Hippocampo-prefrontal cortex pathway: anatomical and electrophysiological characteristics.

abstract：:The past decade has witnessed burgeoning evidence that antidepressant medications and physical exercise increase the expression of hippocampal brain-derived neurotrophic factor (BDNF). This phenomenon has gained widespread appeal, because BDNF is one of the first macromolecules observed to play a central role not only...

journal_title：Hippocampus

authors： Chen MJ,Russo-Neustadt AA

更新日期：2009-10-01 00:00:00

abstract：:The conditioned cue preference (CCP) task was used to study the ability of rats to discriminate between spatial locations. Food-deprived rats explored an eight-arm radial maze with no food present (pre-exposure). On subsequent days, they were alternately confined in one arm of the maze with food and in another arm wit...

journal_title：Hippocampus

authors： Gaskin S,Chai SC,White NM

更新日期：2005-01-01 00:00:00

abstract：:The hippocampus receives two streams of information, spatial and nonspatial, via major afferent inputs from the medial (MEC) and lateral entorhinal cortexes (LEC). The MEC and LEC projections in the temporoammonic pathway are topographically organized along the transverse-axis of area CA1. The potential for functional...

journal_title：Hippocampus

authors： Ito HT,Schuman EM

更新日期：2012-02-01 00:00:00

abstract：:The modulatory actions of GABA(A) receptor subunits are crucial for morphological and transcriptional neuronal activities. In this study, growth of hamster hippocampal neurons on biohybrid membrane substrates allowed us to show for the first time that the two major GABA(A) alpha receptor subunits (alpha(2,5)) are capa...

journal_title：Hippocampus

authors： Giusi G,Facciolo RM,Rende M,Alò R,Di Vito A,Salerno S,Morelli S,De Bartolo L,Drioli E,Canonaco M

更新日期：2009-11-01 00:00:00

abstract：:Light and electron microscopic immunocytochemical techniques were used to study the interneuron population staining for somatostatin (SRIF) in cultured slices of rat hippocampus. The SRIF immunoreactive somata were most dense in stratum oriens of areas CA1 and CA3, and in the dentate hilus. Somatostatin immunoreactive...

journal_title：Hippocampus

authors： Kunkel DD,Nguyen LB,Harrigan MR,Schwartzkroin PA,Malouf AT

更新日期：1994-04-01 00:00:00

abstract：:Previous work has shown that the dorsal hippocampus has greater activity than ventral regions during place navigation. Exposure to a novel context has also been found to increase hippocampal activation, possibly due to increased spatial demands. However, activation patterns in dorsal and ventral regions have not been ...

journal_title：Hippocampus

authors： Lee JQ,Demchuk AM,Morgan E,McHugh R,McNaughton BL,Sutherland RJ,McDonald RJ

更新日期：2019-11-01 00:00:00

abstract：:We review evidence from experiments conducted in our laboratory on retrograde amnesia in rats with damage to the hippocampal formation. In a new experiment reported here, we show that N-methyl-D-aspartate (NMDA)-induced hippocampal damage produced retrograde amnesia for both hidden platform and two-choice visible plat...

journal_title：Hippocampus

authors： Sutherland RJ,Weisend MP,Mumby D,Astur RS,Hanlon FM,Koerner A,Thomas MJ,Wu Y,Moses SN,Cole C,Hamilton DA,Hoesing JM

更新日期：2001-01-01 00:00:00

abstract：:This study examines whether 4-8-Hz theta oscillations can be seen in the human hippocampus, and whether these oscillations increase during virtual movement and searching, as they do in rodents. Recordings from both hippocampal and neocortical depth electrodes were analyzed while six epileptic patients played a virtual...

journal_title：Hippocampus

authors： Ekstrom AD,Caplan JB,Ho E,Shattuck K,Fried I,Kahana MJ

更新日期：2005-01-01 00:00:00

abstract：:GABAergic inhibitory interneurons control fundamental aspects of neuronal network function. Their functional roles are assumed to be defined by the identity of their input synapses, the architecture of their dendritic tree, the passive and active membrane properties and finally the nature of their postsynaptic targets...

journal_title：Hippocampus

authors： Hosp JA,Strüber M,Yanagawa Y,Obata K,Vida I,Jonas P,Bartos M

更新日期：2014-02-01 00:00:00

abstract：:In contextual fear conditioning (CFC), hippocampus is thought to process environmental stimuli into a configural representation of the context and send it to amygdala nuclei, which current evidences point to be the site of CS-US association and fear memory storage. If it is true, hippocampus should influence learning-...

journal_title：Hippocampus

authors： de Oliveira Coelho CA,Ferreira TL,Soares JC,Oliveira MG

更新日期：2013-07-01 00:00:00

abstract：:The hippocampus creates distinct episodes from highly similar events through a process called pattern separation and can retrieve memories from partial or degraded cues through a process called pattern completion. These processes have been studied in humans using tasks where participants must distinguish studied items...

journal_title：Hippocampus

authors： Molitor RJ,Ko PC,Hussey EP,Ally BA

更新日期：2014-06-01 00:00:00

abstract：:In a comparative approach, the anatomical organization of the hippocampus was investigated in two species of megachiropteran bats, the grey-headed flying fox, Pteropus poliocephalus, and the little red flying fox, Pteropus scapulatus. In general, the cytoarchitectonic appearance of the flying fox hippocampus correspon...

journal_title：Hippocampus

authors： Buhl EH,Dann JF

更新日期：1991-04-01 00:00:00

abstract：:Lynn Nadel has been a trailblazer in memory research for decades. In just one example, Nadel and Zola-Morgan [Infantile amnesia, In Infant memory, Springer, Boston, MA, 1984, pp. 145-172] were the first to present the provocative notion that the extended development of the hippocampus may underlie the period of infant...

journal_title：Hippocampus

authors： Edgin JO,Liu Y,Hughes K,Spanò G,Clark CAC

更新日期：2020-08-01 00:00:00

abstract：:For memory retrieval, pattern completion is a crucial process that restores memories from partial or degraded cues. Neurocognitive aging models suggest that the aged memory system is biased toward pattern completion, resulting in a behavioral preference for retrieval over encoding of memories. Here, we built on our pr...

journal_title：Hippocampus

authors： Vieweg P,Riemer M,Berron D,Wolbers T

更新日期：2019-04-01 00:00:00

abstract：:It is argued that while the hippocampus is not vital for all classes of configural learning, it is vital for a specific subclass of configural tasks called "structural learning." The defining feature of structural learning is that in addition to binding stimulus elements to make unique arrays (as in all configural lea...

journal_title：Hippocampus

authors： Aggleton JP,Sanderson DJ,Pearce JM

更新日期：2007-01-01 00:00:00

abstract：:Metabolic integrity of glial cells in field CA1 of the guinea pig hippocampus is critical to maintenance of synaptic transmission (Keyser and Pellmar [1994] Glia 10:237-243). To determine if this tight glial-neuronal coupling is equally important in other brain regions, we compared the effect of fluoroacetate (FAC), a...

journal_title：Hippocampus

authors： Keyser DO,Pellmar TC

更新日期：1997-01-01 00:00:00

abstract：:Space and time are both essential features of episodic memory, for which the hippocampus is critical (Howard & Eichenbaum, 2015). Spatial tasks have been used effectively to study the behavioral relevance of place cells. However, the behavioral paradigms utilized for the study of time cells have not used time duration...

journal_title：Hippocampus

authors： Sabariego M,Tabrizi NS,Marshall GJ,McLagan AN,Jawad S,Hales JB

更新日期：2021-01-01 00:00:00

abstract：:The multifactorial causes impacting the risk of developing sporadic forms of Alzheimer's disease (AD) remain to date poorly understood. Epidemiologic studies in humans and research in rodents have suggested that hypothyroidism could participate in the etiology of AD. Recently, we reported that adult-onset hypothyroidi...

journal_title：Hippocampus

authors： Chaalal A,Poirier R,Blum D,Gillet B,Le Blanc P,Basquin M,Buée L,Laroche S,Enderlin V

更新日期：2014-11-01 00:00:00

abstract：:Human navigation studies show that landmarks are used for orientation, whereas objects contribute to the contextual representation of an environment. What constitutes a landmark? Classic rodent studies show that hippocampal place fields are controlled by distal, polarizing cues. Place fields, however, are also influen...

journal_title：Hippocampus

authors： Scaplen KM,Gulati AA,Heimer-McGinn VL,Burwell RD

更新日期：2014-11-01 00:00:00

abstract：:We have shown previously that chronic nicotine treatment reverses adult-onset hypothyroidism-induced impairment of late-phase long-term potentiation (L-LTP) in area CA1 of the hippocampus. In the present study, basal and stimulated levels of signaling molecules essential for the expression of L-LTP were determined in ...

journal_title：Hippocampus

authors： Alzoubi KH,Aleisa AM,Alkadhi KA

更新日期：2007-01-01 00:00:00

abstract：:A striking similarity has been suggested between past and future thinking in Alzheimer's Disease (AD), a similarity attributable to abnormalities in common modular cognitive functions and neuroanatomical substrates. This study extends this literature by identifying specific executive function deficits underlying past ...

journal_title：Hippocampus

authors： El Haj M,Antoine P,Kapogiannis D

更新日期：2015-11-01 00:00:00

abstract：:A forced-choice discrimination paradigm was used in two experiments, to evaluate retrograde and anterograde amnesia in rats after hippocampal ablation. In a within-subjects design (Experiment 1), rats were trained on a set of 10 olfactory discriminations 4 weeks before surgery and on a separate set of 10 discriminatio...

journal_title：Hippocampus

authors： Jonasson Z,Ballantyne JK,Baxter MG

更新日期：2004-01-01 00:00:00

abstract：:There is extensive research regarding the neural mechanisms involved in satiety and meal termination; in contrast, there is very limited understanding of how meal onset is regulated. On the basis of several converging lines of evidence, we hypothesized that hippocampal neurons form a memory of a meal and inhibit meal ...

journal_title：Hippocampus

authors： Henderson YO,Smith GP,Parent MB

更新日期：2013-01-01 00:00:00

abstract：:The aim of this study was to investigate the role of the human hippocampus in episodic retrieval of odors, in comparison with episodic retrieval of visual objects. Subjects encoded a set of unique odors and objects, and retrieval was tested the next day during functional magnetic resonance imaging (fMRI). Subjects wer...

journal_title：Hippocampus

authors： Lehn H,Kjønigsen LJ,Kjelvik G,Håberg AK

更新日期：2013-02-01 00:00:00

abstract：:Rett syndrome (RTT) is a neurodevelopment disorder associated with intellectual disabilities and caused by loss-of-function mutations in the gene encoding the transcriptional regulator Methyl-CpG-binding Protein-2 (MeCP2). Neuronal dysfunction and changes in cortical excitability occur in RTT individuals and Mecp2-def...

journal_title：Hippocampus

authors： Calfa G,Li W,Rutherford JM,Pozzo-Miller L

更新日期：2015-02-01 00:00:00

abstract：:Hippocampal synaptic plasticity comprises a key cellular mechanism for information storage. In the hippocampus, both long-term potentiation (LTP) and long-term depression (LTD) are triggered by synaptic Ca2+ -elevations that are typically mediated by the opening of voltage-gated cation channels, such as N-methyl-d-asp...

journal_title：Hippocampus

authors： Jansen S,Gottschling C,Faissner A,Manahan-Vaughan D

更新日期：2017-08-01 00:00:00

abstract：:Unilateral injection of kainic acid (KA) into the dorsal hippocampus of adult mice induces spontaneous recurrent partial seizures and replicates histopathological changes observed in human mesial temporal lobe epilepsy (MTLE) (Bouilleret V et al., Neuroscience 1999; 89:717-729). Alterations in pre- and postsynaptic co...

journal_title：Hippocampus

authors： Bouilleret V,Loup F,Kiener T,Marescaux C,Fritschy JM

更新日期：2000-01-01 00:00:00

abstract：:The influence of the learning process on the persistence of the newly acquired behavior is relevant both for our knowledge of the learning/memory mechanisms and for the educational policy. However, it is unclear whether during an operant conditioning process with a continuous reinforcement paradigm, individual differe...

journal_title：Hippocampus

authors： Gradari S,Pérez-Domper P,Butler RG,Martínez-Cué C,de Polavieja GG,Trejo JL

更新日期：2016-07-01 00:00:00

abstract：:C57 and DBA mice were trained in a crossed maze to assess possible strain differences in place or response learning as a function of training duration (8 or 17 days) and extramaze cueing conditions. The first condition consisted of a diffuse visually cued environment (rich cueing). The second was the same plus an expl...

journal_title：Hippocampus

authors： Passino E,Middei S,Restivo L,Bertaina-Anglade V,Ammassari-Teule M

更新日期：2002-01-01 00:00:00

abstract：:Thrombin and other clotting factors regulate long-term potentiation (LTP) in the hippocampus through the activation of the protease activated receptor 1 (PAR1) and consequent potentiation of N-methyl-d-aspartate receptor (NMDAR) functions. We have recently shown that the activation of PAR1 either by thrombin or the an...

journal_title：Hippocampus

authors： Maggio N,Itsekson Z,Ikenberg B,Strehl A,Vlachos A,Blatt I,Tanne D,Chapman J

更新日期：2014-08-01 00:00:00