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Non-invasive quantification of brain tumor-induced astrogliosis.

Abstract：

BACKGROUND:CNS injury including stroke, infection, and tumor growth lead to astrogliosis, a process that involves upregulation of glial fibrillary acidic protein (GFAP) in astrocytes. However, the kinetics of astrogliosis that is related to these insults (i.e. tumor) is largely unknown. RESULTS:Using transgenic mice expressing firefly luciferase under the regulation of the GFAP promoter (GFAP-luc), we developed a model system to monitor astrogliosis upon tumor growth in a rapid, non-invasive manner. A biphasic induction of astrogliosis was observed in our xenograft model in which an early phase of activation of GFAP was associated with inflammatory response followed by a secondary, long-term upregulation of GFAP. These animals reveal GFAP activation with kinetics that is in parallel with tumor growth. Furthermore, a strong correlation between astrogliosis and tumor size was observed. CONCLUSIONS:Our results suggest that non-invasive, quantitative bioluminescent imaging using GFAP-luc reporter animal is a useful tool to monitor temporal-spatial kinetics of host-mediated astrogliosis that is associated with glioma and metastatic brain tumor growth.

journal_name

BMC Neurosci

journal_title

BMC neuroscience

authors

Lee J,Borboa AK,Baird A,Eliceiri BP

doi

10.1186/1471-2202-12-9

subject

Has Abstract

pub_date

2011-01-19 00:00:00

pages

9

issn

1471-2202

pii

1471-2202-12-9

journal_volume

12

pub_type

杂志文章

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