Vestibular effects on cerebral blood flow.

Abstract:

BACKGROUND:Humans demonstrate a number of unique adaptations that allow for the maintenance of blood pressure and brain blood flow when upright. While several physiological systems, including cerebral autoregulation, are involved in this adaptation the unique role the vestibular system plays in helping to maintain brain blood flow is just beginning to be elucidated. In this study, we tested the hypothesis that stimulation of the vestibular system, specifically the otoliths organs, would result in changes in cerebral blood flow. RESULTS:To test our hypothesis, we stimulated the vestibular organs of 25 healthy subjects by pitch tilt (stimulates both canals and otoliths) and by translation on a centrifuge (stimulates otoliths and not the canals) at five frequencies: 0.5, 0.25, 0.125 and 0.0625 Hz for 80 sec and 0.03125 Hz for 160 sec. Changes in cerebral flow velocity (by transcranial Doppler) and blood pressure (by Finapres) were similar during both stimuli and dependent on frequency of stimulation (P < 0.01). However, changes in cerebral blood flow were in opposition to changes in blood pressure and not fully dependent on changes in end tidal CO2. CONCLUSION:The experimental results support our hypothesis and provide evidence that activation of the vestibular apparatus, specifically the otolith organs, directly affects cerebral blood flow regulation, independent of blood pressure and end tidal CO2 changes.

journal_name

BMC Neurosci

journal_title

BMC neuroscience

authors

Serrador JM,Schlegel TT,Black FO,Wood SJ

doi

10.1186/1471-2202-10-119

subject

Has Abstract

pub_date

2009-09-23 00:00:00

pages

119

issn

1471-2202

pii

1471-2202-10-119

journal_volume

10

pub_type

杂志文章
  • The roles of aromatic residues in the glycine receptor transmembrane domain.

    abstract:BACKGROUND:Cys-loop receptors play important roles in fast neuronal signal transmission. Functional receptors are pentamers, with each subunit having an extracellular, transmembrane (TM) and intracellular domain. Each TM domain contains 4 α-helices (M1-M4) joined by loops of varying lengths. Many of the amino acid resi...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/s12868-018-0454-8

    authors: Tang B,Lummis SCR

    更新日期:2018-09-06 00:00:00

  • The type III neurofilament peripherin is expressed in the tuberomammillary neurons of the mouse.

    abstract:BACKGROUND:Peripherin, a type III neuronal intermediate filament, is widely expressed in neurons of the peripheral nervous system and in selected central nervous system hindbrain areas with projections towards peripheral structures, such as cranial nerves and spinal cord neurons. Peripherin appears to play a role in ne...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-9-26

    authors: Eriksson KS,Zhang S,Lin L,Larivière RC,Julien JP,Mignot E

    更新日期:2008-02-24 00:00:00

  • Separate urinary bladder and prostate neurons in the central nervous system of the rat: simultaneous labeling with two immunohistochemically distinguishable pseudorabies viruses.

    abstract:BACKGROUND:This work examines the central nervous system distribution of virus-labeled neurons from the rat urinary bladder and the prostate simultaneously within the same tissue sections. Two immunohistochemically distinct pseudorabies virus strains were simultaneously injected into male Sprague Dawley rats (approxima...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-3-8

    authors: Nadelhaft I,Miranda-Sousa AJ,Vera PL

    更新日期:2002-07-12 00:00:00

  • Auditory temporal processing in healthy aging: a magnetoencephalographic study.

    abstract:BACKGROUND:Impaired speech perception is one of the major sequelae of aging. In addition to peripheral hearing loss, central deficits of auditory processing are supposed to contribute to the deterioration of speech perception in older individuals. To test the hypothesis that auditory temporal processing is compromised ...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-10-34

    authors: Sörös P,Teismann IK,Manemann E,Lütkenhöner B

    更新日期:2009-04-07 00:00:00

  • Expressed sequence tag analysis of adult human optic nerve for NEIBank: identification of cell type and tissue markers.

    abstract:BACKGROUND:The optic nerve is a pure white matter central nervous system (CNS) tract with an isolated blood supply, and is widely used in physiological studies of white matter response to various insults. We examined the gene expression profile of human optic nerve (ON) and, through the NEIBANK online resource, to prov...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-10-121

    authors: Bernstein SL,Guo Y,Peterson K,Wistow G

    更新日期:2009-09-24 00:00:00

  • Social behavioral testing and brain magnetic resonance imaging in chicks exposed to mobile phone radiation during development.

    abstract:BACKGROUND:The potential adverse effect of mobile phone radiation is currently an area of great concern in the field of public health. In the present study, we aimed to investigate the effect of mobile phone radiation (900 MHz radiofrequency) during hatching on postnatal social behaviors in chicks, as well as the effec...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/s12868-016-0266-7

    authors: Zhou Z,Shan J,Zu J,Chen Z,Ma W,Li L,Xu J

    更新日期:2016-06-10 00:00:00

  • Enriched environment and masticatory activity rehabilitation recover spatial memory decline in aged mice.

    abstract:BACKGROUND:To measure the impact of masticatory reduction on learning and memory, previous studies have produced experimental masticatory reduction by modified diet or molar removal. Here we induced spatial learning impairment in mice by reducing masticatory activity and then tested the effect of a combination of envir...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-14-63

    authors: Mendes Fde C,de Almeida MN,Felício AP,Fadel AC,Silva Dde J,Borralho TG,da Silva RP,Bento-Torres J,Vasconcelos PF,Perry VH,Ramos EM,Picanço-Diniz CW,Sosthenes MC

    更新日期:2013-06-28 00:00:00

  • Relationship between ambient light and glucose metabolism in healthy subjects.

    abstract:BACKGROUND:Given the reported inverse association between light and depressive mood, ambient light may also be associated with some of the brain regions in healthy subjects. The present study aims to investigate the effects of ambient light on glucose metabolism in the brain. We used the data of 28 healthy participants...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/s12868-018-0444-x

    authors: Hirakawa H,Terao T,Hatano K,Kohno K,Ishii N

    更新日期:2018-07-24 00:00:00

  • Gamma oscillation underlies hyperthermia-induced epileptiform-like spikes in immature rat hippocampal slices.

    abstract:BACKGROUND:Recently a hyperthermic rat hippocampal slice model system has been used to investigate febrile seizure pathophysiology. Our previous data indicates that heating immature rat hippocampal slices from 34 to 41 degrees C in an interface chamber induced epileptiform-like population spikes accompanied by a spread...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-2-18

    authors: Wu J,Javedan SP,Ellsworth K,Smith K,Fisher RS

    更新日期:2001-01-01 00:00:00

  • Maxillary nerve compression in cynomolgus monkey Macaca fascicularis: altered somatic sensation and peripheral nerve firing.

    abstract:BACKGROUND:Trigeminal nerve is a major source of the sensory input of the face, and trigeminal neuropathology models have been reported in rodents with injury to branches of the maxillary or mandibular division of the trigeminal nerve. Non-human primates are neuroanatomically more closely related to human than rodents;...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-13-150

    authors: Guo N,Gu X,Zhao J,Zhao G,Jin M,Zou H,Zhang Y,Zhao Z,Jin GJ,Yu L

    更新日期:2012-12-13 00:00:00

  • HIV-1 Tat C phosphorylates VE-cadherin complex and increases human brain microvascular endothelial cell permeability.

    abstract:BACKGROUND:Human brain microvascular endothelial cells (hBMVECs) are integral part of the blood brain barrier. Post-translational modifications of adherens junction proteins regulate the permeability of human brain microvascular endothelial cells. Pro-inflammatory signals can induce tyrosine phosphorylation of adherens...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-15-80

    authors: Mishra R,Singh SK

    更新日期:2014-06-26 00:00:00

  • Persistent changes in spinal cord gene expression after recovery from inflammatory hyperalgesia: a preliminary study on pain memory.

    abstract:BACKGROUND:Previous studies found that rats subjected to carrageenan injection develop hyperalgesia, and despite complete recovery in several days, they continue to have an enhanced hyperalgesic response to a new noxious challenge for more than 28d. The study's aim was to identify candidate genes that have a role in th...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-9-32

    authors: Yukhananov R,Kissin I

    更新日期:2008-03-13 00:00:00

  • Neuroprotective effect of nerolidol against neuroinflammation and oxidative stress induced by rotenone.

    abstract:BACKGROUND:Parkinson disease (PD) is a movement disorder affecting 1 % of people over the age of 60. The etiology of the disease is unknown; however, accumulating evidence suggests that mitochondrial defects, oxidative stress, and neuroinflammation play important roles in developing the disease. Current medications for...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/s12868-016-0293-4

    authors: Javed H,Azimullah S,Abul Khair SB,Ojha S,Haque ME

    更新日期:2016-08-22 00:00:00

  • Sonic hedgehog (Shh)/Gli modulates the spatial organization of neuroepithelial cell proliferation in the developing chick optic tectum.

    abstract:BACKGROUND:Sonic hedgehog (Shh)/Gli pathway plays an important regulatory role on the neuroepithelial cells (NEc) proliferation in the dorsal regions of the developing vertebrate Central Nervous System. The aim of this paper was to analyze the effect of the Shh/Gli signaling pathway activation on the proliferation dyna...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-13-117

    authors: Rapacioli M,Botelho J,Cerda G,Duarte S,Elliot M,Palma V,Flores V

    更新日期:2012-10-02 00:00:00

  • Age-dependent kinetics of dentate gyrus neurogenesis in the absence of cyclin D2.

    abstract:BACKGROUND:Adult neurogenesis continuously adds new neurons to the dentate gyrus and the olfactory bulb. It involves the proliferation and subsequent differentiation of neuronal progenitors, and is thus closely linked to the cell cycle machinery. Cell cycle progression is governed by the successive expression, activati...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-13-46

    authors: Ansorg A,Witte OW,Urbach A

    更新日期:2012-05-07 00:00:00

  • Specific ion channels contribute to key elements of pathology during secondary degeneration following neurotrauma.

    abstract:BACKGROUND:Following partial injury to the central nervous system, cells beyond the initial injury site undergo secondary degeneration, exacerbating loss of neurons, compact myelin and function. Changes in Ca2+ flux are associated with metabolic and structural changes, but it is not yet clear how flux through specific ...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/s12868-017-0380-1

    authors: O'Hare Doig RL,Chiha W,Giacci MK,Yates NJ,Bartlett CA,Smith NM,Hodgetts SI,Harvey AR,Fitzgerald M

    更新日期:2017-08-14 00:00:00

  • The expression of apoptosis inducing factor (AIF) is associated with aging-related cell death in the cortex but not in the hippocampus in the TgCRND8 mouse model of Alzheimer's disease.

    abstract:BACKGROUND:Recent evidence has suggested that Alzheimer's disease (AD)-associated neuronal loss may occur via the caspase-independent route of programmed cell death (PCD) in addition to caspase-dependent mechanisms. However, the brain region specificity of caspase-independent PCD in AD-associated neurodegeneration is u...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-15-73

    authors: Yu W,Bonnet M,Farso M,Ma K,Chabot JG,Martin E,Torriglia A,Guan Z,McLaurin J,Quirion R,Krantic S

    更新日期:2014-06-10 00:00:00

  • A prospective longitudinal in vivo 1H MR spectroscopy study of the SIV/macaque model of neuroAIDS.

    abstract:BACKGROUND:The neurological complications of HIV infection remain poorly understood. Clinically, in vivo 1H magnetic resonance spectroscopy (MRS) demonstrates brain injury caused by HIV infection even when the MRI is normal. Our goal was to undertsand the dynamics of cerebral injury by performing a longitudinal in vivo...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-5-10

    authors: Fuller RA,Westmoreland SV,Ratai E,Greco JB,Kim JP,Lentz MR,He J,Sehgal PK,Masliah E,Halpern E,Lackner AA,González RG

    更新日期:2004-03-05 00:00:00

  • Effects of dietary Na+ deprivation on epithelial Na+ channel (ENaC), BDNF, and TrkB mRNA expression in the rat tongue.

    abstract:BACKGROUND:In rodents, dietary Na+ deprivation reduces gustatory responses of primary taste fibers and central taste neurons to lingual Na+ stimulation. However, in the rat taste bud cells Na+ deprivation increases the number of amiloride sensitive epithelial Na+ channels (ENaC), which are considered as the "receptor" ...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-10-19

    authors: Huang T,Stähler F

    更新日期:2009-03-12 00:00:00

  • Mental imagery-induced attention modulates pain perception and cortical excitability.

    abstract:BACKGROUND:Mental imagery is a powerful method of altering brain activity and behavioral outcomes, such as performance of cognition and motor skills. Further, attention and distraction can modulate pain-related neuronal networks and the perception of pain. This exploratory study examined the effects of mental imagery-i...

    journal_title:BMC neuroscience

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/s12868-015-0146-6

    authors: Volz MS,Suarez-Contreras V,Portilla AL,Fregni F

    更新日期:2015-03-15 00:00:00

  • Functional connectivity profile of the human inferior frontal junction: involvement in a cognitive control network.

    abstract:BACKGROUND:The human inferior frontal junction area (IFJ) is critically involved in three main component processes of cognitive control (working memory, task switching and inhibitory control). As it overlaps with several areas in established anatomical labeling schemes, it is considered to be underreported as a functio...

    journal_title:BMC neuroscience

    pub_type: 杂志文章,meta分析

    doi:10.1186/1471-2202-13-119

    authors: Sundermann B,Pfleiderer B

    更新日期:2012-10-03 00:00:00

  • Decreasing the expression of PICALM reduces endocytosis and the activity of β-secretase: implications for Alzheimer's disease.

    abstract:BACKGROUND:Polymorphisms in the gene for phosphatidylinositol binding clathrin assembly protein (PICALM), an endocytic-related protein, are associated with a small, increased risk of developing Alzheimer's disease (AD), strongly suggesting that changes in endocytosis are involved in the aetiology of the disease. We hav...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/s12868-016-0288-1

    authors: Thomas RS,Henson A,Gerrish A,Jones L,Williams J,Kidd EJ

    更新日期:2016-07-18 00:00:00

  • High glucose induces apoptosis and suppresses proliferation of adult rat neural stem cells following in vitro ischemia.

    abstract:BACKGROUND:Post-stroke hyperglycemia appears to be associated with poor outcome from stroke, greater mortality, and reduced functional recovery. Focal cerebral ischemia data support that neural stem cells (NSCs) play an important role in post-ischemic repair. Here we sought to evaluate the negative effects of hyperglyc...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-14-24

    authors: Chen J,Guo Y,Cheng W,Chen R,Liu T,Chen Z,Tan S

    更新日期:2013-03-04 00:00:00

  • Ultrastructure of acetylcholine receptor aggregates parallels mechanisms of aggregation.

    abstract:BACKGROUND:Acetylcholine receptors become aggregated at the developing neuromuscular synapse shortly after contact by a motorneuron in one of the earliest manifestations of synaptic development. While a major physiological signal for receptor aggregation (agrin) is known, the mechanism(s) by which muscle cells respond ...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-2-19

    authors: Kunkel DD,Lee LK,Stollberg J

    更新日期:2001-01-01 00:00:00

  • Cone inputs to murine striate cortex.

    abstract:BACKGROUND:We have recorded responses from single neurons in murine visual cortex to determine the effectiveness of the input from the two murine cone photoreceptor mechanisms and whether there is any unique selectivity for cone inputs at this higher region of the visual system that would support the possibility of col...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-9-113

    authors: Ekesten B,Gouras P

    更新日期:2008-11-14 00:00:00

  • Power spectral aspects of the default mode network in schizophrenia: an MEG study.

    abstract:BACKGROUND:Symptoms of schizophrenia are related to deficits in self-monitoring function, which may be a consequence of irregularity in aspects of the default mode network (DMN). Schizophrenia can also be characterized by a functional abnormality of the brain activity that is reflected in the resting state. Oscillatory...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-15-104

    authors: Kim JS,Shin KS,Jung WH,Kim SN,Kwon JS,Chung CK

    更新日期:2014-09-05 00:00:00

  • Visual laterality in dolphins: importance of the familiarity of stimuli.

    abstract:BACKGROUND:Many studies of cerebral asymmetries in different species lead, on the one hand, to a better understanding of the functions of each cerebral hemisphere and, on the other hand, to develop an evolutionary history of hemispheric laterality. Our animal model is particularly interesting because of its original ev...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-13-9

    authors: Blois-Heulin C,Crével M,Böye M,Lemasson A

    更新日期:2012-01-12 00:00:00

  • Glutamate-induced apoptosis in neuronal cells is mediated via caspase-dependent and independent mechanisms involving calpain and caspase-3 proteases as well as apoptosis inducing factor (AIF) and this process is inhibited by equine estrogens.

    abstract:BACKGROUND:Glutamate, a major excitatory amino acid neurotransmitter, causes apoptotic neuronal cell death at high concentrations. Our previous studies have shown that depending on the neuronal cell type, glutamate-induced apoptotic cell death was associated with regulation of genes such as Bcl-2, Bax, and/or caspase-3...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-7-49

    authors: Zhang Y,Bhavnani BR

    更新日期:2006-06-15 00:00:00

  • Evidence for inflammation-mediated memory dysfunction in gastropods: putative PLA2 and COX inhibitors abolish long-term memory failure induced by systemic immune challenges.

    abstract:BACKGROUND:Previous studies associate lipid peroxidation with long-term memory (LTM) failure in a gastropod model (Lymnaea stagnalis) of associative learning and memory. This process involves activation of Phospholipase A2 (PLA2), an enzyme mediating the release of fatty acids such as arachidonic acid that form the pre...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-14-83

    authors: Hermann PM,Park D,Beaulieu E,Wildering WC

    更新日期:2013-08-06 00:00:00

  • Orienting asymmetries and lateralized processing of sounds in humans.

    abstract:BACKGROUND:Lateralized processing of speech is a well studied phenomenon in humans. Both anatomical and neurophysiological studies support the view that nonhuman primates and other animal species also reveal hemispheric differences in areas involved in sound processing. In recent years, an increasing number of studies ...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-10-14

    authors: Fischer J,Teufel C,Drolet M,Patzelt A,Rübsamen R,von Cramon DY,Schubotz RI

    更新日期:2009-02-24 00:00:00