Mutation of a nicotinic acetylcholine receptor β subunit is associated with resistance to neonicotinoid insecticides in the aphid Myzus persicae.

Abstract:

BACKGROUND:Myzus persicae is a globally important aphid pest with a history of developing resistance to insecticides. Unusually, neonicotinoids have remained highly effective as control agents despite nearly two decades of steadily increasing use. In this study, a clone of M. persicae collected from southern France was found, for the first time, to exhibit sufficiently strong resistance to result in loss of the field effectiveness of neonicotinoids. RESULTS:Bioassays, metabolism and gene expression studies implied the presence of two resistance mechanisms in the resistant clone, one based on enhanced detoxification by cytochrome P450 monooxygenases, and another unaffected by a synergist that inhibits detoxifying enzymes. Binding of radiolabeled imidacloprid (a neonicotinoid) to whole body membrane preparations showed that the high affinity [3H]-imidacloprid binding site present in susceptible M. persicae is lost in the resistant clone and the remaining lower affinity site is altered compared to susceptible clones. This confers a significant overall reduction in binding affinity to the neonicotinoid target: the nicotinic acetylcholine receptor (nAChR). Comparison of the nucleotide sequence of six nAChR subunit (Mpα1-5 and Mpβ1) genes from resistant and susceptible aphid clones revealed a single point mutation in the loop D region of the nAChR β1 subunit of the resistant clone, causing an arginine to threonine substitution (R81T). CONCLUSION:Previous studies have shown that the amino acid at this position within loop D is a key determinant of neonicotinoid binding to nAChRs and this amino acid change confers a vertebrate-like character to the insect nAChR receptor and results in reduced sensitivity to neonicotinoids. The discovery of the mutation at this position and its association with the reduced affinity of the nAChR for imidacloprid is the first example of field-evolved target-site resistance to neonicotinoid insecticides and also provides further validation of exisiting models of neonicotinoid binding and selectivity for insect nAChRs.

journal_name

BMC Neurosci

journal_title

BMC neuroscience

authors

Bass C,Puinean AM,Andrews M,Cutler P,Daniels M,Elias J,Paul VL,Crossthwaite AJ,Denholm I,Field LM,Foster SP,Lind R,Williamson MS,Slater R

doi

10.1186/1471-2202-12-51

subject

Has Abstract

pub_date

2011-05-31 00:00:00

pages

51

issn

1471-2202

pii

1471-2202-12-51

journal_volume

12

pub_type

杂志文章
  • Amyloid-β plaque formation and reactive gliosis are required for induction of cognitive deficits in App knock-in mouse models of Alzheimer's disease.

    abstract:BACKGROUND:Knock-in (KI) mouse models of Alzheimer's disease (AD) that endogenously overproduce Aβ without non-physiological overexpression of amyloid precursor protein (APP) provide important insights into the pathogenic mechanisms of AD. Previously, we reported that AppNL-G-F mice, which harbor three familial AD muta...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/s12868-019-0496-6

    authors: Sakakibara Y,Sekiya M,Saito T,Saido TC,Iijima KM

    更新日期:2019-03-20 00:00:00

  • Callosal connections of dorsal versus ventral premotor areas in the macaque monkey: a multiple retrograde tracing study.

    abstract:BACKGROUND:The lateral premotor cortex plays a crucial role in visually guided limb movements. It is divided into two main regions, the dorsal (PMd) and ventral (PMv) areas, which are in turn subdivided into functionally and anatomically distinct rostral (PMd-r and PMv-r) and caudal (PMd-c and PMv-c) sub-regions. We an...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-6-67

    authors: Boussaoud D,Tanné-Gariépy J,Wannier T,Rouiller EM

    更新日期:2005-11-25 00:00:00

  • The BOLD response and the gamma oscillations respond differently than evoked potentials: an interleaved EEG-fMRI study.

    abstract:BACKGROUND:The integration of EEG and fMRI is attractive because of their complementary precision regarding time and space. But the relationship between the indirect hemodynamic fMRI signal and the more direct EEG signal is uncertain. Event-related EEG responses can be analyzed in two different ways, reflecting two dif...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-4-22

    authors: Foucher JR,Otzenberger H,Gounot D

    更新日期:2003-09-19 00:00:00

  • Inhibition of apoptosis in neuronal cells infected with Chlamydophila (Chlamydia) pneumoniae.

    abstract:BACKGROUND:Chlamydophila (Chlamydia) pneumoniae is an intracellular bacterium that has been identified within cells in areas of neuropathology found in Alzheimer disease (AD), including endothelia, glia, and neurons. Depending on the cell type of the host, infection by C. pneumoniae has been shown to influence apoptoti...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-9-13

    authors: Appelt DM,Roupas MR,Way DS,Bell MG,Albert EV,Hammond CJ,Balin BJ

    更新日期:2008-01-24 00:00:00

  • Recognition of face-name associations after errorless and errorful learning: an fMRI study.

    abstract:BACKGROUND:Errorless learning has advantages over errorful learning. The erroneous items produced during errorful learning compete with correct items at retrieval resulting in decreased memory performance. This interference is associated with an increased demand on executive monitoring processes. Event-related function...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-14-30

    authors: Hammer A,Tempelmann C,Münte TF

    更新日期:2013-03-13 00:00:00

  • Colocalization of connexin 36 and corticotropin-releasing hormone in the mouse brain.

    abstract:BACKGROUND:Gap junction proteins, connexins, are expressed in most endocrine and exocrine glands in the body and are at least in some glands crucial for the hormonal secretion. To what extent connexins are expressed in neurons releasing hormones or neuropeptides from or within the central nervous system is, however, un...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-10-41

    authors: Westberg L,Sawa E,Wang AY,Gunaydin LA,Ribeiro AC,Pfaff DW

    更新日期:2009-04-30 00:00:00

  • The expression of apoptosis inducing factor (AIF) is associated with aging-related cell death in the cortex but not in the hippocampus in the TgCRND8 mouse model of Alzheimer's disease.

    abstract:BACKGROUND:Recent evidence has suggested that Alzheimer's disease (AD)-associated neuronal loss may occur via the caspase-independent route of programmed cell death (PCD) in addition to caspase-dependent mechanisms. However, the brain region specificity of caspase-independent PCD in AD-associated neurodegeneration is u...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-15-73

    authors: Yu W,Bonnet M,Farso M,Ma K,Chabot JG,Martin E,Torriglia A,Guan Z,McLaurin J,Quirion R,Krantic S

    更新日期:2014-06-10 00:00:00

  • Ventral and dorsal streams processing visual motion perception (FDG-PET study).

    abstract:BACKGROUND:Earlier functional imaging studies on visually induced self-motion perception (vection) disclosed a bilateral network of activations within primary and secondary visual cortex areas which was combined with signal decreases, i.e., deactivations, in multisensory vestibular cortex areas. This finding led to the...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-13-81

    authors: Becker-Bense S,Buchholz HG,zu Eulenburg P,Best C,Bartenstein P,Schreckenberger M,Dieterich M

    更新日期:2012-07-16 00:00:00

  • Chronic nicotine pretreatment is sufficient to upregulate α4* nicotinic receptors and increase oral nicotine self-administration in mice.

    abstract:BACKGROUND:Understanding the underlying causes of nicotine addiction will require a multidisciplinary approach examining the key molecular, cellular and neuronal circuit functional changes that drive escalating levels of nicotine self-administration. In this study, we examined whether mice pretreated with chronic nicot...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-15-89

    authors: Renda A,Nashmi R

    更新日期:2014-07-19 00:00:00

  • Neuroprotective effects of edaravone-administration on 6-OHDA-treated dopaminergic neurons.

    abstract:BACKGROUND:Parkinson's disease (PD) is a neurological disorder characterized by the degeneration of nigrostriatal dopaminergic systems. Free radicals induced by oxidative stress are involved in the mechanisms of cell death in PD. This study clarifies the neuroprotective effects of edaravone (MCI-186, 3-methyl-1-phenyl-...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-9-75

    authors: Yuan WJ,Yasuhara T,Shingo T,Muraoka K,Agari T,Kameda M,Uozumi T,Tajiri N,Morimoto T,Jing M,Baba T,Wang F,Leung H,Matsui T,Miyoshi Y,Date I

    更新日期:2008-08-01 00:00:00

  • Tricyclic pyrone compounds prevent aggregation and reverse cellular phenotypes caused by expression of mutant huntingtin protein in striatal neurons.

    abstract:BACKGROUND:Huntington's disease (HD) is a progressive neurodegenerative disorder caused by a CAG repeat expansion mutation in the coding region of a novel gene. The mechanism of HD is unknown. Most data suggest that polyglutamine-mediated aggregation associated with expression of mutant huntingtin protein (mhtt) contri...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-10-73

    authors: Trushina E,Rana S,McMurray CT,Hua DH

    更新日期:2009-07-08 00:00:00

  • Simvastatin protects auditory hair cells from gentamicin-induced toxicity and activates Akt signaling in vitro.

    abstract:BACKGROUND:Inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, known as statins, are commonly used as cholesterol-lowering drugs. During the past decade, evidence has emerged that statins also have neuroprotective effects. Research in the retina has shown that simvastatin, a commonly used statin, increases A...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-12-114

    authors: Brand Y,Setz C,Levano S,Listyo A,Chavez E,Pak K,Sung M,Radojevic V,Ryan AF,Bodmer D

    更新日期:2011-11-14 00:00:00

  • Reducing multi-sensor data to a single time course that reveals experimental effects.

    abstract:BACKGROUND:Multi-sensor technologies such as EEG, MEG, and ECoG result in high-dimensional data sets. Given the high temporal resolution of such techniques, scientific questions very often focus on the time-course of an experimental effect. In many studies, researchers focus on a single sensor or the average over a sub...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-14-122

    authors: Schurger A,Marti S,Dehaene S

    更新日期:2013-10-14 00:00:00

  • A pre-conditioning stress accelerates increases in mouse plasma inflammatory cytokines induced by stress.

    abstract:BACKGROUND:Major depressive disorder is a prevalent disease that is inadequately treated with currently available interventions. Stress increases susceptibility to depression in patients and rodent models. Depression is also associated with aberrant activation of inflammation, such as increases in circulating levels of...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/s12868-015-0169-z

    authors: Cheng Y,Jope RS,Beurel E

    更新日期:2015-05-07 00:00:00

  • Behavioral effects of ketamine and toxic interactions with psychostimulants.

    abstract:BACKGROUND:The anesthetic drug ketamine (KT) has been reported to be an abused drug and fatal cases have been observed in polydrug users. In the present study, considering the possibility of KT-enhanced toxic effects of other drugs, and KT-induced promotion of an overdose without making the subject aware of the danger ...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-7-25

    authors: Hayase T,Yamamoto Y,Yamamoto K

    更新日期:2006-03-16 00:00:00

  • Relationship between ambient light and glucose metabolism in healthy subjects.

    abstract:BACKGROUND:Given the reported inverse association between light and depressive mood, ambient light may also be associated with some of the brain regions in healthy subjects. The present study aims to investigate the effects of ambient light on glucose metabolism in the brain. We used the data of 28 healthy participants...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/s12868-018-0444-x

    authors: Hirakawa H,Terao T,Hatano K,Kohno K,Ishii N

    更新日期:2018-07-24 00:00:00

  • High yield derivation of enriched glutamatergic neurons from suspension-cultured mouse ESCs for neurotoxicology research.

    abstract:BACKGROUND:Recently, there has been a strong emphasis on identifying an in vitro model for neurotoxicity research that combines the biological relevance of primary neurons with the scalability, reproducibility and genetic tractability of continuous cell lines. Derived neurons should be homotypic, exhibit neuron-specifi...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-13-127

    authors: Hubbard KS,Gut IM,Lyman ME,Tuznik KM,Mesngon MT,McNutt PM

    更新日期:2012-10-24 00:00:00

  • Docosahexaenoic fatty acid reduces the pro-inflammatory response induced by IL-1β in astrocytes through inhibition of NF-κB and AP-1 transcription factor activation.

    abstract:BACKGROUND:Astrocytes are responsible for a broad range of functions that maintain homeostasis in the brain. However, their response to the pro-inflammatory cytokines released by activated microglia in various neurological pathologies may exacerbate neurodegenerative processes. Accumulating evidence suggests that omega...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/s12868-021-00611-w

    authors: Zgórzyńska E,Stulczewski D,Dziedzic B,Su KP,Walczewska A

    更新日期:2021-01-27 00:00:00

  • Factors that regulate embryonic gustatory development.

    abstract::Numerous molecular factors orchestrate the development of the peripheral taste system. The unique anatomy/function of the taste system makes this system ideal for understanding the mechanisms by which these factors function; yet the taste system is underutilized for this role. This review focuses on some of the many f...

    journal_title:BMC neuroscience

    pub_type: 杂志文章,评审

    doi:10.1186/1471-2202-8-S3-S4

    authors: Krimm RF

    更新日期:2007-09-18 00:00:00

  • Arc protein expression after unilateral intracranial self-stimulation of the medial forebrain bundle is upregulated in specific nuclei of memory-related areas.

    abstract:BACKGROUND:Intracranial Self-Stimulation (ICSS) of the medial forebrain bundle (MFB) is a deep brain stimulation procedure, which has a powerful enhancement effect on explicit and implicit memory. However, the downstream synaptic plasticity events of MFB-ICSS in memory related areas have not been described thoroughly. ...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/s12868-018-0449-5

    authors: Kádár E,Varela EV,Aldavert-Vera L,Huguet G,Morgado-Bernal I,Segura-Torres P

    更新日期:2018-08-08 00:00:00

  • Looking for a pattern: an MEG study on the abstract mismatch negativity in musicians and nonmusicians.

    abstract:BACKGROUND:The mismatch negativity (MMN) is an early component of event-related potentials/fields, which can be observed in response to violations of regularities in sound sequences. The MMN can be elicited by simple feature (e.g. pitch) deviations in standard oddball paradigms as well as by violations of more complex ...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-10-42

    authors: Herholz SC,Lappe C,Pantev C

    更新日期:2009-04-30 00:00:00

  • Glomerular input patterns in the mouse olfactory bulb evoked by retronasal odor stimuli.

    abstract:BACKGROUND:Odorant stimuli can access the olfactory epithelium either orthonasally, by inhalation through the external nares, or retronasally by reverse airflow from the oral cavity. There is evidence that odors perceived through these two routes can differ in quality and intensity. We were curious whether such differe...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-14-45

    authors: Furudono Y,Cruz G,Lowe G

    更新日期:2013-04-08 00:00:00

  • Anti-PrPC monoclonal antibody infusion as a novel treatment for cognitive deficits in an Alzheimer's disease model mouse.

    abstract:BACKGROUND:Alzheimer's Disease (AD) is the most common of the conformational neurodegenerative disorders characterized by the conversion of a normal biological protein into a β-sheet-rich pathological isoform. In AD the normal soluble Aβ (sAβ) forms oligomers and fibrils which assemble into neuritic plaques. The most t...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-11-130

    authors: Chung E,Ji Y,Sun Y,Kascsak RJ,Kascsak RB,Mehta PD,Strittmatter SM,Wisniewski T

    更新日期:2010-10-14 00:00:00

  • A mathematical model provides mechanistic links to temporal patterns in Drosophila daily activity.

    abstract:BACKGROUND:Circadian clocks are endogenous biochemical oscillators that control daily behavioral rhythms in all living organisms. In fruit fly, the circadian rhythms are typically studied using power spectra of multiday behavioral recordings. Despite decades of study, a quantitative understanding of the temporal shape ...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/s12868-016-0248-9

    authors: Lazopulo A,Syed S

    更新日期:2016-04-18 00:00:00

  • Phase-dependent preference of thermosensation and chemosensation during simultaneous presentation assay in Caenorhabditis elegans.

    abstract:BACKGROUND:Multi-sensory integration is necessary for organisms to discriminate different environmental stimuli and thus determine behavior. Caenorhabditis elegans has 12 pairs of amphid sensory neurons, which are involved in generating behaviors such as thermotaxis toward cultivation temperature, and chemotaxis toward...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-9-106

    authors: Adachi R,Osada H,Shingai R

    更新日期:2008-11-01 00:00:00

  • Orienting asymmetries and lateralized processing of sounds in humans.

    abstract:BACKGROUND:Lateralized processing of speech is a well studied phenomenon in humans. Both anatomical and neurophysiological studies support the view that nonhuman primates and other animal species also reveal hemispheric differences in areas involved in sound processing. In recent years, an increasing number of studies ...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-10-14

    authors: Fischer J,Teufel C,Drolet M,Patzelt A,Rübsamen R,von Cramon DY,Schubotz RI

    更新日期:2009-02-24 00:00:00

  • Disturbed oscillatory brain dynamics in subcortical ischemic vascular dementia.

    abstract:BACKGROUND:White matter hyperintensities (WMH) can lead to dementia but the underlying physiological mechanisms are unclear. We compared relative oscillatory power from electroencephalographic studies (EEGs) of 17 patients with subcortical ischemic vascular dementia, based on extensive white matter hyperintensities (SI...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-13-85

    authors: van Straaten EC,de Haan W,de Waal H,Scheltens P,van der Flier WM,Barkhof F,Koene T,Stam CJ

    更新日期:2012-07-24 00:00:00

  • Noise alters guinea pig's blood-labyrinth barrier ultrastructure and permeability along with a decrease of cochlear Claudin-5 and Occludin.

    abstract:BACKGROUND:Noise exposure (NE) is a severe modern health hazard that induces hearing impairment. However, the noise-induced ultrastructural changes of blood-labyrinth barrier (BLB) and the potential involvements of tight junction proteins (TJP) remain inconclusive. We investigated the effects of NE on not only the ultr...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/s12868-014-0136-0

    authors: Wu YX,Zhu GX,Liu XQ,Sun F,Zhou K,Wang S,Wang CM,Jia JW,Song JT,Lu LJ

    更新日期:2014-12-24 00:00:00

  • Both 5' and 3' flanks regulate Zebrafish brain-derived neurotrophic factor gene expression.

    abstract:BACKGROUND:Precise control of developmental and cell-specific expression of the brain-derived neurotrophic factor (BDNF) gene is essential for normal neuronal development and the diverse functions of BDNF in the adult organism. We previously showed that the zebrafish BDNF gene has multiple promoters. The complexity of ...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-5-19

    authors: Heinrich G,Pagtakhan CJ

    更新日期:2004-05-21 00:00:00

  • Differential production of superoxide by neuronal mitochondria.

    abstract:BACKGROUND:Mitochondrial DNA (mtDNA) mutations, which are present in all mitochondria-containing cells, paradoxically cause tissue-specific disease. For example, Leber's hereditary optic neuropathy (LHON) results from one of three point mutations mtDNA coding for complex I components, but is only manifested in retinal ...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-9-4

    authors: Hoegger MJ,Lieven CJ,Levin LA

    更新日期:2008-01-08 00:00:00