Evidence for neuroprotective properties of human umbilical cord blood cells after neuronal hypoxia in vitro.

abstract：BACKGROUND:Amyloid precursor protein (APP) is enzymatically cleaved by gamma-secretase to form two peptide products, either Abeta40 or the more neurotoxic Abeta42. The Abeta42/40 ratio is increased in many cases of familial Alzheimer's disease (FAD). The transmembrane domain (TM) of APP contains the known dimerization ...

journal_title：BMC neuroscience

authors： Gorman PM,Kim S,Guo M,Melnyk RA,McLaurin J,Fraser PE,Bowie JU,Chakrabartty A

更新日期：2008-01-30 00:00:00

abstract：BACKGROUND:To determine whether early imitative responses fade out following the maturation of attentional mechanisms, the relationship between primitive imitation behaviors and the development of attention was examined in 4-month-old infants. They were divided into high and low imitators, based on an index of imitatio...

journal_title：BMC neuroscience

authors： Nakagawa A,Sukigara M,Benga O

更新日期：2003-12-24 00:00:00

abstract：BACKGROUND:Errorless learning has advantages over errorful learning. The erroneous items produced during errorful learning compete with correct items at retrieval resulting in decreased memory performance. This interference is associated with an increased demand on executive monitoring processes. Event-related function...

journal_title：BMC neuroscience

authors： Hammer A,Tempelmann C,Münte TF

更新日期：2013-03-13 00:00:00

abstract：BACKGROUND:White matter hyperintensities (WMH) can lead to dementia but the underlying physiological mechanisms are unclear. We compared relative oscillatory power from electroencephalographic studies (EEGs) of 17 patients with subcortical ischemic vascular dementia, based on extensive white matter hyperintensities (SI...

journal_title：BMC neuroscience

authors： van Straaten EC,de Haan W,de Waal H,Scheltens P,van der Flier WM,Barkhof F,Koene T,Stam CJ

更新日期：2012-07-24 00:00:00

abstract：BACKGROUND:The mismatch negativity (MMN) is an early component of event-related potentials/fields, which can be observed in response to violations of regularities in sound sequences. The MMN can be elicited by simple feature (e.g. pitch) deviations in standard oddball paradigms as well as by violations of more complex ...

journal_title：BMC neuroscience

authors： Herholz SC,Lappe C,Pantev C

更新日期：2009-04-30 00:00:00

abstract：BACKGROUND:The Na+,K+-ATPase plays an important role for ion homeostasis in virtually all mammalian cells, including neurons. Despite this, there is as yet little known about the isoform specific distribution in neurons. RESULTS:With help of superresolving stimulated emission depletion microscopy the spatial distribut...

journal_title：BMC neuroscience

authors： Blom H,Rönnlund D,Scott L,Spicarova Z,Widengren J,Bondar A,Aperia A,Brismar H

更新日期：2011-01-27 00:00:00

abstract：BACKGROUND:The anesthetic drug ketamine (KT) has been reported to be an abused drug and fatal cases have been observed in polydrug users. In the present study, considering the possibility of KT-enhanced toxic effects of other drugs, and KT-induced promotion of an overdose without making the subject aware of the danger ...

journal_title：BMC neuroscience

authors： Hayase T,Yamamoto Y,Yamamoto K

更新日期：2006-03-16 00:00:00

abstract：BACKGROUND:Alzheimer's disease (AD) is a progressive neuro-degenerative disease with a major manifestation of dementia. MicroRNAs were reported to regulate the transcript expression in patients with Alzheimer's disease (AD). In this study, we investigated the roles of miR-138, a brain-enriched miRNA, in the AD cell mod...

journal_title：BMC neuroscience

authors： Miao J,Jing J,Shao Y,Sun H

更新日期：2020-07-31 00:00:00

abstract：BACKGROUND:Recovery following stroke depends on cellular plasticity in the perilesional zone (PZ). Doublecortin (DCX), a protein mainly labeling immature neurons in neurogenic niches is also highly expressed in the vicinity of focal cortical infarcts. Notably, the number of DCX+ cells positively correlates with the rec...

journal_title：BMC neuroscience

authors： Kunze A,Achilles A,Keiner S,Witte OW,Redecker C

更新日期：2015-04-15 00:00:00

abstract：BACKGROUND:Gap junction proteins, connexins, are expressed in most endocrine and exocrine glands in the body and are at least in some glands crucial for the hormonal secretion. To what extent connexins are expressed in neurons releasing hormones or neuropeptides from or within the central nervous system is, however, un...

journal_title：BMC neuroscience

authors： Westberg L,Sawa E,Wang AY,Gunaydin LA,Ribeiro AC,Pfaff DW

更新日期：2009-04-30 00:00:00

abstract：BACKGROUND:Previous studies found that rats subjected to carrageenan injection develop hyperalgesia, and despite complete recovery in several days, they continue to have an enhanced hyperalgesic response to a new noxious challenge for more than 28d. The study's aim was to identify candidate genes that have a role in th...

journal_title：BMC neuroscience

authors： Yukhananov R,Kissin I

更新日期：2008-03-13 00:00:00

abstract：BACKGROUND:Recent studies have shown that the human right-hemispheric auditory cortex is particularly sensitive to reduction in sound quality, with an increase in distortion resulting in an amplification of the auditory N1m response measured in the magnetoencephalography (MEG). Here, we examined whether this sensitivit...

journal_title：BMC neuroscience

authors： Miettinen I,Tiitinen H,Alku P,May PJ

更新日期：2010-02-22 00:00:00

abstract：BACKGROUND:The effects induced by administering the anticonvulsant lamotrigine, the preferential inhibitor of neuronal nitric oxide synthase 7-nitroindazole and the precursor of NO synthesis L-arginine, alone or in combination, on an experimental model of partial complex seizures (maximal dentate gyrus activation) were...

journal_title：BMC neuroscience

authors： Sardo P,Ferraro G

更新日期：2007-07-03 00:00:00

abstract：BACKGROUND:Chlamydophila (Chlamydia) pneumoniae is an intracellular bacterium that has been identified within cells in areas of neuropathology found in Alzheimer disease (AD), including endothelia, glia, and neurons. Depending on the cell type of the host, infection by C. pneumoniae has been shown to influence apoptoti...

journal_title：BMC neuroscience

authors： Appelt DM,Roupas MR,Way DS,Bell MG,Albert EV,Hammond CJ,Balin BJ

更新日期：2008-01-24 00:00:00

abstract：BACKGROUND:Impaired speech perception is one of the major sequelae of aging. In addition to peripheral hearing loss, central deficits of auditory processing are supposed to contribute to the deterioration of speech perception in older individuals. To test the hypothesis that auditory temporal processing is compromised ...

journal_title：BMC neuroscience

authors： Sörös P,Teismann IK,Manemann E,Lütkenhöner B

更新日期：2009-04-07 00:00:00

abstract：BACKGROUND:CRISPR/Cas9 system is a powerful method to investigate the role of genes by introducing a mutation selectively and efficiently to specific genome positions in cell and animal lines. However, in primary neuron cultures, this method is affected by the issue that the effectiveness of CRISPR/Cas9 is different in...

journal_title：BMC neuroscience

authors： Tsunematsu H,Uyeda A,Yamamoto N,Sugo N

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:The GABAergic system plays an important role in modulating levels of anxiety. When transplanted into the brain, precursor cells from the medial ganglionic eminence (MGE) have the ability to differentiate into GABAergic interneurons and modify the inhibitory tone in the host brain. Currently, two methods have...

journal_title：BMC neuroscience

authors： Romariz SA,Paiva Dde S,Valente MF,Barnabé GF,Frussa-Filho R,Barbosa-Silva RC,Calcagnotto ME,Longo BM

更新日期：2014-08-02 00:00:00

abstract：BACKGROUND:Excitotoxicity (the toxic overstimulation of neurons by the excitatory transmitter Glutamate) is a central process in widespread neurodegenerative conditions such as brain ischemia and chronic neurological diseases. Many mechanisms have been suggested to mediate excitotoxicity, but their significance across ...

journal_title：BMC neuroscience

authors： Del Rosario JS,Feldmann KG,Ahmed T,Amjad U,Ko B,An J,Mahmud T,Salama M,Mei S,Asemota D,Mano I

更新日期：2015-04-23 00:00:00

abstract：:Numerous molecular factors orchestrate the development of the peripheral taste system. The unique anatomy/function of the taste system makes this system ideal for understanding the mechanisms by which these factors function; yet the taste system is underutilized for this role. This review focuses on some of the many f...

journal_title：BMC neuroscience

authors： Krimm RF

更新日期：2007-09-18 00:00:00

abstract：BACKGROUND:During development the switch from a depolarizing to a hyperpolarizing action of GABA is a consequence of a decrease of the Na+-K+-2Cl- co-transporter (NKCC1, Cl--uptake) and increase of the K+-Cl- co-transporter (KCC2, Cl--extrusion) expression. However albino visual cortex neurons don't show a correspondin...

journal_title：BMC neuroscience

authors： Diykov D,Turchinovich A,Zoidl G,Hoffmann KP

更新日期：2008-06-30 00:00:00

abstract：BACKGROUND:Hyperbaric oxygen therapy (HBOT) is a known adjuvant for treating ischemia-related inner ear diseases. Controversies still exist in the role of HBOT in cochlear diseases. Few studies to date have investigated the cellular changes that occur in inner ears after HBOT. Nitric oxide, which is synthesized by nitr...

journal_title：BMC neuroscience

authors： Lin CD,Wei IH,Lai CH,Hsia TC,Kao MC,Tsai MH,Wu CH,Tsai MH

更新日期：2011-02-22 00:00:00

abstract：BACKGROUND:Auditory perceptual learning persistently modifies neural networks in the central nervous system. Central auditory processing comprises a hierarchy of sound analysis and integration, which transforms an acoustical signal into a meaningful object for perception. Based on latencies and source locations of audi...

journal_title：BMC neuroscience

authors： Ross B,Jamali S,Tremblay KL

更新日期：2013-12-05 00:00:00

abstract：BACKGROUND:In rodents, dietary Na+ deprivation reduces gustatory responses of primary taste fibers and central taste neurons to lingual Na+ stimulation. However, in the rat taste bud cells Na+ deprivation increases the number of amiloride sensitive epithelial Na+ channels (ENaC), which are considered as the "receptor" ...

journal_title：BMC neuroscience

authors： Huang T,Stähler F

更新日期：2009-03-12 00:00:00

abstract：BACKGROUND:Rett syndrome (RTT, MIM #312750) is a severe neurological disorder caused by mutations in the X-linked methyl-CpG binding protein 2 (MECP2) gene. Female patients are affected with an incidence of 1/15000 live births and develop normally from birth to 6-18 months of age before the onset of deficits in autonom...

journal_title：BMC neuroscience

authors： Panayotis N,Ghata A,Villard L,Roux JC

更新日期：2011-05-24 00:00:00

abstract：BACKGROUND:Glutamate gated postsynaptic receptors in the central nervous system (CNS) are essential for environmentally stimulated behaviours including learning and memory in both invertebrates and vertebrates. Though their genetics, biochemistry, physiology, and role in behaviour have been intensely studied in vitro a...

journal_title：BMC neuroscience

authors： Ryan TJ,Emes RD,Grant SG,Komiyama NH

更新日期：2008-01-15 00:00:00

abstract：BACKGROUND:Understanding the underlying causes of nicotine addiction will require a multidisciplinary approach examining the key molecular, cellular and neuronal circuit functional changes that drive escalating levels of nicotine self-administration. In this study, we examined whether mice pretreated with chronic nicot...

journal_title：BMC neuroscience

authors： Renda A,Nashmi R

更新日期：2014-07-19 00:00:00

abstract：BACKGROUND:A recent study of lateral septum (LS) suggested a large number of autism-related genes with altered expression in the postpartum state. However, formally testing the findings for enrichment of autism-associated genes proved to be problematic with existing software. Many gene-disease association databases hav...

journal_title：BMC neuroscience

authors： Eisinger BE,Saul MC,Driessen TM,Gammie SC

更新日期：2013-11-19 00:00:00

abstract：BACKGROUND:In the absence of overt stimuli, the brain shows correlated fluctuations in functionally related brain regions. Approximately ten largely independent resting state networks (RSNs) showing this behaviour have been documented to date. Recent studies have reported the existence of an RSN in the basal ganglia - ...

journal_title：BMC neuroscience

authors： Robinson S,Basso G,Soldati N,Sailer U,Jovicich J,Bruzzone L,Kryspin-Exner I,Bauer H,Moser E

更新日期：2009-11-23 00:00:00

abstract：BACKGROUND:Functional magnetic resonance imaging (fMRI) in white matter has long been considered controversial. Recently, this viewpoint has been challenged by an emerging body of evidence demonstrating white matter activation in the corpus callosum. The current study aimed to determine whether white matter activation ...

journal_title：BMC neuroscience

authors： Gawryluk JR,Mazerolle EL,Brewer KD,Beyea SD,D'Arcy RC

更新日期：2011-06-14 00:00:00

abstract：BACKGROUND:Circadian clocks are endogenous biochemical oscillators that control daily behavioral rhythms in all living organisms. In fruit fly, the circadian rhythms are typically studied using power spectra of multiday behavioral recordings. Despite decades of study, a quantitative understanding of the temporal shape ...

journal_title：BMC neuroscience

authors： Lazopulo A,Syed S

更新日期：2016-04-18 00:00:00