Abstract:
:The mechanism supporting the role of the hippocampal formation in novelty detection remains controversial. A comparator function has been variously ascribed to CA1 or subiculum, whereas the theta rhythm has been suggested to separate neural firing into encoding and retrieval phases. We investigated theta phase of firing in principal cells in subiculum and CA1 as rats foraged in familiar and novel environments. We found that the preferred theta phase of firing in CA1, but not subiculum, was shifted to a later phase of the theta cycle during environmental novelty. Furthermore, the amount of phase shift elicited by environmental change correlated with the extent of place cell remapping in CA1. Our results support a relationship between theta phase and novelty-induced plasticity in CA1.
journal_name
Hippocampusjournal_title
Hippocampusauthors
Lever C,Burton S,Jeewajee A,Wills TJ,Cacucci F,Burgess N,O'Keefe Jdoi
10.1002/hipo.20671subject
Has Abstractpub_date
2010-02-01 00:00:00pages
229-34issue
2eissn
1050-9631issn
1098-1063journal_volume
20pub_type
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