Abstract:
BACKGROUND:Mitochondrial DNA (mtDNA) mutations, which are present in all mitochondria-containing cells, paradoxically cause tissue-specific disease. For example, Leber's hereditary optic neuropathy (LHON) results from one of three point mutations mtDNA coding for complex I components, but is only manifested in retinal ganglion cells (RGCs), a central neuron contained within the retina. Given that RGCs use superoxide for intracellular signaling after axotomy, and that LHON mutations increase superoxide levels in non-RGC transmitochondrial cybrids, we hypothesized that RGCs regulate superoxide levels differently than other neuronal cells. To study this, we compared superoxide production and mitochondrial electron transport chain (METC) components in isolated RGC mitochondria to mitochondria isolated from cerebral cortex and neuroblastoma SK-N-AS cells. RESULTS:In the presence of the complex I substrate glutamate/malate or the complex II substrate succinate, the rate of superoxide production in RGC-5 cells was significantly lower than cerebral or neuroblastoma cells. Cerebral but not RGC-5 or neuroblastoma cells increased superoxide production in response to the complex I inhibitor rotenone, while neuroblastoma but not cerebral or RGC-5 cells dramatically decreased superoxide production in response to the complex III inhibitor antimycin A. Immunoblotting and real-time quantitative PCR of METC components demonstrated different patterns of expression among the three different sources of neuronal mitochondria. CONCLUSION:RGC-5 mitochondria produce superoxide at significantly lower rates than cerebral and neuroblastoma mitochondria, most likely as a result of differential expression of complex I components. Diversity in METC component expression and function could explain tissue specificity in diseases associated with inherited mtDNA abnormalities.
journal_name
BMC Neuroscijournal_title
BMC neuroscienceauthors
Hoegger MJ,Lieven CJ,Levin LAdoi
10.1186/1471-2202-9-4subject
Has Abstractpub_date
2008-01-08 00:00:00pages
4issn
1471-2202pii
1471-2202-9-4journal_volume
9pub_type
杂志文章相关文献
BMC NEUROSCIENCE文献大全abstract:BACKGROUND:Precise control of developmental and cell-specific expression of the brain-derived neurotrophic factor (BDNF) gene is essential for normal neuronal development and the diverse functions of BDNF in the adult organism. We previously showed that the zebrafish BDNF gene has multiple promoters. The complexity of ...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-5-19
更新日期:2004-05-21 00:00:00
abstract:BACKGROUND:Low-intensity pulsed ultrasound stimulation (LIPUS) has been proven to be a noninvasive method with high spatial resolution and deep penetration. Previous studies have qualitatively demonstrated that the electromyographic response caused by LIPUS in the mouse motor cortex is affected by the anesthetic state ...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-018-0476-2
更新日期:2018-12-03 00:00:00
abstract:BACKGROUND:Acute subdural hemorrhage (ASDH) is a severe consequence of traumatic brain injury. The occurrence of subdural blood increases the lethality of these patients independent of the amount of blood or elevated intracranial pressure. Thrombin is one of the potential harmful blood components. Possible harmful effe...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-018-0481-5
更新日期:2018-12-27 00:00:00
abstract:BACKGROUND:Transcranial focused ultrasound (tFUS) is a new non-invasive neuromodulation technique that uses mechanical energy to modulate neuronal excitability with high spatial precision. tFUS has been shown to be capable of modulating EEG brain activity in humans that is spatially restricted, and here, we use 7T MRI ...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-018-0456-6
更新日期:2018-09-14 00:00:00
abstract:BACKGROUND:Recent evidence has suggested that Alzheimer's disease (AD)-associated neuronal loss may occur via the caspase-independent route of programmed cell death (PCD) in addition to caspase-dependent mechanisms. However, the brain region specificity of caspase-independent PCD in AD-associated neurodegeneration is u...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-15-73
更新日期:2014-06-10 00:00:00
abstract:BACKGROUND:The mechanisms of steroids actions in the brain mainly involve the binding and nuclear translocation of specific cytoplasmic receptors. These receptors can act as transcription factors and regulate gene expression. However, steroid-dependent transcriptional regulation in different types of neural cells is no...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-017-0352-5
更新日期:2017-04-05 00:00:00
abstract:BACKGROUND:Knock-in (KI) mouse models of Alzheimer's disease (AD) that endogenously overproduce Aβ without non-physiological overexpression of amyloid precursor protein (APP) provide important insights into the pathogenic mechanisms of AD. Previously, we reported that AppNL-G-F mice, which harbor three familial AD muta...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-019-0496-6
更新日期:2019-03-20 00:00:00
abstract:BACKGROUND:Granulocyte-macrophage colony stimulating factor (GM-CSF) is a hematopoietic growth factor involved in the generation of granulocytes, macrophages, and dendritic cells from hematopoietic progenitor cells. We have recently demonstrated that GM-CSF has anti-apoptotic functions on neurons, and is neuroprotectiv...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-8-88
更新日期:2007-10-22 00:00:00
abstract:BACKGROUND:CNS injury including stroke, infection, and tumor growth lead to astrogliosis, a process that involves upregulation of glial fibrillary acidic protein (GFAP) in astrocytes. However, the kinetics of astrogliosis that is related to these insults (i.e. tumor) is largely unknown. RESULTS:Using transgenic mice e...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-12-9
更新日期:2011-01-19 00:00:00
abstract:BACKGROUND:Excitatory transmitting mechanisms are proving to play a critical role on neuronal homeostasis conditions of facultative hibernators such as the Syrian golden hamster. Indeed works have shown that the glutamatergic system of the main olfactory brain station (amygdala) is capable of controlling thermoregulato...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-12-10
更新日期:2011-01-20 00:00:00
abstract:BACKGROUND:The neuropeptide arginine vasopressin (Avp) modulates social behaviors via its two centrally expressed receptors, the Avp 1a receptor and the Avp 1b receptor (Avpr1b). Recent work suggests that, at least in mice, Avp signaling through Avpr1b within the CA2 region of the hippocampus is critical for normal agg...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-016-0310-7
更新日期:2016-11-24 00:00:00
abstract:BACKGROUND:To measure the impact of masticatory reduction on learning and memory, previous studies have produced experimental masticatory reduction by modified diet or molar removal. Here we induced spatial learning impairment in mice by reducing masticatory activity and then tested the effect of a combination of envir...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-14-63
更新日期:2013-06-28 00:00:00
abstract:BACKGROUND:Recent alleged attacks with nerve agent sarin on civilians in Syria indicate their potential threat to both civilian and military population. Acute nerve agent exposure can cause rapid death or leads to multiple and long term neurological effects. The biochemical changes that occur following nerve agent expo...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-15-47
更新日期:2014-04-04 00:00:00
abstract:BACKGROUND:Overexpression and abnormal accumulation of aggregated alpha-synuclein (alphaS) have been linked to Parkinson's disease (PD) and other synucleinopathies. alphaS can misfold and adopt a variety of morphologies but recent studies implicate oligomeric forms as the most cytotoxic species. Both genetic mutations ...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-11-57
更新日期:2010-04-30 00:00:00
abstract:BACKGROUND:Lateralized processing of speech is a well studied phenomenon in humans. Both anatomical and neurophysiological studies support the view that nonhuman primates and other animal species also reveal hemispheric differences in areas involved in sound processing. In recent years, an increasing number of studies ...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-10-14
更新日期:2009-02-24 00:00:00
abstract:BACKGROUND:Recently, there has been a strong emphasis on identifying an in vitro model for neurotoxicity research that combines the biological relevance of primary neurons with the scalability, reproducibility and genetic tractability of continuous cell lines. Derived neurons should be homotypic, exhibit neuron-specifi...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-13-127
更新日期:2012-10-24 00:00:00
abstract:BACKGROUND:The Na+,K+-ATPase plays an important role for ion homeostasis in virtually all mammalian cells, including neurons. Despite this, there is as yet little known about the isoform specific distribution in neurons. RESULTS:With help of superresolving stimulated emission depletion microscopy the spatial distribut...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-12-16
更新日期:2011-01-27 00:00:00
abstract:BACKGROUND:Previous studies found that rats subjected to carrageenan injection develop hyperalgesia, and despite complete recovery in several days, they continue to have an enhanced hyperalgesic response to a new noxious challenge for more than 28d. The study's aim was to identify candidate genes that have a role in th...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-9-32
更新日期:2008-03-13 00:00:00
abstract:BACKGROUND:Distinctive patterns of functional connectivity (FC) abnormalities in neural circuitry has been reported in patients with bipolar depression (BD) and unipolar depression (UD). However, it is unclear that whether this distinct functional connectivity patterns are diagnosis specific between BD and UD. This stu...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-019-0508-6
更新日期:2019-06-17 00:00:00
abstract:BACKGROUND:Auditory perceptual learning persistently modifies neural networks in the central nervous system. Central auditory processing comprises a hierarchy of sound analysis and integration, which transforms an acoustical signal into a meaningful object for perception. Based on latencies and source locations of audi...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-14-151
更新日期:2013-12-05 00:00:00
abstract:BACKGROUND:Functional magnetic resonance imaging (fMRI) in white matter has long been considered controversial. Recently, this viewpoint has been challenged by an emerging body of evidence demonstrating white matter activation in the corpus callosum. The current study aimed to determine whether white matter activation ...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-12-56
更新日期:2011-06-14 00:00:00
abstract:BACKGROUND:The effects induced by administering the anticonvulsant lamotrigine, the preferential inhibitor of neuronal nitric oxide synthase 7-nitroindazole and the precursor of NO synthesis L-arginine, alone or in combination, on an experimental model of partial complex seizures (maximal dentate gyrus activation) were...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-8-47
更新日期:2007-07-03 00:00:00
abstract:BACKGROUND:The anesthetic drug ketamine (KT) has been reported to be an abused drug and fatal cases have been observed in polydrug users. In the present study, considering the possibility of KT-enhanced toxic effects of other drugs, and KT-induced promotion of an overdose without making the subject aware of the danger ...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-7-25
更新日期:2006-03-16 00:00:00
abstract:BACKGROUND:Obesity has deleterious effects on the brain, and metabolic dysfunction may exacerbate the outcomes of seizures and brain injuries. However, it is unclear whether obesity affects excitotoxicity-induced neuronal cell death. The purpose of this study was to investigate the effects of a high-fat diet (HFD) on n...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-015-0202-2
更新日期:2015-10-30 00:00:00
abstract:BACKGROUND:Previous studies in the rat have shown that the spatial organisation of the receptive fields of nociceptive withdrawal reflex (NWR) system are functionally adapted through experience dependent mechanisms, termed somatosensory imprinting, during postnatal development. Here we wanted to clarify 1) if mice exhi...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-9-45
更新日期:2008-05-21 00:00:00
abstract:BACKGROUND:Astrocytes are responsible for a broad range of functions that maintain homeostasis in the brain. However, their response to the pro-inflammatory cytokines released by activated microglia in various neurological pathologies may exacerbate neurodegenerative processes. Accumulating evidence suggests that omega...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-021-00611-w
更新日期:2021-01-27 00:00:00
abstract:BACKGROUND:Accumulating evidence suggests that glial signalling is activated by different brain functions. However, knowledge regarding molecular mechanisms of activation or their relation to neuronal activity is limited. The purpose of the present study is to identify the characteristics of ATP-evoked glial signalling...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/1471-2202-12-96
更新日期:2011-10-03 00:00:00
abstract:BACKGROUND:Major depressive disorder is a prevalent disease that is inadequately treated with currently available interventions. Stress increases susceptibility to depression in patients and rodent models. Depression is also associated with aberrant activation of inflammation, such as increases in circulating levels of...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-015-0169-z
更新日期:2015-05-07 00:00:00
abstract:BACKGROUND:Better treatments for schizophrenia are urgently needed. The therapeutic use of the nitric oxide (NO)-donor sodium nitroprusside (SNP) in patients with schizophrenia has shown promising results. The role of NO in schizophrenia is still unclear, and NO modulation is unexplored in ketamine (KET) animal models ...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-015-0149-3
更新日期:2015-03-07 00:00:00
abstract:BACKGROUND:Perivascular stromal cells (PSCs) are a recently identified cell type that comprises a small percentage of the platelet derived growth factor receptor-β+ cells within the CNS perivascular space. PSCs are activated following injury to the brain or spinal cord, expand in number and contribute to fibrotic scar ...
journal_title:BMC neuroscience
pub_type: 杂志文章
doi:10.1186/s12868-016-0284-5
更新日期:2016-07-15 00:00:00