virtually all mammalian cells, including neurons. Despite this, there is as yet little known about the isoform specific distribution in neurons. RESULTS:With help of superresolving stimulated emission depletion microscopy the spatial distribut...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-12-16
更新日期:2011-01-27 00:00:00
abstract:BACKGROUND:Opioid agonist drugs produce analgesia. However, long-term exposure to opioid agonists may lead to opioid dependence. The analgesic and addictive properties of opioid agonist drugs are mediated primarily via the mu-opioid receptor (MOR). Opioid agonists appear to alter neuronal morphology in key brain region...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-11-33
更新日期:2010-03-09 00:00:00
abstract::Numerous molecular factors orchestrate the development of the peripheral taste system. The unique anatomy/function of the taste system makes this system ideal for understanding the mechanisms by which these factors function; yet the taste system is underutilized for this role. This review focuses on some of the many f...
journal_title:BMC neuroscience
pub_type: 杂志文章,评审
doi:10.1186/1471-2202-8-S3-S4
更新日期:2007-09-18 00:00:00
abstract:INTRODUCTION:NAP (Asn-Ala-Pro-Val-Ser-Ile-Pro-Gln, single amino acid letter code, NAPVSIPQ), an eight amino acid neuroprotective peptide derived from activity-dependent neuroprotective protein (ADNP), exhibits some structural similarity to activity-dependent neurotropic factor-9 (ADNF-9; Ser-Alal-Leu-Leu-Arg-Ser-Ile-Pr...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-9-S3-S3
更新日期:2008-12-10 00:00:00
abstract:BACKGROUND:Polymorphisms in the gene for phosphatidylinositol binding clathrin assembly protein (PICALM), an endocytic-related protein, are associated with a small, increased risk of developing Alzheimer's disease (AD), strongly suggesting that changes in endocytosis are involved in the aetiology of the disease. We hav...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-016-0288-1
更新日期:2016-07-18 00:00:00
abstract:BACKGROUND:The megencephaly mouse, mceph/mceph, is epileptic and displays a dramatically increased brain volume and neuronal count. The responsible mutation was recently revealed to be an eleven base pair deletion, leading to a frame shift, in the gene encoding the potassium channel Kv1.1. The predicted MCEPH protein i...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-6-65
更新日期:2005-11-23 00:00:00
abstract:BACKGROUND:Agmatine is an endogenous polyamine formed by the decarboxylation of L-arginine. We investigated the protective effects of agmatine against hypoxia-induced apoptosis of immortalized rat retinal ganglion cells (RGC-5). RGC-5 cells were cultured in a closed hypoxic chamber (5% O2) with or without agmatine. Cel...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-8-81
更新日期:2007-10-02 00:00:00
abstract:BACKGROUND:To identify mechanisms of cortical plasticity of the visual cortex and to quantify their significance, sensitive parameters are warranted. In this context, multifocal visual evoked potentials (mfVEPs) can make a valuable contribution as they are not associated with cancellation artifacts and include also the...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-020-00600-5
更新日期:2020-11-23 00:00:00
abstract:BACKGROUND:White matter hyperintensities (WMH) can lead to dementia but the underlying physiological mechanisms are unclear. We compared relative oscillatory power from electroencephalographic studies (EEGs) of 17 patients with subcortical ischemic vascular dementia, based on extensive white matter hyperintensities (SI...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-13-85
更新日期:2012-07-24 00:00:00
abstract:BACKGROUND:Multi-sensor technologies such as EEG, MEG, and ECoG result in high-dimensional data sets. Given the high temporal resolution of such techniques, scientific questions very often focus on the time-course of an experimental effect. In many studies, researchers focus on a single sensor or the average over a sub...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-14-122
更新日期:2013-10-14 00:00:00
abstract:BACKGROUND:Noise exposure (NE) is a severe modern health hazard that induces hearing impairment. However, the noise-induced ultrastructural changes of blood-labyrinth barrier (BLB) and the potential involvements of tight junction proteins (TJP) remain inconclusive. We investigated the effects of NE on not only the ultr...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-014-0136-0
更新日期:2014-12-24 00:00:00
abstract:BACKGROUND:In this study, we examined the effects of cyclophosphamide, methothrexate, and 5-Fluorouracil (CMF) drug combination on various aspects of learning and memory. We also examined the effects of CMF on cell proliferation and chromatin remodeling as possible underlying mechanisms to explain chemotherapy-associat...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-12-124
更新日期:2011-12-09 00:00:00
abstract:BACKGROUND:Acetylcholine receptors become aggregated at the developing neuromuscular synapse shortly after contact by a motorneuron in one of the earliest manifestations of synaptic development. While a major physiological signal for receptor aggregation (agrin) is known, the mechanism(s) by which muscle cells respond ...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-2-19
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:Impaired speech perception is one of the major sequelae of aging. In addition to peripheral hearing loss, central deficits of auditory processing are supposed to contribute to the deterioration of speech perception in older individuals. To test the hypothesis that auditory temporal processing is compromised ...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-10-34
更新日期:2009-04-07 00:00:00
abstract:BACKGROUND:Enhanced activity of trigeminal ganglion neurons is thought to underlie neuronal sensitization facilitating the onset of chronic pain attacks, including migraine. Recurrent headache attacks might establish a chronic neuroinflammatory ganglion profile contributing to the hypersensitive phenotype. Since it is ...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-13-143
更新日期:2012-11-21 00:00:00
abstract:BACKGROUND:The zitter (zi/zi) rat, a loss-of-function mutant of the glycosylated transmembrane protein attractin (atrn), exhibits widespread age-dependent spongiform degeneration, hypomyelination, and abnormal metabolism of reactive oxygen species (ROS) in the brain. To date, the mechanisms underlying these phenotypes ...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-9-35
更新日期:2008-04-05 00:00:00
abstract:BACKGROUND:CRISPR/Cas9 system is a powerful method to investigate the role of genes by introducing a mutation selectively and efficiently to specific genome positions in cell and animal lines. However, in primary neuron cultures, this method is affected by the issue that the effectiveness of CRISPR/Cas9 is different in...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-017-0377-9
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:Bone morphogenic proteins (BMPs) promote the survival of neurons, suggesting a therapeutic application of BMPs in the treatment of acute and chronic neurodegenerative disorders. However, the application of recombinant BMPs in vivo is limited by their short half-life. To provide a continuous supply for functi...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-15-38
更新日期:2014-03-11 00:00:00
abstract:BACKGROUND:Precise control of developmental and cell-specific expression of the brain-derived neurotrophic factor (BDNF) gene is essential for normal neuronal development and the diverse functions of BDNF in the adult organism. We previously showed that the zebrafish BDNF gene has multiple promoters. The complexity of ...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-5-19
更新日期:2004-05-21 00:00:00
abstract:BACKGROUND:We previously described planar areal differences in adult mouse visual, somatosensory, and neocortex that collectively discriminated C57BL/6J and DBA/2J inbred strain identity. Here we use a novel application of established methods of two-dimensional geometric morphometrics to examine shape differences in th...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-7-63
更新日期:2006-09-15 00:00:00
abstract:BACKGROUND:To examine which language function depends on early experience, the present study compared deaf native signers, deaf non-native signers and hearing German native speakers while processing German sentences. The participants watched simple written sentences while event-related potentials (ERPs) were recorded. ...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-13-44
更新日期:2012-05-03 00:00:00
abstract:BACKGROUND:Transcranial focused ultrasound (tFUS) is a new non-invasive neuromodulation technique that uses mechanical energy to modulate neuronal excitability with high spatial precision. tFUS has been shown to be capable of modulating EEG brain activity in humans that is spatially restricted, and here, we use 7T MRI ...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-018-0456-6
更新日期:2018-09-14 00:00:00
abstract:BACKGROUND:Mental imagery is a powerful method of altering brain activity and behavioral outcomes, such as performance of cognition and motor skills. Further, attention and distraction can modulate pain-related neuronal networks and the perception of pain. This exploratory study examined the effects of mental imagery-i...
journal_title:BMC neuroscience
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12868-015-0146-6
更新日期:2015-03-15 00:00:00
abstract:BACKGROUND:Granulocyte-macrophage colony stimulating factor (GM-CSF) is a hematopoietic growth factor involved in the generation of granulocytes, macrophages, and dendritic cells from hematopoietic progenitor cells. We have recently demonstrated that GM-CSF has anti-apoptotic functions on neurons, and is neuroprotectiv...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-8-88
更新日期:2007-10-22 00:00:00
abstract:BACKGROUND:Accumulating evidence suggests that glial signalling is activated by different brain functions. However, knowledge regarding molecular mechanisms of activation or their relation to neuronal activity is limited. The purpose of the present study is to identify the characteristics of ATP-evoked glial signalling...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-12-96
更新日期:2011-10-03 00:00:00
abstract:BACKGROUND:Myzus persicae is a globally important aphid pest with a history of developing resistance to insecticides. Unusually, neonicotinoids have remained highly effective as control agents despite nearly two decades of steadily increasing use. In this study, a clone of M. persicae collected from southern France was...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-12-51
更新日期:2011-05-31 00:00:00