Abstract：
BACKGROUND:Previous studies showed that anodal transcranial DC stimulation (tDCS) applied to the primary motor cortex of the affected hemisphere (M1affected hemisphere) after subcortical stroke transiently improves performance of complex tasks that mimic activities of daily living (ADL). It is not known if relatively simpler motor tasks are similarly affected. Here we tested the effects of tDCS on pinch force (PF) and simple reaction time (RT) tasks in patients with chronic stroke in a double-blind cross-over Sham-controlled experimental design. RESULTS:Anodal tDCS shortened reaction times and improved pinch force in the paretic hand relative to Sham stimulation, an effect present in patients with higher impairment. CONCLUSION:tDCS of M1affected hemisphere can modulate performance of motor tasks simpler than those previously studied, a finding that could potentially benefit patients with relatively higher impairment levels.
journal_name
BMC Neuroscijournal_title
BMC neuroscienceauthors
Hummel FC,Voller B,Celnik P,Floel A,Giraux P,Gerloff C,Cohen LGdoi
10.1186/1471-2202-7-73subject
Has Abstractpub_date
2006-11-03 00:00:00pages
73issn
1471-2202pii
1471-2202-7-73journal_volume
7pub_type
临床试验,杂志文章相关文献
BMC NEUROSCIENCE文献大全abstract：BACKGROUND:Errorless learning has advantages over errorful learning. The erroneous items produced during errorful learning compete with correct items at retrieval resulting in decreased memory performance. This interference is associated with an increased demand on executive monitoring processes. Event-related function...
journal_title：BMC neuroscience
pub_type： 杂志文章
doi：10.1186/1471-2202-14-30
更新日期：2013-03-13 00:00:00
abstract：BACKGROUND:The effects induced by administering the anticonvulsant lamotrigine, the preferential inhibitor of neuronal nitric oxide synthase 7-nitroindazole and the precursor of NO synthesis L-arginine, alone or in combination, on an experimental model of partial complex seizures (maximal dentate gyrus activation) were...
journal_title：BMC neuroscience
pub_type： 杂志文章
doi：10.1186/1471-2202-8-47
更新日期：2007-07-03 00:00:00
abstract：BACKGROUND:Lateralized processing of speech is a well studied phenomenon in humans. Both anatomical and neurophysiological studies support the view that nonhuman primates and other animal species also reveal hemispheric differences in areas involved in sound processing. In recent years, an increasing number of studies ...
journal_title：BMC neuroscience
pub_type： 杂志文章
doi：10.1186/1471-2202-10-14
更新日期：2009-02-24 00:00:00
abstract：BACKGROUND:Chlamydophila (Chlamydia) pneumoniae is an intracellular bacterium that has been identified within cells in areas of neuropathology found in Alzheimer disease (AD), including endothelia, glia, and neurons. Depending on the cell type of the host, infection by C. pneumoniae has been shown to influence apoptoti...
journal_title：BMC neuroscience
pub_type： 杂志文章
doi：10.1186/1471-2202-9-13
更新日期：2008-01-24 00:00:00
abstract：BACKGROUND:Hyperbaric oxygen therapy (HBOT) is a known adjuvant for treating ischemia-related inner ear diseases. Controversies still exist in the role of HBOT in cochlear diseases. Few studies to date have investigated the cellular changes that occur in inner ears after HBOT. Nitric oxide, which is synthesized by nitr...
journal_title：BMC neuroscience
pub_type： 杂志文章
doi：10.1186/1471-2202-12-21
更新日期：2011-02-22 00:00:00
abstract：BACKGROUND:Sonic hedgehog (Shh)/Gli pathway plays an important regulatory role on the neuroepithelial cells (NEc) proliferation in the dorsal regions of the developing vertebrate Central Nervous System. The aim of this paper was to analyze the effect of the Shh/Gli signaling pathway activation on the proliferation dyna...
journal_title：BMC neuroscience
pub_type： 杂志文章
doi：10.1186/1471-2202-13-117
更新日期：2012-10-02 00:00:00
abstract：BACKGROUND:Emotional stimuli are preferentially processed compared to neutral ones. Measuring the magnetic resonance blood-oxygen level dependent (BOLD) response or EEG event-related potentials, this has also been demonstrated for emotional versus neutral words. However, it is currently unclear whether emotion effects ...
journal_title：BMC neuroscience
pub_type： 杂志文章
doi：10.1186/1471-2202-11-85
更新日期：2010-07-27 00:00:00
abstract：BACKGROUND:A delay in surgical nerve repair results in impaired nerve function in humans, but mechanisms behind the weakened nerve regeneration are not known. Activating transcription factor 3 (ATF3) increases the intrinsic growth state of injured neurons early after injury, but the role of long-term changes and their ...
journal_title：BMC neuroscience
pub_type： 杂志文章
doi：10.1186/1471-2202-9-88
更新日期：2008-09-18 00:00:00
abstract：BACKGROUND:Anticipatory planning, the ability to anticipate future perceptual-motor demands of a goal-oriented action sequence, is essential for flexible, purposeful behavior. Once an action goal has been defined, movement details necessary to achieve that goal can be selected. Here, we investigate if anticipatory plan...
journal_title：BMC neuroscience
pub_type： 杂志文章
doi：10.1186/1471-2202-14-91
更新日期：2013-08-28 00:00:00
abstract：BACKGROUND:Polymorphisms in the gene for phosphatidylinositol binding clathrin assembly protein (PICALM), an endocytic-related protein, are associated with a small, increased risk of developing Alzheimer's disease (AD), strongly suggesting that changes in endocytosis are involved in the aetiology of the disease. We hav...
journal_title：BMC neuroscience
pub_type： 杂志文章
doi：10.1186/s12868-016-0288-1
更新日期：2016-07-18 00:00:00
abstract：BACKGROUND:Huntington's disease (HD) is a neurodegenerative disorder predominantly affecting the cerebral cortex and striatum. Transgenic mice (R6/1 line), expressing a CAG repeat encoding an expanded polyglutamine tract in the N-terminus of the huntingtin protein, closely model HD. We have previously shown that enviro...
journal_title：BMC neuroscience
pub_type： 杂志文章
doi：10.1186/1471-2202-9-34
更新日期：2008-04-01 00:00:00
abstract：BACKGROUND:Glutamate gated postsynaptic receptors in the central nervous system (CNS) are essential for environmentally stimulated behaviours including learning and memory in both invertebrates and vertebrates. Though their genetics, biochemistry, physiology, and role in behaviour have been intensely studied in vitro a...
journal_title：BMC neuroscience
pub_type： 杂志文章
doi：10.1186/1471-2202-9-6
更新日期：2008-01-15 00:00:00
abstract：BACKGROUND:Astrocytes are responsible for a broad range of functions that maintain homeostasis in the brain. However, their response to the pro-inflammatory cytokines released by activated microglia in various neurological pathologies may exacerbate neurodegenerative processes. Accumulating evidence suggests that omega...
journal_title：BMC neuroscience
pub_type： 杂志文章
doi：10.1186/s12868-021-00611-w
更新日期：2021-01-27 00:00:00
abstract：BACKGROUND:Major depressive disorder is a prevalent disease that is inadequately treated with currently available interventions. Stress increases susceptibility to depression in patients and rodent models. Depression is also associated with aberrant activation of inflammation, such as increases in circulating levels of...
journal_title：BMC neuroscience
pub_type： 杂志文章
doi：10.1186/s12868-015-0169-z
更新日期：2015-05-07 00:00:00
abstract：:Numerous molecular factors orchestrate the development of the peripheral taste system. The unique anatomy/function of the taste system makes this system ideal for understanding the mechanisms by which these factors function; yet the taste system is underutilized for this role. This review focuses on some of the many f...
journal_title：BMC neuroscience
pub_type： 杂志文章,评审
doi：10.1186/1471-2202-8-S3-S4
更新日期：2007-09-18 00:00:00
abstract：BACKGROUND:After unilateral cervical cord lesion at the C7/C8 border interrupting the dorsolateral funiculus in adult monkeys, neutralization of Nogo-A using a specific monoclonal antibody promoted sprouting of corticospinal (CS) axons rostral and caudal to the lesion and, in parallel, improved functional recovery. In ...
journal_title：BMC neuroscience
pub_type： 杂志文章
doi：10.1186/1471-2202-9-5
更新日期：2008-01-14 00:00:00
abstract：BACKGROUND:Alzheimer's disease (AD) is a progressive neuro-degenerative disease with a major manifestation of dementia. MicroRNAs were reported to regulate the transcript expression in patients with Alzheimer's disease (AD). In this study, we investigated the roles of miR-138, a brain-enriched miRNA, in the AD cell mod...
journal_title：BMC neuroscience
pub_type： 杂志文章
doi：10.1186/s12868-020-00579-z
更新日期：2020-07-31 00:00:00
abstract：BACKGROUND:The topological structure of the wiring of the mammalian brain cortex plays an important role in shaping the functional dynamics of large-scale neural activity. Due to their central embedding in the network, high degree hub regions and their connections (often referred to as the 'rich club') have been hypoth...
journal_title：BMC neuroscience
pub_type： 杂志文章
doi：10.1186/s12868-015-0193-z
更新日期：2015-09-02 00:00:00
abstract：BACKGROUND:Synaptic degeneration and accumulation of amyloid β-peptides (Aβ) are hallmarks of the Alzheimer diseased brain. Aβ is synaptotoxic and produced by sequential cleavage of the amyloid precursor protein (APP) by the β-secretase BACE1 and by γ-secretase. If APP is instead cleaved by the α-secretase ADAM10, Aβ w...
journal_title：BMC neuroscience
pub_type： 杂志文章
doi：10.1186/s12868-020-0554-0
更新日期：2020-02-04 00:00:00
abstract：INTRODUCTION:NAP (Asn-Ala-Pro-Val-Ser-Ile-Pro-Gln, single amino acid letter code, NAPVSIPQ), an eight amino acid neuroprotective peptide derived from activity-dependent neuroprotective protein (ADNP), exhibits some structural similarity to activity-dependent neurotropic factor-9 (ADNF-9; Ser-Alal-Leu-Leu-Arg-Ser-Ile-Pr...
journal_title：BMC neuroscience
pub_type： 杂志文章
doi：10.1186/1471-2202-9-S3-S3
更新日期：2008-12-10 00:00:00
abstract：BACKGROUND:In this study, we examined the effects of cyclophosphamide, methothrexate, and 5-Fluorouracil (CMF) drug combination on various aspects of learning and memory. We also examined the effects of CMF on cell proliferation and chromatin remodeling as possible underlying mechanisms to explain chemotherapy-associat...
journal_title：BMC neuroscience
pub_type： 杂志文章
doi：10.1186/1471-2202-12-124
更新日期：2011-12-09 00:00:00
abstract：BACKGROUND:Imprinting behavior is one form of learning and memory in precocial birds. With the aim of elucidating of the neural basis for visual imprinting, we focused on visual information processing. RESULTS:A lesion in the visual wulst, which is similar functionally to the mammalian visual cortex, caused anterograd...
journal_title：BMC neuroscience
pub_type： 杂志文章
doi：10.1186/1471-2202-7-75
更新日期：2006-11-14 00:00:00
abstract：BACKGROUND:Mitochondrial DNA (mtDNA) mutations, which are present in all mitochondria-containing cells, paradoxically cause tissue-specific disease. For example, Leber's hereditary optic neuropathy (LHON) results from one of three point mutations mtDNA coding for complex I components, but is only manifested in retinal ...
journal_title：BMC neuroscience
pub_type： 杂志文章
doi：10.1186/1471-2202-9-4
更新日期：2008-01-08 00:00:00
abstract：BACKGROUND:Gap junction proteins, connexins, are expressed in most endocrine and exocrine glands in the body and are at least in some glands crucial for the hormonal secretion. To what extent connexins are expressed in neurons releasing hormones or neuropeptides from or within the central nervous system is, however, un...
journal_title：BMC neuroscience
pub_type： 杂志文章
doi：10.1186/1471-2202-10-41
更新日期：2009-04-30 00:00:00
abstract：BACKGROUND:Mounting evidence indicates that humans have significant difficulties in understanding emotional expressions from individuals of different ethnic backgrounds, leading to reduced recognition accuracy and stronger amygdala activation. However, the impact of gender on the behavioral and neural reactions during ...
journal_title：BMC neuroscience
pub_type： 杂志文章
doi：10.1186/1471-2202-13-54
更新日期：2012-05-29 00:00:00
abstract：BACKGROUND:Previous studies in the rat have shown that the spatial organisation of the receptive fields of nociceptive withdrawal reflex (NWR) system are functionally adapted through experience dependent mechanisms, termed somatosensory imprinting, during postnatal development. Here we wanted to clarify 1) if mice exhi...
journal_title：BMC neuroscience
pub_type： 杂志文章
doi：10.1186/1471-2202-9-45
更新日期：2008-05-21 00:00:00
abstract：BACKGROUND:Yawning is a stereotyped behavior that enhances blood flow to the skull, and the resulting counterflow has been hypothesized as a mechanism for brain cooling. Studies have shown that yawns are strongly associated with physiological and pathological conditions that increase brain temperature, and that they ar...
journal_title：BMC neuroscience
pub_type： 杂志文章
doi：10.1186/s12868-016-0330-3
更新日期：2017-01-03 00:00:00
abstract：BACKGROUND:Histone deacetylases (HDACs) are enzymes that modulate gene expression and cellular processes by deacetylating histones and non-histone proteins. While small molecule inhibitors of HDAC activity (HDACi) are used clinically in the treatment of cancer, pre-clinical treatment models suggest they also exert neur...
journal_title：BMC neuroscience
pub_type： 杂志文章
doi：10.1186/1471-2202-12-50
更新日期：2011-05-26 00:00:00
abstract：BACKGROUND:Circadian clocks are endogenous biochemical oscillators that control daily behavioral rhythms in all living organisms. In fruit fly, the circadian rhythms are typically studied using power spectra of multiday behavioral recordings. Despite decades of study, a quantitative understanding of the temporal shape ...
journal_title：BMC neuroscience
pub_type： 杂志文章
doi：10.1186/s12868-016-0248-9
更新日期：2016-04-18 00:00:00
abstract：BACKGROUND:Auditory perceptual learning persistently modifies neural networks in the central nervous system. Central auditory processing comprises a hierarchy of sound analysis and integration, which transforms an acoustical signal into a meaningful object for perception. Based on latencies and source locations of audi...
journal_title：BMC neuroscience
pub_type： 杂志文章
doi：10.1186/1471-2202-14-151
更新日期：2013-12-05 00:00:00
