The relationship between behavior acquisition and persistence abilities: Involvement of adult hippocampal neurogenesis.

abstract：:Temporal difference learning (TD) is a popular algorithm in machine learning. Two learning signals that are derived from this algorithm, the predictive value and the prediction error, have been shown to explain changes in neural activity and behavior during learning across species. Here, the predictive value signal is...

journal_title：Hippocampus

authors： Okatan M

更新日期：2009-05-01 00:00:00

abstract：:A large body of evidence exists to demonstrate that excitatory amino acids (EAA) and their receptors are involved in the pathophysiological mechanisms linking several acute brain insults, such as cerebral ischemia, to neuronal degeneration and death. Accordingly, the use of EAA receptor antagonists can be beneficial i...

journal_title：Hippocampus

authors： Virgili M,Contestabile A,Barnabei O

更新日期：1995-01-01 00:00:00

abstract：:LTD of synaptic transmission is a form of long-term synaptic plasticity with the potential to be as significant as LTP to both the activity-dependent development of neural circuitry and adult memory storage. In addition, interactions between LTP and LTD and the dynamic regulation of the gain of synaptic plasticity mec...

journal_title：Hippocampus

authors： Stanton PK

更新日期：1996-01-01 00:00:00

abstract：:C57 and DBA mice were trained in a crossed maze to assess possible strain differences in place or response learning as a function of training duration (8 or 17 days) and extramaze cueing conditions. The first condition consisted of a diffuse visually cued environment (rich cueing). The second was the same plus an expl...

journal_title：Hippocampus

authors： Passino E,Middei S,Restivo L,Bertaina-Anglade V,Ammassari-Teule M

更新日期：2002-01-01 00:00:00

abstract：:Accurate and reproducible in vivo measurement of hippocampal volumes using magnetic resonance (MR) imaging is complicated by the morphological complexity of the structure. Additionally, separation of certain parts of the hippocampus from the adjacent brain structures on MR images is sometimes very difficult. These dif...

journal_title：Hippocampus

authors： Pantel J,O'Leary DS,Cretsinger K,Bockholt HJ,Keefe H,Magnotta VA,Andreasen NC

更新日期：2000-01-01 00:00:00

abstract：:In this review, we aim to reappraise the organization of intrinsic and extrinsic networks of the entorhinal cortex with a focus on the concept of parallel cortical connectivity streams. The concept of two entorhinal areas, the lateral and medial entorhinal cortex, belonging to two parallel input-output streams mediati...

journal_title：Hippocampus

authors： Nilssen ES,Doan TP,Nigro MJ,Ohara S,Witter MP

更新日期：2019-12-01 00:00:00

abstract：:Sleep is important for memory consolidation, and an abundant literature suggests that reactivation in the hippocampus during sleep is instrumental to this process. Yet, the current interpretation of activity during sharp-waves ripples (SWRs), as replay of wake experiences, relies on hypotheses that, while widely accep...

journal_title：Hippocampus

authors： Laventure S,Benchenane K

更新日期：2020-01-01 00:00:00

abstract：:Norepinephrine, is involved in the enhancement of learning and memory formation by regulating synaptic mechanisms through its ability to activate pre- and post-synaptic adrenergic receptors. Here we show that β-agonists of norepinephrine facilitate the induction of both associational LTP and sharp wave ripples (SPW-Rs...

journal_title：Hippocampus

authors： Ul Haq R,Anderson M,Liotta A,Shafiq M,Sherkheli MA,Heinemann U

更新日期：2016-12-01 00:00:00

abstract：:Hippocampal adult neurogenesis results in the persisting formation of new neurons that contribute to hippocampal-dependent learning and memory. This has led to the hypothesis that memory impairments associated with neurodegenerative diseases such as Alzheimer's disease may involve abnormal neurogenesis. Supporting thi...

journal_title：Hippocampus

authors： Dard RF,Dahan L,Rampon C

更新日期：2019-07-01 00:00:00

abstract：:People retain more new verbal episodic information for at least 7 days if they rest for a few minutes after learning than if they attend to new information. It is hypothesized that rest allows for superior consolidation of new memories. In rodents, rest periods promote hippocampal replay of a recently travelled route,...

journal_title：Hippocampus

authors： Craig M,Dewar M,Della Sala S,Wolbers T

更新日期：2015-09-01 00:00:00

abstract：:A couple of papers indicate that patients with depression show a decrease in serum neuropeptide Y (NPY). To study the role of NPY in depression, we examined the effects of infusion of NPY into the hippocampus of learned helplessness (LH) rats (an animal model of depression). Infusion of NPY into the cerebral ventricle...

journal_title：Hippocampus

authors： Ishida H,Shirayama Y,Iwata M,Katayama S,Yamamoto A,Kawahara R,Nakagome K

更新日期：2007-01-01 00:00:00

abstract：:The hippocampus is essential for learning and memory but also regulates emotional behavior. We previously identified the hippocampus as a major brain region that differs in rats bred for emotionality differences. Rats bred for low novelty response (LRs) exhibit high levels of anxiety- and depression-like behavior comp...

journal_title：Hippocampus

authors： Widman AJ,Cohen JL,McCoy CR,Unroe KA,Glover ME,Khan AU,Bredemann T,McMahon LL,Clinton SM

更新日期：2019-10-01 00:00:00

abstract：:In the present study, 93 cells in the superior colliculus (SC) were recorded extracellularly during the simultaneous occurrence of spontaneous theta field activity, sensory-induced (tail pinch) theta field activity, and large amplitude irregular (LIA) field activity, recorded from an electrode located in the stratum m...

journal_title：Hippocampus

authors： Natsume K,Hallworth NE,Szgatti TL,Bland BH

更新日期：1999-01-01 00:00:00

abstract：:Our model of the spatial and temporal aspects of place cell firing and their role in rat navigation is reviewed. The model provides a candidate mechanism, at the level of individual cells, by which place cell information concerning self-localization could be used to guide navigation to previously visited reward sites....

journal_title：Hippocampus

authors： Burgess N,O'Keefe J

更新日期：1996-01-01 00:00:00

abstract：:Multiple factors are involved in the glutamate-induced excitotoxicity phenomenon, such as overload of ionotropic and metabotropic receptors, excess Ca(2+) influx, nitric oxide synthase activation, oxidative damage due to increase in free radicals, and release of endogenous polyamine, among others. In order to attempt ...

journal_title：Hippocampus

authors： Ortuño-Sahagún D,Rivera-Cervantes MC,Gudiño-Cabrera G,Junyent F,Verdaguer E,Auladell C,Pallàs M,Camins A,Beas-Zárate C

更新日期：2012-02-01 00:00:00

abstract：:The hippocampus is essential for the consolidation of some explicit long-term memories, including trace conditioning. Lesions and pharmacological manipulations of the dorsal hippocampus (DH) have provided strong evidence for its involvement in the acquisition and expression of trace fear memories. However, no studies ...

journal_title：Hippocampus

authors： Pierson JL,Pullins SE,Quinn JJ

更新日期：2015-07-01 00:00:00

abstract：:Neural correlates of spatial representation can be found in the activity of the hippocampal place cells. These neurons are characterized by firing whenever the animal is located in a particular area of the space, the place field. Place fields are modulated by sensory cues, such as visual, auditory, or olfactory cues, ...

journal_title：Hippocampus

authors： Gener T,Perez-Mendez L,Sanchez-Vives MV

更新日期：2013-12-01 00:00:00

abstract：:One of the most striking features of the hippocampal network is its ability to self-generate neuronal sequences representing temporally compressed, spatially coherent paths. These brief events, often termed "replay" in the scientific literature, are largely confined to non-exploratory states such as sleep or quiet res...

journal_title：Hippocampus

authors： Pfeiffer BE

更新日期：2020-01-01 00:00:00

abstract：:Spatial navigation relies on multiple mnemonic mechanisms and previous work in younger adults has described two separate types of spatial memory. One type uses directional as well as boundary-related information for spatial memory and mainly implicates the hippocampal formation. The other type has been linked to direc...

journal_title：Hippocampus

authors： Schuck NW,Doeller CF,Schjeide BM,Schröder J,Frensch PA,Bertram L,Li SC

更新日期：2013-10-01 00:00:00

abstract：:Space and time are both essential features of episodic memory, for which the hippocampus is critical (Howard & Eichenbaum, 2015). Spatial tasks have been used effectively to study the behavioral relevance of place cells. However, the behavioral paradigms utilized for the study of time cells have not used time duration...

journal_title：Hippocampus

authors： Sabariego M,Tabrizi NS,Marshall GJ,McLagan AN,Jawad S,Hales JB

更新日期：2021-01-01 00:00:00

abstract：:The importance of the perirhinal cortex for visual recognition memory performance is undisputed. However, it has not been clear whether its contribution to performance is mainly perceptual, or mainly mnemonic, or whether the perirhinal cortex contributes to both perception and memory. We determined the effects of medi...

journal_title：Hippocampus

authors： Buffalo EA,Reber PJ,Squire LR

更新日期：1998-01-01 00:00:00

abstract：:Alzheimer's disease (AD) and ageing are associated with impaired learning and memory, and recent findings point toward modulating chromatin remodeling through histone acetylation as a promising therapeutic strategy. Here we report that systemic administration of the HDAC inhibitor 4-phenylbutyrate (PBA) reinstated fea...

journal_title：Hippocampus

authors： Ricobaraza A,Cuadrado-Tejedor M,Marco S,Pérez-Otaño I,García-Osta A

更新日期：2012-05-01 00:00:00

abstract：:In rodents, chronic stress induces long-lasting structural and functional alterations in the hippocampus, as well as learning and memory impairments. The neural cell adhesion molecule (NCAM) was previously hypothesized to be a key molecule in mediating the effects of stress due to its role in neuronal remodeling and s...

journal_title：Hippocampus

authors： Bisaz R,Schachner M,Sandi C

更新日期：2011-01-01 00:00:00

abstract：:Vasopressin receptors are present in both the developing and mature dentate gyrus of the rat brain and are of the V1 vasopressor type. Because vasopressin has been shown to influence memory function when injected into the dentate gyrus, the influence of this peptide on an electrophysiological model of learning and mem...

journal_title：Hippocampus

authors： Chen C,Díaz Brinton RD,Shors TJ,Thompson RF

更新日期：1993-04-01 00:00:00

abstract：:The electrically induced increase in hippocampal synaptic strength known as long-term potentiation (LTP) is thought to involve some of the same mechanisms as those mediating information storage during spatial learning. Physiological saturation of synaptic weights might therefore be expected to occlude spatial learning...

journal_title：Hippocampus

authors： Jeffery KJ,Morris RG

更新日期：1993-04-01 00:00:00

abstract：:Granule cells born in the adult dentate gyrus undergo a 4-week developmental period characterized by high susceptibility to cell death. Two forms of hippocampus-dependent learning have been shown to rescue many of the new neurons during this critical period. Here, we show that a natural form of associative learning, s...

journal_title：Hippocampus

authors： Olariu A,Cleaver KM,Shore LE,Brewer MD,Cameron HA

更新日期：2005-01-01 00:00:00

abstract：:This study examines whether 4-8-Hz theta oscillations can be seen in the human hippocampus, and whether these oscillations increase during virtual movement and searching, as they do in rodents. Recordings from both hippocampal and neocortical depth electrodes were analyzed while six epileptic patients played a virtual...

journal_title：Hippocampus

authors： Ekstrom AD,Caplan JB,Ho E,Shattuck K,Fried I,Kahana MJ

更新日期：2005-01-01 00:00:00

abstract：:This study investigated the effects of progesterone (P4) on the production and survival of neurons in the hippocampal dentate gyrus of adult male mice. The administration of P4 (4 mg/kg) for 3 consecutive days beginning on the 0-2nd day after the first BrdU-injection (BrdU-D(0-2)) produced an approximately twofold inc...

journal_title：Hippocampus

authors： Zhang Z,Yang R,Zhou R,Li L,Sokabe M,Chen L

更新日期：2010-03-01 00:00:00

abstract：:We have previously shown that in urethane-anesthetized rats the frequency of rhythmical slow activity in the hippocampus ("theta") is controlled by the medial supramammillary nucleus (SuM). In particular, injections of procaine into SuM in urethane-anesthetized animals reduce the frequency of theta. However, it has be...

journal_title：Hippocampus

authors： McNaughton N,Logan B,Panickar KS,Kirk IJ,Pan WX,Brown NT,Heenan A

更新日期：1995-01-01 00:00:00

abstract：:It is argued that while the hippocampus is not vital for all classes of configural learning, it is vital for a specific subclass of configural tasks called "structural learning." The defining feature of structural learning is that in addition to binding stimulus elements to make unique arrays (as in all configural lea...

journal_title：Hippocampus

authors： Aggleton JP,Sanderson DJ,Pearce JM

更新日期：2007-01-01 00:00:00