Abstract:
BACKGROUND:Humans demonstrate a number of unique adaptations that allow for the maintenance of blood pressure and brain blood flow when upright. While several physiological systems, including cerebral autoregulation, are involved in this adaptation the unique role the vestibular system plays in helping to maintain brain blood flow is just beginning to be elucidated. In this study, we tested the hypothesis that stimulation of the vestibular system, specifically the otoliths organs, would result in changes in cerebral blood flow. RESULTS:To test our hypothesis, we stimulated the vestibular organs of 25 healthy subjects by pitch tilt (stimulates both canals and otoliths) and by translation on a centrifuge (stimulates otoliths and not the canals) at five frequencies: 0.5, 0.25, 0.125 and 0.0625 Hz for 80 sec and 0.03125 Hz for 160 sec. Changes in cerebral flow velocity (by transcranial Doppler) and blood pressure (by Finapres) were similar during both stimuli and dependent on frequency of stimulation (P < 0.01). However, changes in cerebral blood flow were in opposition to changes in blood pressure and not fully dependent on changes in end tidal CO2. CONCLUSION:The experimental results support our hypothesis and provide evidence that activation of the vestibular apparatus, specifically the otolith organs, directly affects cerebral blood flow regulation, independent of blood pressure and end tidal CO2 changes.
journal_name
BMC Neuroscijournal_title
BMC neuroscienceauthors
Serrador JM,Schlegel TT,Black FO,Wood SJdoi
10.1186/1471-2202-10-119subject
Has Abstractpub_date
2009-09-23 00:00:00pages
119issn
1471-2202pii
1471-2202-10-119journal_volume
10pub_type
杂志文章相关文献
BMC NEUROSCIENCE文献大全abstract:BACKGROUND:Cys-loop receptors play important roles in fast neuronal signal transmission. Functional receptors are pentamers, with each subunit having an extracellular, transmembrane (TM) and intracellular domain. Each TM domain contains 4 α-helices (M1-M4) joined by loops of varying lengths. Many of the amino acid resi...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-018-0454-8
更新日期:2018-09-06 00:00:00
abstract:BACKGROUND:Peripherin, a type III neuronal intermediate filament, is widely expressed in neurons of the peripheral nervous system and in selected central nervous system hindbrain areas with projections towards peripheral structures, such as cranial nerves and spinal cord neurons. Peripherin appears to play a role in ne...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-9-26
更新日期:2008-02-24 00:00:00
abstract:BACKGROUND:This work examines the central nervous system distribution of virus-labeled neurons from the rat urinary bladder and the prostate simultaneously within the same tissue sections. Two immunohistochemically distinct pseudorabies virus strains were simultaneously injected into male Sprague Dawley rats (approxima...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-3-8
更新日期:2002-07-12 00:00:00
abstract:BACKGROUND:Impaired speech perception is one of the major sequelae of aging. In addition to peripheral hearing loss, central deficits of auditory processing are supposed to contribute to the deterioration of speech perception in older individuals. To test the hypothesis that auditory temporal processing is compromised ...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-10-34
更新日期:2009-04-07 00:00:00
abstract:BACKGROUND:The optic nerve is a pure white matter central nervous system (CNS) tract with an isolated blood supply, and is widely used in physiological studies of white matter response to various insults. We examined the gene expression profile of human optic nerve (ON) and, through the NEIBANK online resource, to prov...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-10-121
更新日期:2009-09-24 00:00:00
abstract:BACKGROUND:The potential adverse effect of mobile phone radiation is currently an area of great concern in the field of public health. In the present study, we aimed to investigate the effect of mobile phone radiation (900 MHz radiofrequency) during hatching on postnatal social behaviors in chicks, as well as the effec...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-016-0266-7
更新日期:2016-06-10 00:00:00
abstract:BACKGROUND:To measure the impact of masticatory reduction on learning and memory, previous studies have produced experimental masticatory reduction by modified diet or molar removal. Here we induced spatial learning impairment in mice by reducing masticatory activity and then tested the effect of a combination of envir...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-14-63
更新日期:2013-06-28 00:00:00
abstract:BACKGROUND:Given the reported inverse association between light and depressive mood, ambient light may also be associated with some of the brain regions in healthy subjects. The present study aims to investigate the effects of ambient light on glucose metabolism in the brain. We used the data of 28 healthy participants...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-018-0444-x
更新日期:2018-07-24 00:00:00
abstract:BACKGROUND:Recently a hyperthermic rat hippocampal slice model system has been used to investigate febrile seizure pathophysiology. Our previous data indicates that heating immature rat hippocampal slices from 34 to 41 degrees C in an interface chamber induced epileptiform-like population spikes accompanied by a spread...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-2-18
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:Trigeminal nerve is a major source of the sensory input of the face, and trigeminal neuropathology models have been reported in rodents with injury to branches of the maxillary or mandibular division of the trigeminal nerve. Non-human primates are neuroanatomically more closely related to human than rodents;...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-13-150
更新日期:2012-12-13 00:00:00
abstract:BACKGROUND:Human brain microvascular endothelial cells (hBMVECs) are integral part of the blood brain barrier. Post-translational modifications of adherens junction proteins regulate the permeability of human brain microvascular endothelial cells. Pro-inflammatory signals can induce tyrosine phosphorylation of adherens...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-15-80
更新日期:2014-06-26 00:00:00
abstract:BACKGROUND:Previous studies found that rats subjected to carrageenan injection develop hyperalgesia, and despite complete recovery in several days, they continue to have an enhanced hyperalgesic response to a new noxious challenge for more than 28d. The study's aim was to identify candidate genes that have a role in th...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-9-32
更新日期:2008-03-13 00:00:00
abstract:BACKGROUND:Parkinson disease (PD) is a movement disorder affecting 1 % of people over the age of 60. The etiology of the disease is unknown; however, accumulating evidence suggests that mitochondrial defects, oxidative stress, and neuroinflammation play important roles in developing the disease. Current medications for...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-016-0293-4
更新日期:2016-08-22 00:00:00
abstract:BACKGROUND:Sonic hedgehog (Shh)/Gli pathway plays an important regulatory role on the neuroepithelial cells (NEc) proliferation in the dorsal regions of the developing vertebrate Central Nervous System. The aim of this paper was to analyze the effect of the Shh/Gli signaling pathway activation on the proliferation dyna...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-13-117
更新日期:2012-10-02 00:00:00
abstract:BACKGROUND:Adult neurogenesis continuously adds new neurons to the dentate gyrus and the olfactory bulb. It involves the proliferation and subsequent differentiation of neuronal progenitors, and is thus closely linked to the cell cycle machinery. Cell cycle progression is governed by the successive expression, activati...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-13-46
更新日期:2012-05-07 00:00:00
abstract:BACKGROUND:Following partial injury to the central nervous system, cells beyond the initial injury site undergo secondary degeneration, exacerbating loss of neurons, compact myelin and function. Changes in Ca2+ flux are associated with metabolic and structural changes, but it is not yet clear how flux through specific ...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-017-0380-1
更新日期:2017-08-14 00:00:00
abstract:BACKGROUND:Recent evidence has suggested that Alzheimer's disease (AD)-associated neuronal loss may occur via the caspase-independent route of programmed cell death (PCD) in addition to caspase-dependent mechanisms. However, the brain region specificity of caspase-independent PCD in AD-associated neurodegeneration is u...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-15-73
更新日期:2014-06-10 00:00:00
abstract:BACKGROUND:The neurological complications of HIV infection remain poorly understood. Clinically, in vivo 1H magnetic resonance spectroscopy (MRS) demonstrates brain injury caused by HIV infection even when the MRI is normal. Our goal was to undertsand the dynamics of cerebral injury by performing a longitudinal in vivo...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-5-10
更新日期:2004-03-05 00:00:00
abstract:BACKGROUND:In rodents, dietary Na+ deprivation reduces gustatory responses of primary taste fibers and central taste neurons to lingual Na+ stimulation. However, in the rat taste bud cells Na+ deprivation increases the number of amiloride sensitive epithelial Na+ channels (ENaC), which are considered as the "receptor" ...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-10-19
更新日期:2009-03-12 00:00:00
abstract:BACKGROUND:Mental imagery is a powerful method of altering brain activity and behavioral outcomes, such as performance of cognition and motor skills. Further, attention and distraction can modulate pain-related neuronal networks and the perception of pain. This exploratory study examined the effects of mental imagery-i...
journal_title:BMC neuroscience
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12868-015-0146-6
更新日期:2015-03-15 00:00:00
abstract:BACKGROUND:The human inferior frontal junction area (IFJ) is critically involved in three main component processes of cognitive control (working memory, task switching and inhibitory control). As it overlaps with several areas in established anatomical labeling schemes, it is considered to be underreported as a functio...
journal_title:BMC neuroscience
pub_type: 杂志文章,meta分析
doi:10.1186/1471-2202-13-119
更新日期:2012-10-03 00:00:00
abstract:BACKGROUND:Polymorphisms in the gene for phosphatidylinositol binding clathrin assembly protein (PICALM), an endocytic-related protein, are associated with a small, increased risk of developing Alzheimer's disease (AD), strongly suggesting that changes in endocytosis are involved in the aetiology of the disease. We hav...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-016-0288-1
更新日期:2016-07-18 00:00:00
abstract:BACKGROUND:Post-stroke hyperglycemia appears to be associated with poor outcome from stroke, greater mortality, and reduced functional recovery. Focal cerebral ischemia data support that neural stem cells (NSCs) play an important role in post-ischemic repair. Here we sought to evaluate the negative effects of hyperglyc...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-14-24
更新日期:2013-03-04 00:00:00
abstract:BACKGROUND:Acetylcholine receptors become aggregated at the developing neuromuscular synapse shortly after contact by a motorneuron in one of the earliest manifestations of synaptic development. While a major physiological signal for receptor aggregation (agrin) is known, the mechanism(s) by which muscle cells respond ...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-2-19
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:We have recorded responses from single neurons in murine visual cortex to determine the effectiveness of the input from the two murine cone photoreceptor mechanisms and whether there is any unique selectivity for cone inputs at this higher region of the visual system that would support the possibility of col...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-9-113
更新日期:2008-11-14 00:00:00
abstract:BACKGROUND:Symptoms of schizophrenia are related to deficits in self-monitoring function, which may be a consequence of irregularity in aspects of the default mode network (DMN). Schizophrenia can also be characterized by a functional abnormality of the brain activity that is reflected in the resting state. Oscillatory...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-15-104
更新日期:2014-09-05 00:00:00
abstract:BACKGROUND:Many studies of cerebral asymmetries in different species lead, on the one hand, to a better understanding of the functions of each cerebral hemisphere and, on the other hand, to develop an evolutionary history of hemispheric laterality. Our animal model is particularly interesting because of its original ev...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-13-9
更新日期:2012-01-12 00:00:00
abstract:BACKGROUND:Glutamate, a major excitatory amino acid neurotransmitter, causes apoptotic neuronal cell death at high concentrations. Our previous studies have shown that depending on the neuronal cell type, glutamate-induced apoptotic cell death was associated with regulation of genes such as Bcl-2, Bax, and/or caspase-3...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-7-49
更新日期:2006-06-15 00:00:00
abstract:BACKGROUND:Previous studies associate lipid peroxidation with long-term memory (LTM) failure in a gastropod model (Lymnaea stagnalis) of associative learning and memory. This process involves activation of Phospholipase A2 (PLA2), an enzyme mediating the release of fatty acids such as arachidonic acid that form the pre...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-14-83
更新日期:2013-08-06 00:00:00
abstract:BACKGROUND:Lateralized processing of speech is a well studied phenomenon in humans. Both anatomical and neurophysiological studies support the view that nonhuman primates and other animal species also reveal hemispheric differences in areas involved in sound processing. In recent years, an increasing number of studies ...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-10-14
更新日期:2009-02-24 00:00:00