Abnormal resting-state cortical coupling in chronic tinnitus.

abstract：BACKGROUND:An individual's ability to recognise and pay attention to others is crucial in order to behave appropriately in various social situations. Studies in humans have shown a sex bias in sociability as well as social memory, indicating that females have better face memory and gaze more at the eyes of others, but ...

journal_title：BMC neuroscience

authors： Karlsson SA,Haziri K,Hansson E,Kettunen P,Westberg L

更新日期：2015-11-25 00:00:00

abstract：BACKGROUND:Human neural stem cells (hNSC) have the potential to provide novel cell-based therapies for neurodegenerative conditions such as multiple sclerosis and Parkinson's disease. In order to realise this goal, protocols need to be developed that allow for large quantities of hNSC to be cultured efficiently. As suc...

journal_title：BMC neuroscience

authors： Hall PE,Lathia JD,Caldwell MA,Ffrench-Constant C

更新日期：2008-07-23 00:00:00

abstract：BACKGROUND:The zitter (zi/zi) rat, a loss-of-function mutant of the glycosylated transmembrane protein attractin (atrn), exhibits widespread age-dependent spongiform degeneration, hypomyelination, and abnormal metabolism of reactive oxygen species (ROS) in the brain. To date, the mechanisms underlying these phenotypes ...

journal_title：BMC neuroscience

authors： Sakakibara S,Nakadate K,Ookawara S,Ueda S

更新日期：2008-04-05 00:00:00

abstract：BACKGROUND:Yawning is a stereotyped behavior that enhances blood flow to the skull, and the resulting counterflow has been hypothesized as a mechanism for brain cooling. Studies have shown that yawns are strongly associated with physiological and pathological conditions that increase brain temperature, and that they ar...

journal_title：BMC neuroscience

authors： Eguibar JR,Uribe CA,Cortes C,Bautista A,Gallup AC

更新日期：2017-01-03 00:00:00

abstract：BACKGROUND:Stress involves alterations of brain functioning that may precipitate to mood disorders. The neurotrophin Brain Derived Neurotrophic Factor (BDNF) has recently been involved in stress-induced adaptation. BDNF is a key regulator of neuronal plasticity and adaptive processes. Regulation of BDNF is complex and ...

journal_title：BMC neuroscience

authors： Tognoli C,Rossi F,Di Cola F,Baj G,Tongiorgi E,Terova G,Saroglia M,Bernardini G,Gornati R

更新日期：2010-01-14 00:00:00

abstract：BACKGROUND:Sonic hedgehog (Shh)/Gli pathway plays an important regulatory role on the neuroepithelial cells (NEc) proliferation in the dorsal regions of the developing vertebrate Central Nervous System. The aim of this paper was to analyze the effect of the Shh/Gli signaling pathway activation on the proliferation dyna...

journal_title：BMC neuroscience

authors： Rapacioli M,Botelho J,Cerda G,Duarte S,Elliot M,Palma V,Flores V

更新日期：2012-10-02 00:00:00

abstract：BACKGROUND:Enhanced activity of trigeminal ganglion neurons is thought to underlie neuronal sensitization facilitating the onset of chronic pain attacks, including migraine. Recurrent headache attacks might establish a chronic neuroinflammatory ganglion profile contributing to the hypersensitive phenotype. Since it is ...

journal_title：BMC neuroscience

authors： Franceschini A,Nair A,Bele T,van den Maagdenberg AM,Nistri A,Fabbretti E

更新日期：2012-11-21 00:00:00

abstract：BACKGROUND:Parkinson disease (PD) is a movement disorder affecting 1 % of people over the age of 60. The etiology of the disease is unknown; however, accumulating evidence suggests that mitochondrial defects, oxidative stress, and neuroinflammation play important roles in developing the disease. Current medications for...

journal_title：BMC neuroscience

authors： Javed H,Azimullah S,Abul Khair SB,Ojha S,Haque ME

更新日期：2016-08-22 00:00:00

abstract：BACKGROUND:Alzheimer's Disease (AD) is the most common of the conformational neurodegenerative disorders characterized by the conversion of a normal biological protein into a β-sheet-rich pathological isoform. In AD the normal soluble Aβ (sAβ) forms oligomers and fibrils which assemble into neuritic plaques. The most t...

journal_title：BMC neuroscience

authors： Chung E,Ji Y,Sun Y,Kascsak RJ,Kascsak RB,Mehta PD,Strittmatter SM,Wisniewski T

更新日期：2010-10-14 00:00:00

abstract：BACKGROUND:Empathy refers to the ability to recognise and share emotions with others. Several research groups have recognised observational fear in mice as a useful behavioural model for assessing their ability to empathise. However, in these observation systems, it remains unclear whether the observer mouse truly reco...

journal_title：BMC neuroscience

authors： Ueno H,Suemitsu S,Murakami S,Kitamura N,Wani K,Takahashi Y,Matsumoto Y,Okamoto M,Ishihara T

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Histone deacetylases (HDACs) are enzymes that modulate gene expression and cellular processes by deacetylating histones and non-histone proteins. While small molecule inhibitors of HDAC activity (HDACi) are used clinically in the treatment of cancer, pre-clinical treatment models suggest they also exert neur...

journal_title：BMC neuroscience

authors： Zhou Q,Dalgard CL,Wynder C,Doughty ML

更新日期：2011-05-26 00:00:00

abstract：BACKGROUND:Previous studies in the rat have shown that the spatial organisation of the receptive fields of nociceptive withdrawal reflex (NWR) system are functionally adapted through experience dependent mechanisms, termed somatosensory imprinting, during postnatal development. Here we wanted to clarify 1) if mice exhi...

journal_title：BMC neuroscience

authors： Thelin J,Schouenborg J

更新日期：2008-05-21 00:00:00

abstract：BACKGROUND:As development proceeds the human embryo attains an ever more complex three dimensional (3D) structure. Analyzing the gene expression patterns that underlie these changes and interpreting their significance depends on identifying the anatomical structures to which they map and following these patterns in dev...

journal_title：BMC neuroscience

authors： Kerwin J,Scott M,Sharpe J,Puelles L,Robson SC,Martínez-de-la-Torre M,Ferran JL,Feng G,Baldock R,Strachan T,Davidson D,Lindsay S

更新日期：2004-08-06 00:00:00

abstract：BACKGROUND:Imprinting behavior is one form of learning and memory in precocial birds. With the aim of elucidating of the neural basis for visual imprinting, we focused on visual information processing. RESULTS:A lesion in the visual wulst, which is similar functionally to the mammalian visual cortex, caused anterograd...

journal_title：BMC neuroscience

authors： Maekawa F,Komine O,Sato K,Kanamatsu T,Uchimura M,Tanaka K,Ohki-Hamazaki H

更新日期：2006-11-14 00:00:00

abstract：BACKGROUND:Transcranial focused ultrasound (tFUS) is a new non-invasive neuromodulation technique that uses mechanical energy to modulate neuronal excitability with high spatial precision. tFUS has been shown to be capable of modulating EEG brain activity in humans that is spatially restricted, and here, we use 7T MRI ...

journal_title：BMC neuroscience

authors： Ai L,Bansal P,Mueller JK,Legon W

更新日期：2018-09-14 00:00:00

abstract：BACKGROUND:Functional magnetic resonance imaging (fMRI) in white matter has long been considered controversial. Recently, this viewpoint has been challenged by an emerging body of evidence demonstrating white matter activation in the corpus callosum. The current study aimed to determine whether white matter activation ...

journal_title：BMC neuroscience

authors： Gawryluk JR,Mazerolle EL,Brewer KD,Beyea SD,D'Arcy RC

更新日期：2011-06-14 00:00:00

abstract：BACKGROUND:The function of synaptotagmins (syt) in Ca2+-dependent transmitter release has been attributed primarily to Ca2+-dependent isoforms such as syt I. Recently, syt IV, an inducible Ca2+-independent isoform has been implicated in transmitter release. We postulated that the effects of syt IV on transmitter releas...

journal_title：BMC neuroscience

authors： Moore-Dotson JM,Papke JB,Harkins AB

更新日期：2010-08-24 00:00:00

abstract：BACKGROUND:Emotional stimuli are preferentially processed compared to neutral ones. Measuring the magnetic resonance blood-oxygen level dependent (BOLD) response or EEG event-related potentials, this has also been demonstrated for emotional versus neutral words. However, it is currently unclear whether emotion effects ...

journal_title：BMC neuroscience

authors： Koban L,Ninck M,Li J,Gisler T,Kissler J

更新日期：2010-07-27 00:00:00

abstract：BACKGROUND:Obesity has deleterious effects on the brain, and metabolic dysfunction may exacerbate the outcomes of seizures and brain injuries. However, it is unclear whether obesity affects excitotoxicity-induced neuronal cell death. The purpose of this study was to investigate the effects of a high-fat diet (HFD) on n...

journal_title：BMC neuroscience

authors： Kang DH,Heo RW,Yi CO,Kim H,Choi CH,Roh GS

更新日期：2015-10-30 00:00:00

abstract：BACKGROUND:Granulocyte-macrophage colony stimulating factor (GM-CSF) is a hematopoietic growth factor involved in the generation of granulocytes, macrophages, and dendritic cells from hematopoietic progenitor cells. We have recently demonstrated that GM-CSF has anti-apoptotic functions on neurons, and is neuroprotectiv...

journal_title：BMC neuroscience

authors： Krüger C,Laage R,Pitzer C,Schäbitz WR,Schneider A

更新日期：2007-10-22 00:00:00

abstract：BACKGROUND:Earlier functional imaging studies on visually induced self-motion perception (vection) disclosed a bilateral network of activations within primary and secondary visual cortex areas which was combined with signal decreases, i.e., deactivations, in multisensory vestibular cortex areas. This finding led to the...

journal_title：BMC neuroscience

authors： Becker-Bense S,Buchholz HG,zu Eulenburg P,Best C,Bartenstein P,Schreckenberger M,Dieterich M

更新日期：2012-07-16 00:00:00

abstract：BACKGROUND:Nitric oxide (NO) is a multifunctional molecule synthesized by three isozymes of the NO synthase (NOSs) acting as a messenger/modulator and/or a potential neurotoxin. In rodents, the role of NOSs in sleep processes and throughout aging is now well established. For example, sleep parameters are highly deterio...

journal_title：BMC neuroscience

authors： Colas D,Gharib A,Bezin L,Morales A,Guidon G,Cespuglio R,Sarda N

更新日期：2006-12-21 00:00:00

abstract：BACKGROUND:Even though more than 600 stroke treatments have been shown effective in preclinical studies, clinically proven treatment alternatives for cerebral infarction remain scarce. Amongst the reasons for the discrepancy may be methodological shortcomings, such as high mortality and outcome variability, in the prec...

journal_title：BMC neuroscience

authors： Ström JO,Ingberg E,Theodorsson A,Theodorsson E

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:To measure the impact of masticatory reduction on learning and memory, previous studies have produced experimental masticatory reduction by modified diet or molar removal. Here we induced spatial learning impairment in mice by reducing masticatory activity and then tested the effect of a combination of envir...

journal_title：BMC neuroscience

authors： Mendes Fde C,de Almeida MN,Felício AP,Fadel AC,Silva Dde J,Borralho TG,da Silva RP,Bento-Torres J,Vasconcelos PF,Perry VH,Ramos EM,Picanço-Diniz CW,Sosthenes MC

更新日期：2013-06-28 00:00:00

abstract：BACKGROUND:One of the most promising options for treatment of stroke using adult stem cells are human umbilical cord blood (HUCB) cells that were already approved for therapeutic efficacy in vivo. However, complexity of animal models has thus far limited the understanding of beneficial cellular mechanisms. To address t...

journal_title：BMC neuroscience

authors： Hau S,Reich DM,Scholz M,Naumann W,Emmrich F,Kamprad M,Boltze J

更新日期：2008-02-29 00:00:00

abstract：BACKGROUND:Immunization with neural derived peptides (INDP) as well as scar removal-separately-have shown to induce morphological and functional improvement after spinal cord injury (SCI). In the present study, we compared the effect of INDP alone versus INDP with scar removal on motor recovery, regeneration-associated...

journal_title：BMC neuroscience

authors： Rodríguez-Barrera R,Flores-Romero A,Fernández-Presas AM,García-Vences E,Silva-García R,Konigsberg M,Blancas-Espinoza L,Buzoianu-Anguiano V,Soria-Zavala K,Suárez-Meade P,Ibarra A

更新日期：2017-01-05 00:00:00

abstract：BACKGROUND:Noise exposure (NE) is a severe modern health hazard that induces hearing impairment. However, the noise-induced ultrastructural changes of blood-labyrinth barrier (BLB) and the potential involvements of tight junction proteins (TJP) remain inconclusive. We investigated the effects of NE on not only the ultr...

journal_title：BMC neuroscience

authors： Wu YX,Zhu GX,Liu XQ,Sun F,Zhou K,Wang S,Wang CM,Jia JW,Song JT,Lu LJ

更新日期：2014-12-24 00:00:00

abstract：BACKGROUND:One of the most basic human traits is language. Linguistic ability, and disability, have been shown to have a strong genetic component in family and twin studies, but molecular genetic studies of language phenotypes are scarce, relative to studies of other cognitive traits and neurodevelopmental phenotypes. ...

journal_title：BMC neuroscience

authors： Nudel R,Christiani CAJ,Ohland J,Uddin MJ,Hemager N,Ellersgaard D,Spang KS,Burton BK,Greve AN,Gantriis DL,Bybjerg-Grauholm J,Jepsen JRM,Thorup AAE,Mors O,Werge T,Nordentoft M

更新日期：2020-07-07 00:00:00

abstract：BACKGROUND:Auditory perceptual learning persistently modifies neural networks in the central nervous system. Central auditory processing comprises a hierarchy of sound analysis and integration, which transforms an acoustical signal into a meaningful object for perception. Based on latencies and source locations of audi...

journal_title：BMC neuroscience

authors： Ross B,Jamali S,Tremblay KL

更新日期：2013-12-05 00:00:00

abstract：BACKGROUND:The topological structure of the wiring of the mammalian brain cortex plays an important role in shaping the functional dynamics of large-scale neural activity. Due to their central embedding in the network, high degree hub regions and their connections (often referred to as the 'rich club') have been hypoth...

journal_title：BMC neuroscience

authors： Schmidt R,LaFleur KJ,de Reus MA,van den Berg LH,van den Heuvel MP

更新日期：2015-09-02 00:00:00