当前位置： SCI文献检索 > BMC NEUROSCIENCE期刊下所有文献 > Apoptosis of supraoptic AVP neurons is involved in the development of central diabetes insipidus after hypophysectomy in rats.

Apoptosis of supraoptic AVP neurons is involved in the development of central diabetes insipidus after hypophysectomy in rats.

Abstract：

BACKGROUND:It has been reported that various types of axonal injury of hypothalamo-neurohypophyseal tract can result in degeneration of the magnocellular neurons (MCNs) in hypothalamus and development of central diabetes insipidus (CDI). However, the mechanism of the degeneration and death of MCNs after hypophysectomy in vivo is still unclear. This present study was aimed to disclose it and to figure out the dynamic change of central diabetes insipidus after hypophysectomy. RESULTS:The analysis on the dynamic change of daily water consumption (DWC), daily urine volume(DUV), specific gravity of urine(USG) and plasma vasopressin concentration showed that the change pattern of them was triphasic and neuron counting showed that the degeneration of vasopressin neurons began at 10 d, aggravated at 20 d and then stabilized at 30 d after hypophysectomy. There was marked upregulation of cleaved Caspase-3 expression of vasopressin neurons in hypophysectomy rats. A "ladder" pattern of migration of DNA internucleosomal fragments was detected and apoptotic ultrastructure was found in these neurons. There was time correlation among the occurrence of diabetes insipidus, the changes of plasma vasopressin concentration and the degeneration of vasopressin neurons after hypophysectomy. CONCLUSION:This study firstly demonstrated that apoptosis was involved in degeneration of supraoptic vasopressin neurons after hypophysectomy in vivo and development of CDI. Our study on time course and correlations among water metabolism, degeneration and apoptosis of vasopressin neurons suggested that there should be an efficient therapeutic window in which irreversible CDI might be prevented by anti-apoptosis.

journal_name

BMC Neurosci

journal_title

BMC neuroscience

authors

Wang Y,Zhao C,Wang Z,Wang C,Feng W,Huang L,Zhang J,Qi S

doi

10.1186/1471-2202-9-54

subject

Has Abstract

pub_date

2008-06-25 00:00:00

pages

54

issn

1471-2202

pii

1471-2202-9-54

journal_volume

9

pub_type

杂志文章

相关文献

BMC NEUROSCIENCE文献大全
  • Docosahexaenoic fatty acid reduces the pro-inflammatory response induced by IL-1β in astrocytes through inhibition of NF-κB and AP-1 transcription factor activation.

    abstract：BACKGROUND:Astrocytes are responsible for a broad range of functions that maintain homeostasis in the brain. However, their response to the pro-inflammatory cytokines released by activated microglia in various neurological pathologies may exacerbate neurodegenerative processes. Accumulating evidence suggests that omega...

    journal_title：BMC neuroscience

    pub_type： 杂志文章

    doi：10.1186/s12868-021-00611-w

    authors： Zgórzyńska E,Stulczewski D,Dziedzic B,Su KP,Walczewska A

    更新日期：2021-01-27 00:00:00

  • Effects of dietary Na+ deprivation on epithelial Na+ channel (ENaC), BDNF, and TrkB mRNA expression in the rat tongue.

    abstract：BACKGROUND:In rodents, dietary Na+ deprivation reduces gustatory responses of primary taste fibers and central taste neurons to lingual Na+ stimulation. However, in the rat taste bud cells Na+ deprivation increases the number of amiloride sensitive epithelial Na+ channels (ENaC), which are considered as the "receptor" ...

    journal_title：BMC neuroscience

    pub_type： 杂志文章

    doi：10.1186/1471-2202-10-19

    authors： Huang T,Stähler F

    更新日期：2009-03-12 00:00:00

  • Neuroprotection by rAAV-mediated gene transfer of bone morphogenic protein 7.

    abstract：BACKGROUND:Bone morphogenic proteins (BMPs) promote the survival of neurons, suggesting a therapeutic application of BMPs in the treatment of acute and chronic neurodegenerative disorders. However, the application of recombinant BMPs in vivo is limited by their short half-life. To provide a continuous supply for functi...

    journal_title：BMC neuroscience

    pub_type： 杂志文章

    doi：10.1186/1471-2202-15-38

    authors： Heinonen AM,Rahman M,Dogbevia G,Jakobi H,Wölfl S,Sprengel R,Schwaninger M

    更新日期：2014-03-11 00:00:00

  • Elucidating a normal function of huntingtin by functional and microarray analysis of huntingtin-null mouse embryonic fibroblasts.

    abstract：BACKGROUND:The polyglutamine expansion in huntingtin (Htt) protein is a cause of Huntington's disease (HD). Htt is an essential gene as deletion of the mouse Htt gene homolog (Hdh) is embryonic lethal in mice. Therefore, in addition to elucidating the mechanisms responsible for polyQ-mediated pathology, it is also impo...

    journal_title：BMC neuroscience

    pub_type： 杂志文章

    doi：10.1186/1471-2202-9-38

    authors： Zhang H,Das S,Li QZ,Dragatsis I,Repa J,Zeitlin S,Hajnóczky G,Bezprozvanny I

    更新日期：2008-04-15 00:00:00

  • Impairment of mitochondrial calcium handling in a mtSOD1 cell culture model of motoneuron disease.

    abstract：BACKGROUND:Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the selective loss of motor neurons (MN) in the brain stem and spinal cord. Intracellular disruptions of cytosolic and mitochondrial calcium have been associated with selective MN degeneration, but the underlying mecha...

    journal_title：BMC neuroscience

    pub_type： 杂志文章

    doi：10.1186/1471-2202-10-64

    authors： Jaiswal MK,Zech WD,Goos M,Leutbecher C,Ferri A,Zippelius A,Carrì MT,Nau R,Keller BU

    更新日期：2009-06-22 00:00:00

  • Estrogen-astrocyte interactions: implications for neuroprotection.

    abstract：BACKGROUND:Recent work has suggested that the ovarian steroid 17beta-estradiol, at physiological concentrations, may exert protective effects in neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease and acute ischemic stroke. While physiological concentrations of estrogen have consistently been s...

    journal_title：BMC neuroscience

    pub_type： 杂志文章

    doi：10.1186/1471-2202-3-6

    authors： Dhandapani KM,Brann DW

    更新日期：2002-06-07 00:00:00

  • Wheel running from a juvenile age delays onset of specific motor deficits but does not alter protein aggregate density in a mouse model of Huntington's disease.

    abstract：BACKGROUND:Huntington's disease (HD) is a neurodegenerative disorder predominantly affecting the cerebral cortex and striatum. Transgenic mice (R6/1 line), expressing a CAG repeat encoding an expanded polyglutamine tract in the N-terminus of the huntingtin protein, closely model HD. We have previously shown that enviro...

    journal_title：BMC neuroscience

    pub_type： 杂志文章

    doi：10.1186/1471-2202-9-34

    authors： van Dellen A,Cordery PM,Spires TL,Blakemore C,Hannan AJ

    更新日期：2008-04-01 00:00:00

  • Calcium signals in the nucleus accumbens: activation of astrocytes by ATP and succinate.

    abstract：BACKGROUND:Accumulating evidence suggests that glial signalling is activated by different brain functions. However, knowledge regarding molecular mechanisms of activation or their relation to neuronal activity is limited. The purpose of the present study is to identify the characteristics of ATP-evoked glial signalling...

    journal_title：BMC neuroscience

    pub_type： 杂志文章

    doi：10.1186/1471-2202-12-96

    authors： Molnár T,Dobolyi A,Nyitrai G,Barabás P,Héja L,Emri Z,Palkovits M,Kardos J

    更新日期：2011-10-03 00:00:00

  • Thai lexical tone perception in native speakers of Thai, English and Mandarin Chinese: an event-related potentials training study.

    abstract：BACKGROUND:Tone languages such as Thai and Mandarin Chinese use differences in fundamental frequency (F0, pitch) to distinguish lexical meaning. Previous behavioral studies have shown that native speakers of a non-tone language have difficulty discriminating among tone contrasts and are sensitive to different F0 dimens...

    journal_title：BMC neuroscience

    pub_type： 杂志文章

    doi：10.1186/1471-2202-9-53

    authors： Kaan E,Barkley CM,Bao M,Wayland R

    更新日期：2008-06-23 00:00:00

  • Development of a versatile enrichment analysis tool reveals associations between the maternal brain and mental health disorders, including autism.

    abstract：BACKGROUND:A recent study of lateral septum (LS) suggested a large number of autism-related genes with altered expression in the postpartum state. However, formally testing the findings for enrichment of autism-associated genes proved to be problematic with existing software. Many gene-disease association databases hav...

    journal_title：BMC neuroscience

    pub_type： 杂志文章

    doi：10.1186/1471-2202-14-147

    authors： Eisinger BE,Saul MC,Driessen TM,Gammie SC

    更新日期：2013-11-19 00:00:00

  • Acupuncture regulates the glucose metabolism in cerebral functional regions in chronic stage ischemic stroke patients--a PET-CT cerebral functional imaging study.

    abstract：BACKGROUND:Acupuncture has been applied to aid in the recovery of post-stroke patients, but its mechanism is unclear. This study aims to analyze the relationship between acupuncture and glucose metabolism in cerebral functional regions in post-stroke patients using (18)FDG PET-CT techniques. Forty-three ischemic stroke...

    journal_title：BMC neuroscience

    pub_type： 杂志文章,随机对照试验

    doi：10.1186/1471-2202-13-75

    authors： Huang Y,Tang C,Wang S,Lu Y,Shen W,Yang J,Chen J,Lin R,Cui S,Xiao H,Qu S,Lai X,Shan B

    更新日期：2012-06-27 00:00:00

  • Physiological and pathological aspects of Abeta in iron homeostasis via 5'UTR in the APP mRNA and the therapeutic use of iron-chelators.

    abstract：:Many studies have highlighted the pathological involvement of iron accumulation and iron-related oxidative stress (OS) in Alzheimer's disease (AD). Iron was further demonstrated to modulate expression of the Alzheimer's amyloid precursor holo-protein (APP) by a mechanism similar to that of regulation of ferritin-L and...

    journal_title：BMC neuroscience

    pub_type： 杂志文章,评审

    doi：10.1186/1471-2202-9-S2-S2

    authors： Avramovich-Tirosh Y,Amit T,Bar-Am O,Weinreb O,Youdim MB

    更新日期：2008-12-03 00:00:00

  • Both 5' and 3' flanks regulate Zebrafish brain-derived neurotrophic factor gene expression.

    abstract：BACKGROUND:Precise control of developmental and cell-specific expression of the brain-derived neurotrophic factor (BDNF) gene is essential for normal neuronal development and the diverse functions of BDNF in the adult organism. We previously showed that the zebrafish BDNF gene has multiple promoters. The complexity of ...

    journal_title：BMC neuroscience

    pub_type： 杂志文章

    doi：10.1186/1471-2202-5-19

    authors： Heinrich G,Pagtakhan CJ

    更新日期：2004-05-21 00:00:00

  • High-fat diet-induced obesity exacerbates kainic acid-induced hippocampal cell death.

    abstract：BACKGROUND:Obesity has deleterious effects on the brain, and metabolic dysfunction may exacerbate the outcomes of seizures and brain injuries. However, it is unclear whether obesity affects excitotoxicity-induced neuronal cell death. The purpose of this study was to investigate the effects of a high-fat diet (HFD) on n...

    journal_title：BMC neuroscience

    pub_type： 杂志文章

    doi：10.1186/s12868-015-0202-2

    authors： Kang DH,Heo RW,Yi CO,Kim H,Choi CH,Roh GS

    更新日期：2015-10-30 00:00:00

  • Tissue sparing, behavioral recovery, supraspinal axonal sparing/regeneration following sub-acute glial transplantation in a model of spinal cord contusion.

    abstract：BACKGROUND:It has been shown that olfactory ensheathing glia (OEG) and Schwann cell (SCs) transplantation are beneficial as cellular treatments for spinal cord injury (SCI), especially acute and sub-acute time points. In this study, we transplanted DsRED transduced adult OEG and SCs sub-acutely (14 days) following a T1...

    journal_title：BMC neuroscience

    pub_type： 杂志文章

    doi：10.1186/1471-2202-14-106

    authors： Barbour HR,Plant CD,Harvey AR,Plant GW

    更新日期：2013-09-27 00:00:00

  • Peroxynitrite decomposition catalyst prevents apoptotic cell death in a human astrocytoma cell line incubated with supernatants of HIV-infected macrophages.

    abstract：BACKGROUND:Oxidative stress has shown to contribute in the mechanisms underlying apoptotic cell death occurring in AIDS-dementia complex. Here we investigated the role of peroxynitrite in apoptosis occurring in astroglial cells incubated with supernatants of HIV-infected human primary macrophages (M/M). RESULTS:Flow c...

    journal_title：BMC neuroscience

    pub_type： 杂志文章

    doi：10.1186/1471-2202-3-13

    authors： Muscoli C,Salvemini D,Paolino D,Iannone M,Palma E,Cufari A,Rotiroti D,Perno CF,Aquaro S,Mollace V

    更新日期：2002-09-16 00:00:00

  • Chemotherapy-induced cognitive impairment is associated with decreases in cell proliferation and histone modifications.

    abstract：BACKGROUND:In this study, we examined the effects of cyclophosphamide, methothrexate, and 5-Fluorouracil (CMF) drug combination on various aspects of learning and memory. We also examined the effects of CMF on cell proliferation and chromatin remodeling as possible underlying mechanisms to explain chemotherapy-associat...

    journal_title：BMC neuroscience

    pub_type： 杂志文章

    doi：10.1186/1471-2202-12-124

    authors： Briones TL,Woods J

    更新日期：2011-12-09 00:00:00

  • The BOLD response and the gamma oscillations respond differently than evoked potentials: an interleaved EEG-fMRI study.

    abstract：BACKGROUND:The integration of EEG and fMRI is attractive because of their complementary precision regarding time and space. But the relationship between the indirect hemodynamic fMRI signal and the more direct EEG signal is uncertain. Event-related EEG responses can be analyzed in two different ways, reflecting two dif...

    journal_title：BMC neuroscience

    pub_type： 杂志文章

    doi：10.1186/1471-2202-4-22

    authors： Foucher JR,Otzenberger H,Gounot D

    更新日期：2003-09-19 00:00:00

  • Quantitative genome-wide association analyses of receptive language in the Danish High Risk and Resilience Study.

    abstract：BACKGROUND:One of the most basic human traits is language. Linguistic ability, and disability, have been shown to have a strong genetic component in family and twin studies, but molecular genetic studies of language phenotypes are scarce, relative to studies of other cognitive traits and neurodevelopmental phenotypes. ...

    journal_title：BMC neuroscience

    pub_type： 杂志文章

    doi：10.1186/s12868-020-00581-5

    authors： Nudel R,Christiani CAJ,Ohland J,Uddin MJ,Hemager N,Ellersgaard D,Spang KS,Burton BK,Greve AN,Gantriis DL,Bybjerg-Grauholm J,Jepsen JRM,Thorup AAE,Mors O,Werge T,Nordentoft M

    更新日期：2020-07-07 00:00:00

  • The type III neurofilament peripherin is expressed in the tuberomammillary neurons of the mouse.

    abstract：BACKGROUND:Peripherin, a type III neuronal intermediate filament, is widely expressed in neurons of the peripheral nervous system and in selected central nervous system hindbrain areas with projections towards peripheral structures, such as cranial nerves and spinal cord neurons. Peripherin appears to play a role in ne...

    journal_title：BMC neuroscience

    pub_type： 杂志文章

    doi：10.1186/1471-2202-9-26

    authors： Eriksson KS,Zhang S,Lin L,Larivière RC,Julien JP,Mignot E

    更新日期：2008-02-24 00:00:00

  • Method parameters' impact on mortality and variability in rat stroke experiments: a meta-analysis.

    abstract：BACKGROUND:Even though more than 600 stroke treatments have been shown effective in preclinical studies, clinically proven treatment alternatives for cerebral infarction remain scarce. Amongst the reasons for the discrepancy may be methodological shortcomings, such as high mortality and outcome variability, in the prec...

    journal_title：BMC neuroscience

    pub_type： 杂志文章,meta分析

    doi：10.1186/1471-2202-14-41

    authors： Ström JO,Ingberg E,Theodorsson A,Theodorsson E

    更新日期：2013-04-01 00:00:00

  • Spatio-temporal characterization of S- and M/L-cone degeneration in the Rd1 mouse model of retinitis pigmentosa.

    abstract：BACKGROUND:The Pde6brd1 (Rd1) mouse is widely used as a murine model for human retinitis pigmentosa. Understanding the spatio-temporal patterns of cone degeneration is important for evaluating potential treatments. In the present study we performed a systematic characterization of the spatio-temporal patterns of S- and...

    journal_title：BMC neuroscience

    pub_type： 杂志文章

    doi：10.1186/s12868-019-0528-2

    authors： Narayan DS,Ao J,Wood JPM,Casson RJ,Chidlow G

    更新日期：2019-09-03 00:00:00

  • The influence of language deprivation in early childhood on L2 processing: An ERP comparison of deaf native signers and deaf signers with a delayed language acquisition.

    abstract：BACKGROUND:To examine which language function depends on early experience, the present study compared deaf native signers, deaf non-native signers and hearing German native speakers while processing German sentences. The participants watched simple written sentences while event-related potentials (ERPs) were recorded. ...

    journal_title：BMC neuroscience

    pub_type： 杂志文章

    doi：10.1186/1471-2202-13-44

    authors： Skotara N,Salden U,Kügow M,Hänel-Faulhaber B,Röder B

    更新日期：2012-05-03 00:00:00

  • Tricyclic pyrone compounds prevent aggregation and reverse cellular phenotypes caused by expression of mutant huntingtin protein in striatal neurons.

    abstract：BACKGROUND:Huntington's disease (HD) is a progressive neurodegenerative disorder caused by a CAG repeat expansion mutation in the coding region of a novel gene. The mechanism of HD is unknown. Most data suggest that polyglutamine-mediated aggregation associated with expression of mutant huntingtin protein (mhtt) contri...

    journal_title：BMC neuroscience

    pub_type： 杂志文章

    doi：10.1186/1471-2202-10-73

    authors： Trushina E,Rana S,McMurray CT,Hua DH

    更新日期：2009-07-08 00:00:00

  • Effects of sex and gonadectomy on social investigation and social recognition in mice.

    abstract：BACKGROUND:An individual's ability to recognise and pay attention to others is crucial in order to behave appropriately in various social situations. Studies in humans have shown a sex bias in sociability as well as social memory, indicating that females have better face memory and gaze more at the eyes of others, but ...

    journal_title：BMC neuroscience

    pub_type： 杂志文章

    doi：10.1186/s12868-015-0221-z

    authors： Karlsson SA,Haziri K,Hansson E,Kettunen P,Westberg L

    更新日期：2015-11-25 00:00:00

  • Anti-Nogo-A antibody treatment does not prevent cell body shrinkage in the motor cortex in adult monkeys subjected to unilateral cervical cord lesion.

    abstract：BACKGROUND:After unilateral cervical cord lesion at the C7/C8 border interrupting the dorsolateral funiculus in adult monkeys, neutralization of Nogo-A using a specific monoclonal antibody promoted sprouting of corticospinal (CS) axons rostral and caudal to the lesion and, in parallel, improved functional recovery. In ...

    journal_title：BMC neuroscience

    pub_type： 杂志文章

    doi：10.1186/1471-2202-9-5

    authors： Beaud ML,Schmidlin E,Wannier T,Freund P,Bloch J,Mir A,Schwab ME,Rouiller EM

    更新日期：2008-01-14 00:00:00

  • Evidence for neuroprotective properties of human umbilical cord blood cells after neuronal hypoxia in vitro.

    abstract：BACKGROUND:One of the most promising options for treatment of stroke using adult stem cells are human umbilical cord blood (HUCB) cells that were already approved for therapeutic efficacy in vivo. However, complexity of animal models has thus far limited the understanding of beneficial cellular mechanisms. To address t...

    journal_title：BMC neuroscience

    pub_type： 杂志文章

    doi：10.1186/1471-2202-9-30

    authors： Hau S,Reich DM,Scholz M,Naumann W,Emmrich F,Kamprad M,Boltze J

    更新日期：2008-02-29 00:00:00

  • Cone inputs to murine striate cortex.

    abstract：BACKGROUND:We have recorded responses from single neurons in murine visual cortex to determine the effectiveness of the input from the two murine cone photoreceptor mechanisms and whether there is any unique selectivity for cone inputs at this higher region of the visual system that would support the possibility of col...

    journal_title：BMC neuroscience

    pub_type： 杂志文章

    doi：10.1186/1471-2202-9-113

    authors： Ekesten B,Gouras P

    更新日期：2008-11-14 00:00:00

  • Purinergic responses of calcium-dependent signaling pathways in cultured adult human astrocytes.

    abstract：BACKGROUND:The properties of Ca2+ signaling mediated by purinergic receptors are intrinsically linked with functional activity of astrocytes. At present little is known concerning Ca2+-dependent purinergic responses in adult human astrocytes. This work has examined effects of purinergic stimulation to alter levels of i...

    journal_title：BMC neuroscience

    pub_type： 杂志文章

    doi：10.1186/1471-2202-15-18

    authors： Hashioka S,Wang YF,Little JP,Choi HB,Klegeris A,McGeer PL,McLarnon JG

    更新日期：2014-01-22 00:00:00

  • Transcriptome analysis of amoeboid and ramified microglia isolated from the corpus callosum of rat brain.

    abstract：BACKGROUND:Microglia, the resident immune cells of the central nervous system (CNS), have two distinct phenotypes in the developing brain: amoeboid form, known to be amoeboid microglial cells (AMC) and ramified form, known to be ramified microglial cells (RMC). The AMC are characterized by being proliferative, phagocyt...

    journal_title：BMC neuroscience

    pub_type： 杂志文章

    doi：10.1186/1471-2202-13-64

    authors： Parakalan R,Jiang B,Nimmi B,Janani M,Jayapal M,Lu J,Tay SS,Ling EA,Dheen ST

    更新日期：2012-06-14 00:00:00