Physiological and pathological aspects of Abeta in iron homeostasis via 5'UTR in the APP mRNA and the therapeutic use of iron-chelators.

abstract：BACKGROUND:CNS injury including stroke, infection, and tumor growth lead to astrogliosis, a process that involves upregulation of glial fibrillary acidic protein (GFAP) in astrocytes. However, the kinetics of astrogliosis that is related to these insults (i.e. tumor) is largely unknown. RESULTS:Using transgenic mice e...

journal_title：BMC neuroscience

authors： Lee J,Borboa AK,Baird A,Eliceiri BP

更新日期：2011-01-19 00:00:00

abstract：BACKGROUND:The properties of Ca2+ signaling mediated by purinergic receptors are intrinsically linked with functional activity of astrocytes. At present little is known concerning Ca2+-dependent purinergic responses in adult human astrocytes. This work has examined effects of purinergic stimulation to alter levels of i...

journal_title：BMC neuroscience

authors： Hashioka S,Wang YF,Little JP,Choi HB,Klegeris A,McGeer PL,McLarnon JG

更新日期：2014-01-22 00:00:00

abstract：BACKGROUND:Errorless learning has advantages over errorful learning. The erroneous items produced during errorful learning compete with correct items at retrieval resulting in decreased memory performance. This interference is associated with an increased demand on executive monitoring processes. Event-related function...

journal_title：BMC neuroscience

authors： Hammer A,Tempelmann C,Münte TF

更新日期：2013-03-13 00:00:00

abstract：BACKGROUND:Noise exposure (NE) is a severe modern health hazard that induces hearing impairment. However, the noise-induced ultrastructural changes of blood-labyrinth barrier (BLB) and the potential involvements of tight junction proteins (TJP) remain inconclusive. We investigated the effects of NE on not only the ultr...

journal_title：BMC neuroscience

authors： Wu YX,Zhu GX,Liu XQ,Sun F,Zhou K,Wang S,Wang CM,Jia JW,Song JT,Lu LJ

更新日期：2014-12-24 00:00:00

abstract：BACKGROUND:Impaired speech perception is one of the major sequelae of aging. In addition to peripheral hearing loss, central deficits of auditory processing are supposed to contribute to the deterioration of speech perception in older individuals. To test the hypothesis that auditory temporal processing is compromised ...

journal_title：BMC neuroscience

authors： Sörös P,Teismann IK,Manemann E,Lütkenhöner B

更新日期：2009-04-07 00:00:00

abstract：BACKGROUND:The use of induced pluripotent stem cells (iPSCs) for the functional replacement of damaged neurons and in vitro disease modeling is of great clinical relevance. Unfortunately, the capacity of iPSC lines to differentiate into neurons is highly variable, prompting the need for a reliable means of assessing th...

journal_title：BMC neuroscience

authors： Koehler KR,Tropel P,Theile JW,Kondo T,Cummins TR,Viville S,Hashino E

更新日期：2011-08-10 00:00:00

abstract：INTRODUCTION:NAP (Asn-Ala-Pro-Val-Ser-Ile-Pro-Gln, single amino acid letter code, NAPVSIPQ), an eight amino acid neuroprotective peptide derived from activity-dependent neuroprotective protein (ADNP), exhibits some structural similarity to activity-dependent neurotropic factor-9 (ADNF-9; Ser-Alal-Leu-Leu-Arg-Ser-Ile-Pr...

journal_title：BMC neuroscience

authors： Gozes I,Divinski I,Piltzer I

更新日期：2008-12-10 00:00:00

abstract：BACKGROUND:Ample evidence suggests a substantial contribution of cellular and molecular changes in the spinal cord to the induction and persistence of chronic neuropathic pain conditions. While for a long time, proteases were mainly considered as protein degrading enzymes, they are now receiving growing interest as sig...

journal_title：BMC neuroscience

authors： Leichsenring A,Bäcker I,Wendt W,Andriske M,Schmitz B,Stichel CC,Lübbert H

更新日期：2008-08-12 00:00:00

abstract：BACKGROUND:Peripherin, a type III neuronal intermediate filament, is widely expressed in neurons of the peripheral nervous system and in selected central nervous system hindbrain areas with projections towards peripheral structures, such as cranial nerves and spinal cord neurons. Peripherin appears to play a role in ne...

journal_title：BMC neuroscience

authors： Eriksson KS,Zhang S,Lin L,Larivière RC,Julien JP,Mignot E

更新日期：2008-02-24 00:00:00

abstract：BACKGROUND:Huntington's disease (HD) is a neurodegenerative disorder predominantly affecting the cerebral cortex and striatum. Transgenic mice (R6/1 line), expressing a CAG repeat encoding an expanded polyglutamine tract in the N-terminus of the huntingtin protein, closely model HD. We have previously shown that enviro...

journal_title：BMC neuroscience

authors： van Dellen A,Cordery PM,Spires TL,Blakemore C,Hannan AJ

更新日期：2008-04-01 00:00:00

abstract：BACKGROUND:White matter hyperintensities (WMH) can lead to dementia but the underlying physiological mechanisms are unclear. We compared relative oscillatory power from electroencephalographic studies (EEGs) of 17 patients with subcortical ischemic vascular dementia, based on extensive white matter hyperintensities (SI...

journal_title：BMC neuroscience

authors： van Straaten EC,de Haan W,de Waal H,Scheltens P,van der Flier WM,Barkhof F,Koene T,Stam CJ

更新日期：2012-07-24 00:00:00

abstract：BACKGROUND:One of the most basic human traits is language. Linguistic ability, and disability, have been shown to have a strong genetic component in family and twin studies, but molecular genetic studies of language phenotypes are scarce, relative to studies of other cognitive traits and neurodevelopmental phenotypes. ...

journal_title：BMC neuroscience

authors： Nudel R,Christiani CAJ,Ohland J,Uddin MJ,Hemager N,Ellersgaard D,Spang KS,Burton BK,Greve AN,Gantriis DL,Bybjerg-Grauholm J,Jepsen JRM,Thorup AAE,Mors O,Werge T,Nordentoft M

更新日期：2020-07-07 00:00:00

abstract：BACKGROUND:Functional magnetic resonance imaging (fMRI) in white matter has long been considered controversial. Recently, this viewpoint has been challenged by an emerging body of evidence demonstrating white matter activation in the corpus callosum. The current study aimed to determine whether white matter activation ...

journal_title：BMC neuroscience

authors： Gawryluk JR,Mazerolle EL,Brewer KD,Beyea SD,D'Arcy RC

更新日期：2011-06-14 00:00:00

abstract：BACKGROUND:It has been reported that various types of axonal injury of hypothalamo-neurohypophyseal tract can result in degeneration of the magnocellular neurons (MCNs) in hypothalamus and development of central diabetes insipidus (CDI). However, the mechanism of the degeneration and death of MCNs after hypophysectomy ...

journal_title：BMC neuroscience

authors： Wang Y,Zhao C,Wang Z,Wang C,Feng W,Huang L,Zhang J,Qi S

更新日期：2008-06-25 00:00:00

abstract：BACKGROUND:Alzheimer's Disease (AD) and Fronto temporal lobar dementia (FTLD) are common causes of dementia in the aging population for which limited therapeutical options are available. These disorders are associated with Tau accumulation. We have previously shown that Cerebrolysin™ (CBL), a neuropeptide mixture with ...

journal_title：BMC neuroscience

authors： Rockenstein E,Ubhi K,Trejo M,Mante M,Patrick C,Adame A,Novak P,Jech M,Doppler E,Moessler H,Masliah E

更新日期：2014-07-21 00:00:00

abstract：BACKGROUND:Understanding the underlying causes of nicotine addiction will require a multidisciplinary approach examining the key molecular, cellular and neuronal circuit functional changes that drive escalating levels of nicotine self-administration. In this study, we examined whether mice pretreated with chronic nicot...

journal_title：BMC neuroscience

authors： Renda A,Nashmi R

更新日期：2014-07-19 00:00:00

abstract：BACKGROUND:To date, functional imaging studies of treatment-induced recovery from chronic aphasia only assessed short-term treatment effects after intensive language training. In the present study, we show with functional magnetic resonance imaging (fMRI), that different brain regions may be involved in immediate versu...

journal_title：BMC neuroscience

authors： Menke R,Meinzer M,Kugel H,Deppe M,Baumgärtner A,Schiffbauer H,Thomas M,Kramer K,Lohmann H,Flöel A,Knecht S,Breitenstein C

更新日期：2009-09-22 00:00:00

abstract：BACKGROUND:Recent studies have shown that the human right-hemispheric auditory cortex is particularly sensitive to reduction in sound quality, with an increase in distortion resulting in an amplification of the auditory N1m response measured in the magnetoencephalography (MEG). Here, we examined whether this sensitivit...

journal_title：BMC neuroscience

authors： Miettinen I,Tiitinen H,Alku P,May PJ

更新日期：2010-02-22 00:00:00

abstract：BACKGROUND:The aim of this study was to assess the distribution of key SNARE proteins in glutamatergic and GABAergic synapses of the adult rat cerebellar cortex using light microscopy immunohistochemical techniques. Analysis was made of co-localizations of vGluT-1 and vGluT-2, vesicular transporters of glutamate and ma...

journal_title：BMC neuroscience

authors： Benagiano V,Lorusso L,Flace P,Girolamo F,Rizzi A,Bosco L,Cagiano R,Nico B,Ribatti D,Ambrosi G

更新日期：2011-11-17 00:00:00

abstract：BACKGROUND:Glutamate, a major excitatory amino acid neurotransmitter, causes apoptotic neuronal cell death at high concentrations. Our previous studies have shown that depending on the neuronal cell type, glutamate-induced apoptotic cell death was associated with regulation of genes such as Bcl-2, Bax, and/or caspase-3...

journal_title：BMC neuroscience

authors： Zhang Y,Bhavnani BR

更新日期：2006-06-15 00:00:00

abstract：BACKGROUND:Circadian clocks are endogenous biochemical oscillators that control daily behavioral rhythms in all living organisms. In fruit fly, the circadian rhythms are typically studied using power spectra of multiday behavioral recordings. Despite decades of study, a quantitative understanding of the temporal shape ...

journal_title：BMC neuroscience

authors： Lazopulo A,Syed S

更新日期：2016-04-18 00:00:00

abstract：BACKGROUND:Multi-sensor technologies such as EEG, MEG, and ECoG result in high-dimensional data sets. Given the high temporal resolution of such techniques, scientific questions very often focus on the time-course of an experimental effect. In many studies, researchers focus on a single sensor or the average over a sub...

journal_title：BMC neuroscience

authors： Schurger A,Marti S,Dehaene S

更新日期：2013-10-14 00:00:00

abstract：BACKGROUND:One of the most promising options for treatment of stroke using adult stem cells are human umbilical cord blood (HUCB) cells that were already approved for therapeutic efficacy in vivo. However, complexity of animal models has thus far limited the understanding of beneficial cellular mechanisms. To address t...

journal_title：BMC neuroscience

authors： Hau S,Reich DM,Scholz M,Naumann W,Emmrich F,Kamprad M,Boltze J

更新日期：2008-02-29 00:00:00

abstract：BACKGROUND:Several studies have shown that Stroop interference is stronger in children than in adults. However, in a standard Stroop paradigm, stimulus interference and response interference are confounded. The purpose of the present study was to determine whether interference at the stimulus level and the response lev...

journal_title：BMC neuroscience

authors： Jongen EM,Jonkman LM

更新日期：2008-09-05 00:00:00

abstract：BACKGROUND:The GABAergic system plays an important role in modulating levels of anxiety. When transplanted into the brain, precursor cells from the medial ganglionic eminence (MGE) have the ability to differentiate into GABAergic interneurons and modify the inhibitory tone in the host brain. Currently, two methods have...

journal_title：BMC neuroscience

authors： Romariz SA,Paiva Dde S,Valente MF,Barnabé GF,Frussa-Filho R,Barbosa-Silva RC,Calcagnotto ME,Longo BM

更新日期：2014-08-02 00:00:00

abstract：BACKGROUND:Transcranial focused ultrasound (tFUS) is a new non-invasive neuromodulation technique that uses mechanical energy to modulate neuronal excitability with high spatial precision. tFUS has been shown to be capable of modulating EEG brain activity in humans that is spatially restricted, and here, we use 7T MRI ...

journal_title：BMC neuroscience

authors： Ai L,Bansal P,Mueller JK,Legon W

更新日期：2018-09-14 00:00:00

abstract：BACKGROUND:It has been shown that olfactory ensheathing glia (OEG) and Schwann cell (SCs) transplantation are beneficial as cellular treatments for spinal cord injury (SCI), especially acute and sub-acute time points. In this study, we transplanted DsRED transduced adult OEG and SCs sub-acutely (14 days) following a T1...

journal_title：BMC neuroscience

authors： Barbour HR,Plant CD,Harvey AR,Plant GW

更新日期：2013-09-27 00:00:00

abstract：BACKGROUND:Alzheimer's disease (AD) is the most prevalent form of dementia and represents one of the highest unmet requirements in medicine today. There is shortage of novel molecules entering into market because of poor pharmacokinetic properties and safety issues. Drug repurposing offers an opportunity to reinvigorat...

journal_title：BMC neuroscience

authors： Kumar S,Chowdhury S,Kumar S

更新日期：2017-10-27 00:00:00

abstract：BACKGROUND:How living neural networks retain information is still incompletely understood. Two prominent ideas on this topic have developed in parallel, but have remained somewhat unconnected. The first of these, the "synaptic hypothesis," holds that information can be retained in synaptic connection strengths, or weig...

journal_title：BMC neuroscience

authors： Chen W,Hobbs JP,Tang A,Beggs JM

更新日期：2010-01-06 00:00:00

abstract：:Numerous molecular factors orchestrate the development of the peripheral taste system. The unique anatomy/function of the taste system makes this system ideal for understanding the mechanisms by which these factors function; yet the taste system is underutilized for this role. This review focuses on some of the many f...

journal_title：BMC neuroscience

authors： Krimm RF

更新日期：2007-09-18 00:00:00