Astaxanthin alleviates cerebral edema by modulating NKCC1 and AQP4 expression after traumatic brain injury in mice.

abstract：BACKGROUND:Immunization with neural derived peptides (INDP) as well as scar removal-separately-have shown to induce morphological and functional improvement after spinal cord injury (SCI). In the present study, we compared the effect of INDP alone versus INDP with scar removal on motor recovery, regeneration-associated...

journal_title：BMC neuroscience

authors： Rodríguez-Barrera R,Flores-Romero A,Fernández-Presas AM,García-Vences E,Silva-García R,Konigsberg M,Blancas-Espinoza L,Buzoianu-Anguiano V,Soria-Zavala K,Suárez-Meade P,Ibarra A

更新日期：2017-01-05 00:00:00

abstract：BACKGROUND:The megencephaly mouse, mceph/mceph, is epileptic and displays a dramatically increased brain volume and neuronal count. The responsible mutation was recently revealed to be an eleven base pair deletion, leading to a frame shift, in the gene encoding the potassium channel Kv1.1. The predicted MCEPH protein i...

journal_title：BMC neuroscience

authors： Persson AS,Klement G,Almgren M,Sahlholm K,Nilsson J,Petersson S,Arhem P,Schalling M,Lavebratt C

更新日期：2005-11-23 00:00:00

abstract：BACKGROUND:To examine which language function depends on early experience, the present study compared deaf native signers, deaf non-native signers and hearing German native speakers while processing German sentences. The participants watched simple written sentences while event-related potentials (ERPs) were recorded. ...

journal_title：BMC neuroscience

authors： Skotara N,Salden U,Kügow M,Hänel-Faulhaber B,Röder B

更新日期：2012-05-03 00:00:00

abstract：BACKGROUND:Rett syndrome (RTT, MIM #312750) is a severe neurological disorder caused by mutations in the X-linked methyl-CpG binding protein 2 (MECP2) gene. Female patients are affected with an incidence of 1/15000 live births and develop normally from birth to 6-18 months of age before the onset of deficits in autonom...

journal_title：BMC neuroscience

authors： Panayotis N,Ghata A,Villard L,Roux JC

更新日期：2011-05-24 00:00:00

abstract：BACKGROUND:Post-traumatic stress disorder (PTSD) is an anxious disorder associated with low levels of corticosterone and enhanced negative feedback of the hypothalamic-pituitary-adrenal (HPA) axis. Previous studies showed that the amygdala not only has an excitatory effect on the HPA axis but also plays a key role in f...

journal_title：BMC neuroscience

authors： Han F,Ding J,Shi Y

更新日期：2014-06-19 00:00:00

abstract：BACKGROUND:Human neural stem cells (hNSC) have the potential to provide novel cell-based therapies for neurodegenerative conditions such as multiple sclerosis and Parkinson's disease. In order to realise this goal, protocols need to be developed that allow for large quantities of hNSC to be cultured efficiently. As suc...

journal_title：BMC neuroscience

authors： Hall PE,Lathia JD,Caldwell MA,Ffrench-Constant C

更新日期：2008-07-23 00:00:00

abstract：BACKGROUND:Excitotoxicity (the toxic overstimulation of neurons by the excitatory transmitter Glutamate) is a central process in widespread neurodegenerative conditions such as brain ischemia and chronic neurological diseases. Many mechanisms have been suggested to mediate excitotoxicity, but their significance across ...

journal_title：BMC neuroscience

authors： Del Rosario JS,Feldmann KG,Ahmed T,Amjad U,Ko B,An J,Mahmud T,Salama M,Mei S,Asemota D,Mano I

更新日期：2015-04-23 00:00:00

abstract：BACKGROUND:Recent research has revealed that the community of microorganisms inhabiting the gut affects brain development, function and behaviour. In particular, disruption of the gut microbiome during critical developmental windows can have lasting effects on host physiology. Both antibiotic exposure and germ-free con...

journal_title：BMC neuroscience

authors： Johnson KVA,Burnet PWJ

更新日期：2020-07-22 00:00:00

abstract：BACKGROUND:Growing evidence shows that, in vivo, the precursor of Nerve Growth Factor (NGF), proNGF, displays biological activities different from those of its mature NGF counterpart, mediated by distinct, and somewhat complementary, receptor binding properties. NGF and proNGF induce distinct transcriptional signatures...

journal_title：BMC neuroscience

authors： Arisi I,D'Onofrio M,Brandi R,Malerba F,Paoletti F,Storti AE,Florenzano F,Fasulo L,Cattaneo A

更新日期：2014-04-08 00:00:00

abstract：BACKGROUND:An individual's ability to recognise and pay attention to others is crucial in order to behave appropriately in various social situations. Studies in humans have shown a sex bias in sociability as well as social memory, indicating that females have better face memory and gaze more at the eyes of others, but ...

journal_title：BMC neuroscience

authors： Karlsson SA,Haziri K,Hansson E,Kettunen P,Westberg L

更新日期：2015-11-25 00:00:00

abstract：BACKGROUND:Yawning is a stereotyped behavior that enhances blood flow to the skull, and the resulting counterflow has been hypothesized as a mechanism for brain cooling. Studies have shown that yawns are strongly associated with physiological and pathological conditions that increase brain temperature, and that they ar...

journal_title：BMC neuroscience

authors： Eguibar JR,Uribe CA,Cortes C,Bautista A,Gallup AC

更新日期：2017-01-03 00:00:00

abstract：BACKGROUND:How does the brain repair obliterated speech and cope with acoustically ambivalent situations? A widely discussed possibility is to use top-down information for solving the ambiguity problem. In the case of speech, this may lead to a match of bottom-up sensory input with lexical expectations resulting in res...

journal_title：BMC neuroscience

authors： Eulitz C,Hannemann R

更新日期：2010-06-02 00:00:00

abstract：BACKGROUND:Nitric oxide (NO) is a multifunctional molecule synthesized by three isozymes of the NO synthase (NOSs) acting as a messenger/modulator and/or a potential neurotoxin. In rodents, the role of NOSs in sleep processes and throughout aging is now well established. For example, sleep parameters are highly deterio...

journal_title：BMC neuroscience

authors： Colas D,Gharib A,Bezin L,Morales A,Guidon G,Cespuglio R,Sarda N

更新日期：2006-12-21 00:00:00

abstract：BACKGROUND:Alzheimer's Disease (AD) and Fronto temporal lobar dementia (FTLD) are common causes of dementia in the aging population for which limited therapeutical options are available. These disorders are associated with Tau accumulation. We have previously shown that Cerebrolysin™ (CBL), a neuropeptide mixture with ...

journal_title：BMC neuroscience

authors： Rockenstein E,Ubhi K,Trejo M,Mante M,Patrick C,Adame A,Novak P,Jech M,Doppler E,Moessler H,Masliah E

更新日期：2014-07-21 00:00:00

abstract：BACKGROUND:To reach and grasp an object in space on the basis of its image cast on the retina requires different coordinate transformations that take into account gaze and limb positioning. Eye position in the orbit influences the image's conversion from retinotopic (eye-centered) coordinates to an egocentric frame nec...

journal_title：BMC neuroscience

authors： Andersson F,Etard O,Denise P,Petit L

更新日期：2004-09-19 00:00:00

abstract：BACKGROUND:Magnetoencephalography (MEG) has become an increasingly popular technique for non-invasively characterizing neuromagnetic field changes in the brain at a high temporal resolution. To examine the reliability of the MEG signal, we compared magnetic and electrophysiological responses to complex natural stimuli ...

journal_title：BMC neuroscience

authors： Zhu Z,Zumer JM,Lowenthal ME,Padberg J,Recanzone GH,Krubitzer LA,Nagarajan SS,Disbrow EA

更新日期：2009-01-15 00:00:00

abstract：BACKGROUND:Knock-in (KI) mouse models of Alzheimer's disease (AD) that endogenously overproduce Aβ without non-physiological overexpression of amyloid precursor protein (APP) provide important insights into the pathogenic mechanisms of AD. Previously, we reported that AppNL-G-F mice, which harbor three familial AD muta...

journal_title：BMC neuroscience

authors： Sakakibara Y,Sekiya M,Saito T,Saido TC,Iijima KM

更新日期：2019-03-20 00:00:00

abstract：BACKGROUND:Excitatory transmitting mechanisms are proving to play a critical role on neuronal homeostasis conditions of facultative hibernators such as the Syrian golden hamster. Indeed works have shown that the glutamatergic system of the main olfactory brain station (amygdala) is capable of controlling thermoregulato...

journal_title：BMC neuroscience

authors： Alò R,Avolio E,Carelli A,Facciolo RM,Canonaco M

更新日期：2011-01-20 00:00:00

abstract：BACKGROUND:Oxidative stress has shown to contribute in the mechanisms underlying apoptotic cell death occurring in AIDS-dementia complex. Here we investigated the role of peroxynitrite in apoptosis occurring in astroglial cells incubated with supernatants of HIV-infected human primary macrophages (M/M). RESULTS:Flow c...

journal_title：BMC neuroscience

authors： Muscoli C,Salvemini D,Paolino D,Iannone M,Palma E,Cufari A,Rotiroti D,Perno CF,Aquaro S,Mollace V

更新日期：2002-09-16 00:00:00

abstract：BACKGROUND:The Na+,K+-ATPase plays an important role for ion homeostasis in virtually all mammalian cells, including neurons. Despite this, there is as yet little known about the isoform specific distribution in neurons. RESULTS:With help of superresolving stimulated emission depletion microscopy the spatial distribut...

journal_title：BMC neuroscience

authors： Blom H,Rönnlund D,Scott L,Spicarova Z,Widengren J,Bondar A,Aperia A,Brismar H

更新日期：2011-01-27 00:00:00

abstract：BACKGROUND:Impaired speech perception is one of the major sequelae of aging. In addition to peripheral hearing loss, central deficits of auditory processing are supposed to contribute to the deterioration of speech perception in older individuals. To test the hypothesis that auditory temporal processing is compromised ...

journal_title：BMC neuroscience

authors： Sörös P,Teismann IK,Manemann E,Lütkenhöner B

更新日期：2009-04-07 00:00:00

abstract：BACKGROUND:Given the reported inverse association between light and depressive mood, ambient light may also be associated with some of the brain regions in healthy subjects. The present study aims to investigate the effects of ambient light on glucose metabolism in the brain. We used the data of 28 healthy participants...

journal_title：BMC neuroscience

authors： Hirakawa H,Terao T,Hatano K,Kohno K,Ishii N

更新日期：2018-07-24 00:00:00

abstract：BACKGROUND:CRISPR/Cas9 system is a powerful method to investigate the role of genes by introducing a mutation selectively and efficiently to specific genome positions in cell and animal lines. However, in primary neuron cultures, this method is affected by the issue that the effectiveness of CRISPR/Cas9 is different in...

journal_title：BMC neuroscience

authors： Tsunematsu H,Uyeda A,Yamamoto N,Sugo N

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Recent work has suggested that the ovarian steroid 17beta-estradiol, at physiological concentrations, may exert protective effects in neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease and acute ischemic stroke. While physiological concentrations of estrogen have consistently been s...

journal_title：BMC neuroscience

authors： Dhandapani KM,Brann DW

更新日期：2002-06-07 00:00:00

abstract：BACKGROUND:Alzheimer's disease (AD) is the most prevalent form of dementia and represents one of the highest unmet requirements in medicine today. There is shortage of novel molecules entering into market because of poor pharmacokinetic properties and safety issues. Drug repurposing offers an opportunity to reinvigorat...

journal_title：BMC neuroscience

authors： Kumar S,Chowdhury S,Kumar S

更新日期：2017-10-27 00:00:00

abstract：BACKGROUND:Many studies of cerebral asymmetries in different species lead, on the one hand, to a better understanding of the functions of each cerebral hemisphere and, on the other hand, to develop an evolutionary history of hemispheric laterality. Our animal model is particularly interesting because of its original ev...

journal_title：BMC neuroscience

authors： Blois-Heulin C,Crével M,Böye M,Lemasson A

更新日期：2012-01-12 00:00:00

abstract：BACKGROUND:The potential adverse effect of mobile phone radiation is currently an area of great concern in the field of public health. In the present study, we aimed to investigate the effect of mobile phone radiation (900 MHz radiofrequency) during hatching on postnatal social behaviors in chicks, as well as the effec...

journal_title：BMC neuroscience

authors： Zhou Z,Shan J,Zu J,Chen Z,Ma W,Li L,Xu J

更新日期：2016-06-10 00:00:00

abstract：BACKGROUND:Neurogenesis continues to occur throughout life but dramatically decreases with increasing age. This decrease is mostly related to a decline in proliferative activity as a result of an impoverishment of the microenvironment of the aged brain, including a reduction in trophic factors and increased inflammatio...

journal_title：BMC neuroscience

authors： Bachstetter AD,Pabon MM,Cole MJ,Hudson CE,Sanberg PR,Willing AE,Bickford PC,Gemma C

更新日期：2008-02-14 00:00:00

abstract：BACKGROUND:Recovery following stroke depends on cellular plasticity in the perilesional zone (PZ). Doublecortin (DCX), a protein mainly labeling immature neurons in neurogenic niches is also highly expressed in the vicinity of focal cortical infarcts. Notably, the number of DCX+ cells positively correlates with the rec...

journal_title：BMC neuroscience

authors： Kunze A,Achilles A,Keiner S,Witte OW,Redecker C

更新日期：2015-04-15 00:00:00

abstract：BACKGROUND:Precise control of developmental and cell-specific expression of the brain-derived neurotrophic factor (BDNF) gene is essential for normal neuronal development and the diverse functions of BDNF in the adult organism. We previously showed that the zebrafish BDNF gene has multiple promoters. The complexity of ...

journal_title：BMC neuroscience

authors： Heinrich G,Pagtakhan CJ

更新日期：2004-05-21 00:00:00