Abstract:
:One of the most striking features of the hippocampal network is its ability to self-generate neuronal sequences representing temporally compressed, spatially coherent paths. These brief events, often termed "replay" in the scientific literature, are largely confined to non-exploratory states such as sleep or quiet rest. Early studies examining the content of replay noted a strong correlation between the encoded spatial information and the animal's prior behavior; thus, replay was initially hypothesized to play a role in memory formation and/or systems-level consolidation via "off-line" reactivation of previous experiences. However, recent findings indicate that replay may also serve as a memory retrieval mechanism to guide future behavior or may be an incidental reflection of pre-existing network assemblies. Here, I will review what is known regarding the content of replay events and their correlation with past and future actions, and I will discuss how this knowledge might inform or constrain models which seek to explain the circuit-level mechanisms underlying these events and their role in mnemonic processes.
journal_name
Hippocampusjournal_title
Hippocampusauthors
Pfeiffer BEdoi
10.1002/hipo.22824subject
Has Abstractpub_date
2020-01-01 00:00:00pages
6-18issue
1eissn
1050-9631issn
1098-1063journal_volume
30pub_type
杂志文章相关文献
HIPPOCAMPUS文献大全abstract::Several recent studies have compared episodic and spatial memory in neuroimaging paradigms in order to understand better the contribution of the hippocampus to each of these tasks. In the present study, we build on previous findings showing common neural activation in default network areas during episodic and spatial ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22352
更新日期:2015-01-01 00:00:00
abstract::The modulatory actions of GABA(A) receptor subunits are crucial for morphological and transcriptional neuronal activities. In this study, growth of hamster hippocampal neurons on biohybrid membrane substrates allowed us to show for the first time that the two major GABA(A) alpha receptor subunits (alpha(2,5)) are capa...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20584
更新日期:2009-11-01 00:00:00
abstract::Two experiments assessed the effects of 1) combined subicular complex and posterior cingulate cortical lesions on training-induced neuronal activity (TIA) in the anterior ventral (AV) and medial dorsal (MD) thalamic nuclei; 2) hippocampal (Ammon's horn and dentate gyrus) lesions on TIA in cingulate cortex and in the A...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/(SICI)1098-1063(1998)8:5<491::AID-HIPO8>3.
更新日期:1998-01-01 00:00:00
abstract::For well over a century, ethanol was believed to exert its effects on cognition and behavior by producing a ubiquitous depression of central nervous system activity. A general disruption in brain function was consistent with the belief that ethanol's effects on cognition and behavior were also quite general. Substanti...
journal_title:Hippocampus
pub_type: 杂志文章,评审
doi:10.1002/(SICI)1098-1063(2000)10:1<88::AID-HIPO10>3
更新日期:2000-01-01 00:00:00
abstract::In the mammalian brain, newly acquired memories depend on the hippocampus (HPC) for maintenance and recall, but over time, the neocortex takes over these functions, rendering memories HPC-independent. The process responsible for this transformation is called systems memory consolidation. Reactivation of a well-consoli...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.23187
更新日期:2020-07-01 00:00:00
abstract::Functional neuroimaging is uniquely placed to examine the dynamic nature of normal human memory, the distributed brain networks that support it, and how they are modulated. Memory has traditionally been classified into context-specific memories personally experienced ("episodic memory") and impersonal non-context-spec...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/(SICI)1098-1063(1999)9:1<54::AID-HIPO6>3.0
更新日期:1999-01-01 00:00:00
abstract::It has been well-established that cell proliferation and neurogenesis in the adult mouse dentate gyrus (DG) can be regulated by voluntary exercise. Recent evidence has suggested that the effects of voluntary exercise can in turn be influenced by environmental factors that regulate the amount of stress an animal is exp...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20514
更新日期:2009-10-01 00:00:00
abstract::Entorhinal cortex lesion (ECL) leads to anterograde degeneration of perforant path axons and is known to induce a rapid and intense reaction of astrocytes and microglial cells in the deafferented dentate gyrus. Phagocytosis of degenerating axons involves the establishment and maintenance of cell-matrix and cell-cell i...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/(SICI)1098-1063(1997)7:3<341::AID-HIPO8>3.
更新日期:1997-01-01 00:00:00
abstract::This study examines the extent to which simultaneous olfactory discrimination learning increases spine density on hippocampal CA1 pyramidal neurons in C57BL/6J (C57) and DBA/2J (DBA) inbred mice, characterized by spontaneous differences in hippocampal plasticity and hippocampus-related learning. The behavioral data fi...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20174
更新日期:2006-01-01 00:00:00
abstract::At the neuromuscular junction, spontaneous miniature excitatory synaptic currents mediated by acetylcholine are considered elementary, "quantal" transmissions. These miniature conductances can be quantitatively dichotomized into a large-mode class whose mode is the mean of a normal, bell-shaped distribution and a smal...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.450030110
更新日期:1993-01-01 00:00:00
abstract::Hippocampal synaptic plasticity comprises a key cellular mechanism for information storage. In the hippocampus, both long-term potentiation (LTP) and long-term depression (LTD) are triggered by synaptic Ca2+ -elevations that are typically mediated by the opening of voltage-gated cation channels, such as N-methyl-d-asp...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22742
更新日期:2017-08-01 00:00:00
abstract::We often engage in counterfactual (CF) thinking, which involves reflecting on "what might have been." Creating alternative versions of reality seems to have parallels with recollecting the past and imagining the future in requiring the simulation of internally generated models of complex events. Given that episodic me...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22323
更新日期:2014-11-01 00:00:00
abstract::Both natural and synthetic cannabinoid receptor (e.g., CB1) agonists such as Δ(9)-THC, WIN 55,212-2 (WIN-2), and HU-210 disrupt spatial cognition presumably through the inhibition of synchrony of hippocampal ensemble firing to task-related events. Although the CB1 receptor agonist CP 55,940 also disrupts the synchrono...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20769
更新日期:2011-05-01 00:00:00
abstract::Ontogenesis of GABAergic signaling may play an important role in developmental changes in seizure susceptibility in the high-potassium model of ictogenesis in vitro. The age-dependent effects of [K(+)](o) on the reversal potential of the GABA(A)-mediated responses and membrane potential in hippocampal slices in vitro ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20259
更新日期:2007-01-01 00:00:00
abstract::We investigated the effects of a surgical lesion of one vestibular inner ear (unilateral vestibular damage [UVD]) on the field potential responses of CA1 neurons in vitro. Hippocampal slices were removed from rats at 4-6 weeks or 5-6 months post-UVD, and the field responses of CA1 neurons to electrical stimulation of ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.10174
更新日期:2003-01-01 00:00:00
abstract::The functional organization of the perforant path input to the dentate gyrus of the exposed hippocampus was studied in adult rabbits anesthetized with urethane and chloralose. Electrical stimulation of perforant path fibers caused excitation of granule cells along narrow, nearly transverse strips (lamellae) of tissue....
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20538
更新日期:2009-07-01 00:00:00
abstract::Recent evidence suggests that activity-regulated cytoskeleton associated protein (Arc) and brain-derived neurotrophic factor (BDNF) are key players in the cellular mechanisms that trigger synaptic changes and memory consolidation. Cholinergic deafferentiation of hippocampus has been largely shown to induce memory impa...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20812
更新日期:2011-09-01 00:00:00
abstract::Persistent neural activity lasting for seconds after transient stimulation has been observed in several brain areas. This activity has been taken to be indicative of the integration of inputs on long time scales. Passive membrane properties render neural time constants to be on the order of milliseconds. Intense synap...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20112
更新日期:2005-01-01 00:00:00
abstract::In this article, we present a framework to perform statistical shape analysis for segmented hippocampi, including an efficient permutation test for detecting subtle class differences, and a regularized discriminative direction method for visualizing the shape discrepancy. Fisher permutation and bootstrap tests are pre...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20639
更新日期:2009-06-01 00:00:00
abstract::The aim of this study was to investigate the role of the human hippocampus in episodic retrieval of odors, in comparison with episodic retrieval of visual objects. Subjects encoded a set of unique odors and objects, and retrieval was tested the next day during functional magnetic resonance imaging (fMRI). Subjects wer...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22073
更新日期:2013-02-01 00:00:00
abstract::By acting on serotonin 5-HT2A receptors (5-HT2A Rs), serotonergic psychedelic drugs induce perceptual and visual hallucinations by increasing neuronal excitability and altering visual-evoked neuronal responses. The present study was designed to examine whether the perceptual alterations induced by a serotonergic psych...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22712
更新日期:2017-05-01 00:00:00
abstract::The goal of the present research was to assess the degree to which a pattern completion process operates in cue-induced relapse to cocaine-seeking behavior. Using a novel cue-preference version of the place preference task, rats were administered cocaine or saline, which resulted in a preference for the cocaine-paired...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22570
更新日期:2016-07-01 00:00:00
abstract::Granule cells born in the adult dentate gyrus undergo a 4-week developmental period characterized by high susceptibility to cell death. Two forms of hippocampus-dependent learning have been shown to rescue many of the new neurons during this critical period. Here, we show that a natural form of associative learning, s...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20097
更新日期:2005-01-01 00:00:00
abstract::The induction of long-lasting memory storage depends on the behavioral state of humans and animals. This behavioral state is mediated by neuromodulatory systems, like the cholinergic-septum-hippocampal circuit. Cholinergic neurotransmission is known to affect short-term activity-dependent plasticity in various brain a...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20902
更新日期:2012-02-01 00:00:00
abstract::Lynn Nadel has been a trailblazer in memory research for decades. In just one example, Nadel and Zola-Morgan [Infantile amnesia, In Infant memory, Springer, Boston, MA, 1984, pp. 145-172] were the first to present the provocative notion that the extended development of the hippocampus may underlie the period of infant...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.23149
更新日期:2020-08-01 00:00:00
abstract::The mechanism supporting the role of the hippocampal formation in novelty detection remains controversial. A comparator function has been variously ascribed to CA1 or subiculum, whereas the theta rhythm has been suggested to separate neural firing into encoding and retrieval phases. We investigated theta phase of firi...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20671
更新日期:2010-02-01 00:00:00
abstract::Watermaze tests of place learning and memory in rodents and corresponding reverse-translated human paradigms in real or virtual environments are key tools to study hippocampal function. In common variants, the animal or human participant has to find a hidden goal that remains in the same place over many trials, allowi...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22992
更新日期:2018-11-01 00:00:00
abstract::Neurogenesis persists in the adult rat rostral forebrain subventricular zone (SVZ) and is stimulated by status epilepticus (SE). More caudal SVZ (cSVZ) neural progenitors migrate to the hippocampus after ischemic injury and contribute to CA1 pyramidal cell regeneration. Because SE also damages the hippocampus, we exam...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20166
更新日期:2006-01-01 00:00:00
abstract::High-frequency stimulation of excitatory synapses in many regions of the brain triggers a lasting increase in the efficacy of synaptic transmission referred to as long-term potentiation (LTP) and believed to contribute to learning and memory. One hypothesis proposed to account for the stability and properties of this ...
journal_title:Hippocampus
pub_type: 杂志文章,评审
doi:10.1002/1098-1063(2000)10:5<596::AID-HIPO10>3.0.CO
更新日期:2000-01-01 00:00:00
abstract::The past decade has witnessed burgeoning evidence that antidepressant medications and physical exercise increase the expression of hippocampal brain-derived neurotrophic factor (BDNF). This phenomenon has gained widespread appeal, because BDNF is one of the first macromolecules observed to play a central role not only...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20579
更新日期:2009-10-01 00:00:00