Abstract:
BACKGROUND:Alzheimer's disease (AD) is a progressive neuro-degenerative disease with a major manifestation of dementia. MicroRNAs were reported to regulate the transcript expression in patients with Alzheimer's disease (AD). In this study, we investigated the roles of miR-138, a brain-enriched miRNA, in the AD cell model. METHODS:The targets of miRNA-138 was predicted by bioinformatic analysis. The expression levels of DEK at both mRNA and protein levels were determined by qRT-PCR and Western blot, respectively. Luciferase assays were carried out to examine cell viabilities. Hoechst 33258 staining was used to detect cell apoptosis. RESULTS:Our results demonstrated that the expression levels of miR-138 were increased in AD model, and DEK was a target of miR-138. Overexpression of miR-138 in SH-SY5Y cells obviously down-regulated the expression of DEK in SH-SY5Y cells, resulting in the inactivation of AKT and increased expression levels of proapoptotic caspase-3. MiR-138 mediated-suppression of DEK increased the susceptibility of cell apoptosis. CONCLUSIONS:MicroRNA-138 promotes cell apoptosis of SH-SY5Y by targeting DEK in SH-SY5Y AD cell model. The regulation of miR-138 may contribute to AD via down-regulation of the DEK/AKT pathway.
journal_name
BMC Neuroscijournal_title
BMC neuroscienceauthors
Miao J,Jing J,Shao Y,Sun Hdoi
10.1186/s12868-020-00579-zsubject
Has Abstractpub_date
2020-07-31 00:00:00pages
33issue
1issn
1471-2202pii
10.1186/s12868-020-00579-zjournal_volume
21pub_type
杂志文章相关文献
BMC NEUROSCIENCE文献大全abstract::Numerous molecular factors orchestrate the development of the peripheral taste system. The unique anatomy/function of the taste system makes this system ideal for understanding the mechanisms by which these factors function; yet the taste system is underutilized for this role. This review focuses on some of the many f...
journal_title:BMC neuroscience
pub_type: 杂志文章,评审
doi:10.1186/1471-2202-8-S3-S4
更新日期:2007-09-18 00:00:00
abstract:BACKGROUND:Odorant stimuli can access the olfactory epithelium either orthonasally, by inhalation through the external nares, or retronasally by reverse airflow from the oral cavity. There is evidence that odors perceived through these two routes can differ in quality and intensity. We were curious whether such differe...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-14-45
更新日期:2013-04-08 00:00:00
abstract:BACKGROUND:Perivascular stromal cells (PSCs) are a recently identified cell type that comprises a small percentage of the platelet derived growth factor receptor-β+ cells within the CNS perivascular space. PSCs are activated following injury to the brain or spinal cord, expand in number and contribute to fibrotic scar ...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-016-0284-5
更新日期:2016-07-15 00:00:00
abstract:BACKGROUND:Multi-sensory integration is necessary for organisms to discriminate different environmental stimuli and thus determine behavior. Caenorhabditis elegans has 12 pairs of amphid sensory neurons, which are involved in generating behaviors such as thermotaxis toward cultivation temperature, and chemotaxis toward...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-9-106
更新日期:2008-11-01 00:00:00
abstract:BACKGROUND:During development the switch from a depolarizing to a hyperpolarizing action of GABA is a consequence of a decrease of the Na+-K+-2Cl- co-transporter (NKCC1, Cl--uptake) and increase of the K+-Cl- co-transporter (KCC2, Cl--extrusion) expression. However albino visual cortex neurons don't show a correspondin...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-9-57
更新日期:2008-06-30 00:00:00
abstract:BACKGROUND:Polymorphisms in the gene for phosphatidylinositol binding clathrin assembly protein (PICALM), an endocytic-related protein, are associated with a small, increased risk of developing Alzheimer's disease (AD), strongly suggesting that changes in endocytosis are involved in the aetiology of the disease. We hav...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-016-0288-1
更新日期:2016-07-18 00:00:00
abstract:BACKGROUND:The properties of Ca2+ signaling mediated by purinergic receptors are intrinsically linked with functional activity of astrocytes. At present little is known concerning Ca2+-dependent purinergic responses in adult human astrocytes. This work has examined effects of purinergic stimulation to alter levels of i...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-15-18
更新日期:2014-01-22 00:00:00
abstract:BACKGROUND:We have recorded responses from single neurons in murine visual cortex to determine the effectiveness of the input from the two murine cone photoreceptor mechanisms and whether there is any unique selectivity for cone inputs at this higher region of the visual system that would support the possibility of col...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-9-113
更新日期:2008-11-14 00:00:00
abstract:BACKGROUND:Symptoms of schizophrenia are related to deficits in self-monitoring function, which may be a consequence of irregularity in aspects of the default mode network (DMN). Schizophrenia can also be characterized by a functional abnormality of the brain activity that is reflected in the resting state. Oscillatory...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-15-104
更新日期:2014-09-05 00:00:00
abstract:BACKGROUND:Traumatic brain injury (TBI) initiates a complex sequence of destructive and neuroprotective cellular responses. The initial mechanical injury is followed by an extended time period of secondary brain damage. Due to the complicated pathological picture a better understanding of the molecular events occurring...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-6-69
更新日期:2005-11-30 00:00:00
abstract:BACKGROUND:Acupuncture has been applied to aid in the recovery of post-stroke patients, but its mechanism is unclear. This study aims to analyze the relationship between acupuncture and glucose metabolism in cerebral functional regions in post-stroke patients using (18)FDG PET-CT techniques. Forty-three ischemic stroke...
journal_title:BMC neuroscience
pub_type: 杂志文章,随机对照试验
doi:10.1186/1471-2202-13-75
更新日期:2012-06-27 00:00:00
abstract:BACKGROUND:Evoked potentials have been proposed to result from phase-locking of electroencephalographic (EEG) activities within specific frequency bands. However, the respective contribution of phasic activity and phase resetting of ongoing EEG oscillation remains largely debated. We here applied the EEGlab procedure i...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-8-75
更新日期:2007-09-18 00:00:00
abstract:BACKGROUND:Glutamate, a major excitatory amino acid neurotransmitter, causes apoptotic neuronal cell death at high concentrations. Our previous studies have shown that depending on the neuronal cell type, glutamate-induced apoptotic cell death was associated with regulation of genes such as Bcl-2, Bax, and/or caspase-3...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-7-49
更新日期:2006-06-15 00:00:00
abstract:BACKGROUND:Human neural stem cells (hNSC) have the potential to provide novel cell-based therapies for neurodegenerative conditions such as multiple sclerosis and Parkinson's disease. In order to realise this goal, protocols need to be developed that allow for large quantities of hNSC to be cultured efficiently. As suc...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-9-71
更新日期:2008-07-23 00:00:00
abstract:BACKGROUND:Yawning is a stereotyped behavior that enhances blood flow to the skull, and the resulting counterflow has been hypothesized as a mechanism for brain cooling. Studies have shown that yawns are strongly associated with physiological and pathological conditions that increase brain temperature, and that they ar...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-016-0330-3
更新日期:2017-01-03 00:00:00
abstract:BACKGROUND:The topological structure of the wiring of the mammalian brain cortex plays an important role in shaping the functional dynamics of large-scale neural activity. Due to their central embedding in the network, high degree hub regions and their connections (often referred to as the 'rich club') have been hypoth...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-015-0193-z
更新日期:2015-09-02 00:00:00
abstract:BACKGROUND:Human brain microvascular endothelial cells (hBMVECs) are integral part of the blood brain barrier. Post-translational modifications of adherens junction proteins regulate the permeability of human brain microvascular endothelial cells. Pro-inflammatory signals can induce tyrosine phosphorylation of adherens...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-15-80
更新日期:2014-06-26 00:00:00
abstract:BACKGROUND:Previous studies associate lipid peroxidation with long-term memory (LTM) failure in a gastropod model (Lymnaea stagnalis) of associative learning and memory. This process involves activation of Phospholipase A2 (PLA2), an enzyme mediating the release of fatty acids such as arachidonic acid that form the pre...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-14-83
更新日期:2013-08-06 00:00:00
abstract:BACKGROUND:The effects induced by administering the anticonvulsant lamotrigine, the preferential inhibitor of neuronal nitric oxide synthase 7-nitroindazole and the precursor of NO synthesis L-arginine, alone or in combination, on an experimental model of partial complex seizures (maximal dentate gyrus activation) were...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-8-47
更新日期:2007-07-03 00:00:00
abstract:BACKGROUND:Recent discoveries suggest that arealization of the mammalian cortical sheet develops in a manner consonant with principles established for embryonic patterning of the body. Signaling centers release morphogens that determine regional growth and tissue identity by regulating regional expression of transcript...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-6-18
更新日期:2005-03-17 00:00:00
abstract:BACKGROUND:Errorless learning has advantages over errorful learning. The erroneous items produced during errorful learning compete with correct items at retrieval resulting in decreased memory performance. This interference is associated with an increased demand on executive monitoring processes. Event-related function...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-14-30
更新日期:2013-03-13 00:00:00
abstract:BACKGROUND:Parkinson disease (PD) is a movement disorder affecting 1 % of people over the age of 60. The etiology of the disease is unknown; however, accumulating evidence suggests that mitochondrial defects, oxidative stress, and neuroinflammation play important roles in developing the disease. Current medications for...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-016-0293-4
更新日期:2016-08-22 00:00:00
abstract:BACKGROUND:CNS injury including stroke, infection, and tumor growth lead to astrogliosis, a process that involves upregulation of glial fibrillary acidic protein (GFAP) in astrocytes. However, the kinetics of astrogliosis that is related to these insults (i.e. tumor) is largely unknown. RESULTS:Using transgenic mice e...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-12-9
更新日期:2011-01-19 00:00:00
abstract:BACKGROUND:The megencephaly mouse, mceph/mceph, is epileptic and displays a dramatically increased brain volume and neuronal count. The responsible mutation was recently revealed to be an eleven base pair deletion, leading to a frame shift, in the gene encoding the potassium channel Kv1.1. The predicted MCEPH protein i...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-6-65
更新日期:2005-11-23 00:00:00
abstract:BACKGROUND:One of the most promising options for treatment of stroke using adult stem cells are human umbilical cord blood (HUCB) cells that were already approved for therapeutic efficacy in vivo. However, complexity of animal models has thus far limited the understanding of beneficial cellular mechanisms. To address t...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-9-30
更新日期:2008-02-29 00:00:00
abstract::Many studies have highlighted the pathological involvement of iron accumulation and iron-related oxidative stress (OS) in Alzheimer's disease (AD). Iron was further demonstrated to modulate expression of the Alzheimer's amyloid precursor holo-protein (APP) by a mechanism similar to that of regulation of ferritin-L and...
journal_title:BMC neuroscience
pub_type: 杂志文章,评审
doi:10.1186/1471-2202-9-S2-S2
更新日期:2008-12-03 00:00:00
abstract:BACKGROUND:The polyglutamine expansion in huntingtin (Htt) protein is a cause of Huntington's disease (HD). Htt is an essential gene as deletion of the mouse Htt gene homolog (Hdh) is embryonic lethal in mice. Therefore, in addition to elucidating the mechanisms responsible for polyQ-mediated pathology, it is also impo...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-9-38
更新日期:2008-04-15 00:00:00
abstract:BACKGROUND:Previous studies showed that anodal transcranial DC stimulation (tDCS) applied to the primary motor cortex of the affected hemisphere (M1affected hemisphere) after subcortical stroke transiently improves performance of complex tasks that mimic activities of daily living (ADL). It is not known if relatively s...
journal_title:BMC neuroscience
pub_type: 临床试验,杂志文章
doi:10.1186/1471-2202-7-73
更新日期:2006-11-03 00:00:00
abstract:BACKGROUND:Recent studies have shown that the human right-hemispheric auditory cortex is particularly sensitive to reduction in sound quality, with an increase in distortion resulting in an amplification of the auditory N1m response measured in the magnetoencephalography (MEG). Here, we examined whether this sensitivit...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-11-24
更新日期:2010-02-22 00:00:00
abstract:BACKGROUND:Reuptake of synaptic norepinephrine (NE) via the antidepressant-sensitive NE transporter (NET) supports efficient noradrenergic signaling and presynaptic NE homeostasis. Limited, and somewhat contradictory, information currently describes the axonal transport and localization of NET in neurons. RESULTS:We e...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-10-65
更新日期:2009-06-23 00:00:00