Abstract:
:For memory retrieval, pattern completion is a crucial process that restores memories from partial or degraded cues. Neurocognitive aging models suggest that the aged memory system is biased toward pattern completion, resulting in a behavioral preference for retrieval over encoding of memories. Here, we built on our previously developed behavioral recognition memory paradigm-the Memory Image Completion (MIC) task-a task to specifically target pattern completion. First, we used the original design with concurrent eye-tracking in order to rule out perceptual confounds that could interact with recognition performance. Second, we developed parallel versions of the task to accommodate test settings in clinical environments or longitudinal studies. The results show that older adults have a deficit in pattern completion ability with a concurrent bias toward pattern completion. Importantly, eye-tracking data during encoding could not account for age-related performance differences. At retrieval, spatial viewing patterns for both age groups were more driven by stimulus identity than by response choice, but compared to young adults, older adults' fixation patterns overlapped more between stimuli that they (wrongly) thought had the same identity. This supports the observation that older adults choose responses perceived as similar to a learned stimulus, indicating a bias toward pattern completion. Additionally, two shorter versions of the task yielded comparable results, and no general learning effects were observed for repeated testing. Together, we present evidence that the MIC is a reliable behavioral task that targets pattern completion, that is easily and repeatedly applicable, and that is made freely available online.
journal_name
Hippocampusjournal_title
Hippocampusauthors
Vieweg P,Riemer M,Berron D,Wolbers Tdoi
10.1002/hipo.23030subject
Has Abstractpub_date
2019-04-01 00:00:00pages
340-351issue
4eissn
1050-9631issn
1098-1063journal_volume
29pub_type
杂志文章相关文献
HIPPOCAMPUS文献大全abstract::By acting on serotonin 5-HT2A receptors (5-HT2A Rs), serotonergic psychedelic drugs induce perceptual and visual hallucinations by increasing neuronal excitability and altering visual-evoked neuronal responses. The present study was designed to examine whether the perceptual alterations induced by a serotonergic psych...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22712
更新日期:2017-05-01 00:00:00
abstract::Previous investigation of CA1-evoked subicular responses has used either single low-frequency pulses (LF), paired-pulses (PP), or high-frequency bursts. Here we test for the first time how subiculum responds to naturalistic stimulation trains (NSTs). We recorded CA1-evoked field potentials from dorsal rat subiculum in...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20629
更新日期:2010-02-01 00:00:00
abstract::In all species examined, the dentate gyrus develops over an extended period that begins during gestation and continues up to adulthood. The aim of this study was to investigate the pattern of postnatal cell production in the dentate gyrus of the guinea pig, a rodent whose brain development has features more closely re...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20050
更新日期:2005-01-01 00:00:00
abstract::Processing of multimodal sensory information by the morphological subdivisions of the hippocampus and its input and output structures was investigated in unanesthetized rabbits by extracellular recording of neuronal activity. Analysis shows principal differences between CA3 neurons with uniform multimodal, mainly inhi...
journal_title:Hippocampus
pub_type: 杂志文章,评审
doi:10.1002/hipo.1073
更新日期:2001-01-01 00:00:00
abstract::Presenting stimuli again after presentation of intervening stimuli improves their retention, an effect known as the spacing effect. However, using event-related potentials (ERPs), we had observed that immediate, in comparison to spaced, repetition of pictures induced a positive frontal potential at 200-300 ms. This po...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22534
更新日期:2016-04-01 00:00:00
abstract::The precise timing of pre-postsynaptic activity is vital for the induction of long-term potentiation (LTP) or depression (LTD) at many central synapses. We show in synapses of rat CA1 pyramidal neurons in vitro that spike timing dependent plasticity (STDP) protocols that induce LTP at glutamatergic synapses can evoke ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22196
更新日期:2013-12-01 00:00:00
abstract::The conditioned cue preference (CCP) task was used to study the ability of rats to discriminate between spatial locations. Food-deprived rats explored an eight-arm radial maze with no food present (pre-exposure). On subsequent days, they were alternately confined in one arm of the maze with food and in another arm wit...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20127
更新日期:2005-01-01 00:00:00
abstract::We often engage in counterfactual (CF) thinking, which involves reflecting on "what might have been." Creating alternative versions of reality seems to have parallels with recollecting the past and imagining the future in requiring the simulation of internally generated models of complex events. Given that episodic me...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22323
更新日期:2014-11-01 00:00:00
abstract::A large body of evidence exists to demonstrate that excitatory amino acids (EAA) and their receptors are involved in the pathophysiological mechanisms linking several acute brain insults, such as cerebral ischemia, to neuronal degeneration and death. Accordingly, the use of EAA receptor antagonists can be beneficial i...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.450050111
更新日期:1995-01-01 00:00:00
abstract::The goal of the present research was to assess the degree to which a pattern completion process operates in cue-induced relapse to cocaine-seeking behavior. Using a novel cue-preference version of the place preference task, rats were administered cocaine or saline, which resulted in a preference for the cocaine-paired...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22570
更新日期:2016-07-01 00:00:00
abstract::The hippocampal formation plays a role in mnemonic tasks and epileptic discharges in vivo. In vitro, these functions and malfunctions may relate to persistent firing (PF) and depolarization block (DB), respectively. Pyramidal neurons of the CA1 field have previously been reported to engage in either PF or DB during ch...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.23078
更新日期:2019-09-01 00:00:00
abstract::Animal studies on the effects of chronic variable stress during the peripubertal-juvenile period on hippocampal structure and function are lacking. Twenty-eight-day-old Sprague-Dawley rats were subjected to random, variable physical or social stress regimens for 4 weeks. Hippocampal volume was found to continue to gro...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.10207
更新日期:2004-01-01 00:00:00
abstract::One functional aspect of theta oscillations that recent studies have begun to explore in humans is their role for the recollection of personal events. A specific role of theta for recollection but not for stimulus-familiarity would support links between cortical theta oscillations and hippocampal functioning, given th...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20125
更新日期:2005-01-01 00:00:00
abstract::Temporal difference learning (TD) is a popular algorithm in machine learning. Two learning signals that are derived from this algorithm, the predictive value and the prediction error, have been shown to explain changes in neural activity and behavior during learning across species. Here, the predictive value signal is...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20535
更新日期:2009-05-01 00:00:00
abstract::Hippocampal adult neurogenesis results in the persisting formation of new neurons that contribute to hippocampal-dependent learning and memory. This has led to the hypothesis that memory impairments associated with neurodegenerative diseases such as Alzheimer's disease may involve abnormal neurogenesis. Supporting thi...
journal_title:Hippocampus
pub_type: 杂志文章,评审
doi:10.1002/hipo.23052
更新日期:2019-07-01 00:00:00
abstract::L-aspartate is the amino-acid residue most susceptible to spontaneous isomerization. This denaturation causes an alteration in the biological activity of the protein and is regarded as an aging process of the protein. Protein L-isoaspartyl methyltransferase (PIMT) repairs this post-translational modification and thus ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.1043
更新日期:2001-01-01 00:00:00
abstract::Effective navigation depends upon reliable estimates of head direction (HD). Visual, vestibular, and outflow motor signals combine for this purpose in a brain system that includes dorsal tegmental nucleus, lateral mammillary nuclei, anterior dorsal thalamic nucleus, and the postsubiculum. Learning is needed to combine...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22040
更新日期:2012-12-01 00:00:00
abstract::Down syndrome (DS), the leading genetic cause of mental retardation, is characterized by reduced number of cortical neurons and brain size. The occurrence of these defects starting from early life stages points at altered developmental neurogenesis as their major determinant. The goal of our study was to obtain compar...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20308
更新日期:2007-01-01 00:00:00
abstract::Various paradigms have been used to assess the capacity of the adult brain to undergo activity-dependent morphological plasticity. In this report we have employed recurrent limbic seizures as a means of studying the effects of this form of enhanced neuronal activity on cellular morphology and, in particular, on the in...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.450040510
更新日期:1994-10-01 00:00:00
abstract::There is an ongoing debate regarding the respective role of anterior subhippocampal structures and the hippocampus in recognition memory. Here, we report a double anatomo-functional dissociation observed in two brain-damaged patients, FRG and JMG. They both suffered from complete destruction of left MTL structures. In...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20848
更新日期:2011-09-01 00:00:00
abstract::This study examines whether 4-8-Hz theta oscillations can be seen in the human hippocampus, and whether these oscillations increase during virtual movement and searching, as they do in rodents. Recordings from both hippocampal and neocortical depth electrodes were analyzed while six epileptic patients played a virtual...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20109
更新日期:2005-01-01 00:00:00
abstract::Although there are many types of epilepsy, temporal lobe epilepsy (TLE) is probably in humans the most common and most often studied. TLE represents 40% of the total epilepsy form of the disease and is difficult to treat. Despite a wealth of descriptive data obtained from the disease history of patients, the EEG recor...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22246
更新日期:2014-06-01 00:00:00
abstract::Granule cells of the mouse fascia dentata are widely used in studies on neuronal development and plasticity. In contrast to the rat, however, high-resolution morphometric data on these cells are scarce. Thus, we have analyzed granule cells in the fascia dentata of the adult Thy1-GFP mouse (C57BL/6 background). In this...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20398
更新日期:2008-01-01 00:00:00
abstract::In the present study, 93 cells in the superior colliculus (SC) were recorded extracellularly during the simultaneous occurrence of spontaneous theta field activity, sensory-induced (tail pinch) theta field activity, and large amplitude irregular (LIA) field activity, recorded from an electrode located in the stratum m...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/(SICI)1098-1063(1999)9:5<500::AID-HIPO3>3.
更新日期:1999-01-01 00:00:00
abstract::Replicas of an aspect of an experienced event can serve as effective reminders, yet little is known about the neural basis of such reminding effects. Here we examined the neural activity underlying the memory-enhancing effect of reminders 1 week after encoding of naturalistic film clip events. We used fMRI to determin...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.23260
更新日期:2021-01-01 00:00:00
abstract::We analyzed intracranial electroencephalographic (EEG) recordings from the medial temporal lobes of 12 epilepsy patients during a continuous word recognition paradigm, contrasting trials of correctly recognized repeated words (hits) and correctly identified new words (correct rejections). Using a wavelet-based analysi...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20117
更新日期:2005-01-01 00:00:00
abstract::The hippocampus and the medial temporal lobe cortex [medial temporal lobe cortices (MTLC)] both contribute to long-term memory. Although their contributions are thought to be dissociable, the nature of the representations that each region supports remains unclear. The Complementary Learning Systems (CLS) modeling appr...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20967
更新日期:2012-05-01 00:00:00
abstract::This study investigated the effects of progesterone (P4) on the production and survival of neurons in the hippocampal dentate gyrus of adult male mice. The administration of P4 (4 mg/kg) for 3 consecutive days beginning on the 0-2nd day after the first BrdU-injection (BrdU-D(0-2)) produced an approximately twofold inc...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20642
更新日期:2010-03-01 00:00:00
abstract::The survival of adult-born dentate gyrus granule cells critically depends on their synaptic integration into the existing neuronal network. Excitatory inputs are thought to increase the survival rate of adult born neurons. Therefore, whether enhancing the stability of newly formed excitatory synapses by overexpressing...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22524
更新日期:2016-03-01 00:00:00
abstract::To minimize the variability in the extent of lesions made by injections of the excitotoxin ibotenic acid in rhesus monkeys, we developed and validated an MRI-based method to determine the efficacy of the injections soon after surgery. T2-weighted MR images were obtained 6-11 days after surgery from 17 brain hemisphere...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.1050
更新日期:2001-01-01 00:00:00