Death Associated Protein Kinase (DAPK) -mediated neurodegenerative mechanisms in nematode excitotoxicity.

Abstract:

BACKGROUND:Excitotoxicity (the toxic overstimulation of neurons by the excitatory transmitter Glutamate) is a central process in widespread neurodegenerative conditions such as brain ischemia and chronic neurological diseases. Many mechanisms have been suggested to mediate excitotoxicity, but their significance across diverse excitotoxic scenarios remains unclear. Death Associated Protein Kinase (DAPK), a critical molecular switch that controls a range of key signaling and cell death pathways, has been suggested to have an important role in excitotoxicity. However, the molecular mechanism by which DAPK exerts its effect is controversial. A few distinct mechanisms have been suggested by single (sometimes contradicting) studies, and a larger array of potential mechanisms is implicated by the extensive interactome of DAPK. RESULTS:Here we analyze a well-characterized model of excitotoxicity in the nematode C. elegans to show that DAPK is an important mediator of excitotoxic neurodegeneration across a large evolutionary distance. We further show that some proposed mechanisms of DAPK's action (modulation of synaptic strength, involvement of the DANGER-related protein MAB-21, and autophagy) do not have a major role in nematode excitotoxicity. In contrast, Pin1/PINN-1 (a DAPK interaction-partner and a peptidyl-prolyl isomerase involved in chronic neurodegenerative conditions) suppresses neurodegeneration in our excitotoxicity model. CONCLUSIONS:Our studies highlight the prominence of DAPK and Pin1/PINN-1 as conserved mediators of cell death processes in diverse scenarios of neurodegeneration.

journal_name

BMC Neurosci

journal_title

BMC neuroscience

authors

Del Rosario JS,Feldmann KG,Ahmed T,Amjad U,Ko B,An J,Mahmud T,Salama M,Mei S,Asemota D,Mano I

doi

10.1186/s12868-015-0158-2

subject

Has Abstract

pub_date

2015-04-23 00:00:00

pages

25

issn

1471-2202

pii

10.1186/s12868-015-0158-2

journal_volume

16

pub_type

杂志文章
  • Inhibition of apoptosis in neuronal cells infected with Chlamydophila (Chlamydia) pneumoniae.

    abstract:BACKGROUND:Chlamydophila (Chlamydia) pneumoniae is an intracellular bacterium that has been identified within cells in areas of neuropathology found in Alzheimer disease (AD), including endothelia, glia, and neurons. Depending on the cell type of the host, infection by C. pneumoniae has been shown to influence apoptoti...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-9-13

    authors: Appelt DM,Roupas MR,Way DS,Bell MG,Albert EV,Hammond CJ,Balin BJ

    更新日期:2008-01-24 00:00:00

  • High yield derivation of enriched glutamatergic neurons from suspension-cultured mouse ESCs for neurotoxicology research.

    abstract:BACKGROUND:Recently, there has been a strong emphasis on identifying an in vitro model for neurotoxicity research that combines the biological relevance of primary neurons with the scalability, reproducibility and genetic tractability of continuous cell lines. Derived neurons should be homotypic, exhibit neuron-specifi...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-13-127

    authors: Hubbard KS,Gut IM,Lyman ME,Tuznik KM,Mesngon MT,McNutt PM

    更新日期:2012-10-24 00:00:00

  • Berberine chloride can ameliorate the spatial memory impairment and increase the expression of interleukin-1beta and inducible nitric oxide synthase in the rat model of Alzheimer's disease.

    abstract:BACKGROUND:Berberine is the major alkaloidal component of Rhizoma coptidis, and has multiple pharmacological effects including inhibiting acetylcholinesterase, reducing cholesterol and glucose, lowering mortality in patients with chronic congestive heart failure and anti-inflammation etc. Thus berberine is a promising ...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-7-78

    authors: Zhu F,Qian C

    更新日期:2006-12-01 00:00:00

  • Separate urinary bladder and prostate neurons in the central nervous system of the rat: simultaneous labeling with two immunohistochemically distinguishable pseudorabies viruses.

    abstract:BACKGROUND:This work examines the central nervous system distribution of virus-labeled neurons from the rat urinary bladder and the prostate simultaneously within the same tissue sections. Two immunohistochemically distinct pseudorabies virus strains were simultaneously injected into male Sprague Dawley rats (approxima...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-3-8

    authors: Nadelhaft I,Miranda-Sousa AJ,Vera PL

    更新日期:2002-07-12 00:00:00

  • Purinergic responses of calcium-dependent signaling pathways in cultured adult human astrocytes.

    abstract:BACKGROUND:The properties of Ca2+ signaling mediated by purinergic receptors are intrinsically linked with functional activity of astrocytes. At present little is known concerning Ca2+-dependent purinergic responses in adult human astrocytes. This work has examined effects of purinergic stimulation to alter levels of i...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-15-18

    authors: Hashioka S,Wang YF,Little JP,Choi HB,Klegeris A,McGeer PL,McLarnon JG

    更新日期:2014-01-22 00:00:00

  • A truncated Kv1.1 protein in the brain of the megencephaly mouse: expression and interaction.

    abstract:BACKGROUND:The megencephaly mouse, mceph/mceph, is epileptic and displays a dramatically increased brain volume and neuronal count. The responsible mutation was recently revealed to be an eleven base pair deletion, leading to a frame shift, in the gene encoding the potassium channel Kv1.1. The predicted MCEPH protein i...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-6-65

    authors: Persson AS,Klement G,Almgren M,Sahlholm K,Nilsson J,Petersson S,Arhem P,Schalling M,Lavebratt C

    更新日期:2005-11-23 00:00:00

  • Differential neuronal expression of receptor interacting protein 3 in rat retina: involvement in ischemic stress response.

    abstract:BACKGROUND:Receptor-interacting protein 3 (RIP3), a member of RIP family proteins, has been shown to participate in programmed necrosis or necroptosis in cell biology studies. Evidence suggests that necroptosis may be a mode of neuronal death in the retina. RESULTS:In the present study we determined the expression of ...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-14-16

    authors: Huang JF,Shang L,Zhang MQ,Wang H,Chen D,Tong JB,Huang H,Yan XX,Zeng LP,Xiong K

    更新日期:2013-02-02 00:00:00

  • Correction to: Wnt3a induces exosome secretion from primary cultured rat microglia.

    abstract::Following the publication of this article [1], it has been noted by the authors that an image of the same cell nuclei has been used in error twice, in Fig. 8, parts A and B. These images are redundant in this figure as the images in parts D and E show Wnt3a treated and control cells stained with both Hoechst 33342 (as...

    journal_title:BMC neuroscience

    pub_type: 杂志文章,已发布勘误

    doi:10.1186/s12868-020-0558-9

    authors: Hooper C,Sainz-Fuertes R,Lynham S,Hye A,Killick R,Warley A,Bolondi C,Pocock J,Lovestone S

    更新日期:2020-03-06 00:00:00

  • Genomic responses in rat cerebral cortex after traumatic brain injury.

    abstract:BACKGROUND:Traumatic brain injury (TBI) initiates a complex sequence of destructive and neuroprotective cellular responses. The initial mechanical injury is followed by an extended time period of secondary brain damage. Due to the complicated pathological picture a better understanding of the molecular events occurring...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-6-69

    authors: von Gertten C,Flores Morales A,Holmin S,Mathiesen T,Nordqvist AC

    更新日期:2005-11-30 00:00:00

  • Adult zebrafish as a model organism for behavioural genetics.

    abstract::Recent research has demonstrated the suitability of adult zebrafish to model some aspects of complex behaviour. Studies of reward behaviour, learning and memory, aggression, anxiety and sleep strongly suggest that conserved regulatory processes underlie behaviour in zebrafish and mammals. The isolation and molecular a...

    journal_title:BMC neuroscience

    pub_type: 杂志文章,评审

    doi:10.1186/1471-2202-11-90

    authors: Norton W,Bally-Cuif L

    更新日期:2010-08-02 00:00:00

  • Sensitivity of the human auditory cortex to acoustic degradation of speech and non-speech sounds.

    abstract:BACKGROUND:Recent studies have shown that the human right-hemispheric auditory cortex is particularly sensitive to reduction in sound quality, with an increase in distortion resulting in an amplification of the auditory N1m response measured in the magnetoencephalography (MEG). Here, we examined whether this sensitivit...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-11-24

    authors: Miettinen I,Tiitinen H,Alku P,May PJ

    更新日期:2010-02-22 00:00:00

  • Method parameters' impact on mortality and variability in rat stroke experiments: a meta-analysis.

    abstract:BACKGROUND:Even though more than 600 stroke treatments have been shown effective in preclinical studies, clinically proven treatment alternatives for cerebral infarction remain scarce. Amongst the reasons for the discrepancy may be methodological shortcomings, such as high mortality and outcome variability, in the prec...

    journal_title:BMC neuroscience

    pub_type: 杂志文章,meta分析

    doi:10.1186/1471-2202-14-41

    authors: Ström JO,Ingberg E,Theodorsson A,Theodorsson E

    更新日期:2013-04-01 00:00:00

  • Plasticity in neuromagnetic cortical responses suggests enhanced auditory object representation.

    abstract:BACKGROUND:Auditory perceptual learning persistently modifies neural networks in the central nervous system. Central auditory processing comprises a hierarchy of sound analysis and integration, which transforms an acoustical signal into a meaningful object for perception. Based on latencies and source locations of audi...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-14-151

    authors: Ross B,Jamali S,Tremblay KL

    更新日期:2013-12-05 00:00:00

  • Upregulation of synaptotagmin IV inhibits transmitter release in PC12 cells with targeted synaptotagmin I knockdown.

    abstract:BACKGROUND:The function of synaptotagmins (syt) in Ca2+-dependent transmitter release has been attributed primarily to Ca2+-dependent isoforms such as syt I. Recently, syt IV, an inducible Ca2+-independent isoform has been implicated in transmitter release. We postulated that the effects of syt IV on transmitter releas...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-11-104

    authors: Moore-Dotson JM,Papke JB,Harkins AB

    更新日期:2010-08-24 00:00:00

  • Phase-dependent preference of thermosensation and chemosensation during simultaneous presentation assay in Caenorhabditis elegans.

    abstract:BACKGROUND:Multi-sensory integration is necessary for organisms to discriminate different environmental stimuli and thus determine behavior. Caenorhabditis elegans has 12 pairs of amphid sensory neurons, which are involved in generating behaviors such as thermotaxis toward cultivation temperature, and chemotaxis toward...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-9-106

    authors: Adachi R,Osada H,Shingai R

    更新日期:2008-11-01 00:00:00

  • Decreasing the expression of PICALM reduces endocytosis and the activity of β-secretase: implications for Alzheimer's disease.

    abstract:BACKGROUND:Polymorphisms in the gene for phosphatidylinositol binding clathrin assembly protein (PICALM), an endocytic-related protein, are associated with a small, increased risk of developing Alzheimer's disease (AD), strongly suggesting that changes in endocytosis are involved in the aetiology of the disease. We hav...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/s12868-016-0288-1

    authors: Thomas RS,Henson A,Gerrish A,Jones L,Williams J,Kidd EJ

    更新日期:2016-07-18 00:00:00

  • Enriched environment and masticatory activity rehabilitation recover spatial memory decline in aged mice.

    abstract:BACKGROUND:To measure the impact of masticatory reduction on learning and memory, previous studies have produced experimental masticatory reduction by modified diet or molar removal. Here we induced spatial learning impairment in mice by reducing masticatory activity and then tested the effect of a combination of envir...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-14-63

    authors: Mendes Fde C,de Almeida MN,Felício AP,Fadel AC,Silva Dde J,Borralho TG,da Silva RP,Bento-Torres J,Vasconcelos PF,Perry VH,Ramos EM,Picanço-Diniz CW,Sosthenes MC

    更新日期:2013-06-28 00:00:00

  • The excitation cascade of Limulus ventral photoreceptors: guanylate cyclase as the link between InsP3-mediated Ca2+ release and the opening of cGMP-gated channels.

    abstract:BACKGROUND:Early stages in the excitation cascade of Limulus photoreceptors are mediated by activation of Gq by rhodopsin, generation of inositol-1,4,5-trisphosphate by phospholipase-C and the release of Ca2+. At the end of the cascade, cGMP-gated channels open and generate the depolarizing receptor potential. A major ...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-5-7

    authors: Garger AV,Richard EA,Lisman JE

    更新日期:2004-02-26 00:00:00

  • Factors that regulate embryonic gustatory development.

    abstract::Numerous molecular factors orchestrate the development of the peripheral taste system. The unique anatomy/function of the taste system makes this system ideal for understanding the mechanisms by which these factors function; yet the taste system is underutilized for this role. This review focuses on some of the many f...

    journal_title:BMC neuroscience

    pub_type: 杂志文章,评审

    doi:10.1186/1471-2202-8-S3-S4

    authors: Krimm RF

    更新日期:2007-09-18 00:00:00

  • Qualitative and quantitative differences between taste buds of the rat and mouse.

    abstract:BACKGROUND:Numerous electrophysiological, ultrastructural, and immunocytochemical studies on rodent taste buds have been carried out on rat taste buds. In recent years, however, the mouse has become the species of choice for molecular and other studies on sensory transduction in taste buds. Do rat and mouse taste buds ...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-8-5

    authors: Ma H,Yang R,Thomas SM,Kinnamon JC

    更新日期:2007-01-05 00:00:00

  • Morphological and behavioural changes occur following the X-ray irradiation of the adult mouse olfactory neuroepithelium.

    abstract:BACKGROUND:The olfactory neuroepithelium lines the upper nasal cavity and is in direct contact with the external environment and the olfactory bulbs. The ability to self-renew throughout life and the reproducible recovery after injury, make it a model tissue to study mechanisms underlying neurogenesis. In this study, X...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-13-134

    authors: Cunha C,Hort Y,Shine J,Doyle KL

    更新日期:2012-10-31 00:00:00

  • Disturbed oscillatory brain dynamics in subcortical ischemic vascular dementia.

    abstract:BACKGROUND:White matter hyperintensities (WMH) can lead to dementia but the underlying physiological mechanisms are unclear. We compared relative oscillatory power from electroencephalographic studies (EEGs) of 17 patients with subcortical ischemic vascular dementia, based on extensive white matter hyperintensities (SI...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-13-85

    authors: van Straaten EC,de Haan W,de Waal H,Scheltens P,van der Flier WM,Barkhof F,Koene T,Stam CJ

    更新日期:2012-07-24 00:00:00

  • Stage effects of negative emotion on spatial and verbal working memory.

    abstract:BACKGROUND:The effects of negative emotion on different processing periods in spatial and verbal working memory (WM) and the possible brain mechanism of the interaction between negative emotion and WM were explored using a high-time resolution event-related potential (ERP) technique and time-locked delayed matching-to-...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-11-60

    authors: Li X,Chan RC,Luo YJ

    更新日期:2010-05-07 00:00:00

  • Neurotrophins regulate ApoER2 proteolysis through activation of the Trk signaling pathway.

    abstract:BACKGROUND:ApoER2 and the neurotrophin receptors Trk and p75(NTR) are expressed in the CNS and regulate key functional aspects of neurons, including development, survival, and neuronal function. It is known that both ApoER2 and p75(NTR) are processed by metalloproteinases, followed by regulated intramembrane proteolysi...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-15-108

    authors: Larios JA,Jausoro I,Benitez ML,Bronfman FC,Marzolo MP

    更新日期:2014-09-19 00:00:00

  • Evidence for neuroprotective properties of human umbilical cord blood cells after neuronal hypoxia in vitro.

    abstract:BACKGROUND:One of the most promising options for treatment of stroke using adult stem cells are human umbilical cord blood (HUCB) cells that were already approved for therapeutic efficacy in vivo. However, complexity of animal models has thus far limited the understanding of beneficial cellular mechanisms. To address t...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-9-30

    authors: Hau S,Reich DM,Scholz M,Naumann W,Emmrich F,Kamprad M,Boltze J

    更新日期:2008-02-29 00:00:00

  • Curcumin reduces alpha-synuclein induced cytotoxicity in Parkinson's disease cell model.

    abstract:BACKGROUND:Overexpression and abnormal accumulation of aggregated alpha-synuclein (alphaS) have been linked to Parkinson's disease (PD) and other synucleinopathies. alphaS can misfold and adopt a variety of morphologies but recent studies implicate oligomeric forms as the most cytotoxic species. Both genetic mutations ...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-11-57

    authors: Wang MS,Boddapati S,Emadi S,Sierks MR

    更新日期:2010-04-30 00:00:00

  • Fetal brain genomic reprogramming following asphyctic preconditioning.

    abstract:BACKGROUND:Fetal asphyctic (FA) preconditioning is effective in attenuating brain damage incurred by a subsequent perinatal asphyctic insult. Unraveling mechanisms of this endogenous neuroprotection, activated by FA preconditioning, is an important step towards new clinical strategies for asphyctic neonates. Genomic re...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-14-61

    authors: Cox-Limpens KE,Vles JS,Schlechter J,Zimmermann LJ,Strackx E,Gavilanes AW

    更新日期:2013-06-22 00:00:00

  • Secondhand smoke exposure induces Raf/ERK/MAPK-mediated upregulation of cerebrovascular endothelin ETA receptors.

    abstract:BACKGROUND:Cigarette smoking enhances the risk of stroke. However, the underlying molecular mechanisms are largely unknown. The present study established an in vivo rat secondhand cigarette smoking (SHS) model and examined the hypothesis that SHS upregulates endothelin receptors with increased cerebrovascular contracti...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-12-109

    authors: Cao L,Xu CB,Zhang Y,Cao YX,Edvinsson L

    更新日期:2011-11-01 00:00:00

  • Orienting asymmetries and lateralized processing of sounds in humans.

    abstract:BACKGROUND:Lateralized processing of speech is a well studied phenomenon in humans. Both anatomical and neurophysiological studies support the view that nonhuman primates and other animal species also reveal hemispheric differences in areas involved in sound processing. In recent years, an increasing number of studies ...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-10-14

    authors: Fischer J,Teufel C,Drolet M,Patzelt A,Rübsamen R,von Cramon DY,Schubotz RI

    更新日期:2009-02-24 00:00:00

  • Evidence for inflammation-mediated memory dysfunction in gastropods: putative PLA2 and COX inhibitors abolish long-term memory failure induced by systemic immune challenges.

    abstract:BACKGROUND:Previous studies associate lipid peroxidation with long-term memory (LTM) failure in a gastropod model (Lymnaea stagnalis) of associative learning and memory. This process involves activation of Phospholipase A2 (PLA2), an enzyme mediating the release of fatty acids such as arachidonic acid that form the pre...

    journal_title:BMC neuroscience

    pub_type: 杂志文章

    doi:10.1186/1471-2202-14-83

    authors: Hermann PM,Park D,Beaulieu E,Wildering WC

    更新日期:2013-08-06 00:00:00