Counterfactual thinking in patients with amnesia.

abstract：:We aimed at identifying the cerebral structures whose synaptic function subserves the recollection of lifetime's episodic autobiographical memory (AM) via autonoetic consciousness. Twelve healthy middle-aged subjects (mean age: 59 years +/- 2.5) underwent a specially designed cognitive test to assess the ability to re...

journal_title：Hippocampus

authors： Piolino P,Desgranges B,Hubert V,Bernard FA,Matuszewski V,Chételat G,Baron JC,Eustache F

更新日期：2008-01-01 00:00:00

abstract：:The mechanisms underlying memory are under intense investigation. One of the most promising candidates at the cellular level is long-term potentiation (LTP). Numerous pharmacological and molecular genetic manipulations have led to alteration in both LTP and memory. However, the causal relationship between these phenot...

journal_title：Hippocampus

authors： Gerlai R

更新日期：2002-01-01 00:00:00

abstract：:Two experiments assessed the effects of 1) combined subicular complex and posterior cingulate cortical lesions on training-induced neuronal activity (TIA) in the anterior ventral (AV) and medial dorsal (MD) thalamic nuclei; 2) hippocampal (Ammon's horn and dentate gyrus) lesions on TIA in cingulate cortex and in the A...

journal_title：Hippocampus

authors： Kang E,Gabriel M

更新日期：1998-01-01 00:00:00

abstract：:An extensive cortical network consisting of structures in the medial temporal lobe (hippocampus and parahippocampal cortex), lateral parietal cortex, retrosplenial cortex, and medial prefrontal cortex has recently attracted attention in cognitive neuroscience research, linking the network to both episodic memory and s...

journal_title：Hippocampus

authors： Peters J,Daum I,Gizewski E,Forsting M,Suchan B

更新日期：2009-02-01 00:00:00

abstract：:Although there are many types of epilepsy, temporal lobe epilepsy (TLE) is probably in humans the most common and most often studied. TLE represents 40% of the total epilepsy form of the disease and is difficult to treat. Despite a wealth of descriptive data obtained from the disease history of patients, the EEG recor...

journal_title：Hippocampus

authors： Mériaux C,Franck J,Park DB,Quanico J,Kim YH,Chung CK,Park YM,Steinbusch H,Salzet M,Fournier I

更新日期：2014-06-01 00:00:00

abstract：:This study examines the extent to which simultaneous olfactory discrimination learning increases spine density on hippocampal CA1 pyramidal neurons in C57BL/6J (C57) and DBA/2J (DBA) inbred mice, characterized by spontaneous differences in hippocampal plasticity and hippocampus-related learning. The behavioral data fi...

journal_title：Hippocampus

authors： Restivo L,Roman FS,Ammassari-Teule M,Marchetti E

更新日期：2006-01-01 00:00:00

abstract：:Norepinephrine, is involved in the enhancement of learning and memory formation by regulating synaptic mechanisms through its ability to activate pre- and post-synaptic adrenergic receptors. Here we show that β-agonists of norepinephrine facilitate the induction of both associational LTP and sharp wave ripples (SPW-Rs...

journal_title：Hippocampus

authors： Ul Haq R,Anderson M,Liotta A,Shafiq M,Sherkheli MA,Heinemann U

更新日期：2016-12-01 00:00:00

abstract：:The role of perforant pathway-dentate granule cell synapses in cognitive behavior was examined focusing on synaptic Zn(2+) signaling in the dentate gyrus. Object recognition memory was transiently impaired when extracellular Zn(2+) levels were decreased by injection of clioquinol and N,N,N',N'-tetrakis-(2-pyridylmethy...

journal_title：Hippocampus

authors： Takeda A,Tamano H,Ogawa T,Takada S,Nakamura M,Fujii H,Ando M

更新日期：2014-11-01 00:00:00

abstract：:Fear can be extinguished by repeated exposure to a cue that signals threat. However, extinction does not erase fear, as an extinguished cue presented in a context distinct from that of extinction results in renewed fear of that cue. The hippocampus, which is involved in the formation of contextual representations, is ...

journal_title：Hippocampus

authors： Zelikowsky M,Pham DL,Fanselow MS

更新日期：2012-05-01 00:00:00

abstract：:Hippocampal neurogenesis declines substantially in chronic temporal lobe epilepsy (TLE). However, it is unclear whether this decline is linked to altered production of new cells and/or diminished survival and neuronal fate-choice decision of newly born cells. We quantified different components of hippocampal neurogene...

journal_title：Hippocampus

authors： Hattiangady B,Shetty AK

更新日期：2010-01-01 00:00:00

abstract：:Effective navigation depends upon reliable estimates of head direction (HD). Visual, vestibular, and outflow motor signals combine for this purpose in a brain system that includes dorsal tegmental nucleus, lateral mammillary nuclei, anterior dorsal thalamic nucleus, and the postsubiculum. Learning is needed to combine...

journal_title：Hippocampus

authors： Fortenberry B,Gorchetchnikov A,Grossberg S

更新日期：2012-12-01 00:00:00

abstract：:In contextual fear conditioning (CFC), the use of pharmacological and lesion approaches has helped to understand that there are differential roles for the dorsal hippocampus (DH) and the ventral hippocampus (VH) in the acquisition, consolidation and retrieval phases. Concomitant analysis of the DH and the VH in indivi...

journal_title：Hippocampus

authors： Sase S,Sase A,Sialana FJ Jr,Gröger M,Bennett KL,Stork O,Lubec G,Li L

更新日期：2015-12-01 00:00:00

abstract：:Nitric oxide (NO) is a gaseous neuromessenger. Although increasing evidence reveals significant physiological effects of NO in the hippocampal synaptic plasticity, the spatial distribution of NO production has remained largely uncharacterized due to the poor development of techniques for real-time NO imaging. In this ...

journal_title：Hippocampus

authors： Takata N,Harada T,Rose JA,Kawato S

更新日期：2005-01-01 00:00:00

abstract：:Space and time are both essential features of episodic memory, for which the hippocampus is critical (Howard & Eichenbaum, 2015). Spatial tasks have been used effectively to study the behavioral relevance of place cells. However, the behavioral paradigms utilized for the study of time cells have not used time duration...

journal_title：Hippocampus

authors： Sabariego M,Tabrizi NS,Marshall GJ,McLagan AN,Jawad S,Hales JB

更新日期：2021-01-01 00:00:00

abstract：:The survival of adult-born dentate gyrus granule cells critically depends on their synaptic integration into the existing neuronal network. Excitatory inputs are thought to increase the survival rate of adult born neurons. Therefore, whether enhancing the stability of newly formed excitatory synapses by overexpressing...

journal_title：Hippocampus

authors： Doengi M,Krupp AJ,Körber N,Stein V

更新日期：2016-03-01 00:00:00

abstract：:Entorhinal cortex lesion (ECL) leads to anterograde degeneration of perforant path axons and is known to induce a rapid and intense reaction of astrocytes and microglial cells in the deafferented dentate gyrus. Phagocytosis of degenerating axons involves the establishment and maintenance of cell-matrix and cell-cell i...

journal_title：Hippocampus

authors： Hailer NP,Bechmann I,Heizmann S,Nitsch R

更新日期：1997-01-01 00:00:00

abstract：:The hippocampus creates distinct episodes from highly similar events through a process called pattern separation and can retrieve memories from partial or degraded cues through a process called pattern completion. These processes have been studied in humans using tasks where participants must distinguish studied items...

journal_title：Hippocampus

authors： Molitor RJ,Ko PC,Hussey EP,Ally BA

更新日期：2014-06-01 00:00:00

abstract：:Neuronal mechanisms of episodic memory, the conscious recollection of autobiographical events, are largely unknown because electrophysiological studies in humans are conducted only in exceptional circumstances. Unit recording studies in animals are thus crucial for understanding the neurophysiological substrate that e...

journal_title：Hippocampus

authors： Ferbinteanu J,Kennedy PJ,Shapiro ML

更新日期：2006-01-01 00:00:00

abstract：:The importance of the hippocampal theta oscillation (4-8 Hz) to memory formation has been well-established through studies in animals, prompting researchers to propose comprehensive theories of memory and learning that rely on theta oscillations for integrating information in the hippocampus and neocortex. Yet, empiri...

journal_title：Hippocampus

authors： Lega BC,Jacobs J,Kahana M

更新日期：2012-04-01 00:00:00

abstract：:High-frequency stimulation of excitatory synapses in many regions of the brain triggers a lasting increase in the efficacy of synaptic transmission referred to as long-term potentiation (LTP) and believed to contribute to learning and memory. One hypothesis proposed to account for the stability and properties of this ...

journal_title：Hippocampus

authors： Muller D,Toni N,Buchs PA

更新日期：2000-01-01 00:00:00

abstract：:Presenting stimuli again after presentation of intervening stimuli improves their retention, an effect known as the spacing effect. However, using event-related potentials (ERPs), we had observed that immediate, in comparison to spaced, repetition of pictures induced a positive frontal potential at 200-300 ms. This po...

journal_title：Hippocampus

authors： Thézé R,Guggisberg AG,Nahum L,Schnider A

更新日期：2016-04-01 00:00:00

abstract：:Galantamine, a novel Alzheimer's drug, is known to inhibit acetylcholinesterase activity and potentiate nicotinic acetylcholine receptor (nAChR) in the brain. We previously reported that galantamine potentiates the NMDA-induced currents in primary cultured rat cortical neurons. We now studied the effects of galantamin...

journal_title：Hippocampus

authors： Moriguchi S,Shioda N,Han F,Yeh JZ,Narahashi T,Fukunaga K

更新日期：2009-09-01 00:00:00

abstract：:Various forms of synaptic plasticity in the brain have been proposed to result from modifications in the properties of glutamate receptors by calcium-dependent mechanisms. In the present study, changes in glutamate receptors elicited by calcium treatment of previously frozen mouse brain sections were evaluated by qual...

journal_title：Hippocampus

authors： Lapierre L,Valastro B,Miceli D,Massicotte G

更新日期：2000-01-01 00:00:00

abstract：:Converging behavioral, electrophysiological, and neurochemical data suggest that lesions to the peripheral vestibular system result in impairment of the hippocampus. Nonetheless, relatively few studies have examined the hippocampus or behavior related to it, over a long period of time following the lesion, to determin...

journal_title：Hippocampus

authors： Zheng Y,Goddard M,Darlington CL,Smith PF

更新日期：2007-01-01 00:00:00

abstract：:Dual-process theories of episodic memory state that retrieval is contingent on two independent processes: familiarity (providing a sense of oldness) and recollection (recovering events and their context). A variety of studies have reported distinct neural signatures for familiarity and recollection, supporting dual-pr...

journal_title：Hippocampus

authors： Greve A,Donaldson DI,van Rossum MC

更新日期：2010-02-01 00:00:00

abstract：:This study investigated the effects of neonatal hippocampal ablation on the development of spatial learning and memory abilities in rats. Newborn rats sustained bilateral electrolytic lesions of the hippocampus or were sham-operated on postnatal day 1 (PN1). At PN20-25, PN50-55, or PN90-95, separate groups of rats wer...

journal_title：Hippocampus

authors： Altemus KL,Almli CR

更新日期：1997-01-01 00:00:00

abstract：:Both natural and synthetic cannabinoid receptor (e.g., CB1) agonists such as Δ(9)-THC, WIN 55,212-2 (WIN-2), and HU-210 disrupt spatial cognition presumably through the inhibition of synchrony of hippocampal ensemble firing to task-related events. Although the CB1 receptor agonist CP 55,940 also disrupts the synchrono...

journal_title：Hippocampus

authors： Goonawardena AV,Riedel G,Hampson RE

更新日期：2011-05-01 00:00:00

abstract：:The hippocampus, the prefrontal cortex, and interconnected neural circuits are implicated in several aspects of cognitive and memory processes. The present review is dedicated to the description of the anatomo-functional characteristics of the hippocampo-prefrontal pathway and related neuronal circuits in the rat. Thi...

journal_title：Hippocampus

authors： Thierry AM,Gioanni Y,Dégénétais E,Glowinski J

更新日期：2000-01-01 00:00:00

abstract：:Various paradigms have been used to assess the capacity of the adult brain to undergo activity-dependent morphological plasticity. In this report we have employed recurrent limbic seizures as a means of studying the effects of this form of enhanced neuronal activity on cellular morphology and, in particular, on the in...

journal_title：Hippocampus

authors： Bundman MC,Pico RM,Gall CM

更新日期：1994-10-01 00:00:00

abstract：:To clarify the specific contribution of the medial temporal lobe structures in spatial memory, we tested monkeys (Macaca mulatta) with sham operations and with lesions of either the hippocampal formation, areas TH/TF or perirhinal cortex on two versions of the visual-paired comparison task, measuring Spatial Location,...

journal_title：Hippocampus

authors： Bachevalier J,Nemanic S

更新日期：2008-01-01 00:00:00