解剖学和形态学
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听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
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急诊医学
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肠胃学和肝脏学
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卫生保健科学和服务
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生理学
基本医疗保健
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热带医学
泌尿学和肾脏学
病毒学
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健康政策和服务
心理学,临床
abstract::Hippocampal theta oscillations have been implicated in spatial memory function in both rodents and humans. What is less clear is how hippocampal theta interacts with higher frequency oscillations to support long-term memory. Here we asked 10 presurgical epilepsy patients undergoing intracranial EEG recording to perfor...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.23284
更新日期:2021-02-01 00:00:00
abstract::Replicas of an aspect of an experienced event can serve as effective reminders, yet little is known about the neural basis of such reminding effects. Here we examined the neural activity underlying the memory-enhancing effect of reminders 1 week after encoding of naturalistic film clip events. We used fMRI to determin...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.23260
更新日期:2021-01-01 00:00:00
abstract::Place and grid cells in the hippocampal formation are commonly thought to support a unified and coherent cognitive map of space. This mapping mechanism faces a challenge when a navigator is placed in a familiar environment that has been deformed from its original shape. Under such circumstances, many transformations c...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.23265
更新日期:2021-01-01 00:00:00
abstract::Space and time are both essential features of episodic memory, for which the hippocampus is critical (Howard & Eichenbaum, 2015). Spatial tasks have been used effectively to study the behavioral relevance of place cells. However, the behavioral paradigms utilized for the study of time cells have not used time duration...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.23261
更新日期:2021-01-01 00:00:00
abstract::Structural integrity of the human hippocampus is widely acknowledged to be necessary for the successful encoding and retrieval of autobiographical memories. However, evidence for an association between hippocampal volume and the ability to recall such memories in healthy individuals is mixed. Here we examined this iss...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.23293
更新日期:2020-12-15 00:00:00
abstract::Adaptive memory requires the organism to form associations that bridge between events separated in time. Many studies show interactions between hippocampus (HPC) and prefrontal cortex (PFC) during formation of such associations. We analyze neural recording from monkey HPC and PFC during a memory task that requires the...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.23282
更新日期:2020-12-01 00:00:00
abstract::The rodent hippocampus expresses a variety of neuronal network oscillations depending on the behavioral state of the animal. Locomotion and active exploration are accompanied by theta-nested gamma oscillations while resting states and slow-wave sleep are dominated by intermittent sharp wave-ripple complexes. It is bel...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.23214
更新日期:2020-10-01 00:00:00
abstract::Lynn Nadel has been a trailblazer in memory research for decades. In just one example, Nadel and Zola-Morgan [Infantile amnesia, In Infant memory, Springer, Boston, MA, 1984, pp. 145-172] were the first to present the provocative notion that the extended development of the hippocampus may underlie the period of infant...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.23149
更新日期:2020-08-01 00:00:00
abstract::Hippocampal mossy fibers have long been proposed to impose new patterns to learn onto CA3 neurons during new memory formation. However, inconsistent with this theory, we found in our previous study that mossy fiber stimulation induces only transient changes in CA3 spatial firing in a familiar environment. Here, we tes...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.23190
更新日期:2020-07-01 00:00:00
abstract::In the mammalian brain, newly acquired memories depend on the hippocampus (HPC) for maintenance and recall, but over time, the neocortex takes over these functions, rendering memories HPC-independent. The process responsible for this transformation is called systems memory consolidation. Reactivation of a well-consoli...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.23187
更新日期:2020-07-01 00:00:00
abstract::In rodents, pyramidal cell firing patterns from waking may be replayed in nonrapid eye movement sleep (NREM) sleep during hippocampal sharp wave ripples (HC-SWR). In humans, HC-SWR have only been recorded with electrodes implanted to localize epileptogenicity. Here, we characterize human HC-SWR with rigorous rejection...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.23183
更新日期:2020-06-01 00:00:00
abstract::The ventral portion of the rodent hippocampus (HPC; anterior in primates) has been implicated in the detection and resolution of approach-avoidance conflict, which arises when an organism encounters a stimulus that predicts both positive and negative outcomes. Previous work has found differential regulation of approac...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.23182
更新日期:2020-06-01 00:00:00
abstract::Nearby grid cells have been observed to express a remarkable degree of long-range order, which is often idealized as extending potentially to infinity. Yet their strict periodic firing and ensemble coherence are theoretically possible only in flat environments, much unlike the burrows which rodents usually live in. Ar...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.23144
更新日期:2020-04-01 00:00:00
abstract::Our lives are a continuous stream of experience. Our episodic memories on the other hand have a definitive beginning, middle, and end. Theories of event segmentation suggest that salient changes in our environment produce event boundaries which partition the past from the present and, as a result, produce discretized ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.23161
更新日期:2020-02-01 00:00:00
abstract::One of the most striking features of the hippocampal network is its ability to self-generate neuronal sequences representing temporally compressed, spatially coherent paths. These brief events, often termed "replay" in the scientific literature, are largely confined to non-exploratory states such as sleep or quiet res...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22824
更新日期:2020-01-01 00:00:00
abstract::Sleep is important for memory consolidation, and an abundant literature suggests that reactivation in the hippocampus during sleep is instrumental to this process. Yet, the current interpretation of activity during sharp-waves ripples (SWRs), as replay of wake experiences, relies on hypotheses that, while widely accep...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.23143
更新日期:2020-01-01 00:00:00
abstract::In this review, we aim to reappraise the organization of intrinsic and extrinsic networks of the entorhinal cortex with a focus on the concept of parallel cortical connectivity streams. The concept of two entorhinal areas, the lateral and medial entorhinal cortex, belonging to two parallel input-output streams mediati...
journal_title:Hippocampus
pub_type: 杂志文章,评审
doi:10.1002/hipo.23145
更新日期:2019-12-01 00:00:00
abstract::Previous work has shown that the dorsal hippocampus has greater activity than ventral regions during place navigation. Exposure to a novel context has also been found to increase hippocampal activation, possibly due to increased spatial demands. However, activation patterns in dorsal and ventral regions have not been ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.23157
更新日期:2019-11-01 00:00:00
abstract::The hippocampal theta rhythm is frequently viewed as a clocking mechanism that coordinates the spiking activity of neurons across the hippocampus to form coherent neural assemblies. Phase precession is a form of temporal coding evidencing this mechanism and is degraded following systemic pharmacological disruption of ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.23100
更新日期:2019-11-01 00:00:00
abstract::The hippocampus is essential for learning and memory but also regulates emotional behavior. We previously identified the hippocampus as a major brain region that differs in rats bred for emotionality differences. Rats bred for low novelty response (LRs) exhibit high levels of anxiety- and depression-like behavior comp...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.23092
更新日期:2019-10-01 00:00:00
abstract::The hippocampal formation plays a role in mnemonic tasks and epileptic discharges in vivo. In vitro, these functions and malfunctions may relate to persistent firing (PF) and depolarization block (DB), respectively. Pyramidal neurons of the CA1 field have previously been reported to engage in either PF or DB during ch...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.23078
更新日期:2019-09-01 00:00:00
abstract::Hippocampal adult neurogenesis results in the persisting formation of new neurons that contribute to hippocampal-dependent learning and memory. This has led to the hypothesis that memory impairments associated with neurodegenerative diseases such as Alzheimer's disease may involve abnormal neurogenesis. Supporting thi...
journal_title:Hippocampus
pub_type: 杂志文章,评审
doi:10.1002/hipo.23052
更新日期:2019-07-01 00:00:00
abstract::White matter hyperintensities (WMH) constitute the visible spectrum of cerebral small vessel disease (SVD) markers and are associated with cognitive decline, although they do not fully account for memory decline observed in individuals with SVD. We hypothesize that WMH might exert their effect on memory decline indire...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.23039
更新日期:2019-06-01 00:00:00
abstract::For memory retrieval, pattern completion is a crucial process that restores memories from partial or degraded cues. Neurocognitive aging models suggest that the aged memory system is biased toward pattern completion, resulting in a behavioral preference for retrieval over encoding of memories. Here, we built on our pr...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.23030
更新日期:2019-04-01 00:00:00
abstract::Watermaze tests of place learning and memory in rodents and corresponding reverse-translated human paradigms in real or virtual environments are key tools to study hippocampal function. In common variants, the animal or human participant has to find a hidden goal that remains in the same place over many trials, allowi...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22992
更新日期:2018-11-01 00:00:00
abstract::Key pathological features of Parkinson's Disease (PD) include the progressive degeneration of midbrain dopaminergic (DA) neurons and hindbrain noradrenergic (NA) neurons. The loss of DA neurons has been extensively studied and is the main cause of motor dysfunction. Importantly, however, there are a range of 'non-move...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22835
更新日期:2018-05-01 00:00:00
abstract::Both the hippocampus and ventromedial prefrontal cortex (vmPFC) appear to be critical for episodic future simulation. Damage to either structure affects one's ability to remember the past and imagine the future, and both structures are commonly activated as part of a wider core network during future simulation. Howeve...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22812
更新日期:2018-02-01 00:00:00
abstract::The ERK/MAPK signaling pathway has been extensively studied in the context of learning and memory. Defects in this pathway underlie genetic diseases associated with intellectual disability, including impaired learning and memory. Numerous studies have investigated the impact of acute ERK/MAPK inhibition on long-term p...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22769
更新日期:2017-12-01 00:00:00
abstract::Williams syndrome (WS), a genetic deletion syndrome, is characterized by severe visuospatial deficits affecting performance on both tabletop spatial tasks and on tasks which assess orientation and navigation. Nevertheless, previous studies of WS spatial capacities have ignored the fact that two different spatial memor...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22764
更新日期:2017-11-01 00:00:00
abstract::Functional differences in the anterior and posterior hippocampus during episodic memory processing have not been examined in human electrophysiological data. This is in spite of strong evidence for such differences in rodent data, including greater place cell specificity in the dorsal hippocampus, greater sensitivity ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22751
更新日期:2017-10-01 00:00:00
abstract::Autism spectrum disorder (ASD) is a class of neurodevelopmental disorders characterized by persistent deficits in social communication/interaction, together with restricted/repetitive patterns of behavior. ASD is among the most heritable neuropsychiatric conditions, and while available evidence points to a complex set...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22741
更新日期:2017-08-01 00:00:00
abstract::Hippocampal synaptic plasticity comprises a key cellular mechanism for information storage. In the hippocampus, both long-term potentiation (LTP) and long-term depression (LTD) are triggered by synaptic Ca2+ -elevations that are typically mediated by the opening of voltage-gated cation channels, such as N-methyl-d-asp...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22742
更新日期:2017-08-01 00:00:00
abstract::By acting on serotonin 5-HT2A receptors (5-HT2A Rs), serotonergic psychedelic drugs induce perceptual and visual hallucinations by increasing neuronal excitability and altering visual-evoked neuronal responses. The present study was designed to examine whether the perceptual alterations induced by a serotonergic psych...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22712
更新日期:2017-05-01 00:00:00
abstract::Episodic memory deficits are evident in late-life depression (LLD) and are associated with subtle synaptic and neurochemical changes in the medial temporal lobes (MTL). However, the particular mechanisms by which memory impairment occurs in LLD are currently unknown. We tested older adults with (DS+) and without (DS-)...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22705
更新日期:2017-04-01 00:00:00
abstract::The advent of high-resolution magnetic resonance imaging (MRI) has enabled in vivo research in a variety of populations and diseases on the structure and function of hippocampal subfields and subdivisions of the parahippocampal gyrus. Because of the many extant and highly discrepant segmentation protocols, comparing r...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22671
更新日期:2017-01-01 00:00:00
abstract::Norepinephrine, is involved in the enhancement of learning and memory formation by regulating synaptic mechanisms through its ability to activate pre- and post-synaptic adrenergic receptors. Here we show that β-agonists of norepinephrine facilitate the induction of both associational LTP and sharp wave ripples (SPW-Rs...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22665
更新日期:2016-12-01 00:00:00
abstract::Individual variation in the attribution of motivational salience to reward-related cues is believed to underlie addiction vulnerability. Pavlovian conditioned approach measures individual variation in motivational salience by identifying rats that are attracted to and motivated by reward cues (sign-trackers) or motiva...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22619
更新日期:2016-11-01 00:00:00
abstract::Kowalczyk et al. (Hippocampus 2014; 24:7-20) were probably the first to conduct a systemic study of posterior hypothalamic area (PHa) theta rhythm in anesthetized rats. They demonstrated that local PHa theta field potentials were tail-pinch resistant and could be generated in urethane-anesthetized rats independently o...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22612
更新日期:2016-10-01 00:00:00
abstract::The mammalian hippocampus plays a key role in spatial learning and memory, but the exact nature of the hippocampal representation of space is still being explored. Recently, there has been a fair amount of success in modeling hippocampal spatial maps in rats, assuming a topological perspective on spatial information p...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22610
更新日期:2016-10-01 00:00:00
abstract::In this study the subcortical afferents for the rat PER areas 35 and 36, POR, and the lateral and medial entorhinal areas (LEA and MEA) were characterized. We analyzed 33 retrograde tract-tracing experiments distributed across the five regions. For each experiment, we estimated the total numbers, percentages, and dens...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22603
更新日期:2016-09-01 00:00:00