Abstract:
BACKGROUND:Following partial injury to the central nervous system, cells beyond the initial injury site undergo secondary degeneration, exacerbating loss of neurons, compact myelin and function. Changes in Ca2+ flux are associated with metabolic and structural changes, but it is not yet clear how flux through specific ion channels contributes to the various pathologies. Here, partial optic nerve transection in adult female rats was used to model secondary degeneration. Treatment with combinations of three ion channel inhibitors was used as a tool to investigate which elements of oxidative and structural damage related to long term functional outcomes. The inhibitors employed were the voltage gated Ca2+ channel inhibitor Lomerizine (Lom), the Ca2+ permeable AMPA receptor inhibitor YM872 and the P2X7 receptor inhibitor oxATP. RESULTS:Following partial optic nerve transection, hyper-phosphorylation of Tau and acetylated tubulin immunoreactivity were increased, and Nogo-A immunoreactivity was decreased, indicating that axonal changes occurred acutely. All combinations of ion channel inhibitors reduced hyper-phosphorylation of Tau and increased Nogo-A immunoreactivity at day 3 after injury. However, only Lom/oxATP or all three inhibitors in combination significantly reduced acetylated tubulin immunoreactivity. Most combinations of ion channel inhibitors were effective in restoring the lengths of the paranode and the paranodal gap, indicative of the length of the node of Ranvier, following injury. However, only all three inhibitors in combination restored to normal Ankyrin G length at the node of Ranvier. Similarly, HNE immunoreactivity and loss of oligodendrocyte precursor cells were only limited by treatment with all three ion channel inhibitors in combination. CONCLUSIONS:Data indicate that inhibiting any of a range of ion channels preserves certain elements of axon and node structure and limits some oxidative damage following injury, whereas ionic flux through all three channels must be inhibited to prevent lipid peroxidation and preserve Ankyrin G distribution and OPCs.
journal_name
BMC Neuroscijournal_title
BMC neuroscienceauthors
O'Hare Doig RL,Chiha W,Giacci MK,Yates NJ,Bartlett CA,Smith NM,Hodgetts SI,Harvey AR,Fitzgerald Mdoi
10.1186/s12868-017-0380-1subject
Has Abstractpub_date
2017-08-14 00:00:00pages
62issue
1issn
1471-2202pii
10.1186/s12868-017-0380-1journal_volume
18pub_type
杂志文章相关文献
BMC NEUROSCIENCE文献大全abstract:BACKGROUND:Alzheimer's disease (AD) is the most prevalent form of dementia and represents one of the highest unmet requirements in medicine today. There is shortage of novel molecules entering into market because of poor pharmacokinetic properties and safety issues. Drug repurposing offers an opportunity to reinvigorat...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-017-0394-8
更新日期:2017-10-27 00:00:00
abstract:BACKGROUND:The neuropeptide arginine vasopressin (Avp) modulates social behaviors via its two centrally expressed receptors, the Avp 1a receptor and the Avp 1b receptor (Avpr1b). Recent work suggests that, at least in mice, Avp signaling through Avpr1b within the CA2 region of the hippocampus is critical for normal agg...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-016-0310-7
更新日期:2016-11-24 00:00:00
abstract:BACKGROUND:One of the most promising options for treatment of stroke using adult stem cells are human umbilical cord blood (HUCB) cells that were already approved for therapeutic efficacy in vivo. However, complexity of animal models has thus far limited the understanding of beneficial cellular mechanisms. To address t...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-9-30
更新日期:2008-02-29 00:00:00
abstract:BACKGROUND:Many studies of cerebral asymmetries in different species lead, on the one hand, to a better understanding of the functions of each cerebral hemisphere and, on the other hand, to develop an evolutionary history of hemispheric laterality. Our animal model is particularly interesting because of its original ev...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-13-9
更新日期:2012-01-12 00:00:00
abstract:BACKGROUND:To determine whether early imitative responses fade out following the maturation of attentional mechanisms, the relationship between primitive imitation behaviors and the development of attention was examined in 4-month-old infants. They were divided into high and low imitators, based on an index of imitatio...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-4-33
更新日期:2003-12-24 00:00:00
abstract:BACKGROUND:Chlamydophila (Chlamydia) pneumoniae is an intracellular bacterium that has been identified within cells in areas of neuropathology found in Alzheimer disease (AD), including endothelia, glia, and neurons. Depending on the cell type of the host, infection by C. pneumoniae has been shown to influence apoptoti...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-9-13
更新日期:2008-01-24 00:00:00
abstract:BACKGROUND:Humans demonstrate a number of unique adaptations that allow for the maintenance of blood pressure and brain blood flow when upright. While several physiological systems, including cerebral autoregulation, are involved in this adaptation the unique role the vestibular system plays in helping to maintain brai...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-10-119
更新日期:2009-09-23 00:00:00
abstract:BACKGROUND:Protein aggregation plays important roles in several neurodegenerative disorders. For instance, insoluble aggregates of phosphorylated tau and of Aβ peptides are cornerstones in the pathology of Alzheimer's disease. Soluble protein aggregates are therefore potential diagnostic and prognostic biomarkers for t...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-11-124
更新日期:2010-10-05 00:00:00
abstract:BACKGROUND:Magnetoencephalography (MEG) has become an increasingly popular technique for non-invasively characterizing neuromagnetic field changes in the brain at a high temporal resolution. To examine the reliability of the MEG signal, we compared magnetic and electrophysiological responses to complex natural stimuli ...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-10-4
更新日期:2009-01-15 00:00:00
abstract:BACKGROUND:Alzheimer's Disease (AD) is the most common of the conformational neurodegenerative disorders characterized by the conversion of a normal biological protein into a β-sheet-rich pathological isoform. In AD the normal soluble Aβ (sAβ) forms oligomers and fibrils which assemble into neuritic plaques. The most t...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-11-130
更新日期:2010-10-14 00:00:00
abstract:BACKGROUND:This work examines the central nervous system distribution of virus-labeled neurons from the rat urinary bladder and the prostate simultaneously within the same tissue sections. Two immunohistochemically distinct pseudorabies virus strains were simultaneously injected into male Sprague Dawley rats (approxima...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-3-8
更新日期:2002-07-12 00:00:00
abstract:BACKGROUND:In this study, we examined the effects of cyclophosphamide, methothrexate, and 5-Fluorouracil (CMF) drug combination on various aspects of learning and memory. We also examined the effects of CMF on cell proliferation and chromatin remodeling as possible underlying mechanisms to explain chemotherapy-associat...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-12-124
更新日期:2011-12-09 00:00:00
abstract:BACKGROUND:Previous studies associate lipid peroxidation with long-term memory (LTM) failure in a gastropod model (Lymnaea stagnalis) of associative learning and memory. This process involves activation of Phospholipase A2 (PLA2), an enzyme mediating the release of fatty acids such as arachidonic acid that form the pre...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-14-83
更新日期:2013-08-06 00:00:00
abstract:BACKGROUND:Even though more than 600 stroke treatments have been shown effective in preclinical studies, clinically proven treatment alternatives for cerebral infarction remain scarce. Amongst the reasons for the discrepancy may be methodological shortcomings, such as high mortality and outcome variability, in the prec...
journal_title:BMC neuroscience
pub_type: 杂志文章,meta分析
doi:10.1186/1471-2202-14-41
更新日期:2013-04-01 00:00:00
abstract:BACKGROUND:ApoER2 and the neurotrophin receptors Trk and p75(NTR) are expressed in the CNS and regulate key functional aspects of neurons, including development, survival, and neuronal function. It is known that both ApoER2 and p75(NTR) are processed by metalloproteinases, followed by regulated intramembrane proteolysi...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-15-108
更新日期:2014-09-19 00:00:00
abstract:BACKGROUND:Symptoms of schizophrenia are related to deficits in self-monitoring function, which may be a consequence of irregularity in aspects of the default mode network (DMN). Schizophrenia can also be characterized by a functional abnormality of the brain activity that is reflected in the resting state. Oscillatory...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-15-104
更新日期:2014-09-05 00:00:00
abstract:BACKGROUND:Overexpression and abnormal accumulation of aggregated alpha-synuclein (alphaS) have been linked to Parkinson's disease (PD) and other synucleinopathies. alphaS can misfold and adopt a variety of morphologies but recent studies implicate oligomeric forms as the most cytotoxic species. Both genetic mutations ...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-11-57
更新日期:2010-04-30 00:00:00
abstract:BACKGROUND:Parkinson's disease (PD) is a neurological disorder characterized by the degeneration of nigrostriatal dopaminergic systems. Free radicals induced by oxidative stress are involved in the mechanisms of cell death in PD. This study clarifies the neuroprotective effects of edaravone (MCI-186, 3-methyl-1-phenyl-...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-9-75
更新日期:2008-08-01 00:00:00
abstract:BACKGROUND:Multi-sensor technologies such as EEG, MEG, and ECoG result in high-dimensional data sets. Given the high temporal resolution of such techniques, scientific questions very often focus on the time-course of an experimental effect. In many studies, researchers focus on a single sensor or the average over a sub...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-14-122
更新日期:2013-10-14 00:00:00
abstract:BACKGROUND:Immunization with neural derived peptides (INDP) as well as scar removal-separately-have shown to induce morphological and functional improvement after spinal cord injury (SCI). In the present study, we compared the effect of INDP alone versus INDP with scar removal on motor recovery, regeneration-associated...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-016-0331-2
更新日期:2017-01-05 00:00:00
abstract:BACKGROUND:Growing evidence shows that, in vivo, the precursor of Nerve Growth Factor (NGF), proNGF, displays biological activities different from those of its mature NGF counterpart, mediated by distinct, and somewhat complementary, receptor binding properties. NGF and proNGF induce distinct transcriptional signatures...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-15-48
更新日期:2014-04-08 00:00:00
abstract:BACKGROUND:GABAA receptor-mediated neurotransmission is greatly influenced by cation-chloride cotransporter activity during developmental stages. In embryonic neurons Na-K-2Cl (NKCC1) cotransporters mediate active chloride uptake, thus increasing the intracellular chloride concentration associated with GABA-induced dep...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-015-0180-4
更新日期:2015-07-14 00:00:00
abstract:BACKGROUND:Acetylcholine receptors become aggregated at the developing neuromuscular synapse shortly after contact by a motorneuron in one of the earliest manifestations of synaptic development. While a major physiological signal for receptor aggregation (agrin) is known, the mechanism(s) by which muscle cells respond ...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-2-19
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:Synaptic degeneration and accumulation of amyloid β-peptides (Aβ) are hallmarks of the Alzheimer diseased brain. Aβ is synaptotoxic and produced by sequential cleavage of the amyloid precursor protein (APP) by the β-secretase BACE1 and by γ-secretase. If APP is instead cleaved by the α-secretase ADAM10, Aβ w...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-020-0554-0
更新日期:2020-02-04 00:00:00
abstract:BACKGROUND:It has been shown that olfactory ensheathing glia (OEG) and Schwann cell (SCs) transplantation are beneficial as cellular treatments for spinal cord injury (SCI), especially acute and sub-acute time points. In this study, we transplanted DsRED transduced adult OEG and SCs sub-acutely (14 days) following a T1...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-14-106
更新日期:2013-09-27 00:00:00
abstract:BACKGROUND:Odorant stimuli can access the olfactory epithelium either orthonasally, by inhalation through the external nares, or retronasally by reverse airflow from the oral cavity. There is evidence that odors perceived through these two routes can differ in quality and intensity. We were curious whether such differe...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-14-45
更新日期:2013-04-08 00:00:00
abstract:BACKGROUND:Sonic hedgehog (Shh)/Gli pathway plays an important regulatory role on the neuroepithelial cells (NEc) proliferation in the dorsal regions of the developing vertebrate Central Nervous System. The aim of this paper was to analyze the effect of the Shh/Gli signaling pathway activation on the proliferation dyna...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-13-117
更新日期:2012-10-02 00:00:00
abstract:BACKGROUND:The human inferior frontal junction area (IFJ) is critically involved in three main component processes of cognitive control (working memory, task switching and inhibitory control). As it overlaps with several areas in established anatomical labeling schemes, it is considered to be underreported as a functio...
journal_title:BMC neuroscience
pub_type: 杂志文章,meta分析
doi:10.1186/1471-2202-13-119
更新日期:2012-10-03 00:00:00
abstract:BACKGROUND:The aim of this study was to assess the distribution of key SNARE proteins in glutamatergic and GABAergic synapses of the adult rat cerebellar cortex using light microscopy immunohistochemical techniques. Analysis was made of co-localizations of vGluT-1 and vGluT-2, vesicular transporters of glutamate and ma...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-12-118
更新日期:2011-11-17 00:00:00
abstract:BACKGROUND:The GABAergic system plays an important role in modulating levels of anxiety. When transplanted into the brain, precursor cells from the medial ganglionic eminence (MGE) have the ability to differentiate into GABAergic interneurons and modify the inhibitory tone in the host brain. Currently, two methods have...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-15-94
更新日期:2014-08-02 00:00:00